# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to insulin stimulus	51	1.548517e-64	3.995477490784314e-62	2.112104	637	0.02835017	433	0.002669892721824481	1.245256	112	148	0.009815091	
GO Biological Process	regulation of DNA-templated transcription in response to stress	64	2.829788e-59	5.818309420624999e-57	2.444378	429	0.01909297	754	0.029889516651193635	1.216853	88	119	0.007711857	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	77	1.877827e-55	3.2091331809090913e-53	2.17967	508	0.02260893	475	0.004163141918315789	1.231484	116	155	0.01016563	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	157	9.530268e-41	7.987821440254777e-39	2.576906	264	0.01174952	826	0.040778928519370455	1.396197	28	33	0.002453773	
GO Biological Process	triglyceride homeostasis	173	1.285448e-38	9.777578168786127e-37	3.621418	149	0.006631359	495	0.004925286097575758	1.49125	29	32	0.002541407	
GO Biological Process	regulation of mitochondrial membrane permeability	190	2.031962e-36	1.4072941030526317e-34	2.32226	287	0.01277315	848	0.04569065497169812	1.262315	56	73	0.004907545	
GO Biological Process	regulation of membrane permeability	245	6.734563e-33	3.6171475313061223e-31	2.156117	303	0.01348525	788	0.03293999956218274	1.259532	62	81	0.005433354	
GO Biological Process	regulation of extracellular matrix organization	272	3.752079e-31	1.8152061603308823e-29	2.491262	212	0.009435222	727	0.024388387408528202	1.433193	27	31	0.002366138	
GO Biological Process	protein-lipid complex subunit organization	343	3.585991e-28	1.3757450603206998e-26	2.545862	183	0.008144555	321	0.0005693460666666666	1.470462	42	47	0.003680659	
GO Biological Process	apoptotic mitochondrial changes	356	1.595257e-27	5.896625523314607e-26	2.198986	240	0.01068138	605	0.012549525145950414	1.338726	48	59	0.004206467	
GO Biological Process	regulation of plasma lipoprotein particle levels	437	6.983161e-24	2.102778388993135e-22	2.09318	231	0.01028083	411	0.0021557736552554746	1.35248	60	73	0.005258084	
GO Biological Process	high-density lipoprotein particle remodeling	449	2.824978e-23	8.279261804454342e-22	4.094881	75	0.003337932	504	0.0054653478351190474	1.645517	17	17	0.001489791	
GO Biological Process	plasma lipoprotein particle organization	451	4.611322e-23	1.3454631086031042e-21	2.447971	159	0.007076416	294	0.0003676198946632653	1.495925	40	44	0.00350539	
GO Biological Process	anion homeostasis	493	3.660428e-21	9.770298590669371e-20	2.232472	175	0.007788509	604	0.012545777528145695	1.40471	35	41	0.003067216	
GO Biological Process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	495	3.793578e-21	1.0084786444848486e-19	2.41187	149	0.006631359	784	0.03272388176530612	1.426115	26	30	0.002278503	
GO Biological Process	reverse cholesterol transport	505	9.369036e-21	2.4413295984950495e-19	3.616389	77	0.003426944	504	0.0054653478351190474	1.645517	17	17	0.001489791	
GO Biological Process	protein-lipid complex assembly	542	1.006261e-19	2.4430606086715868e-18	2.761729	108	0.004806622	612	0.013341953103267976	1.475292	26	29	0.002278503	
GO Biological Process	drug transport	578	1.017845e-18	2.3172703036332182e-17	2.530179	119	0.005296186	841	0.04395293762187871	1.41855	25	29	0.002190868	
GO Biological Process	monosaccharide transport	608	2.35928e-18	5.106211434210527e-17	2.01302	191	0.008500601	625	0.014206972232800002	1.346332	45	55	0.003943563	
GO Biological Process	plasma lipoprotein particle remodeling	671	3.079821e-17	6.03984568390462e-16	2.489586	112	0.004984646	477	0.0042402353289308185	1.527981	26	28	0.002278503	
GO Molecular Function	drug transporter activity	26	2.489296e-29	4.042233735384616e-27	3.53518	115	0.005118163	98	0.036256218208163264	1.508391	22	24	0.001927964	
GO Molecular Function	aldo-keto reductase (NADP) activity	96	4.682039e-16	2.0591217352083332e-14	2.563787	98	0.004361565	90	0.025917300551111112	1.513876	23	25	0.002015599	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	67	5.302978e-48	7.247667096417911e-46	2.294661	392	0.01744626	130	0.0000787919700076923	1.380111	78	93	0.00683551	
Mouse Phenotype Single KO	decreased fatty acid level	80	2.474111e-44	2.831929303375e-42	2.095217	442	0.01967155	152	0.0002976725630986842	1.316414	96	120	0.008412935	
Mouse Phenotype Single KO	abnormal Mullerian duct morphology	315	2.233027e-21	6.491374044126985e-20	2.187867	185	0.008233566	284	0.009540617038380281	1.457458	31	35	0.002716677	
Mouse Phenotype Single KO	increased respiratory quotient	413	6.182939e-18	1.3708758455932203e-16	2.088727	170	0.00756598	315	0.013627866005714286	1.376862	41	49	0.003593024	
Mouse Phenotype Single KO	decreased total retina thickness	509	2.530315e-15	4.5520814253438116e-14	2.138479	135	0.006008278	180	0.0007818897764444445	1.515608	35	38	0.003067216	
Mouse Phenotype	extramedullary hematopoiesis	29	1.342078e-86	4.4246923303448275e-84	2.220628	766	0.03409141	182	0.0000680754231923077	1.278802	136	175	0.01191832	
Mouse Phenotype	decreased circulating free fatty acid level	81	2.755835e-54	3.2529059796296292e-52	2.175885	499	0.02220838	118	0.0000022699620866949153	1.382788	100	119	0.008763474	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	159	1.785475e-37	1.073643174528302e-35	3.030021	185	0.008233566	644	0.041704072453416154	1.41855	25	29	0.002190868	
Mouse Phenotype	abnormal Mullerian duct morphology	228	8.765402e-31	3.675702128157894e-29	2.174904	277	0.0123281	308	0.001384990318051948	1.458527	39	44	0.003417755	
Mouse Phenotype	lymph node hyperplasia	352	5.279225e-23	1.433939495028409e-21	2.170069	204	0.009079176	618	0.036285774150485436	1.346332	36	44	0.003154851	
Mouse Phenotype	abnormal sebaceous gland physiology	384	6.957449e-22	1.732296090859375e-20	2.980377	107	0.004762117	572	0.026853940583916085	1.5541	17	18	0.001489791	
Mouse Phenotype	spontaneous skin ulceration	389	1.36204e-21	3.347677233933162e-20	2.325688	164	0.007298945	640	0.04095980205	1.357552	33	40	0.002891946	
Mouse Phenotype	increased incidence of corneal inflammation	404	5.343381e-21	1.2645560826980199e-19	2.879408	108	0.004806622	649	0.04294904323266564	1.488802	19	21	0.00166506	
Mouse Phenotype	increased liver adenoma incidence	677	3.56884e-14	5.040129872968982e-13	2.407368	96	0.004272553	512	0.01722432637089844	1.469212	25	28	0.002190868