# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	17	6.371576e-50	4.931974622588236e-47	2.103918	493	0.02723606	124	1.3256503945161292e-13	1.406144	205	252	0.0188714	
GO Biological Process	rRNA metabolic process	19	1.494857e-49	1.0353064875263157e-46	2.07938	503	0.02778852	135	3.443049425777778e-13	1.394835	209	259	0.01923962	
GO Biological Process	endoplasmic reticulum unfolded protein response	22	2.583583e-48	1.5453349407727273e-45	2.602237	309	0.01707088	305	0.000008063710081639346	1.394952	92	114	0.008469115	
GO Biological Process	cellular response to topologically incorrect protein	25	5.135483e-46	2.7031128318800003e-43	2.371686	350	0.01933595	272	0.0000015193052425000001	1.380335	111	139	0.01021817	
GO Biological Process	positive regulation of nuclease activity	26	1.975576e-44	9.998694070769231e-42	5.906925	103	0.005690293	922	0.046201163366594356	1.613293	14	15	0.001288778	
GO Biological Process	response to topologically incorrect protein	30	4.4166e-43	1.93726798e-40	2.118345	417	0.0230374	239	2.78566119456067e-7	1.354014	141	180	0.01297984	
GO Biological Process	cellular response to unfolded protein	33	2.123299e-42	8.466815618484848e-40	2.385072	318	0.01756809	304	0.000007020837276973685	1.385679	97	121	0.008929393	
GO Biological Process	IRE1-mediated unfolded protein response	34	4.607534e-42	1.7832511737058825e-39	3.397836	177	0.009778465	776	0.022285682203608242	1.341099	45	58	0.004142502	
GO Biological Process	mRNA catabolic process	36	6.686887e-42	2.444242945361111e-39	2.037038	445	0.02458428	166	6.887369073795181e-11	1.395807	172	213	0.01583356	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	37	1.636072e-41	5.818667958918919e-39	2.630759	259	0.0143086	194	4.486720450257732e-9	1.479503	101	118	0.009297616	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	1.998591e-41	6.920910255e-39	2.090696	413	0.02281642	178	3.5875529553932583e-10	1.39679	160	198	0.0147289	
GO Biological Process	response to unfolded protein	42	1.557149e-39	4.878696116904762e-37	2.112476	384	0.0212143	259	9.316831115444015e-7	1.361216	126	160	0.01159901	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	48	6.674331e-38	1.8297400339375e-35	2.344161	293	0.01618695	267	0.000001238516701610487	1.422594	93	113	0.008561171	
GO Biological Process	protein targeting to ER	51	1.771628e-37	4.5711476180392155e-35	2.655599	229	0.01265123	145	1.4261461019999998e-12	1.591615	93	101	0.008561171	
GO Biological Process	viral gene expression	52	1.786976e-37	4.5220802276923073e-35	2.446985	266	0.01469532	129	2.036467458527132e-13	1.551592	114	127	0.01049434	
GO Biological Process	multi-organism metabolic process	54	2.409853e-36	5.872454745740742e-34	2.215134	316	0.0174576	130	2.105457207923077e-13	1.516872	129	147	0.01187517	
GO Biological Process	cotranslational protein targeting to membrane	58	1.192689e-34	2.705964577758621e-32	2.626831	215	0.0118778	186	1.349723582311828e-9	1.53451	87	98	0.008008837	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	60	2.699585e-34	5.920639835833334e-32	3.982788	117	0.006463731	824	0.029741192480582525	1.512462	21	24	0.001933168	
