# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mitochondrial transport 33 4.000707e-26 1.5953122246363636e-23 2.041226 267 0.03137854 476 0.043930077476890754 1.265839 107 239 0.01611203 GO Biological Process macromolecular complex disassembly 51 2.867923e-22 7.399803677843136e-20 2.098006 211 0.02479727 144 0.00038191786056944444 1.450726 98 191 0.01475681 GO Biological Process regulation of DNA-templated transcription in response to stress 52 7.139524e-22 1.806711467615385e-19 2.377242 158 0.01856857 495 0.0478785296989899 1.378078 58 119 0.008733624 GO Biological Process mitochondrial membrane organization 61 4.446689e-20 9.592455828032788e-18 2.190655 171 0.02009637 499 0.04982588104609218 1.368114 60 124 0.009034784 GO Biological Process platelet aggregation 87 8.958093e-18 1.3549373078965517e-15 3.101904 80 0.00940181 225 0.003964735933822221 1.86197 27 41 0.004065653 GO Biological Process cell redox homeostasis 88 1.058865e-17 1.5833641517045454e-15 2.510657 113 0.01328006 323 0.0145830074996904 1.570798 40 72 0.006023189 GO Biological Process regulation of intrinsic apoptotic signaling pathway 92 2.01951e-17 2.888557835869565e-15 2.016751 178 0.02091903 273 0.008127263508058608 1.404597 77 155 0.01159464 GO Biological Process regulation of cellular response to heat 95 2.298531e-17 3.183828360947368e-15 2.396019 121 0.01422024 154 0.0005379955466818181 1.703711 47 78 0.007077247 GO Biological Process cellular response to topologically incorrect protein 117 5.48231e-16 6.165958742735042e-14 2.104583 146 0.0171583 430 0.037083561513953485 1.362865 67 139 0.01008884 GO Biological Process regulation of membrane permeability 120 9.163484e-16 1.0048523829666668e-13 2.273633 121 0.01422024 480 0.04624711359791667 1.466078 42 81 0.006324349 GO Biological Process multi-organism metabolic process 141 8.298757e-15 7.744917969007092e-13 2.072773 139 0.01633564 384 0.028170262896093746 1.365632 71 147 0.01069116 GO Biological Process tRNA transport 165 1.392296e-13 1.1103771553939394e-11 3.14762 58 0.006816312 301 0.0107706415 1.858029 23 35 0.003463334 GO Biological Process viral gene expression 188 5.122324e-13 3.585354335957447e-11 2.152615 110 0.01292749 431 0.037126057635730854 1.380323 62 127 0.009335943 GO Biological Process regulation of megakaryocyte differentiation 199 1.311533e-12 8.672594345226131e-11 2.220183 99 0.01163474 312 0.012671648843269231 1.56253 42 76 0.006324349 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 218 4.566564e-12 2.756486957614679e-10 2.160754 100 0.01175226 451 0.040859511966740585 1.389756 58 118 0.008733624 GO Biological Process endoplasmic reticulum unfolded protein response 246 2.059637e-11 1.1017383448373983e-9 2.00646 112 0.01316253 484 0.046377536099173555 1.388916 56 114 0.008432465 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 260 3.538403e-11 1.7908401952692307e-9 2.405006 73 0.008579151 308 0.012246897586688312 1.675517 32 54 0.004818551 GO Biological Process JAK-STAT cascade 268 5.078878e-11 2.493767000074627e-9 2.12062 94 0.01104713 359 0.022065326429526466 1.68443 28 47 0.004216232 GO Biological Process protein-DNA complex disassembly 269 5.491477e-11 2.686332559219331e-9 3.219971 44 0.005170995 483 0.046291182455486544 1.979205 14 20 0.002108116 GO Biological Process negative regulation of viral transcription 274 6.433424e-11 3.089687095474453e-9 3.061859 47 0.005523563 490 0.047404411281632655 1.884957 16 24 0.002409276 GO Cellular Component ficolin-1-rich granule lumen 38 5.789811e-16 2.6328403705263157e-14 