# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	13	3.798708e-43	3.845169120923077e-40	2.371464	324	0.03632287	183	0.000037361644010382515	1.406843	132	248	0.01858108	
GO Biological Process	chromatin assembly or disassembly	34	1.096331e-24	4.243123420294118e-22	2.175052	217	0.02432735	259	0.0016265814496525097	1.395825	94	178	0.01323198	
GO Biological Process	chromatin assembly	45	2.036112e-22	5.954043957333333e-20	2.189025	193	0.02163677	302	0.004975975632450331	1.388495	83	158	0.01168356	
GO Biological Process	gene silencing	51	1.30836e-21	3.3758253411764704e-19	2.155845	192	0.02152466	461	0.026724087881778744	1.306895	89	180	0.01252815	
GO Biological Process	nucleosome organization	55	2.801476e-21	6.702658669818182e-19	2.111894	198	0.02219731	254	0.0014958845538188977	1.406593	91	171	0.01280968	
GO Biological Process	multi-organism metabolic process	58	4.194684e-21	9.516870130344827e-19	2.304441	162	0.01816143	160	0.0000038222314023125	1.582299	88	147	0.01238739	
GO Biological Process	viral gene expression	60	5.790267e-21	1.2699020575499998e-18	2.520119	135	0.01513453	168	0.00001175379895297619	1.602545	77	127	0.01083896	
GO Biological Process	nuclear-transcribed mRNA catabolic process	63	3.280117e-20	6.851279302063492e-18	2.054511	200	0.02242152	129	2.2703171696124033e-7	1.548517	116	198	0.01632883	
GO Biological Process	regulation of gene silencing	66	5.083728e-20	1.0135875265454545e-17	2.256002	160	0.01793722	381	0.012918359536482939	1.392198	69	131	0.009712838	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	81	3.209854e-18	5.214625776049382e-16	2.473434	120	0.01345291	194	0.00011576487807216494	1.567976	70	118	0.009853604	
GO Biological Process	viral transcription	83	6.746952e-18	1.0696764020240963e-15	2.437615	121	0.01356502	169	0.000012961147816568046	1.637355	70	113	0.009853604	
GO Biological Process	translational initiation	88	6.240394e-17	9.331516437045454e-15	2.170304	145	0.01625561	315	0.00558002590920635	1.404756	76	143	0.0106982	
GO Biological Process	nucleosome assembly	100	9.166984e-16	1.20628342456e-13	2.019327	159	0.01782511	377	0.012487252247480107	1.377421	74	142	0.01041667	
GO Biological Process	regulation of DNA-templated transcription in response to stress	105	3.507853e-15	4.3961750120952377e-13	2.066772	144	0.0161435	415	0.01745710990120482	1.399319	63	119	0.008868243	
GO Biological Process	cotranslational protein targeting to membrane	107	4.10203e-15	5.04473016542056e-13	2.45452	99	0.01109865	260	0.0017253878353846155	1.537347	57	98	0.008023649	
GO Biological Process	ribonucleoprotein complex export from nucleus	116	4.063561e-14	4.60968958612069e-12	2.149759	121	0.01356502	344	0.008976251187790697	1.416733	67	125	0.009431306	
GO Biological Process	ribonucleoprotein complex localization	123	1.986272e-13	2.1249880689430894e-11	2.090878	122	0.01367713	340	0.008534207525294117	1.415235	68	127	0.009572072	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	128	3.428525e-13	3.524684412109375e-11	2.382542	90	0.01008969	338	0.007931384803846154	1.493959	52	92	0.00731982	
GO Biological Process	protein targeting to ER	131	4.809751e-13	4.831413237328244e-11	2.282635	97	0.01087444	345	0.00898072762057971	1.465514	56	101	0.007882883	
GO Biological Process	snRNA metabolic process	138	8.581105e-13	8.182518890942028e-11	2.381281	87	0.009753363	346	0.008996112318208092	1.505986	49	86	0.006897523	
GO Cellular Component	ribosomal subunit	32	4.339302e-19	2.3432230800000002e-17	2.155192	168	0.01883408	48	0.0000044047332000000005	1.500171	105	185	0.01478041	
GO Cellular Component	nuclear chromosome, telomeric region	39	1.848291e-14	8.189350892307692e-13	2.152061	124	0.01390135	84	0.010211151085714285	1.381651	69	132	0.009712838	
GO Cellular Component	mitochondrial ribosome	52	6.231542e-11	2.0707893415384616e-9	2.443165	69	0.007735426	89	0.015208784251685394	1.461511	47	85	0.006615991	
GO Cellular Component	cytoplasmic stress granule	54	8.177803e-11	2.61689696e-9	2.427198	69	0.007735426	114	0.03256875284210527	1.598189	26	43	0.00365991	
GO Cellular Component	small ribosomal subunit	55	9.033038e-11	2.8380163025454545e-9	2.337882	74	0.008295964	55	0.0005880839563636364	1.651974	45	72	0.006334459	
GO Cellular Component	PcG protein complex	56	9.499836e-11	2.931377965714286e-9	2.224295	82	0.009192825	118	0.04746102833898305	1.551419	27	46	0.003800676	
GO Cellular Component	intrinsic component of mitochondrial membrane	61	6.874949e-10	1.9475265363934425e-8	2.201838	76	0.008520179	85	0.011777899595294117	1.545231	38	65	0.005349099	
GO Cellular Component	host cell	67	1.421173e-9	3.6653536477611944e-8	2.128008	79	0.008856502	79	0.007681815250632912	1.554799	40	68	0.005630631	