GO Biological Process	regulation of DNA-templated transcription in response to stress	62	6.910541e-34	1.466706597080645e-31	2.171354	307	0.01696039	274	0.00000159176979040146	1.408968	97	119	0.008929393	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	64	7.88591e-33	1.62141702640625e-30	2.635189	202	0.0111596	167	8.181612189820359e-11	1.578221	84	92	0.007732671	
GO Cellular Component	ribosomal subunit	27	1.201352e-39	7.6886528e-38	2.206299	349	0.0192807	37	1.9276493837837837e-14	1.476256	158	185	0.01454479	
GO Cellular Component	large ribosomal subunit	37	1.63531e-32	7.637339675675676e-31	2.431616	232	0.01281697	53	1.6234921901886795e-9	1.488037	99	115	0.009113505	
GO Cellular Component	mitochondrial ribosome	40	8.110482e-26	3.503728224e-24	2.669669	153	0.008452572	73	5.242778038356165e-7	1.484501	73	85	0.006720059	
GO Cellular Component	cytosolic large ribosomal subunit	45	2.61093e-19	1.00259712e-17	2.350027	142	0.00784487	82	0.0000036851370146341464	1.530172	54	61	0.004971002	
GO Cellular Component	nuclear ubiquitin ligase complex	51	1.981437e-17	6.713574776470588e-16	2.765514	94	0.005193083	197	0.024007174172588835	1.382822	32	40	0.002945779	
GO Cellular Component	mitochondrial large ribosomal subunit	62	1.274547e-15	3.552285832258064e-14	2.642104	90	0.004972101	137	0.0022712163503649636	1.423494	42	51	0.003866335	
GO Cellular Component	mitochondrial nucleoid	76	8.238282e-14	1.8731251705263158e-12	2.396505	94	0.005193083	87	0.000009958511668965518	1.605062	39	42	0.003590168	
GO Cellular Component	endopeptidase complex	83	6.034824e-13	1.256406731566265e-11	2.001087	131	0.007237169	129	0.0014236858046511628	1.377812	55	69	0.005063058	
GO Cellular Component	ESCRT complex	103	8.430461e-11	1.4143530687378638e-9	2.570255	62	0.003425225	178	0.015491558831460675	1.481595	24	28	0.002209334	
GO Cellular Component	mitochondrial small ribosomal subunit	130	5.10418e-9	6.784633107692308e-8	2.516846	52	0.002872769	118	0.000712376493559322	1.605062	26	28	0.002393446	
GO Cellular Component	COPI-coated vesicle	151	5.421584e-8	6.204302749668874e-7	2.291317	54	0.002983261	199	0.024700969809045226	1.503068	20	23	0.001841112	
GO Cellular Component	very-low-density lipoprotein particle	158	9.22211e-8	0.0000010085953215189873	2.384505	48	0.002651787	186	0.018994668387096774	1.555675	18	20	0.001657001	
GO Cellular Component	mitochondrial inner membrane presequence translocase complex	164	1.334267e-7	0.0000014058618146341462	3.6422	24	0.001325894	193	0.021707932849740933	1.728528	11	11	0.001012612	
GO Cellular Component	CCR4-NOT complex	169	2.046885e-7	0.000002092909633136095	2.367247	46	0.002541296	184	0.01865280208695652	1.620495	15	16	0.001380834	
GO Cellular Component	anaphase-promoting complex	262	0.0001173032	0.0007736638534351145	2.074073	33	0.001823104	175	0.012810137965714286	1.563906	19	21	0.001749056	
GO Molecular Function	structural constituent of ribosome	8	4.567006e-36	2.4102374165e-33	2.197642	319	0.01762334	10	2.1233784818e-13	1.50446	141	162	0.01297984	
GO Molecular Function	unfolded protein binding	11	1.10785e-28	4.252129727272727e-26	2.391193	210	0.01160157	57	0.000022091163171929824	1.402391	86	106	0.007916782	
GO Molecular Function	rRNA binding	15	6.413426e-22	1.8051656381333333e-19	2.982634	107	0.005911276	75	0.00033273593258666666	1.469249	51	60	0.004694836	
GO Molecular Function	ribonuclease activity	16	5.010465e-21	1.322136451875e-18	2.055697	210	0.01160157	86	0.001194977206511628	1.344411	77	99	0.007088281	
