# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to topologically incorrect protein	42	1.28425e-17	4.023677559523809e-15	2.052189	173	0.01673114	269	0.00988434126951673	1.360044	80	139	0.01006796	
GO Biological Process	endoplasmic reticulum unfolded protein response	45	2.168314e-16	6.340631983555556e-14	2.137659	145	0.01402321	340	0.021709234413235294	1.368096	66	114	0.008306066	
GO Biological Process	viral gene expression	84	2.943632e-13	4.611339700952381e-11	2.045198	127	0.0122824	310	0.016788095140967744	1.358303	73	127	0.009187012	
GO Biological Process	regulation of mitochondrial membrane permeability	92	8.113538e-13	1.1605005058913045e-10	2.07479	118	0.01141199	295	0.012759474917288136	1.489061	46	73	0.005789076	
GO Biological Process	'de novo' protein folding	120	1.030815e-11	1.1303745487500001e-9	2.915582	55	0.005319149	421	0.047675057	1.620395	24	35	0.003020388	
GO Biological Process	transcription from RNA polymerase III promoter	175	4.280822e-10	3.2189335256e-8	2.52668	59	0.005705996	318	0.01729749722389937	1.631648	29	42	0.003649635	
GO Biological Process	posttranscriptional gene silencing by RNA	191	1.251662e-9	8.623361391623037e-8	2.112224	81	0.007833656	385	0.03537033244415585	1.529049	33	51	0.004153033	
GO Biological Process	mitochondrial DNA metabolic process	199	1.824138e-9	1.2062227106532663e-7	4.59592	24	0.002321083	405	0.04038721290370371	2.148251	10	11	0.001258495	
GO Biological Process	RNA methylation	247	1.669119e-8	8.892282154251013e-7	2.04901	75	0.007253385	245	0.006426227190612245	1.575384	40	60	0.005033979	
GO Biological Process	positive regulation of nuclease activity	282	7.186999e-8	0.000003353678008546099	3.112203	31	0.002998066	332	0.021354976134036145	2.047999	13	15	0.001636043	
GO Biological Process	mitochondrial genome maintenance	291	1.248842e-7	0.000005647254940893471	2.595764	40	0.003868472	302	0.015187285558609273	1.912966	17	21	0.002139441	
GO Biological Process	termination of RNA polymerase II transcription	306	2.262264e-7	0.000009728474501960785	2.033696	64	0.006189555	343	0.02414957711282799	1.472641	43	69	0.005411528	
GO Biological Process	platelet formation	314	2.681628e-7	0.000011238070971974521	2.552462	39	0.00377176	275	0.010664292854545454	1.989959	16	19	0.002013592	
GO Biological Process	translesion synthesis	353	7.234456e-7	0.000026968330454390932	2.101757	54	0.005222437	404	0.04045545633663366	1.575384	28	42	0.003523786	
GO Biological Process	platelet morphogenesis	383	0.00000203483	0.00006991208347258486	2.343403	39	0.00377176	347	0.025567311283861673	1.890461	16	20	0.002013592	
GO Biological Process	positive regulation of mitochondrial membrane permeability	463	0.000007348346	0.00020884856374514036	2.214073	39	0.00377176	242	0.0059830057925619835	2.008614	17	20	0.002139441	
GO Biological Process	positive regulation of membrane permeability	561	0.00003056681	0.0007169851208377897	2.07274	39	0.00377176	375	0.032523156277066666	1.826013	17	22	0.002139441	
GO Biological Process	mitochondrial outer membrane permeabilization involved in programmed cell death	568	0.00003342316	0.0007743228211971831	2.161629	35	0.003384913	222	0.0034532387200450453	2.100512	16	18	0.002013592	
