# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 119 4.751754e-47 5.2544815870588234e-45 3.578722 186 0.006854868 996 0.030792178906626506 1.460336 16 16 0.001244361 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 135 5.663296e-45 5.520245338074074e-43 2.18289 409 0.01507334 807 0.010708583851672863 1.201869 93 113 0.007232851 GO Biological Process regulation of DNA-templated transcription in response to stress 143 9.051384e-44 8.329172171748252e-42 2.085467 442 0.01628953 667 0.003930997737031485 1.214901 99 119 0.007699487 GO Biological Process cellular response to epidermal growth factor stimulus 154 2.318453e-42 1.981072923831169e-40 2.486632 294 0.01083511 432 0.0003127678029398148 1.421906 37 38 0.002877586 GO Biological Process endoplasmic reticulum unfolded protein response 159 1.376803e-41 1.1394560174213838e-39 2.162907 385 0.01418884 445 0.0003990536241348315 1.255377 98 114 0.007621714 GO Biological Process cellular response to topologically incorrect protein 163 9.36778e-41 7.562614541104295e-39 2.016103 446 0.01643694 319 0.000012202311824451412 1.271228 121 139 0.009410484 GO Biological Process response to epidermal growth factor 167 5.175568e-40 4.078161635449102e-38 2.374767 303 0.0111668 385 0.00008454842067792208 1.425566 41 42 0.003188676 GO Biological Process positive regulation of mRNA metabolic process 179 1.029213e-37 7.566152998324023e-36 2.444782 269 0.009913761 1004 0.030876099350597607 1.263752 45 52 0.003499767 GO Biological Process cellular response to unfolded protein 191 1.118043e-36 7.702789443455497e-35 2.011357 402 0.01481536 386 0.0000862972674507772 1.267234 105 121 0.008166122 GO Biological Process regulation of cyclin-dependent protein serine/threonine kinase activity 200 3.808468e-36 2.5057815206000002e-34 2.044603 380 0.01400457 525 0.0013119440286285715 1.280048 71 81 0.005521854 GO Biological Process regulation of cyclin-dependent protein kinase activity 202 7.309381e-36 4.7615913157920794e-34 2.002672 397 0.01463109 545 0.0014854741174862385 1.271351 74 85 0.005755172 GO Biological Process IRE1-mediated unfolded protein response 215 2.685663e-34 1.6437506705581394e-32 2.663675 208 0.007665659 771 0.008850833857457847 1.284089 51 58 0.003966402 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 240 1.761748e-32 9.659517471666667e-31 2.00664 356 0.01312007 873 0.016435606073310422 1.211768 78 94 0.006066262 GO Biological Process liver regeneration 257 4.045752e-31 2.0715194773540855e-29 2.570502 200 0.007370826 482 0.0008097690959128632 1.418612 34 35 0.002644268 GO Biological Process regulation of plasma lipoprotein particle levels 270 1.876218e-30 9.144130615555555e-29 2.1385 285 0.01050343 617 0.002599305587682334 1.280295 64 73 0.004977446 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 277 9.369817e-30 4.451170465812274e-28 2.059888 304 0.01120366 889 0.01735590688863892 1.18807 96 118 0.007466169 GO Biological Process regulation of mitochondrial membrane permeability 313 1.940822e-27 8.159513322044728e-26 2.003411 299 0.01101939 282 0.00000245048297893617 1.380318 69 73 0.005366309 GO Biological Process cholesterol homeostasis 374 7.027448e-25 2.4725718778609628e-23 2.040938 257 0.009471512 1041 0.03592074548799232 1.241286 51 60 0.003966402 GO Biological Process cotranslational protein targeting to membrane 390 3.712338e-24 1.2525809164615383e-22 2.037616 250 0.009213533 554 0.0016716856311552346 1.251717 84 98 0.006532898 GO Biological Process plasma lipoprotein particle clearance 430 3.473071e-22 1.0628404950930234e-20 2.240007 183 0.006744306 492 0.0009234330924593496 1.3891 39 41 0.003033131 GO Cellular Component high-density lipoprotein particle 59 3.179996e-32 9.31361540338983e-31 3.88343 113 0.004164517 116 0.007210722041379311 1.406249 26 27 0.002022087 GO Cellular Component plasma lipoprotein particle 108 1.060534e-17 1.6968544e-16 2.108277 164 0.006044078 108 0.0048001424 1.350811 37 40 0.002877586 GO Cellular Component protein-lipid complex 109 1.094105e-17 1.734507743119266e-16 2.081226 169 0.006228348 100 0.002795302656 1.356026 39 42 0.003033131 GO Molecular Function unfolded protein binding 38 4.273297e-25 4.7478578773684213e-23 2.020532 266 0.009803199 99 0.009181830749494949 1.226131 89 106 0.006921761 Human Phenotype CNS hypomyelination 291 5.507748e-9 1.262996646185567e-7 2.033134 82 0.003022039 241 0.03428883670124481 1.36298 28 30 0.002177633 Mouse Phenotype Single KO extramedullary hematopoiesis 57 5.322266e-43 8.550173642456141e-41 2.008565 476 0.01754257 255 0.008462231477647058 1.216947 95 114 0.007388396 Mouse Phenotype Single KO pale liver 74 6.991862e-37 8.651956801891893e-35 2.153697 343 0.01264097 169 0.0010653410931952662 1.296048 71 80 0.005521854 Mouse Phenotype Single KO disorganized yolk sac vascular plexus 333 1.7679e-16 4.86145954954955e-15 2.141782 146 0.005380703 324 0.02112433982469136 1.460336 19 19 0.001477679 Mouse Phenotype pancytopenia 222 4.686566e-26 2.0183899786486487e-24 2.517684 172 0.006338911 600 0.027053184134999998 1.359623 27 29 0.00209986 Mouse Phenotype increased follicular B cell number 300 1.519135e-21 4.8414832450000006e-20 2.151395 194 0.007149701 709 0.04428309979125529 1.323429 29 32 0.002255405 Mouse Phenotype decreased liver cholesterol level 305 3.148097e-21 9.868509972786885e-20 2.260811 171 0.006302056 709 0.04428309979125529 1.323429 29 32 0.002255405 Mouse Phenotype abnormal lipid metabolism 473 2.279758e-15 4.608195821987315e-14 2.458338 101 0.003722267 709 0.04428309979125529 1.323429 29 32 0.002255405