# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process viral gene expression 2 2.682871e-14 1.76519497445e-10 2.990465 66 0.01795918 185 0.0010584793742162164 1.760124 49 127 0.01190476 GO Biological Process viral transcription 3 8.403703e-13 3.6861442592333332e-9 2.933854 60 0.01632653 213 0.0018856840822065726 1.776336 44 113 0.01068999 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 4 9.21419e-12 3.0312381552499997e-8 3.148485 49 0.01333333 278 0.0065243268690647485 1.785112 36 92 0.008746356 GO Biological Process cotranslational protein targeting to membrane 7 2.70566e-11 5.086254277142857e-8 3.008908 50 0.01360544 309 0.01119376509935275 1.72237 37 98 0.00898931 GO Biological Process translational initiation 8 4.732091e-11 7.783698183625e-8 2.470409 68 0.0185034 231 0.0031323729172294374 1.658892 52 143 0.01263362 GO Biological Process protein targeting to ER 9 5.260282e-11 7.691116759777778e-8 2.913013 51 0.01387755 353 0.019424570247592067 1.671211 37 101 0.00898931 GO Biological Process multi-organism metabolic process 11 6.269087e-11 7.499537803e-8 2.416886 70 0.01904762 268 0.006148577120522389 1.613752 52 147 0.01263362 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 12 7.508378e-11 8.233562175166666e-8 2.751625 55 0.01496599 409 0.029897000263325185 1.585085 41 118 0.009961127 GO Biological Process establishment of protein localization to endoplasmic reticulum 20 1.532875e-9 0.00000100855510625 2.603346 52 0.01414966 363 0.02104362992038567 1.650993 38 105 0.009232264 GO Biological Process regulation of neuronal synaptic plasticity 61 3.161006e-7 0.00006818963599016393 2.253831 49 0.01333333 178 0.0008411668969101123 2.280977 25 50 0.006073858 GO Biological Process cellular response to monosaccharide stimulus 64 3.660829e-7 0.0000752700762671875 2.145584 54 0.01469388 327 0.014673979170948013 1.851227 28 69 0.006802721 GO Biological Process cellular response to hexose stimulus 70 5.141814e-7 0.00009665875775142856 2.138466 53 0.01442177 378 0.024069321848148147 1.811364 27 68 0.006559767 GO Biological Process cellular response to glucose stimulus 77 8.179431e-7 0.00013978328899870129 2.121813 52 0.01414966 390 0.025502857309743592 1.824781 26 65 0.006316812 GO Biological Process cellular response to drug 83 0.000001072637 0.0001700581961807229 2.084758 53 0.01442177 332 0.015670387222891567 1.866254 27 66 0.006559767 GO Biological Process regulation of posttranscriptional gene silencing 113 0.000005975887 0.0006958999737433628 2.021306 49 0.01333333 317 0.01260526761955836 1.674111 40 109 0.009718173 GO Biological Process regulation of gene silencing by RNA 113 0.000005975887 0.0006958999737433628 2.021306 49 0.01333333 317 0.01260526761955836 1.674111 40 109 0.009718173 GO Biological Process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 132 0.00001555513 0.001550681482348485 2.614767 26 0.00707483 197 0.001240567062893401 3.121337 13 19 0.003158406 GO Biological Process regulation of short-term neuronal synaptic plasticity 177 0.00004806054 0.003573043196949153 2.751936 21 0.005714286 143 0.00025901908739160836 3.649563 12 15 0.002915452 GO Biological Process positive regulation of TOR signaling 198 0.00009749101 0.006479213134292929 2.379509 25 0.006802721 422 0.03145253577962086 2.146802 16 34 0.003887269 GO Biological Process regulation of systemic arterial blood pressure by endothelin 254 0.0003015042 0.015620054203937007 3.95374 10 0.002721088 350 0.018992249350285716 4.561953 5 5 0.001214772 GO Cellular Component ribosomal subunit 10 1.381988e-14 2.388075264e-12 2.615553 84 0.02285714 87 0.01163817335172414 1.479552 60 185 0.01457726 GO Cellular Component ribosome 15 4.246831e-11 4.892349312e-9 2.100843 96 0.02612245 117 0.046964942769230765 1.353122 70 236 0.0170068 