# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	57	3.195168e-41	7.376353633684211e-39	2.341261	321	0.01535885	478	0.00564990199079498	1.231753	93	114	0.007478289	
GO Biological Process	cellular response to unfolded protein	85	2.941977e-35	4.5545265109411765e-33	2.143604	330	0.01578947	433	0.0031391083207852194	1.235365	99	121	0.007960759	
GO Biological Process	cellular response to topologically incorrect protein	95	1.521156e-33	2.107041242526316e-31	2.048193	349	0.01669856	615	0.02388893418699187	1.184015	109	139	0.008764876	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	143	2.958977e-24	2.722879604405594e-22	2.084904	237	0.01133971	532	0.010939544190789473	1.21559	95	118	0.007639112	
GO Biological Process	regulation of mitochondrial membrane permeability	173	1.847949e-21	1.4056162364739884e-19	2.000756	230	0.01100478	576	0.017204380444965278	1.261689	61	73	0.004905114	
GO Biological Process	IRE1-mediated unfolded protein response	192	1.297865e-20	8.895107049479165e-19	2.410757	145	0.006937799	654	0.030835038018348623	1.275597	49	58	0.003940174	
GO Biological Process	cotranslational protein targeting to membrane	209	7.664523e-19	4.825715701291866e-17	2.031661	192	0.009186603	296	0.0001460119528074324	1.309599	85	98	0.006834995	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	224	8.269617e-18	4.858030808169643e-16	2.033711	180	0.00861244	267	0.00007062474727715356	1.32936	81	92	0.006513348	
GO Biological Process	membrane protein proteolysis	428	5.560525e-11	1.7096015998831778e-9	2.049664	102	0.004880383	682	0.035360818492668616	1.342125	32	36	0.002573175	
GO Biological Process	mismatch repair	559	2.207225e-9	5.195862929338104e-8	2.238904	69	0.003301435	611	0.023719452857610474	1.402041	26	28	0.002090704	
GO Molecular Function	ankyrin binding	19	8.823756e-16	1.9607314648421052e-13	2.496087	101	0.004832536	94	0.017799493868085107	1.509891	19	19	0.001527822	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	48	5.877877e-27	1.1213274935208333e-24	2.027805	284	0.01358852	257	0.002643205818171206	1.361862	46	51	0.003698939	
Mouse Phenotype Single KO	decreased mean corpuscular hemoglobin	53	4.414197e-26	7.626566401698113e-24	2.135778	242	0.01157895	202	0.0009994140193069307	1.334831	61	69	0.004905114	
Mouse Phenotype Single KO	microcytosis	112	1.698712e-16	1.3888487307142857e-14	3.01699	77	0.003684211	302	0.0052651658437086095	1.509891	21	21	0.001688646	
Mouse Phenotype Single KO	increased mean platelet volume	132	1.285541e-15	8.917953740151516e-14	2.006267	161	0.007703349	315	0.005932410415238096	1.369436	39	43	0.003136057	
Mouse Phenotype Single KO	microcytic anemia	192	1.067395e-12	5.090695841145833e-11	2.402852	85	0.004066986	445	0.028941778820224716	1.441259	21	22	0.001688646	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	41	2.618402e-36	6.1059857370731705e-34	2.681599	218	0.01043062	763	0.035015113714285714	1.316315	34	39	0.002733998	
Mouse Phenotype	microcytic anemia	114	4.711412e-19	3.9513868536842104e-17	2.658093	111	0.005311005	594	0.012538557764141414	1.40576	27	29	0.002171116	
Mouse Phenotype	microcytosis	117	7.037365e-19	5.750790321794871e-17	3.071284	87	0.004162679	364	0.0013226708413186811	1.509891	24	24	0.001929881	
Mouse Phenotype	abnormal circulating interleukin-10 level	180	3.078243e-15	1.6350600734999998e-13	2.283483	116	0.005550239	740	0.032058911578378375	1.337332	31	35	0.002492763	
Mouse Phenotype	decreased circulating ketone body level	1051	0.0002800161	0.0025473205823977165	2.179886	26	0.001244019	779	0.038252088188703466	1.509891	14	14	0.001125764