# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	16	2.743632e-40	2.256465843e-37	2.178418	362	0.03348751	133	6.440229299473684e-10	1.559467	145	239	0.01984942	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	1.451987e-37	9.5533484665e-35	2.799903	209	0.01933395	204	5.887342405441176e-7	1.683291	74	113	0.01013005	
GO Biological Process	mRNA catabolic process	21	1.188859e-34	7.449616943333334e-32	2.2382	292	0.02701203	212	0.0000010827281063679246	1.484334	123	213	0.01683778	
GO Biological Process	nuclear-transcribed mRNA catabolic process	23	2.924313e-33	1.6730884681304345e-30	2.280185	269	0.02488437	192	1.8324860156770836e-7	1.531873	118	198	0.01615332	
GO Biological Process	regulation of DNA-templated transcription in response to stress	24	5.448934e-33	2.9876051044166668e-30	2.546289	215	0.01988899	206	6.552766788834952e-7	1.66322	77	119	0.01054073	
GO Biological Process	RNA catabolic process	26	4.870503e-32	2.4650364991153843e-29	2.081357	317	0.0293247	235	0.000005390965681021277	1.429202	134	241	0.0183436	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	43	3.44188e-27	1.0532953237209303e-24	2.832044	146	0.01350601	230	0.00000309232666726087	1.779529	54	78	0.007392197	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	1.124726e-25	2.846205660384616e-23	2.63627	155	0.01433858	302	0.00009892090886754967	1.546615	71	118	0.00971937	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	55	8.222528e-25	1.9672771991272727e-22	2.59193	154	0.01424607	341	0.0003383130277302053	1.524061	67	113	0.0091718	
GO Biological Process	mitochondrial membrane organization	56	1.359862e-24	3.1954328675e-22	2.178134	216	0.0199815	273	0.00004309907982197802	1.554696	75	124	0.01026694	
GO Biological Process	viral gene expression	57	5.656747e-24	1.3059146275964912e-21	2.480004	161	0.01489362	250	0.0000117191632744	1.57869	78	127	0.01067762	
GO Biological Process	multi-organism metabolic process	59	1.286703e-23	2.8697838605084748e-21	2.253673	192	0.01776133	220	0.0000019946442106818183	1.573733	90	147	0.01232033	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	61	2.136226e-23	4.608294743278689e-21	8.024917	41	0.003792784	619	0.011964126660581584	2.336756	10	11	0.001368925	
GO Biological Process	cellular response to epidermal growth factor stimulus	69	1.485969e-22	2.833893633478261e-20	2.717455	128	0.01184089	638	0.014740961367241378	1.691073	25	38	0.003422313	
GO Biological Process	regulation of mitochondrial membrane permeability	74	2.601585e-22	4.626250947972973e-20	2.489136	148	0.01369103	450	0.002011062774733333	1.584512	45	73	0.006160164	
GO Biological Process	viral transcription	75	2.941927e-22	5.161708985733333e-20	2.476881	149	0.01378353	233	0.000004408132845236052	1.637797	72	113	0.009856263	
GO Biological Process	regulation of cellular amino acid metabolic process	76	6.716561e-22	1.1629371868289472e-19	3.300869	92	0.008510638	352	0.00045448157934659084	1.713621	40	60	0.005475702	
GO Biological Process	regulation of membrane permeability	79	1.615042e-21	2.690169326329114e-19	2.351717	159	0.0147086	445	0.001973582680089888	1.554952	49	81	0.006707734	
GO Biological Process	regulation of hematopoietic stem cell differentiation	81	3.146716e-21	5.112053807901235e-19	2.551125	134	0.01239593	434	0.0015984983178801845	1.497339	60	103	0.008213552	
GO Biological Process	response to epidermal growth factor	88	9.921597e-21	1.4836169877613638e-18	2.557466	130	0.0120259	766	0.036400525437336816	1.591219	26	42	0.003559206	
GO Cellular Component	spliceosomal complex	33	7.116141e-29	3.726270196363636e-27	2.117593	273	0.02525439	58	0.000002548788976551724	1.492508	108	186	0.01478439	
GO Cellular Component	catalytic step 2 spliceosome	36	5.278088e-26	2.53348224e-24	2.627882	158	0.0146161	125	0.0118164040704	1.419092	53	96	0.007255305	