GO Cellular Component small ribosomal subunit 18 4.502264e-10 4.3221734399999996e-8 3.143997 41 0.01115646 92 0.015391729878260868 1.774093 28 72 0.006802721 GO Cellular Component terminal bouton 24 1.876851e-8 0.00000135133272 2.262261 59 0.01605442 52 0.0012853817723076923 2.060237 28 62 0.006802721 GO Cellular Component cytosolic ribosome 27 5.083713e-8 0.00000325357632 2.24951 56 0.0152381 58 0.0016483734620689654 1.751464 43 112 0.01044704 GO Cellular Component cytosolic small ribosomal subunit 35 6.933121e-7 0.00003422980882285714 3.046759 27 0.007346939 80 0.00937470672 2.073615 20 44 0.004859086 GO Cellular Component postsynaptic density membrane 40 0.00000336743 0.000145472976 3.197322 22 0.005986395 71 0.0038127833239436615 3.991709 7 8 0.00170068 GO Cellular Component postsynaptic specialization membrane 44 0.000004712055 0.00018505525090909092 3.128696 22 0.005986395 85 0.011596575472941177 3.548186 7 9 0.00170068 GO Cellular Component nucleosome 45 0.000004900853 0.00018819275519999998 2.48506 32 0.008707483 102 0.02035765270588235 1.607545 37 105 0.00898931 GO Cellular Component voltage-gated calcium channel complex 58 0.00002498256 0.0007443079944827587 2.089055 39 0.01061224 59 0.0016617754250847457 2.280977 21 42 0.005102041 GO Cellular Component axon initial segment 65 0.00004216215 0.0011208645415384615 3.192395 17 0.00462585 97 0.019766431670103096 3.041302 8 12 0.001943635 GO Cellular Component DNA packaging complex 68 0.0000487283 0.0012382720941176472 2.143746 34 0.009251701 99 0.020340410181818185 1.588537 39 112 0.009475219 GO Cellular Component clathrin-sculpted vesicle 86 0.0001815566 0.003648020986046512 3.210858 14 0.003809524 97 0.019766431670103096 3.041302 8 12 0.001943635 GO Cellular Component node of Ranvier 102 0.0004211635 0.007135005176470588 2.534242 18 0.004897959 107 0.025396480598130843 2.737172 9 15 0.002186589 GO Cellular Component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 136 0.001612889 0.020493177882352942 2.96059 11 0.002993197 110 0.03214436596363636 3.421465 6 8 0.001457726 GO Cellular Component nuclear telomere cap complex 138 0.001798081 0.022515101217391306 3.113699 10 0.002721088 112 0.03595923257142857 2.807356 8 13 0.001943635 GO Molecular Function voltage-gated calcium channel activity 15 1.255024e-7 0.000035324742186666674 2.403043 46 0.01251701 32 0.0001451519641875 2.623123 23 40 0.005587949 GO Molecular Function sodium channel activity 16 4.966891e-7 0.0001310638362625 2.389324 42 0.01142857 47 0.001436498669787234 2.331665 23 45 0.005587949 GO Molecular Function neuropeptide hormone activity 61 0.0003179605 0.022007036573770494 2.451048 20 0.005442177 83 0.0500110702433735 2.280977 14 28 0.003401361 Mouse Phenotype Single KO absence seizures 6 3.961665e-7 0.00060461610675 2.441073 41 0.01115646 53 0.000010294898924339621 3.090355 21 31 0.005102041 Mouse Phenotype Single KO impaired conditioned place preference behavior 7 5.282614e-7 0.0006910413771142857 2.673389 34 0.009251701 128 0.00303623656734375 2.737172 15 25 0.003644315 Mouse Phenotype Single KO abnormal conditioned place preference behavior 8 8.301514e-7 0.000950212046225 2.463645 38 0.01034014 173 0.009539169776878612 2.350097 17 33 0.004130224 Mouse Phenotype Single KO abnormal carbon dioxide level 18 0.000005932125 0.0030178038125000003 3.931806 16 0.004353741 125 0.0028158383024800004 4.05507 8 9 0.001943635 Mouse Phenotype Single KO decreased body temperature 21 0.000007704966 0.003359732079142857 2.017899 48 0.01306122 119 0.0019547794173109243 2.042666 30 67 0.00728863 Mouse Phenotype Single KO pup cannibalization 36 0.0000217393 0.005529632502777778 3.23239 18 0.004897959 265 0.026980361029056602 2.932684 9 14 0.002186589 Mouse Phenotype Single KO hypercapnia 49 0.00007031069 