# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process tumor necrosis factor-mediated signaling pathway 82 3.074753e-29 4.934228625243902e-27 2.231706 247 0.01595504 475 0.0002808820408631579 1.308246 99 128 0.008918115 GO Biological Process intrinsic apoptotic signaling pathway in response to DNA damage 112 5.851597e-26 6.875104010982144e-24 2.516604 171 0.0110458 461 0.00020915311368112797 1.421815 58 69 0.005224755 GO Biological Process DNA replication-dependent nucleosome assembly 115 1.349382e-25 1.544045020695652e-23 7.599399 47 0.00303598 736 0.008897068086141303 1.480036 28 32 0.002522295 GO Biological Process telomere organization 119 7.972551e-25 8.816033496554622e-23 2.229439 208 0.01343582 249 1.0951009640562249e-7 1.431243 99 117 0.008918115 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 128 2.23533e-23 2.29802402109375e-21 2.256517 190 0.01227311 365 0.00002131456604821918 1.361776 95 118 0.008557788 GO Biological Process translational elongation 138 1.348125e-22 1.2855055706521738e-20 2.235 187 0.01207932 162 1.2364659401851852e-10 1.51024 100 112 0.009008197 GO Biological Process regulation of type I interferon production 142 4.282329e-22 3.9683920641549296e-20 2.000001 237 0.01530909 647 0.00391939086228748 1.265164 92 123 0.008287542 GO Biological Process negative regulation of gene expression, epigenetic 144 8.35303e-22 7.633161234027778e-20 2.206812 185 0.01195013 715 0.00733495726979021 1.261183 85 114 0.007656968 GO Biological Process endoplasmic reticulum unfolded protein response 148 2.48736e-21 2.2115655567567567e-19 2.067813 210 0.01356502 246 8.587076623983739e-8 1.439233 97 114 0.008737952 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 152 3.66324e-21 3.1713536289473686e-19 3.169989 94 0.006071959 660 0.004421124931818182 1.691469 16 16 0.001441312 GO Biological Process positive regulation of gene expression, epigenetic 156 9.815447e-21 8.279581222628206e-19 2.44301 142 0.009172534 560 0.0013986555411071428 1.353175 64 80 0.005765246 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 158 1.302016e-20 1.0843815534177214e-18 2.48081 137 0.008849558 521 0.0008298032565642995 1.440881 46 54 0.004143771 GO Biological Process viral gene expression 168 6.585714e-20 5.1584172932142856e-18 2.075919 193 0.01246689 296 0.0000014042320103040542 1.38514 104 127 0.009368525 GO Biological Process cotranslational protein targeting to membrane 185 5.155015e-19 3.6667482370270274e-17 2.228547 156 0.01007687 326 0.000005740847867177914 1.415311 82 98 0.007386722 GO Biological Process mitochondrial translational termination 189 6.27364e-19 4.367980357671958e-17 2.3655 137 0.008849558 187 3.1865004045989305e-9 1.535932 79 87 0.007116476 GO Biological Process regulation of hematopoietic progenitor cell differentiation 190 8.415181e-19 5.828177198894737e-17 2.09194 178 0.01149797 462 0.000215360165517316 1.332219 89 113 0.008017296 GO Biological Process mitochondrial translational elongation 191 9.774316e-19 6.734043154136126e-17 2.369612 135 0.008720367 179 1.1409036784916201e-9 1.552172 78 85 0.007026394 GO Biological Process interferon-gamma-mediated signaling pathway 199 2.659913e-18 1.7588841792462312e-16 2.225808 150 0.009689297 618 0.0029291657192556638 1.374319 52 64 0.004684263 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 208 7.083579e-18 4.481385387548076e-16 2.226982 146 0.009430915 389 0.00003903290912082262 