# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	lipid homeostasis	29	5.666759e-48	2.5713407476206897e-45	2.336155	377	0.01919356	447	0.000971614341588367	1.33123	80	104	0.007373272	
GO Biological Process	triglyceride homeostasis	50	1.05293e-36	2.771101174e-34	3.753394	135	0.006873027	606	0.006398874267656765	1.514274	28	32	0.002580645	
GO Biological Process	cellular response to xenobiotic stimulus	93	2.079404e-30	2.9422448640860215e-28	2.227719	259	0.01318603	719	0.018871433541029208	1.254287	79	109	0.007281106	
GO Biological Process	xenobiotic metabolic process	95	2.625904e-30	3.6372916564210523e-28	2.240106	255	0.01298238	668	0.0131562618248503	1.269106	77	105	0.007096774	
GO Biological Process	response to xenobiotic stimulus	116	1.625167e-27	1.843583840775862e-25	2.042314	285	0.01450972	731	0.02110375975102599	1.242481	84	117	0.007741935	
GO Biological Process	regulation of cholesterol metabolic process	138	8.794267e-26	8.385779670507246e-24	2.493051	173	0.008807657	602	0.006130515794352159	1.404071	43	53	0.003963134	
GO Biological Process	cholesterol homeostasis	165	7.990088e-24	6.372216241939395e-22	2.216033	202	0.01028409	499	0.0020087714544088178	1.413323	49	60	0.004516129	
GO Biological Process	regulation of lipid catabolic process	198	6.843764e-21	4.548337902828282e-19	2.142995	189	0.009622238	433	0.0008110535974364896	1.452467	47	56	0.004331797	
GO Biological Process	acute-phase response	224	1.335177e-19	7.843568813839285e-18	2.499409	128	0.006516648	815	0.03050083437668712	1.392921	33	41	0.003041475	
GO Biological Process	positive regulation of lipid catabolic process	237	4.389487e-19	2.437183942320675e-17	2.471307	127	0.006465737	643	0.010148396799066874	1.53831	24	27	0.002211982	
GO Biological Process	cotranslational protein targeting to membrane	241	6.072961e-19	3.3159375020331954e-17	2.071707	184	0.009367681	132	9.489581946287879e-9	1.518689	86	98	0.007926267	
GO Biological Process	reverse cholesterol transport	244	9.51996e-19	5.1341456409836065e-17	3.653351	68	0.003461969	737	0.021304296016282226	1.628799	16	17	0.001474654	
GO Biological Process	sterol transport	245	1.009321e-18	5.4210836893877553e-17	2.05625	185	0.009418593	921	0.04511942489250815	1.305042	46	61	0.004239631	
GO Biological Process	plasma lipoprotein particle clearance	254	3.444408e-18	1.7844474359055117e-16	2.316578	137	0.00697485	656	0.01145674895167683	1.435131	34	41	0.003133641	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	274	9.653066e-18	4.635937791751824e-16	2.067786	172	0.008756746	122	4.47469745647541e-9	1.54249	82	92	0.007557604	
GO Biological Process	regulation of cholesterol biosynthetic process	279	1.593386e-17	7.515185080286738e-16	2.287508	135	0.006873027	754	0.023246856941644564	1.400961	34	42	0.003133641	
GO Biological Process	bile acid metabolic process	298	8.158891e-17	3.602780089563759e-15	2.239089	135	0.006873027	448	0.00098937586375	1.543507	33	37	0.003041475	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	323	4.416779e-16	1.799393029752322e-14	2.381308	113	0.005752978	885	0.04147444698644068	1.504869	20	23	0.001843318	
GO Biological Process	ethanol oxidation	515	1.172072e-11	2.994814650097087e-10	3.50753	42	0.002138275	764	0.023804338195026177	1.730599	12	12	0.001105991	