GO Molecular Function	protein channel activity	20	4.823972e-19	1.0183404892e-16	4.691984	52	0.002872769	148	0.03999691731081081	1.728528	12	12	0.001104667	
GO Molecular Function	NF-kappaB binding	23	9.434289e-16	1.731807311217391e-13	2.70872	87	0.004806364	97	0.0021173582449484536	1.605062	26	28	0.002393446	
GO Molecular Function	snRNA binding	25	1.652162e-15	2.7901711856e-13	2.934459	75	0.004143417	106	0.00465857471509434	1.50109	33	38	0.003037835	
GO Molecular Function	endoribonuclease activity	26	2.312675e-15	3.755428403846154e-13	2.214543	125	0.006905696	122	0.011080770504918033	1.388996	45	56	0.004142502	
GO Molecular Function	ubiquitin protein ligase activity involved in ERAD pathway	224	0.000006195639	0.00011677673150892857	2.595558	29	0.001602121	137	0.024985555623357664	1.728528	13	13	0.001196723	
Human Phenotype	Increased serum lactate	1	1.190141e-25	7.941810893000001e-22	2.227859	216	0.01193304	33	9.106283162424241e-7	1.469249	85	100	0.007824726	
Human Phenotype	Abnormal CSF metabolite level	12	2.530113e-18	1.4069536707499999e-15	2.404927	128	0.007071433	68	0.00017625012183823528	1.481595	54	63	0.004971002	
Human Phenotype	Increased CSF lactate	17	2.135015e-16	8.380561820588235e-14	2.385876	115	0.00635324	76	0.00026841545442105264	1.49011	50	58	0.00460278	
Human Phenotype	Progressive external ophthalmoplegia	18	3.835482e-16	1.4218984103333332e-13	3.738077	56	0.003093752	159	0.011376457754716981	1.728528	15	15	0.001380834	
Human Phenotype	Exercise intolerance	23	4.421203e-14	1.282725548652174e-11	2.120986	125	0.006905696	153	0.009456622323529413	1.358129	55	70	0.005063058	
Human Phenotype	Glycosuria	37	7.373267e-12	1.3297786673243243e-9	2.324075	84	0.004640628	223	0.03173170095964126	1.49011	25	29	0.00230139	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	141	4.597445e-7	0.000021757979067375887	2.69635	34	0.001878349	204	0.024221547454411765	1.632499	17	18	0.001564945	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	71	1.601983e-14	2.0661068071830984e-12	2.73751	78	0.004309154	220	0.03412127957454545	1.571389	20	22	0.001841112	
Mouse Phenotype Single KO	abnormal DNA replication	316	5.770655e-7	0.000016722116403481015	2.086934	56	0.003093752	201	0.023509772914427858	1.578221	21	23	0.001933168	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	321	6.813285e-7	0.000019435903658878506	2.075405	56	0.003093752	236	0.04712576328389831	1.62685	16	17	0.00147289	
Mouse Phenotype	dry eyes	22	8.169887e-33	3.5505586185e-30	3.609553	126	0.006960941	382	0.04971164360732984	1.620495	15	16	0.001380834	
Mouse Phenotype	absent segment of posterior cerebral artery	100	1.601983e-14	1.5316559463e-12	2.73751	78	0.004309154	308	0.0254476321012987	1.571389	20	22	0.001841112	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	117	2.861994e-13	2.3387627892307692e-11	2.546452	80	0.004419645	296	0.022655173878040537	1.498058	26	30	0.002393446	
Mouse Phenotype	abnormal cerebral artery morphology	196	1.568239e-10	7.649965856632652e-9	2.24066	79	0.0043644	376	0.0473563449893617	1.512462	21	24	0.001933168	
Mouse Phenotype	increased blood uric acid level	236	1.565923e-9	6.343978730084745e-8	2.273835	68	0.003756699	334	0.03476754597305389	1.62685	16	17	0.00147289