1.397301 76 92 0.00684623 GO Biological Process viral transcription 215 1.168077e-17 7.149174531627907e-16 2.042952 176 0.01136877 351 0.000012486867522222221 1.377125 92 113 0.008287542 GO Cellular Component ribosomal subunit 35 9.473051e-26 4.676980608e-24 2.017926 273 0.01763452 46 1.4848670191304348e-10 1.398891 153 185 0.01378254 GO Cellular Component mitochondrial ribosome 41 3.691434e-24 1.5558043785365853e-22 2.75425 135 0.008720367 64 4.6679301e-7 1.472573 74 85 0.006666066 GO Cellular Component nucleosome 51 2.947484e-19 9.98676931764706e-18 2.433432 132 0.008526581 142 0.00473708443943662 1.272629 79 105 0.007116476 GO Cellular Component large ribosomal subunit 60 1.368052e-16 3.9399897599999996e-15 2.034317 166 0.01072282 62 4.3467059612903224e-7 1.412009 96 115 0.00864787 GO Cellular Component DNA packaging complex 61 1.5861e-16 4.493083278688525e-15 2.155337 144 0.009301725 129 0.0018926020465116278 1.283704 85 112 0.007656968 GO Cellular Component mitochondrial large ribosomal subunit 72 4.793619e-14 1.1504685600000001e-12 2.677353 78 0.005038434 96 0.000096470892 1.492473 45 51 0.004053689 GO Cellular Component small ribosomal subunit 85 1.83631e-11 3.733110211764706e-10 2.020597 111 0.007170079 112 0.00046131922285714286 1.386065 59 72 0.005314837 GO Cellular Component mitochondrial small ribosomal subunit 101 8.082603e-11 1.3828453449504952e-9 2.886204 51 0.003294361 150 0.005961611519999999 1.51024 25 28 0.002252049 GO Cellular Component anaphase-promoting complex 178 9.003897e-7 0.000008740861806741573 2.572063 35 0.002260836 174 0.018435168000000002 1.530377 19 21 0.001711558 GO Cellular Component proteasome accessory complex 236 0.00002280507 0.00016697949559322034 2.150534 37 0.002390026 182 0.025710826549450554 1.480036 21 24 0.001891721 GO Cellular Component pronucleus 241 0.00002824248 0.0002025020972614108 2.272776 32 0.00206705 198 0.03728848581818182 1.578705 14 15 0.001261148 GO Cellular Component Seh1-associated complex 255 0.00005711498 0.00038703798211764704 2.25318 30 0.001937859 198 0.03728848581818182 1.578705 14 15 0.001261148 GO Molecular Function rRNA binding 9 1.958831e-26 9.189093868888888e-24 3.454822 106 0.006847103 80 0.000728476546 1.437749 51 60 0.004594181 GO Molecular Function unfolded protein binding 12 8.574699e-20 3.0168649315e-17 2.210075 166 0.01072282 128 0.021301032306250002 1.260623 79 106 0.007116476 GO Molecular Function mitogen-activated protein kinase binding 33 2.278436e-11 2.9150172096969697e-9 2.382878 76 0.004909244 99 0.005444473703030303 1.566175 25 27 0.002252049 GO Molecular Function polyubiquitin binding 35 3.282438e-11 3.9595580674285716e-9 2.172278 91 0.005878173 108 0.009381944664814814 1.428352 38 45 0.003423115 GO Molecular Function sequence-specific single stranded DNA binding 262 0.0002752814 0.004436023170992367 2.081046 29 0.001873264 127 0.021113523874015747 1.691469 14 14 0.001261148 Human Phenotype Increased CSF lactate 22 1.229575e-12 3.729524534090909e-10 2.280245 94 0.006071959 181 0.0037813826425414365 1.399837 48 58 0.004323935 Human Phenotype Abnormal CSF metabolite level 26 4.403856e-12 1.1302665803076923e-9 2.174856 99 0.006394936 198 0.0064324754222222225 1.369285 51 63 0.004594181 Human Phenotype Abnormality of fatty-acid metabolism 139 0.000001708723 0.00008203099697122302 2.27845 42 0.002713003 302 0.03981854226490066 1.488493 22 25 0.001981803 Mouse Phenotype