# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to topologically incorrect protein	14	4.674167e-44	4.393383110928572e-41	2.436229	317	0.01986216	150	4.2497867766666663e-13	1.491414	125	139	0.01104045	
GO Biological Process	endoplasmic reticulum unfolded protein response	18	2.209569e-41	1.6153176928333335e-38	2.569274	269	0.01685464	195	2.3817594302051283e-10	1.483879	102	114	0.009009009	
GO Biological Process	IRE1-mediated unfolded protein response	19	5.431081e-40	3.761452362052632e-37	3.505296	161	0.01008772	328	0.000004594625325609756	1.515483	53	58	0.004681152	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	20	9.151704e-40	6.0213636468e-37	8.882276	67	0.004197995	1013	0.04966401451924975	1.658453	11	11	0.0009715598	
GO Biological Process	response to topologically incorrect protein	21	5.353717e-37	3.3547410477619047e-34	2.097161	364	0.02280702	181	2.5977225520994475e-11	1.409685	153	180	0.01351351	
GO Biological Process	cellular response to unfolded protein	22	1.065309e-36	6.37200051409091e-34	2.36477	278	0.01741855	187	8.34923772513369e-11	1.480272	108	121	0.009538951	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	25	8.504486e-36	4.476421250960001e-33	2.395485	264	0.01654135	308	0.0000014864026156168832	1.394274	95	113	0.008390744	
GO Biological Process	nuclear-transcribed mRNA catabolic process	32	3.022199e-32	1.24278489503125e-29	2.009456	350	0.02192982	134	5.548239972164179e-14	1.4323	171	198	0.01510334	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	33	3.449393e-32	1.3754715905151515e-29	4.092388	106	0.006641604	766	0.012430872675065274	1.520248	22	24	0.00194312	
GO Biological Process	regulation of DNA-templated transcription in response to stress	37	6.051773e-32	2.1523048893783784e-29	2.213967	276	0.01729323	279	2.081809454551971e-7	1.407594	101	119	0.008920685	
GO Biological Process	response to unfolded protein	43	4.433638e-30	1.3567963358604654e-27	2.015268	323	0.0202381	213	1.6654024222065726e-9	1.399319	135	160	0.01192369	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	45	2.4716e-29	7.227507644444444e-27	2.419192	210	0.01315789	241	2.2067735822821577e-8	1.433578	102	118	0.009009009	
GO Biological Process	protein targeting to ER	49	2.666863e-28	7.161887799387755e-26	2.498908	190	0.01190476	208	1.2968782859134616e-9	1.494249	91	101	0.008037449	
GO Biological Process	viral gene expression	52	9.949043e-28	2.51768186225e-25	2.295313	220	0.01378446	202	9.261375857920793e-10	1.449514	111	127	0.009803922	
GO Biological Process	multi-organism metabolic process	55	2.683543e-27	6.420498606727273e-25	2.098874	264	0.01654135	193	2.1087331590673574e-10	1.432813	127	147	0.0112171	
GO Biological Process	cotranslational protein targeting to membrane	58	1.300825e-25	2.9513027887931035e-23	2.452656	177	0.01109023	238	2.0725502405882353e-8	1.4723	87	98	0.007684155	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	62	5.568035e-25	1.1817705252419355e-22	2.485646	168	0.01052632	229	7.782054465065501e-9	1.496213	83	92	0.00733086	
GO Biological Process	protein localization to endoplasmic reticulum	68	3.049748e-24	5.901710872352941e-22	2.137083	223	0.01397243	191	1.3223995814659687e-10	1.471208	110	124	0.009715598	
GO Biological Process	viral transcription	72	2.380826e-23	4.351290185277778e-21	2.218084	197	0.01234336	246	3.199114445447155e-8	1.438304	98	113	0.008655715	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	74	4.72362e-23	8.39974534864865e-21	2.224899	193	0.01209273	210	1.462474967904762e-9	1.48471	94	105	0.00830242	
GO Cellular Component	ribosomal subunit	29	1.159776e-26	6.910665268965517e-25	2.021891	282	0.01766917	56	9.257065714285714e-11	1.389514	155	185	0.01369016	