GO Cellular Component	ribosomal subunit	38	5.543319e-25	2.5207513768421053e-23	2.222978	210	0.01942646	55	0.0000018206085469090909	1.500576	108	185	0.01478439	
GO Cellular Component	large ribosomal subunit	42	2.48862e-22	1.0238893714285715e-20	2.527239	144	0.013321	75	0.00019772234496	1.519907	68	115	0.009308693	
GO Cellular Component	PRC1 complex	44	2.699249e-20	1.0600686981818182e-18	7.76796	36	0.00333025	146	0.025906625753424655	2.142026	10	12	0.001368925	
GO Cellular Component	mitochondrial large ribosomal subunit	47	2.058288e-17	7.567492902127659e-16	3.391824	69	0.006382979	131	0.016661653007633587	1.562419	31	51	0.004243669	
GO Cellular Component	proton-transporting ATP synthase complex	48	2.256183e-17	8.1222588e-16	4.689814	47	0.004347826	100	0.006187940352	1.927823	18	24	0.002464066	
GO Cellular Component	ficolin-1-rich granule lumen	50	8.469255e-17	2.926974528e-15	2.074376	160	0.01480111	66	0.000023410331345454547	1.554696	75	124	0.01026694	
GO Cellular Component	U12-type spliceosomal complex	51	1.414521e-16	4.792729976470588e-15	4.073756	52	0.004810361	70	0.000054155001600000005	2.17498	22	26	0.003011636	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	52	1.559235e-16	5.1814578461538455e-15	4.638876	45	0.004162812	115	0.010514484813913044	1.899884	17	23	0.002327173	
GO Cellular Component	Bcl-2 family protein complex	53	4.078365e-16	1.3297008905660376e-14	6.064213	34	0.003145236	132	0.017626450909090912	2.570431	7	7	0.0009582478	
GO Cellular Component	mitochondrial ribosome	55	5.850871e-16	1.8382372887272728e-14	2.658792	91	0.008418131	98	0.006153252832653062	1.481778	49	85	0.006707734	
GO Cellular Component	endopeptidase complex	56	6.505881e-16	2.0075289942857144e-14	2.532251	99	0.009158187	61	0.000006642086399999999	1.788126	48	69	0.006570842	
GO Cellular Component	nuclear ubiquitin ligase complex	57	7.173907e-16	2.1748265431578946e-14	3.251388	66	0.006105458	119	0.010741934843697478	1.67078	26	40	0.003559206	
GO Cellular Component	spliceosomal snRNP complex	58	7.938204e-16	2.3650373296551726e-14	2.771597	84	0.007770583	165	0.039508604509090904	1.45105	35	62	0.004791239	
GO Cellular Component	PcG protein complex	59	1.656118e-15	4.850460854237288e-14	2.394977	107	0.009898242	88	0.0016644708654545454	1.732247	31	46	0.004243669	
GO Cellular Component	proteasome complex	60	4.09065e-15	1.1781072e-13	2.482497	97	0.008973173	63	0.000011617138285714284	1.776622	47	68	0.006433949	
GO Cellular Component	tethering complex	62	2.022354e-14	5.63649630967742e-13	2.049455	139	0.01285846	76	0.00020675635957894734	1.654935	47	73	0.006433949	
GO Cellular Component	small nuclear ribonucleoprotein complex	63	1.180847e-13	3.2388946285714286e-12	2.445824	89	0.008233117	167	0.04792814946107785	1.4156	38	69	0.005201916	
GO Cellular Component	peptidase complex	73	2.801761e-11	6.632113709589042e-10	2.026004	108	0.009990749	71	0.0000546815378028169	1.635729	56	88	0.007665982	
GO Molecular Function	ribonucleoprotein complex binding	8	1.74064e-23	9.1862276e-21	2.4056	167	0.01544866	83	0.009868925	1.430501	64	115	0.008761123	
GO Molecular Function	unfolded protein binding	9	1.539234e-22	7.22071772e-20	2.612118	137	0.01267345	79	0.008658210384810128	1.454961	60	106	0.008213552	
GO Molecular Function	structural constituent of ribosome	12	2.037584e-18	7.1688997066666675e-16	2.064886	179	0.01655874	29	0.00001675459935862069	1.523218	96	162	0.01314168	
GO Molecular Function	peroxisome proliferator activated receptor binding	13	3.267263e-18	1.0611064912307692e-15	4.736962	49	0.00453284	128	0.04364604646875	2.313388	9	10	0.001232033	
GO Molecular Function	thyroid hormone receptor binding	20	5.111042e-13	1.0789409662000001e-10	3.047911	58	0.005365402	76	0.006296518586842105	1.927823	21	28	0.002874743	
GO Molecular Function	ribonuclease activity	22	8.356446e-13	1.603677955090909e-10	2.032537	124	0.01147086	124	0.03820034956451614	1.402053	54	99	0.007392197	