GO Biological Process	regulation of establishment of protein localization to chromosome	602	0.00005072803	0.0011088540644019933	2.602476	23	0.002224371	405	0.04038721290370371	2.148251	10	11	0.001258495	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	651	0.00008711003	0.0017608001302150537	2.714537	20	0.001934236	381	0.03544813556430446	2.363076	8	8	0.001006796	
GO Cellular Component	mitochondrial nucleoid	63	1.068203e-8	2.9299282285714287e-7	2.410051	54	0.005222437	111	0.019335541621621623	1.575384	28	42	0.003523786	
GO Cellular Component	spliceosomal snRNP complex	84	1.408164e-7	0.000002896794514285714	2.104194	61	0.00589942	94	0.0063290592	1.524565	40	62	0.005033979	
GO Cellular Component	Bcl-2 family protein complex	195	0.000462552	0.004098922338461539	2.796996	15	0.001450677	137	0.030606752233576645	2.363076	7	7	0.0008809464	
GO Molecular Function	unfolded protein binding	13	3.906079e-19	1.268574272153846e-16	2.491652	125	0.01208897	71	0.01646255322253521	1.40447	63	106	0.007928517	
GO Molecular Function	ribonucleoprotein complex binding	17	8.235566e-14	2.045327038352941e-11	2.03304	135	0.01305609	68	0.01242019888529412	1.397297	68	115	0.008557765	
GO Molecular Function	TPR domain binding	62	1.39458e-7	0.000009496639935483871	4.681687	18	0.001740812	88	0.04924147386363637	2.363076	8	8	0.001006796	
GO Molecular Function	FAD binding	67	1.866819e-7	0.000011763745997014927	2.806951	34	0.003288201	59	0.007873686515254238	2.008614	17	20	0.002139441	
GO Molecular Function	peroxiredoxin activity	144	0.00005131403	0.0015044988518055555	3.44376	15	0.001450677	88	0.04924147386363637	2.363076	8	8	0.001006796	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	22	1.967346e-14	8.188630600909092e-12	2.664352	81	0.007833656	138	0.016819225918115945	1.792678	22	29	0.002768689	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	28	5.163551e-14	1.6886655895357143e-11	2.513765	87	0.008413926	118	0.009726868046610168	1.755428	26	35	0.003272087	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	67	9.88405e-10	1.3508693410447762e-7	2.112552	82	0.007930368	150	0.019782422624666667	1.535999	39	60	0.00490813	
Mouse Phenotype Single KO	abnormal carbon dioxide level	636	0.001713623	0.024672399073899374	2.0088	23	0.002224371	161	0.02468840382795031	2.363076	9	9	0.001132645	
Mouse Phenotype	pancytopenia	30	9.352139e-14	2.9805266993e-11	2.765659	72	0.00696325	263	0.03646140062737643	1.711193	21	29	0.002642839	
Mouse Phenotype	abnormal embryonic erythropoiesis	38	1.259066e-11	3.1678763226315785e-9	2.337113	81	0.007833656	274	0.04117434181751825	1.677022	22	31	0.002768689	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	41	2.06199e-11	4.8084600951219515e-9	2.212856	89	0.00860735	240	0.02460491081625	1.635976	27	39	0.003397936	
Mouse Phenotype	early cellular replicative senescence	46	6.824818e-11	1.4185235847391306e-8	2.015715	105	0.01015474	210	0.013023147368571429	1.489061	46	73	0.005789076	
Mouse Phenotype	microcytosis	80	3.610929e-9	4.315511521125e-7	2.925569	41	0.003965184	201	0.012437900143283583	1.870768	19	24	0.00239114	
Mouse Phenotype	thin ventricle myocardium compact layer	139	3.298061e-7	0.000022685439727338127	2.04993	61	0.00589942	129	0.0020303680306976743	2.114331	17	19	0.002139441	
Mouse Phenotype	hyperlipidemia	243	0.00001353598	0.0005325823241975309	2.178171	38	0.003675048	262	0.03382229659580152	1.826013	17	22	0.002139441	
Mouse Phenotype	abnormal carbon dioxide level	572	0.001713623	0.028643268361888113	2.0088	23	0.002224371	223	0.018610760896412556	2.363076	9	9	0.001132645