GO Biological Process	cytoplasmic translation	516	1.272593e-11	3.2453587765503876e-10	2.339024	81	0.004123816	891	0.04183848667003367	1.368381	34	43	0.003133641	
GO Cellular Component	blood microparticle	31	1.238162e-38	6.9017546322580644e-37	2.340796	300	0.01527339	104	0.002947283446153846	1.28303	86	116	0.007926267	
GO Cellular Component	high-density lipoprotein particle	46	5.059681e-21	1.9006801669565218e-19	3.655576	77	0.003920171	119	0.007200825761344537	1.53831	24	27	0.002211982	
GO Cellular Component	protein-lipid complex	66	3.745852e-14	9.807321600000001e-13	2.126526	125	0.006363914	132	0.017437431272727275	1.400961	34	42	0.003133641	
GO Cellular Component	plasma lipoprotein particle	73	4.752014e-13	1.1248603002739727e-11	2.09553	118	0.006007535	149	0.030913409718120805	1.384479	32	40	0.002949309	
GO Molecular Function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	29	2.272005e-14	3.3077259e-12	2.342064	103	0.005243865	101	0.008038152934653466	1.520829	29	33	0.002672811	
Human Phenotype	Lipid accumulation in hepatocytes	19	5.576011e-18	1.958353758052632e-15	2.002861	189	0.009622238	102	0.00712242655	1.370058	57	72	0.005253456	
Human Phenotype	Hepatic steatosis	21	1.065066e-17	3.3843740085714284e-15	2.05579	174	0.008858568	70	0.0014331583034285715	1.446894	51	61	0.004700461	
Mouse Phenotype Single KO	increased CD4-positive NK T cell number	102	3.917472e-18	3.5168912847058824e-16	4.718627	49	0.002494654	545	0.04020366568440367	1.730599	11	11	0.001013825	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	562	4.614181e-7	0.000007518159326868328	2.057516	59	0.003003767	509	0.03281455025933202	1.514274	21	24	0.001935484	
Mouse Phenotype	decreased epididymal fat pad weight	92	3.250919e-23	3.3784822346739132e-21	2.073465	229	0.01165869	461	0.0024999795852494572	1.395644	50	62	0.004608295	
Mouse Phenotype	decreased liver regeneration	108	1.922811e-21	1.702221849166667e-19	2.637314	128	0.006516648	916	0.047580598319869	1.406112	26	32	0.002396313	
Mouse Phenotype	increased CD4-positive NK T cell number	153	3.917472e-18	2.448035934117647e-16	4.718627	49	0.002494654	786	0.029106481748091603	1.730599	11	11	0.001013825	
Mouse Phenotype	abnormal bile salt homeostasis	160	7.368684e-18	4.40324923275e-16	2.104953	166	0.008451278	764	0.026832633640052353	1.362387	37	47	0.003410138	
Mouse Phenotype	decreased hepatocyte proliferation	177	4.295072e-17	2.3200668583050846e-15	2.100227	159	0.008094899	724	0.02268670792127072	1.411805	31	38	0.002857143	
Mouse Phenotype	abnormal bile salt level	222	2.285871e-15	9.844690374324325e-14	2.065541	147	0.007483963	668	0.014889468390718563	1.442166	30	36	0.002764977	
Mouse Phenotype	abnormal pituitary intermediate lobe morphology	273	1.196408e-13	4.1900574681318674e-12	2.556919	82	0.004174728	626	0.012191469361341852	1.730599	13	13	0.001198157	
Mouse Phenotype	lymphoid hyperplasia	309	1.21379e-12	3.755678378640777e-11	2.07882	116	0.005905712	916	0.047580598319869	1.406112	26	32	0.002396313	
Mouse Phenotype	decreased brain cholesterol level	647	1.088799e-7	0.0000016089655701700156	2.509616	43	0.002189186	889	0.04455291565241845	1.730599	10	10	0.000921659	
Mouse Phenotype	increased thyroid carcinoma incidence	788	9.12711e-7	0.00001107414958248731	2.055258	56	0.002851033	702	0.01882317108119658	1.730599	12	12	0.001105991