0.013139489557755103 4.002181 12 0.003265306 224 0.020650318615178572 4.561953 5 5 0.001214772 Mouse Phenotype Single KO sporadic seizures 52 0.00007933719 0.013970974015961538 2.464006 24 0.006530612 202 0.014474039249009902 2.578495 13 23 0.003158406 Mouse Phenotype Single KO decreased grooming behavior 70 0.0002361114 0.030886744140000002 2.201761 26 0.00707483 169 0.00940758211775148 2.6957 13 22 0.003158406 Mouse Phenotype Single KO decreased chondrocyte number 72 0.0002587343 0.03290597201527778 2.188297 26 0.00707483 265 0.026980361029056602 2.932684 9 14 0.002186589 Mouse Phenotype Single KO abnormal nursing 81 0.0003455986 0.039069708397530864 2.145852 26 0.00707483 186 0.01214345216451613 2.443904 15 28 0.003644315 Mouse Phenotype Single KO abnormal spike wave discharge 95 0.0005144637 0.049588885272631576 2.161852 24 0.006530612 189 0.012348563338095237 2.737172 12 20 0.002915452 Mouse Phenotype abnormal neurotransmitter secretion 1 1.448703e-11 1.3851049383e-7 2.115927 99 0.02693878 45 1.3150764561333333e-7 2.387069 45 86 0.01093294 Mouse Phenotype impaired synaptic plasticity 9 1.500753e-7 0.0001594299937 2.291187 50 0.01360544 130 0.0007877697694615386 2.329508 24 47 0.005830904 Mouse Phenotype decreased neurotransmitter release 11 3.693564e-7 0.0003210378673090909 2.480058 40 0.01088435 255 0.011110493154117647 2.219329 18 37 0.004373178 Mouse Phenotype impaired conditioned place preference behavior 16 0.000001266026 0.0007565296616249999 2.567637 34 0.009251701 212 0.00647340132735849 2.534419 15 27 0.003644315 Mouse Phenotype abnormal conditioned place preference behavior 23 0.000003224693 0.001340490859695652 2.264978 40 0.01088435 205 0.0055991501312195125 2.346147 18 35 0.004373178 Mouse Phenotype hyporesponsive to tactile stimuli 28 0.000005101447 0.0017419619559642858 2.050886 48 0.01306122 299 0.01795132429966555 1.967901 22 51 0.005344995 Mouse Phenotype abnormal carbon dioxide level 31 0.000005932125 0.0018295821653225807 3.931806 16 0.004353741 164 0.002240907762987805 4.05507 8 9 0.001943635 Mouse Phenotype absence seizures 35 0.00001069868 0.0029225736994285714 2.062811 44 0.01197279 70 0.000007136413717285714 2.881234 24 38 0.005830904 Mouse Phenotype decreased paired-pulse facilitation 40 0.00001557836 0.0037236174990000004 2.242593 35 0.00952381 348 0.027685661318965514 2.207397 15 31 0.003644315 Mouse Phenotype pup cannibalization 43 0.00001802815 0.004008538189534884 2.785037 23 0.006258503 373 0.03245690356568364 2.509074 11 20 0.002672498 Mouse Phenotype hypercapnia 68 0.00007031069 0.009885889810147059 4.002181 12 0.003265306 290 0.01665431908758621 4.561953 5 5 0.001214772 Mouse Phenotype abnormal neuroendocrine cell morphology 74 0.00009797728 0.01265892937945946 2.332464 26 0.00707483 297 0.017938415803030305 2.471058 13 24 0.003158406 Mouse Phenotype sporadic seizures 84 0.0001650354 0.018784564992857144 2.178904 28 0.007619048 318 0.02020850843207547 2.154256 17 36 0.004130224 Mouse Phenotype abnormal solitary pulmonary neuroendocrine cell morphology 90 0.0003045258 0.03235079082 3.047956 14 0.003809524 424 0.0461414536485849 3.421465 6 8 0.001457726 Mouse Phenotype thin cerebellar granule layer 91 0.0003121451 0.032795816495604396 2.393063 21 0.005714286 408 0.04484528465441177 2.534419 10 18 0.002429543 Mouse Phenotype small sebaceous gland 98 0.0004134913 0.04034071754387755 5.359025 7 0.001904762 388 0.03794792934278351 3.193367 7 10 0.00170068 Mouse Phenotype abnormal spike wave discharge 99 0.0004258448 0.04112628416969697 2.151996 25 0.006802721 220 0.007545571621363637 2.6957 13 22 0.003158406 Mouse Phenotype increased adrenocorticotropin level 107 0.0005633813 0.05034101504018692 2.012557 28 0.007619048 297 0.017938415803030305 2.471058 13 24 0.003158406