# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	maintenance of protein location in cell	25	5.156136e-24	2.71398374496e-21	2.064898	240	0.0114882	671	0.006639486213412816	1.337443	61	82	0.005840674	
GO Biological Process	corpus callosum development	29	5.693086e-23	2.5832868508275864e-20	3.166028	103	0.004930353	937	0.027388527483457846	1.678016	14	15	0.001340483	
GO Biological Process	positive regulation of mRNA catabolic process	32	4.771781e-22	1.9622458180937498e-19	2.614511	134	0.006414245	997	0.03652732501905717	1.510214	21	25	0.002010724	
GO Biological Process	negative regulation of Notch signaling pathway	90	6.816691e-17	9.96675965211111e-15	2.260271	133	0.006366378	454	0.0003508493738105727	1.634431	30	33	0.002872463	
GO Biological Process	negative regulation of carbohydrate metabolic process	97	1.599214e-16	2.1694904150515463e-14	2.163084	143	0.006845053	800	0.012706437316875001	1.44707	33	41	0.003159709	
GO Biological Process	regulation of pri-miRNA transcription from RNA polymerase II promoter	104	3.471947e-16	4.393014478173077e-14	2.033245	162	0.007754535	729	0.008618681095610425	1.549892	25	29	0.002393719	
GO Biological Process	regulation of mRNA catabolic process	135	9.412336e-15	9.17458736474074e-13	2.056307	142	0.006797185	1036	0.04158522168050194	1.449899	25	31	0.002393719	
GO Biological Process	negative regulation of cellular carbohydrate metabolic process	136	1.07978e-14	1.0447665455882353e-12	2.095741	135	0.006462113	974	0.03223374058521561	1.419375	30	38	0.002872463	
GO Biological Process	IRE1-mediated unfolded protein response	138	1.742429e-14	1.6614944355797103e-12	2.129033	128	0.00612704	1002	0.036677573776447106	1.332907	43	58	0.004117196	
GO Biological Process	gene silencing by miRNA	147	5.037629e-14	4.50953469462585e-12	2.050764	135	0.006462113	812	0.013064433462315271	1.430127	35	44	0.003351206	
GO Biological Process	nucleus localization	247	7.059035e-11	3.7607223305668016e-9	2.281226	79	0.003781533	967	0.03189733435160289	1.55271	19	22	0.001819226	
GO Biological Process	mitral valve morphogenesis	295	4.044862e-10	1.8042826799322032e-8	2.336879	69	0.003302858	1003	0.03711057098005982	1.797874	10	10	0.0009574876	
GO Biological Process	response to water	393	8.625351e-9	2.888066000229008e-7	2.648201	46	0.002201905	1037	0.04177617042719382	1.669455	13	14	0.001244734	
GO Biological Process	anatomical structure regression	1193	0.0001407899	0.0015529373797988266	2.005054	35	0.001675363	902	0.02294289156430155	1.797874	11	11	0.001053236	
GO Cellular Component	nuclear transcriptional repressor complex	38	1.236899e-17	5.624635452631579e-16	2.392828	124	0.00593557	125	0.0066005356032	1.549892	25	29	0.002393719	
GO Cellular Component	cytoplasmic stress granule	40	5.777868e-17	2.496038976e-15	2.177859	145	0.006940788	140	0.014404546285714288	1.421575	34	43	0.003255458	
GO Cellular Component	TOR complex	90	6.301264e-9	1.209842688e-7	2.344118	59	0.002824183	151	0.022317840953642386	1.678016	14	15	0.001340483	
GO Cellular Component	Ino80 complex	146	9.552965e-7	0.00001130652295890411	2.750975	31	0.001483893	138	0.014410706086956524	1.685507	15	16	0.001436231	
GO Cellular Component	INO80-type complex	153	0.000001377657	0.000015559420235294118	2.354441	40	0.0019147	143	0.017939213874125875	1.563369	20	23	0.001914975	
GO Molecular Function	protein deacetylase activity	24	2.523071e-16	4.438502400833333e-14	2.072635	156	0.00746733	131	0.01785683942137405	1.4383	36	45	0.003446955	
GO Molecular Function	histone deacetylase activity	25	4.467718e-16	7.545082158400001e-14	2.069086	154	0.007371595	141	0.024139198164539008	1.430127	35	44	0.003351206	