2.190616 133 0.01563051 64 0.0019257725700000002 1.482124 65 124 0.009787683 GO Cellular Component ribosomal subunit 40 6.961912e-16 3.007545984e-14 2.057569 153 0.01798096 88 0.02232501381818182 1.314375 86 185 0.01294986 GO Cellular Component mitochondrial ribosome 59 8.483486e-12 2.4846548827118646e-10 2.561174 69 0.008109061 113 0.04242181890265487 1.43035 43 85 0.006474928 GO Cellular Component platelet dense tubular network membrane 60 1.546448e-11 4.4537702399999995e-10 4.632885 30 0.003525679 96 0.027128628000000002 2.513276 8 9 0.001204638 GO Cellular Component Bcl-2 family protein complex 152 0.000004066829 0.00004623342442105263 3.852047 17 0.001997885 76 0.015706992505263157 2.827436 7 7 0.001054058 GO Cellular Component paranodal junction 230 0.0001730872 0.001300411659130435 2.444644 22 0.002585498 76 0.015706992505263157 2.827436 7 7 0.001054058 GO Molecular Function ribonucleoprotein complex binding 21 6.429627e-18 1.2926611997142856e-15 2.360717 129 0.01516042 60 0.005287403404666667 1.49977 61 115 0.009185364 Mouse Phenotype Single KO abnormal platelet activation 10 5.933709e-43 5.4334973313e-40 3.205416 195 0.02291691 257 0.04935986429571984 1.463614 44 85 0.006625508 Mouse Phenotype Single KO abnormal platelet physiology 33 1.00144e-32 2.7788442666666666e-30 2.530413 215 0.02526736 247 0.04120386782591093 1.413718 55 110 0.008281885 Mouse Phenotype Single KO decreased erythroid progenitor cell number 38 2.779057e-29 6.696796039210526e-27 2.806051 160 0.01880362 213 0.02257764106901408 1.663197 30 51 0.004517392 Mouse Phenotype Single KO decreased circulating alanine transaminase level 50 1.695779e-26 3.1056496605999998e-24 2.547769 170 0.01997885 209 0.020947649589473687 1.545665 41 75 0.006173769 Mouse Phenotype Single KO abnormal erythropoiesis 59 2.020092e-25 3.135251261694915e-23 2.169409 225 0.02644259 69 0.00028478469065217385 1.619349 63 110 0.009486523 Mouse Phenotype Single KO cortical renal glomerulopathies 75 5.21215e-23 6.363687673333333e-21 2.076149 224 0.02632507 156 0.005295059903461539 1.455918 69 134 0.01039 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 88 1.600904e-21 1.6658497645454544e-19 2.480531 143 0.01680574 88 0.0005471437571022727 1.867174 35 53 0.005270291 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 97 1.871848e-20 1.7670631068041237e-18 2.012703 213 0.02503232 251 0.047652079466135464 1.347302 71 149 0.01069116 Mouse Phenotype Single KO glomerulonephritis 107 1.102395e-19 9.434234593457944e-18 2.376962 141 0.01657069 167 0.007921687800598801 1.567013 46 83 0.006926668 Mouse Phenotype Single KO increased T cell proliferation 148 4.295285e-15 2.6575624827702704e-13 2.032372 149 0.01751087 191 0.01689002896910995 1.45125 58 113 0.008733624 Mouse Phenotype Single KO spleen hyperplasia 173 2.051758e-13 1.0860085552601155e-11 2.096727 121 0.01422024 253 0.0489838694624506 1.486216 41 78 0.006173769 Mouse Phenotype Single KO chronic inflammation 224 2.027565e-11 8.288577100446429e-10 2.298845 82 0.009636855 168 0.007983437789880952 1.677292 35 59 0.005270291 Mouse Phenotype Single KO increased B cell derived lymphoma incidence 283 1.150356e-9 3.722194308127208e-8 2.174919 76 0.008931719 239 0.03678752336903766 1.649337 28 48 0.004216232 Mouse Phenotype Single KO increased hemoglobin concentration distribution width 617 0.00001644873 0.00024411834782820096 3.306007 18 0.002115407 225 0.02811470861155555 2.827436 7 7 0.001054058 Mouse Phenotype Single KO increased circulating interleukin-17 level 681 