# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of fibroblast growth factor receptor signaling pathway 52 3.954508e-16 1.0007186686923078e-13 2.437424 108 0.01024376 639 0.015827227159780907 2.104702 11 12 0.001345072 GO Biological Process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 385 8.082615e-7 0.00002762574825584415 2.033203 58 0.00550128 753 0.03217836851394422 1.812662 15 19 0.001834189 GO Biological Process response to corticosterone 457 0.000004217101 0.0001214285165404814 2.088778 47 0.004457934 613 0.013971987921207178 1.913365 15 18 0.001834189 GO Biological Process vesicle transport along actin filament 731 0.0001249335 0.002248973907660739 2.640605 20 0.001896993 828 0.04717469714975846 2.296038 7 7 0.000855955 GO Biological Process signal complex assembly 1102 0.001549005 0.018496694006352087 2.390269 16 0.001517595 699 0.02432613403004292 2.296038 8 8 0.0009782343 GO Cellular Component cytoplasmic side of endoplasmic reticulum membrane 73 9.196341e-7 0.000021768872942465755 3.16627 25 0.002371242 124 0.04767850219354839 2.066434 9 10 0.001100514 GO Cellular Component G-protein coupled receptor dimeric complex 219 0.004421737 0.03488932208219178 2.037054 18 0.001707294 121 0.04239112462809917 2.296038 7 7 0.000855955 GO Molecular Function ankyrin binding 14 8.764074e-9 0.000002642994316285714 2.498564 51 0.004837333 71 0.019826268194366198 1.933506 16 19 0.001956469 GO Molecular Function adenylate cyclase binding 60 0.00004203902 0.0029581457073333335 2.063251 38 0.003604287 82 0.039571925558536586 2.104702 11 12 0.001345072 Mouse Phenotype Single KO decreased vocalization 6 1.460122e-21 2.2283895256666667e-18 2.799472 116 0.01100256 719 0.03148652916828929 1.749362 16 21 0.001956469 Mouse Phenotype Single KO abnormal keratinocyte physiology 8 8.000598e-20 9.15768448575e-17 2.442091 135 0.0128047 599 0.01701431748580968 1.457802 40 63 0.004891171 Mouse Phenotype Single KO abnormal epidermis stratum granulosum morphology 33 3.426792e-13 9.508828589090909e-11 2.040626 127 0.01204591 255 0.00040687890611764706 1.629446 44 62 0.005380289 Mouse Phenotype Single KO abnormal keratinocyte morphology 61 1.708238e-10 2.5643172731147543e-8 2.036273 98 0.009295267 470 0.008072961218936171 1.561306 34 50 0.004157496 Mouse Phenotype Single KO enlarged inguinal lymph nodes 65 3.207237e-10 4.518256801384615e-8 3.667193 34 0.003224889 613 0.019302791681892334 2.296038 8 8 0.0009782343 Mouse Phenotype Single KO acanthosis 69 5.429668e-10 7.205720271884057e-8 2.387066 65 0.006165228 587 0.016522363531516183 1.589565 27 39 0.003301541 Mouse Phenotype Single KO abnormal epidermis stratum spinosum morphology 72 7.16235e-10 9.109116520833332e-8 2.028816 92 0.008726169 573 0.015808969210296682 1.478804 38 59 0.004646613 Mouse Phenotype Single KO epidermis stratum spinosum hyperplasia 100 2.004276e-8 0.0000018353155331999999 2.124472 68 0.006449777 461 0.007816548284381778 1.624027 29 41 0.003546099 Mouse Phenotype Single KO dermal-epidermal separation 110 3.995276e-8 0.000003325885666545454 3.764078 25 0.002371242 751 0.03619343877496671 2.296038 7 7 0.000855955 Mouse Phenotype Single KO abnormal epidermis suprabasal layer morphology 144 6.277286e-7 0.000039917436043055556 2.572726 36 0.003414588 638 0.021738890231974922 1.968033 12 14 0.001467351 Mouse Phenotype Single KO abnormal prostate gland dorsolateral lobe morphology 531 0.001379273 0.023785316122410548 2.27967 18 0.001707294 751 0.03619343877496671 2.296038 7 7 0.000855955 Mouse Phenotype decreased chondrocyte number 2 4.524608e-31 2.1629888543999998e-27 2.909887 161 0.0152708 1103 0.03810975593200363 1.722029 15 20 0.001834189 Mouse Phenotype abnormal keratinocyte proliferation 18 5.261621e-18 2.7947976878333336e-15 2.185377 153 0.014512 602 0.0025767022056478405 1.498803 47 72 0.005747126 Mouse Phenotype abnormal enteric neuron morphology 21 7.725564e-17 3.5173389240000005e-14 2.229447 136 0.01289955 1057 0.03184218234437086 1.578526 22 32 0.002690144 Mouse Phenotype decreased vocalization 23 5.956755e-16 2.476197154565217e-13 2.25473 125 0.01185621 699 0.005606458239484979 1.817697 19 24 0.002323306 Mouse Phenotype increased keratinocyte proliferation 29 3.503875e-15 1.1551913405172415e-12 2.424443 102 0.009674666 1088 0.03726972706985294 1.452596 31 49 0.003790658 Mouse Phenotype absent mandible 49 1.717983e-13 3.352170502653061e-11 2.005958 136 0.01289955 1005 0.02941418342089552 1.607227 21 30 0.002567865 Mouse Phenotype parakeratosis 69 7.966187e-12 1.1038364334347827e-9 2.454066 75 0.007113725 1218 0.048998021266009856 1.530692 22 33 0.002690144 Mouse Phenotype abnormal intestinal enteroendocrine cell morphology 77 1.84924e-11 2.2961796935064938e-9 3.136981 48 0.004552784 1174 0.04823128703918229 1.913365 10 12 0.001222793 Mouse Phenotype abnormal epidermis suprabasal layer morphology 110 6.348581e-10 5.518071176454546e-8 2.292785 70 0.006639476 671 0.004442650452160954 1.785807 21 27 0.002567865 Mouse Phenotype enlarged submandibular lymph nodes 146 1.009971e-8 6.613926528082192e-7 4.196399 24 0.002276392 989 0.028696147583417597 2.296038 7 7 0.000855955 Mouse Phenotype abnormal epidermal-dermal junction morphology 216 0.000001111242 0.00004918789241666666 2.78358 30 0.00284549 1044 0.031333100396551725 2.066434 9 10 0.001100514 Mouse Phenotype small sebaceous gland 442 0.0001468226 0.0031759522140271494 3.469159 13 0.001233046 1044 0.031333100396551725 2.066434 9 10 0.001100514