GO Molecular Function	NAD-dependent protein deacetylase activity	86	1.569099e-9	7.703181369767442e-8	2.29003	67	0.003207123	136	0.02101142250882353	1.692117	16	17	0.00153198	
GO Molecular Function	NAD-dependent histone deacetylase activity	88	2.842568e-9	1.3637866018181815e-7	2.287143	65	0.003111388	150	0.032392732066666666	1.685507	15	16	0.001436231	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase inhibitor activity	308	0.00007547279	0.0010345653226623377	2.252618	29	0.001388158	143	0.02581376858181818	1.797874	12	12	0.001148985	
Human Phenotype	Aplasia/hypoplasia of the femur	125	9.487831e-11	5.06498370104e-9	2.029111	102	0.004882485	217	0.045672195331797234	1.470988	27	33	0.002585216	
Mouse Phenotype Single KO	thin interventricular septum	8	5.085455e-24	5.820938929375e-21	3.108911	111	0.005313293	429	0.004952718201165501	1.703249	18	19	0.001723478	
Mouse Phenotype Single KO	abnormal interventricular septum thickness	10	9.520191e-24	8.7176388987e-21	2.323839	182	0.008711886	291	0.0006657872189347079	1.547008	37	43	0.003542704	
Mouse Phenotype Single KO	thoracic vertebral transformation	90	6.117232e-14	6.223943713777778e-12	2.033048	137	0.006557848	319	0.0013473107456739811	1.498229	40	48	0.00382995	
Mouse Phenotype Single KO	decreased spongiotrophoblast size	110	3.035443e-13	2.5268683228181817e-11	2.636592	75	0.003590063	703	0.03799253628165007	1.598111	16	18	0.00153198	
Mouse Phenotype Single KO	abnormal synaptic vesicle recycling	274	8.14119e-9	2.72076192810219e-7	2.480491	52	0.00248911	575	0.018327616060869568	1.685507	15	16	0.001436231	
Mouse Phenotype Single KO	fusion of atlas and odontoid process	277	9.344589e-9	3.089111966534296e-7	2.246577	63	0.003015653	697	0.03716174668436155	1.797874	10	10	0.0009574876	
Mouse Phenotype Single KO	fusion of atlas and occipital bones	387	1.886563e-7	0.00000446389079870801	2.457857	43	0.002058303	697	0.03716174668436155	1.797874	10	10	0.0009574876	
Mouse Phenotype	abnormal sternebra number	33	2.939329e-20	8.516037748181819e-18	4.509398	58	0.002776315	1209	0.043759415873449135	1.659576	12	13	0.001148985	
Mouse Phenotype	abnormal neck morphology	34	3.023755e-20	8.502976927941178e-18	4.178687	63	0.003015653	1048	0.02580582323187023	1.797874	10	10	0.0009574876	
Mouse Phenotype	fusion of atlas and occipital bones	86	4.319952e-15	4.80268152e-13	3.307239	61	0.002919918	1086	0.028983977814917124	1.669455	13	14	0.001244734	
Mouse Phenotype	decreased spongiotrophoblast size	87	5.059392e-15	5.560097346206896e-13	2.75893	80	0.0038294	958	0.017940767392484343	1.608624	17	19	0.001627729	
Mouse Phenotype	ectopic cortical neuron	196	3.606666e-11	1.7593537564285715e-9	2.956197	51	0.002441243	1190	0.04087498633865546	1.797874	9	9	0.0008617388	
Mouse Phenotype	ectopic thymus	259	6.68933e-10	2.4693700436293436e-8	2.144796	81	0.003877268	1209	0.043759415873449135	1.659576	12	13	0.001148985	
Mouse Phenotype	fusion of atlas and odontoid process	285	1.954453e-9	6.556675485263159e-8	2.310108	65	0.003111388	930	0.016167846332258064	1.797874	11	11	0.001053236	
Mouse Phenotype	abnormal stapedial artery morphology	319	5.341131e-9	1.6008323978369906e-7	2.087122	77	0.003685798	1228	0.04467411507654723	1.528193	17	20	0.001627729	
Mouse Phenotype	delayed hepatic development	376	4.51295e-8	0.000001147561567819149	2.031672	72	0.00344646	693	0.0037278532151515157	1.797874	14	14	0.001340483	
Mouse Phenotype	enlarged inguinal lymph nodes	381	5.309517e-8	0.000001332396116456693	2.485625	46	0.002201905	1190	0.04087498633865546	1.797874	9	9	0.0008617388