# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	21	5.872357e-35	3.6797307506190475e-32	2.374807	262	0.01639857	379	0.00020668185086015833	1.345986	88	113	0.008100147	
GO Biological Process	regulation of DNA-templated transcription in response to stress	24	5.239169e-34	2.872592702958333e-31	2.259689	282	0.01765037	381	0.0002210632907847769	1.336218	92	119	0.008468336	
GO Biological Process	multi-organism metabolic process	51	1.151029e-24	2.9698805119607843e-22	2.033107	256	0.01602303	136	5.471565416544117e-9	1.434429	122	147	0.01122975	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	54	4.89256e-24	1.1922443896296297e-21	2.25551	196	0.01226763	160	2.3008569070624998e-8	1.464719	100	118	0.009204713	
GO Biological Process	cotranslational protein targeting to membrane	56	3.077204e-23	7.230879899285716e-21	2.366994	171	0.01070289	148	9.267981503378377e-9	1.516732	86	98	0.007916053	
GO Biological Process	protein targeting to ER	60	4.234995e-22	9.2880498675e-20	2.286038	174	0.01089066	153	1.2856351600653596e-8	1.505906	88	101	0.008100147	
GO Biological Process	viral gene expression	61	4.535311e-22	9.783632368688525e-20	2.126117	204	0.01276835	151	1.2098637322516558e-8	1.456185	107	127	0.009849043	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	62	4.699904e-22	9.975167215483871e-20	2.283636	174	0.01089066	411	0.0004916625024817518	1.39599	63	78	0.005798969	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	65	8.212575e-22	1.662604221923077e-19	2.364763	160	0.0100144	158	2.1090478979746833e-8	1.521716	81	92	0.007455817	
GO Biological Process	endoplasmic reticulum unfolded protein response	69	4.356203e-21	8.307721054637682e-19	2.041783	214	0.01339425	817	0.03920391451040392	1.228052	81	114	0.007455817	
GO Biological Process	viral transcription	93	6.377784e-19	9.024221468387096e-17	2.069508	184	0.01151656	149	9.904072776510066e-9	1.483644	97	113	0.008928571	
GO Biological Process	regulation of cellular amino acid metabolic process	97	1.278693e-18	1.7346722873195877e-16	2.646047	109	0.006822307	654	0.014182337602905198	1.353889	47	60	0.004326215	
GO Biological Process	triglyceride homeostasis	98	1.508292e-18	2.0252667783673469e-16	3.007901	88	0.005507918	582	0.006863605523195876	1.512323	28	32	0.00257732	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	113	1.178088e-17	1.3718991143362834e-15	2.03828	177	0.01107843	174	4.7406250393103446e-8	1.481459	90	105	0.008284242	
GO Biological Process	plasma lipoprotein particle remodeling	144	2.683785e-16	2.4524949177083333e-14	2.750934	88	0.005507918	753	0.027935910409030547	1.481459	24	28	0.002209131	
GO Biological Process	regulation of plasma lipoprotein particle levels	149	3.964306e-16	3.501094137852349e-14	2.038933	160	0.0100144	503	0.0021565644154671972	1.373225	58	73	0.005338733	
GO Biological Process	snRNA metabolic process	182	3.197546e-14	2.311896033736264e-12	2.062979	135	0.008449646	493	0.001984903293083164	1.34652	67	86	0.006167158	
GO Biological Process	cytoplasmic translation	200	1.877882e-13	1.2355524618999999e-11	2.662572	75	0.004694248	694	0.01830370255706052	1.406812	35	43	0.003221649	
GO Biological Process	mitochondrial translational termination	204	2.357304e-13	1.5205766341176473e-11	2.074569	124	0.007761157	343	0.00008180405525072886	1.410508	71	87	0.006535346	
GO Biological Process	mitochondrial translational elongation	223	7.557471e-13	4.459585690089686e-11	2.05794	121	0.007573387	323	0.000052970148972136225	1.423363	70	85	0.006443299	
GO Cellular Component	ribosomal subunit	35	5.640771e-26	2.7849292251428573e-24	2.005416	280	0.01752519	28	4.3813797942857145e-13	1.457435	156	185	0.01435935	
GO Cellular Component	large ribosomal subunit	44	6.429193e-18	2.5249194327272725e-16	2.066158	174	0.01089066	45	1.308610176e-7	1.442812	96	115	0.008836524	
GO Cellular Component	mitochondrial ribosome	54	6.174164e-14	1.97573248e-12	2.21407	112	0.007010077	92	0.0007093066226086957	1.362361	67	85	0.006167158	
GO Cellular Component	mitochondrial large ribosomal subunit	68	2.460688e-11	6.253042447058824e-10	2.427938	73	0.004569068	126	0.007996033371428573	1.389473	41	51	0.003773932	
GO Cellular Component	DNA-directed RNA polymerase III complex	93	1.264822e-8	2.350120877419355e-7	3.454371	30	0.001877699	161	0.034473428273291924	1.546435	17	19	0.001564801	
GO Cellular Component	cytosolic proteasome complex	137	0.000002257858	0.000028478676087591243	2.9313	26	0.001627339	148	0.016388235243243243	1.728369	12	12	0.001104566	
GO Molecular Function	unfolded protein binding	9	8.886139e-26	4.168586539777778e-23	2.399472	186	0.01164173	107	0.04423061899065421	1.255513	77	106	0.007087629	
GO Molecular Function	rRNA binding	12	7.326495e-19	2.5777051575e-16	2.937017	93	0.005820867	67	0.0014492292265671641	1.440307	50	60	0.004602356	
GO Molecular Function	mRNA 5'-UTR binding	77	6.324206e-7	0.00003467636069090909	2.225271	48	0.003004319	102	0.03398721589803922	1.571244	20	22	0.001840943	
Human Phenotype	Abnormality of mitochondrial metabolism	12	9.249452e-15	5.143466099666667e-12	2.073787	139	0.008700006	209	0.02464044841004785	1.327588	53	69	0.004878498	
Human Phenotype	Abnormality of the mitochondrion	13	2.398991e-14	1.231420534076923e-11	2.040873	140	0.008762596	226	0.03092359732300885	1.314534	54	71	0.004970545	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	76	6.162619e-13	7.425145024078948e-11	2.050804	123	0.007698567	347	0.01860057715533141	1.353889	47	60	0.004326215	
Mouse Phenotype Single KO	decreased creatinine clearance	215	2.926244e-8	0.000001246307735255814	2.600955	44	0.002753959	243	0.0034200648874074075	1.728369	17	17	0.001564801	
Mouse Phenotype	early cellular replicative senescence	71	1.823201e-16	2.4551584170422536e-14	2.037553	164	0.01026476	472	0.011828571431567797	1.325872	56	73	0.005154639	
Mouse Phenotype	increased urine uric acid level	276	1.493132e-8	5.172404004347827e-7	2.630489	45	0.002816549	663	0.03499950421266968	1.728369	11	11	0.001012518	
Mouse Phenotype	decreased creatinine clearance	300	2.926244e-8	9.325939628000001e-7	2.600955	44	0.002753959	326	0.002661785919386503	1.728369	17	17	0.001564801