Single KO abnormal B cell activation 43 6.586119e-49 1.402537015883721e-46 2.166884 450 0.02906789 81 7.486474924074073e-9 1.413267 127 152 0.01144041 Mouse Phenotype Single KO abnormal B cell proliferation 55 5.460196e-41 9.090729958545453e-39 2.087503 409 0.02641948 92 7.298645574239132e-8 1.409558 115 138 0.01035943 Mouse Phenotype Single KO spleen hyperplasia 64 1.00253e-36 1.4344011265625e-34 2.457286 258 0.01666559 137 0.00000392718531540146 1.474614 68 78 0.006125574 Mouse Phenotype Single KO abnormal marginal zone B cell morphology 75 5.137025e-32 6.271965056666667e-30 2.344946 245 0.01582585 195 0.00015001687696923076 1.387385 73 89 0.006575984 Mouse Phenotype Single KO abnormal spleen marginal zone morphology 76 5.757067e-32 6.93650822618421e-30 2.203491 279 0.01802209 182 0.00008432097667032967 1.362572 87 108 0.007837132 Mouse Phenotype Single KO decreased B cell proliferation 78 2.673704e-31 3.1388599394871794e-29 2.269575 256 0.0165364 202 0.00020640127324257426 1.399117 67 81 0.006035492 Mouse Phenotype Single KO increased T cell proliferation 89 2.965573e-27 3.051208085505618e-25 2.061718 275 0.01776371 305 0.007216313456721311 1.272344 85 113 0.007656968 Mouse Phenotype Single KO abnormal spleen secondary B follicle morphology 93 4.231864e-26 4.166793403010753e-24 2.054171 265 0.01711776 180 0.00006641511053333333 1.376392 83 102 0.007476804 Mouse Phenotype Single KO abnormal dendritic cell morphology 94 1.239146e-25 1.2071127576595745e-23 2.005362 276 0.01782831 380 0.02456006199210526 1.239439 85 116 0.007656968 Mouse Phenotype Single KO abnormal spleen germinal center morphology 97 5.079994e-25 4.79561907814433e-23 2.045432 256 0.0165364 190 0.00012071658641578948 1.37009 81 100 0.00729664 Mouse Phenotype Single KO abnormal transitional stage B cell morphology 107 6.517707e-24 5.577817102710281e-22 2.418051 169 0.01091661 418 0.03496225845454546 1.34041 42 53 0.003783443 Mouse Phenotype Single KO increased autoantibody level 118 1.604164e-22 1.244858453220339e-20 2.00303 241 0.01556747 190 0.00012071658641578948 1.37009 81 100 0.00729664 Mouse Phenotype Single KO abnormal B cell apoptosis 120 1.851311e-22 1.4127045689166667e-20 2.351448 167 0.01078742 164 0.000026174234795121948 1.604727 37 39 0.003333033 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 121 2.475108e-22 1.8731044591735537e-20 2.082266 217 0.01401718 294 0.005459612079931973 1.288738 80 105 0.007206558 Mouse Phenotype Single KO decreased T cell apoptosis 132 9.074545e-21 6.295121860984848e-19 2.563134 130 0.00839739 235 0.0012562819510638296 1.578705 28 30 0.002522295 Mouse Phenotype Single KO decreased interleukin-6 secretion 151 2.432398e-19 1.4750641381456953e-17 2.01213 202 0.01304825 400 0.030039332467500002 1.273577 64 85 0.005765246 Mouse Phenotype Single KO increased integument system tumor incidence 172 1.893604e-17 1.008123943488372e-15 2.108146 161 0.01039984 298 0.00624906866442953 1.33537 60 76 0.005404918 Mouse Phenotype Single KO increased B cell proliferation 183 5.480564e-17 2.7423783906010928e-15 2.022084 173 0.01117499 201 0.0002037832036766169 1.449831 54 63 0.004864427 Mouse Phenotype Single KO decreased marginal zone B cell number 188 8.403835e-17 4.0932934625e-15 2.134414 150 0.009689297 242 0.0015732478992975206 1.424395 48 57 0.004323935 Mouse Phenotype Single KO abnormal follicular B cell morphology 189 1.003881e-16 4.863776887301587e-15 