GO Cellular Component	mitochondrial ribosome	43	2.591616e-21	1.0414680111627906e-19	2.59243	131	0.00820802	82	4.823773112195121e-8	1.482852	76	85	0.006712595	
GO Cellular Component	large ribosomal subunit	45	1.303441e-20	5.00521344e-19	2.163456	182	0.01140351	80	2.6050247999999998e-8	1.427711	99	115	0.008744038	
GO Cellular Component	mitochondrial large ribosomal subunit	50	5.064373e-16	1.7502473088e-14	2.796768	84	0.005263158	108	0.000033500512	1.495859	46	51	0.004062886	
GO Cellular Component	nuclear ubiquitin ligase complex	53	3.56118e-15	1.1610790641509435e-13	2.736097	82	0.005137845	147	0.00038396089469387755	1.492607	36	40	0.00317965	
GO Cellular Component	endopeptidase complex	65	1.036e-12	2.754166153846154e-11	2.061633	119	0.00745614	184	0.00444985732173913	1.321955	55	69	0.004857799	
GO Cellular Component	proteasome complex	70	4.317155e-12	1.0657205485714286e-10	2.028129	117	0.007330827	190	0.005758463595789474	1.317006	54	68	0.004769475	
GO Cellular Component	spliceosomal snRNP complex	73	8.549892e-12	2.023864846027397e-10	2.167781	97	0.006077694	150	0.0006105859200000001	1.39096	52	62	0.004592828	
GO Cellular Component	COPI-coated vesicle	81	4.425677e-11	9.441444266666665e-10	2.743064	57	0.003571429	260	0.036978861046153846	1.442133	20	23	0.001766472	
GO Cellular Component	MLL1 complex	91	4.482911e-10	8.512604624175824e-9	2.524968	59	0.003696742	157	0.0009089398868789808	1.544077	27	29	0.002384738	
GO Cellular Component	DNA-directed RNA polymerase III complex	94	9.14417e-10	1.680970825531915e-8	3.688587	32	0.002005013	263	0.03842004976425855	1.483879	17	19	0.001501502	
GO Cellular Component	ESCRT complex	97	1.963222e-9	3.4973686762886595e-8	2.538914	54	0.003383459	234	0.025725548307692307	1.421531	24	28	0.002119767	
GO Cellular Component	INO80-type complex	132	1.114254e-7	0.000001458659781818182	2.773681	36	0.002255639	130	0.00011656629415384615	1.658453	23	23	0.002031443	
GO Cellular Component	Ino80 complex	187	0.000004090284	0.00003779684894117647	2.903965	25	0.001566416	173	0.003036826154913295	1.658453	16	16	0.001413178	
GO Cellular Component	retromer complex	196	0.000007877961	0.00006945467657142856	2.004638	49	0.003070175	224	0.01979073	1.500505	19	21	0.001678149	
GO Cellular Component	proteasome accessory complex	199	0.000008633394	0.00007496736096482411	2.198747	39	0.002443609	240	0.027310139999999997	1.451146	21	24	0.001854796	
GO Cellular Component	CCR4-NOT complex	202	0.000009247523	0.00007910752348514851	2.217885	38	0.002380952	235	0.02581966570212766	1.554799	15	16	0.001324854	
GO Cellular Component	pronucleus	234	0.00004954158	0.0003658455138461538	2.204564	32	0.002005013	255	0.03722598550588235	1.547889	14	15	0.001236531	
GO Cellular Component	exosome (RNase complex)	249	0.00008876738	0.0006160242274698796	2.009556	37	0.002318296	260	0.036978861046153846	1.442133	20	23	0.001766472	
GO Cellular Component	very-low-density lipoprotein particle	251	0.00009164994	0.0006309605431075697	2.028286	36	0.002255639	186	0.005285574812903226	1.57553	19	20	0.001678149	
GO Molecular Function	rRNA binding	9	8.069989e-22	3.7857215064444446e-19	3.129833	99	0.006203008	150	0.026167519726666668	1.326762	48	60	0.004239534	
GO Molecular Function	unfolded protein binding	11	6.345082e-19	2.4353578367272726e-16	2.156659	167	0.01046366	86	0.0004616389293255814	1.329891	85	106	0.007507508	
GO Molecular Function	SUMO transferase activity	16	4.488183e-14	1.184319289125e-11	3.129103	61	0.003822055	148	0.02568067444054054	1.571166	18	19	0.001589825	
GO Molecular Function	snRNA binding	21	2.444949e-13	4.9155117514285717e-11	2.884363	65	0.004072682	157	0.036260472203821656	1.396592	32	38	0.002826356	