GO Cellular Component	integral component of mitochondrial membrane	72	5.604285e-9	1.3450284e-7	2.12967	73	0.008183857	91	0.017318452747252747	1.528076	37	64	0.005208333	
GO Cellular Component	other organism cell	73	5.702825e-9	1.34992898630137e-7	2.03839	81	0.009080717	87	0.014230332248275863	1.500171	42	74	0.005912162	
GO Cellular Component	BLOC complex	93	2.117746e-7	0.000003934908696774194	2.897862	32	0.003587444	113	0.03089046201769911	1.838719	16	23	0.002252252	
GO Cellular Component	transcription factor TFIIIC complex	101	0.000001267809	0.000021690831207920792	6.040458	12	0.001345291	116	0.04362906537931034	2.643159	6	6	0.0008445946	
GO Cellular Component	commitment complex	102	0.000002266332	0.000038394330352941175	5.70411	12	0.001345291	82	0.00882427855609756	2.643159	8	8	0.001126126	
GO Cellular Component	PRC1 complex	106	0.00000278296	0.000045367498867924524	4.183938	16	0.001793722	109	0.02703845988990826	2.202632	10	12	0.001407658	
GO Cellular Component	Seh1-associated complex	115	0.0000058407	0.00008776286608695651	2.998035	23	0.002578475	96	0.019433142	2.114527	12	15	0.001689189	
GO Cellular Component	cytosolic small ribosomal subunit	118	0.000006355097	0.0000930644713220339	2.092085	45	0.005044843	102	0.021995136	1.621938	27	44	0.003800676	
GO Cellular Component	nuclear pore outer ring	131	0.00002008626	0.00026495463572519083	3.745341	15	0.001681614	93	0.019407651096774194	2.378843	9	10	0.001266892	
GO Cellular Component	GATOR2 complex	175	0.0003098087	0.0030591396205714287	2.692407	17	0.00190583	83	0.008996149127710842	2.402872	10	11	0.001407658	
GO Molecular Function	structural constituent of ribosome	8	6.494823e-17	3.42764283825e-14	2.124944	152	0.01704036	43	0.00001325850369767442	1.533685	94	162	0.01323198	
GO Molecular Function	5S rRNA binding	39	0.000001003497	0.00010863498292307692	4.286044	17	0.00190583	91	0.020047851509890108	2.402872	10	11	0.001407658	
GO Molecular Function	ATPase activator activity	82	0.00001835796	0.0009452110624390243	2.199136	36	0.004035874	92	0.021935598332608695	1.953639	17	23	0.002393018	
Mouse Phenotype Single KO	extramedullary hematopoiesis	3	9.118166e-18	2.7831682020666663e-14	2.105095	164	0.01838565	158	0.013470451214556962	1.437507	62	114	0.008727477	
Mouse Phenotype Single KO	abnormal erythrocyte physiology	16	3.909608e-14	2.2375175285e-11	2.747995	75	0.008408072	98	0.002171732052040816	1.820843	31	45	0.004363739	
Mouse Phenotype Single KO	microcytosis	23	1.523847e-13	6.066898686521738e-11	3.947598	43	0.004820628	174	0.02097817126091954	2.013835	16	21	0.002252252	
Mouse Phenotype Single KO	microcytic anemia	64	3.28503e-9	4.7001593296875003e-7	2.848117	43	0.004820628	210	0.04130717031380953	1.922297	16	22	0.002252252	
Mouse Phenotype Single KO	decreased liver function	80	2.157036e-8	0.0000024689973315	4.547785	21	0.00235426	216	0.046950270643518525	2.643159	7	7	0.0009853604	
Mouse Phenotype	abnormal erythrocyte physiology	14	4.794294e-15	3.2741603524285716e-12	2.643268	86	0.009641256	177	0.0016107508528813558	1.730068	36	55	0.005067568	
Mouse Phenotype	abnormal platelet activation	15	1.088622e-14	6.938876628e-12	2.053419	141	0.01580717	260	0.012907408836923078	1.453737	55	100	0.007742117	
Mouse Phenotype	abnormal platelet aggregation	21	5.228288e-14	2.3803648365714285e-11	2.033028	137	0.01535874	239	0.0077431578690376575	1.490292	53	94	0.007460586	
Mouse Phenotype	microcytosis	26	3.061004e-13	1.1256253555384617e-10	3.722157	45	0.005044843	333	0.0304574124954955	1.872237	17	24	0.002393018	
Mouse Phenotype	microcytic anemia	29	3.877387e-13	1.278334383e-10	3.142076	56	0.006278027	181	0.001836296752872928	2.005155	22	29	0.003096847	
Mouse Phenotype	decreased platelet aggregation	40	3.043821e-12	7.27549314525e-10	2.158081	102	0.01143498	360	0.04406502894166667	1.468422	40	72	0.005630631	
Mouse Phenotype	abnormal circulating interleukin-1 beta level	106	1.202736e-8	0.0000010848451788679245	2.153226	68	0.007623318	273	0.014873683471428572	1.604775	34	56	0.004786036	
Mouse Phenotype	abnormal conotruncus septation	107	2.040496e-8	0.0000018232880613084112	3.775237	26	0.002914798	336	0.03151393811607143	2.643159	7	7	0.0009853604	
Mouse Phenotype	increased circulating interleukin-1 beta level	119	4.50984e-8	0.000003623410104201681	2.302912	54	0.006053812	272	0.014874589021323529	1.762106	24	36	0.003378378	
Mouse Phenotype	pancytopenia	219	0.000003997125	0.0001745046215753425	2.092761	47	0.005269058	298	0.021223440423825506	1.822868	20	29	0.002815315	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	237	0.000006257042	0.00025242016270886076	2.02157	49	0.005493274	298	0.021223440423825506	1.822868	20	29	0.002815315