GO Molecular Function	telomeric DNA binding	47	9.080483e-10	8.156978558723403e-8	2.544983	56	0.005180389	111	0.02454835496036036	1.738821	23	34	0.003148528	
GO Molecular Function	phosphate transmembrane transporter activity	139	0.00000221686	0.0000673351289208633	2.279114	41	0.003792784	131	0.04929333253435114	1.820722	17	24	0.002327173	
GO Molecular Function	L-serine transmembrane transporter activity	148	0.000003563229	0.00010164832998648649	3.712083	18	0.001665125	70	0.0047722677354285715	2.570431	10	10	0.001368925	
GO Molecular Function	mannosyltransferase activity	151	0.00000403216	0.00011274026172185431	2.513742	32	0.002960222	131	0.04929333253435114	1.820722	17	24	0.002327173	
GO Molecular Function	cullin family protein binding	291	0.0002166203	0.0031428553491408932	2.144488	28	0.002590194	119	0.03262699511764706	1.999224	14	18	0.001916496	
Human Phenotype	Abnormal CNS myelination	8	1.189833e-16	9.92469451125e-14	2.020662	169	0.01563367	36	0.0002571763078333333	1.542259	75	125	0.01026694	
Human Phenotype	Increased serum lactate	9	1.120038e-15	8.304459526666666e-13	2.210654	128	0.01184089	49	0.0008401898037142857	1.567963	61	100	0.008350445	
Human Phenotype	Leukodystrophy	28	2.914286e-10	6.945368027857143e-8	2.27565	74	0.006845513	38	0.0003659520613421053	1.85071	36	50	0.004928131	
Human Phenotype	Abnormality of mitochondrial metabolism	32	7.209138e-10	1.5033305585625e-7	2.028648	92	0.008510638	40	0.00045690765030000004	1.713621	46	69	0.006297057	
Human Phenotype	Nevus	50	5.809965e-8	0.000007753979289	2.227951	57	0.005272895	101	0.01461363215049505	1.904023	20	27	0.002737851	
Mouse Phenotype Single KO	extramedullary hematopoiesis	1	2.240016e-37	2.0511826512e-33	2.563199	242	0.02238668	214	0.04555004164953271	1.375406	61	114	0.008350445	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	49	2.750831e-12	5.140685605510204e-10	2.267129	92	0.008510638	41	0.0000030967522280487807	1.927823	45	60	0.006160164	
Mouse Phenotype Single KO	early cellular replicative senescence	63	2.421174e-11	3.5191571933333333e-9	2.291522	82	0.007585569	44	0.000005414088736818182	1.977255	40	52	0.005475702	
Mouse Phenotype Single KO	empty decidua capsularis	122	1.00552e-8	7.547169377049181e-7	4.363397	23	0.00212766	211	0.04323118213696683	2.17498	11	13	0.001505818	
Mouse Phenotype Single KO	abnormal adrenal medulla morphology	245	0.000003334003	0.00012461006314693878	2.215346	42	0.003885291	208	0.04048514411778846	1.999224	14	18	0.001916496	
Mouse Phenotype	extramedullary hematopoiesis	2	1.09758e-33	5.24698119e-30	2.060778	342	0.03163737	222	0.003758712484594595	1.366001	93	175	0.01273101	
Mouse Phenotype	increased bone marrow cell number	17	1.229084e-21	6.912513014117647e-19	2.58026	134	0.01239593	365	0.03308690137808219	1.562419	31	51	0.004243669	
Mouse Phenotype	early cellular replicative senescence	54	2.482667e-13	4.395699849444445e-11	2.130064	116	0.0107308	63	7.75171430047619e-7	1.866203	53	73	0.007255305	
Mouse Phenotype	spleen atrophy	76	3.919933e-12	4.93137887013158e-10	2.588024	70	0.006475486	390	0.041262089	1.779529	18	26	0.002464066	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	94	2.512061e-11	2.555086725638298e-9	2.878168	54	0.004995375	240	0.00542428595125	1.884983	22	30	0.003011636	
Mouse Phenotype	decreased cellular sensitivity to gamma-irradiation	176	2.1611e-8	0.0000011739930170454546	2.699852	42	0.003885291	284	0.01205555916338028	1.927823	18	24	0.002464066	
Mouse Phenotype	decreased level of surface class I molecules	197	9.08721e-8	0.0000044102951680203044	5.113601	17	0.001572618	264	0.008604088763636364	2.356229	11	12	0.001505818	
Mouse Phenotype	heterochrony	420	0.00004393584	0.001000168014857143	2.081746	37	0.003422757	400	0.044550913649999996	1.965624	13	17	0.001779603