GO Molecular Function	DNA polymerase binding	27	3.853264e-11	6.025363188148148e-9	3.987091	34	0.002130326	128	0.010028374767187499	1.658453	16	16	0.001413178	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	45	1.439964e-9	1.3510062240000003e-7	2.278424	68	0.004260652	145	0.024390488176551723	1.388472	36	43	0.00317965	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	64	4.151818e-8	0.000002738902436875	2.07123	69	0.004323308	135	0.016351074186666665	1.486889	26	29	0.002296414	
GO Molecular Function	pseudouridine synthase activity	145	0.000004958273	0.00014437123176551722	3.22622	21	0.001315789	158	0.03711357116455696	1.658453	13	13	0.001148207	
GO Molecular Function	intramolecular transferase activity	146	0.000005368205	0.0001552367226712329	2.088313	46	0.002882206	97	0.0015155534944329896	1.594666	25	26	0.00220809	
GO Molecular Function	mannosyltransferase activity	202	0.00003006581	0.0006284051971287129	2.075048	39	0.002443609	142	0.02151480357605634	1.520248	22	24	0.00194312	
GO Molecular Function	ubiquitin protein ligase activity involved in ERAD pathway	306	0.00023954	0.0033050257516339865	2.334696	23	0.001441103	158	0.03711357116455696	1.658453	13	13	0.001148207	
GO Molecular Function	aminoacyl-tRNA editing activity	308	0.0002521723	0.0034567254889610387	2.326007	23	0.001441103	158	0.03711357116455696	1.658453	13	13	0.001148207	
Human Phenotype	Increased serum lactate	2	2.921799e-19	9.7485823635e-16	2.105602	180	0.0112782	9	7.508207508888889e-12	1.558945	94	100	0.00830242	
Human Phenotype	Abnormality of mitochondrial metabolism	8	7.739973e-14	6.456104978625e-11	2.031191	136	0.008521303	57	0.00002836497963508772	1.466168	61	69	0.005387741	
Human Phenotype	Abnormality of the mitochondrion	9	9.405876e-14	6.973934505333334e-11	2.013861	138	0.008646617	52	0.000014233496167307694	1.471585	63	71	0.005564388	
Human Phenotype	Exercise intolerance	14	3.245566e-13	1.546975851285714e-10	2.155338	112	0.007017544	76	0.00028324505548684207	1.421531	60	70	0.005299417	
Human Phenotype	Abnormal CSF metabolite level	16	4.428698e-13	1.847043859625e-10	2.216128	104	0.006516291	50	0.000012071803996	1.500505	57	63	0.005034446	
Human Phenotype	Increased CSF lactate	23	2.745508e-12	7.965554297391304e-10	2.235339	95	0.005952381	53	0.000014419370935849055	1.515483	53	58	0.004681152	
Human Phenotype	External ophthalmoplegia	67	2.806549e-8	0.0000027952390264179106	2.023296	75	0.004699248	111	0.0013124252001801803	1.554799	30	32	0.002649709	
Human Phenotype	Abnormal glycosylation	96	1.40859e-7	0.00000979116778125	2.621369	39	0.002443609	245	0.04599195020408164	1.507684	20	22	0.001766472	
Human Phenotype	Dysphonia	145	0.000002398615	0.00011038591651724137	2.016675	54	0.003383459	218	0.03389446275688073	1.514239	21	23	0.001854796	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	45	2.460934e-12	5.007727252888889e-10	2.019606	121	0.007581454	48	0.000009386455342916668	1.520248	55	60	0.004857799	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	247	0.00001018221	0.0003774837934008097	2.017167	47	0.002944862	172	0.03852407929825581	1.520248	22	24	0.00194312	
Mouse Phenotype Single KO	abnormal antigen presentation via MHC class I	331	0.00007973219	0.0022057633348338368	2.586423	22	0.001378446	177	0.04330623114067797	1.658453	14	14	0.001236531	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	75	2.892397e-11	3.6872276956e-9	2.490946	69	0.004323308	172	0.0029522377977906976	1.547889	28	30	0.002473061	
Mouse Phenotype	abnormal antigen presentation via MHC class I	289	0.000008262943	0.0002733633149584775	2.784238	25	0.001566416	233	0.012475837039055793	1.658453	16	16	0.001413178	
Mouse Phenotype	abnormal level of surface class I molecules	369	0.00005941303	0.0015394254195934959	2.794688	20	0.001253133	279	0.028685971106451616	1.658453	14	14	0.001236531