2.003773 174 0.01123958 430 0.038515151223255814 1.318773 46 59 0.004143771 Mouse Phenotype abnormal B cell activation 57 9.715893e-55 1.6297132100526316e-52 2.032878 586 0.03785285 73 1.6414180730136988e-12 1.419184 172 205 0.0154941 Mouse Phenotype abnormal B cell proliferation 60 1.57134e-50 2.50393029e-48 2.021203 548 0.03539823 82 9.108227185243903e-12 1.422982 159 189 0.01432303 Mouse Phenotype abnormal marginal zone B cell morphology 61 1.856634e-49 2.9100455203278685e-47 2.320933 393 0.02538596 143 1.1856890284615386e-7 1.399417 115 139 0.01035943 Mouse Phenotype abnormal spleen marginal zone morphology 68 2.994747e-47 4.210702362794117e-45 2.163299 436 0.02816356 148 1.6874241200675676e-7 1.367793 131 162 0.01180074 Mouse Phenotype abnormal follicular B cell morphology 89 3.135176e-37 3.3680244647191015e-35 2.249026 313 0.02021833 231 0.000038886855150649355 1.379451 84 103 0.007566886 Mouse Phenotype abnormal spleen germinal center morphology 94 4.439315e-34 4.51535007606383e-32 2.042317 356 0.02299593 178 0.0000018603589688764045 1.37046 111 137 0.009999099 Mouse Phenotype decreased marginal zone B cell number 96 8.074411e-33 8.0416087053125e-31 2.206361 286 0.01847426 176 0.000001841536604659091 1.426141 86 102 0.00774705 Mouse Phenotype decreased susceptibility to experimental autoimmune encephalomyelitis 113 9.781149e-29 8.275890760088495e-27 2.189125 253 0.01634261 381 0.004398800287401575 1.288738 80 105 0.007206558 Mouse Phenotype abnormal transitional stage B cell morphology 115 1.555962e-28 1.293613276695652e-26 2.16295 258 0.01666559 333 0.0015032527735135137 1.34151 69 87 0.006215656 Mouse Phenotype abnormal dendritic cell number 117 3.117582e-28 2.54762406e-26 2.01262 303 0.01957238 516 0.022656920343023256 1.227679 90 124 0.008107378 Mouse Phenotype abnormal B cell apoptosis 125 2.974827e-27 2.27538567576e-25 2.058599 276 0.01782831 183 0.000003153595537868852 1.48575 65 74 0.005855328 Mouse Phenotype decreased T cell apoptosis 127 6.428869e-27 4.839875315669291e-25 2.595514 168 0.01085201 293 0.0006014795731740614 1.499257 39 44 0.003513197 Mouse Phenotype increased B cell proliferation 134 3.201223e-26 2.2840965002238808e-24 2.227198 221 0.01427556 215 0.00001526825884744186 1.440881 69 81 0.006215656 Mouse Phenotype lymph node hyperplasia 138 3.133186e-25 2.1707529960869567e-23 2.532048 164 0.01059363 293 0.0006014795731740614 1.499257 39 44 0.003513197 Mouse Phenotype decreased single-positive T cell number 147 6.862105e-24 4.463169109183673e-22 2.034161 247 0.01595504 162 4.7128234648148144e-7 1.487678 73 83 0.006575984 Mouse Phenotype increased follicular B cell number 149 1.201595e-23 7.710368989932886e-22 2.68233 138 0.008914153 236 0.000045759067538135586 1.638611 31 32 0.002792541 Mouse Phenotype increased spleen white pulp amount 153 2.428403e-23 1.5175137962745098e-21 2.90916 119 0.007686842 491 0.019032926919959267 1.442724 29 34 0.002612377 Mouse Phenotype increased IgE level 154 2.930904e-23 1.8196346197402598e-21 2.069831 230 0.01485692 544 0.02992517425919118 1.263741 65 87 0.005855328 Mouse Phenotype decreased follicular B cell number 156 5.199415e-23 3.1866414624999995e-21 2.149557 208 0.01343582 469 0.015147734892537314 1.294705 62 81 0.005585082 Mouse Phenotype increased transitional stage B cell number 168 9.03638e-22 5.142668403571428e-20 2.493342 144 0.009301725 353 0.002618837800708215 1.503528 32 36 0.002882623