0.00004492983 0.0006041445716740088 2.767956 21 0.002467975 214 0.02277561988084112 2.261949 12 15 0.001806957 Mouse Phenotype Single KO abnormal thymocyte activation 857 0.0004903478 0.005239340495449242 2.004896 29 0.003408156 227 0.030494718044493396 2.083374 14 19 0.002108116 Mouse Phenotype abnormal platelet activation 10 1.200046e-45 1.1473639806e-42 3.190737 209 0.02456223 386 0.04518313105958549 1.413718 50 100 0.007528987 Mouse Phenotype abnormal platelet aggregation 12 2.785603e-45 2.21942919025e-42 3.204618 206 0.02420966 356 0.03389170388764045 1.443797 48 94 0.007227827 Mouse Phenotype abnormal platelet physiology 27 3.229892e-35 1.1437406448888887e-32 2.484952 240 0.02820543 238 0.007888270912184874 1.435138 67 132 0.01008884 Mouse Phenotype decreased erythroid progenitor cell number 49 1.12671e-28 2.1984641448979594e-26 2.50261 191 0.02244682 215 0.005563852741395349 1.599733 43 76 0.006474928 Mouse Phenotype extramedullary hematopoiesis 52 3.744095e-28 6.884094672115384e-26 2.089849 273 0.03208368 69 0.000005823706252608695 1.567207 97 175 0.01460623 Mouse Phenotype abnormal erythropoiesis 58 6.325094e-27 1.0426590298965516e-24 2.068279 267 0.03137854 128 0.0002523926972109375 1.518086 80 149 0.01204638 Mouse Phenotype decreased circulating alanine transaminase level 63 4.332379e-26 6.574900891904762e-24 2.470961 177 0.0208015 237 0.007768118859493671 1.545226 47 86 0.007077247 Mouse Phenotype abnormal third pharyngeal arch artery morphology 86 2.319987e-22 2.579232058953488e-20 3.465339 88 0.01034199 315 0.025125181926666667 2.019597 15 21 0.002258696 Mouse Phenotype decreased pre-B cell number 90 6.275024e-22 6.666167162666667e-20 2.067124 215 0.02526736 272 0.013477617954044117 1.468092 54 104 0.008131306 Mouse Phenotype abnormal splenic cell ratio 91 1.322113e-21 1.3890903728571428e-19 2.586104 133 0.01563051 327 0.02612334194495413 1.575948 34 61 0.005119711 Mouse Phenotype decreased fibroblast proliferation 115 4.444934e-19 3.695479476e-17 2.100892 178 0.02091903 145 0.0007798835168275861 1.522465 70 130 0.01054058 Mouse Phenotype abnormal embryonic hematopoiesis 124 5.189753e-18 4.0015506800806446e-16 2.223716 147 0.01727583 154 0.0010107460817532468 1.761353 38 61 0.00572203 Mouse Phenotype abnormal third pharyngeal arch morphology 132 3.25677e-17 2.358937725e-15 2.791716 91 0.01069456 379 0.04314937321899736 1.817637 18 28 0.002710435 Mouse Phenotype glomerulonephritis 135 7.646027e-17 5.415086233111111e-15 2.014506 172 0.02021389 233 0.00726500586695279 1.460842 62 120 0.009335943 Mouse Phenotype increased pre-B cell number 154 4.495262e-15 2.7908571416883115e-13 2.628676 87 0.01022447 253 0.009212155766798418 1.834012 24 37 0.003613914 Mouse Phenotype increased B cell derived lymphoma incidence 157 5.365836e-15 3.267691592101911e-13 2.199093 123 0.01445528 156 0.0010696515842307693 1.667462 46 78 0.006926668 Mouse Phenotype decreased mean corpuscular hemoglobin 248 1.336979e-11 5.15437750766129e-10 2.007395 114 0.01339758 398 0.04936877602010051 1.468798 40 77 0.006023189 Mouse Phenotype early cellular replicative senescence 249 2.014151e-11 7.733854502409639e-10 2.169526 93 0.0109296 173 0.0018706400462427744 1.665476 43 73 0.006474928 Mouse Phenotype enlarged liver sinusoidal spaces 269 7.11763e-11 2.5298015029739775e-9 2.277351 79 0.009284287 397 0.04922515770528968 1.655084 24 41 0.003613914 Mouse Phenotype chronic inflammation 292 2.161684e-10 7.078034494520548e-9 2.10782 89 0.01045951 335 0.028402531632537312 1.538458 37 68 0.00557145