# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process SRP-dependent cotranslational protein targeting to membrane 7 9.099393e-14 1.7105558926714285e-10 2.835116 69 0.01200626 203 0.00015941357110344826 1.758554 50 92 0.008616233 GO Biological Process viral gene expression 8 1.025224e-13 1.686365327e-10 2.491778 86 0.01496433 214 0.00020907646404672896 1.630609 64 127 0.01102878 GO Biological Process protein targeting to ER 9 1.180403e-13 1.7258803418888888e-10 2.702838 74 0.01287628 197 0.00012993857889847716 1.73 54 101 0.009305532 GO Biological Process cotranslational protein targeting to membrane 13 6.180861e-13 6.256457684538462e-10 2.693724 70 0.01218027 239 0.000564689579246862 1.683906 51 98 0.008788558 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 18 3.278764e-12 2.3969586375555553e-9 2.463392 77 0.01339829 243 0.0005960138902880659 1.61787 59 118 0.01016715 GO Biological Process establishment of protein localization to endoplasmic reticulum 24 1.967002e-11 1.0784908049166667e-8 2.401076 75 0.01305029 215 0.0002213955846511628 1.694911 55 105 0.009477856 GO Biological Process viral transcription 26 2.315072e-11 1.1716935556923078e-8 2.376386 76 0.01322429 242 0.000597221215 1.632188 57 113 0.009822506 GO Biological Process multi-organism metabolic process 31 6.573999e-11 2.7905565432580645e-8 2.09748 95 0.01653036 267 0.0015503327598876404 1.518817 69 147 0.0118904 GO Biological Process protein localization to endoplasmic reticulum 36 2.134556e-10 7.802395112222223e-8 2.182338 82 0.01426831 269 0.0016214955172118958 1.565681 60 124 0.01033948 GO Biological Process translational initiation 40 5.077913e-10 1.6705064291749998e-7 2.067598 89 0.01548634 278 0.0020671577235971223 1.516046 67 143 0.01154575 GO Biological Process long-term memory 102 5.330386e-7 0.00006876720526862745 2.121481 54 0.009396207 313 0.00444659847028754 2.059107 21 33 0.003618818 GO Biological Process peptidyl-serine dephosphorylation 210 0.00003235328 0.002027318150095238 3.134984 18 0.003132069 527 0.03915696413092979 2.831273 7 8 0.001206273 GO Biological Process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 256 0.00007609311 0.003911364197226563 2.122216 33 0.005742126 448 0.024750266700223213 2.213927 13 19 0.002240221 GO Biological Process antigen processing and presentation of endogenous antigen 378 0.000454834 0.015833758216931216 4.10726 9 0.001566034 556 0.04658312033992806 2.588592 8 10 0.001378597 GO Biological Process negative regulation of catecholamine secretion 381 0.0004665489 0.016113692848031495 2.010599 29 0.005046111 452 0.024599064867035402 2.489031 10 13 0.001723247 GO Biological Process regulation of short-term neuronal synaptic plasticity 408 0.0006257461 0.020181845416421568 2.094958 25 0.004350096 319 0.005184749126959248 2.588592 12 15 0.002067896 GO Biological Process regulation of interleukin-12 secretion 475 0.001109996 0.030750394450526315 3.107268 11 0.001914042 455 0.025153226053846154 3.23574 6 6 0.001033948 GO Biological Process cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation 509 0.001398686 0.036159742777996065 2.498571 15 0.002610057 455 0.025153226053846154 3.23574 6 6 0.001033948 GO Cellular Component cytosolic large ribosomal subunit 45 1.381701e-7 0.000005305731839999999 2.397749 46 0.008004176 63 0.00044687478857142863 1.856572 35 61 0.006031363 GO Cellular Component postsynaptic density membrane 52 0.000001061232 0.00003526555569230769 2.788053 30 0.005220115 115 0.02356365412173913 2.831273 7 8 0.001206273 GO Cellular Component MHC class I peptide loading complex 60 0.000004721431 0.0001359772128 37.95276 4 0.0006960153 123 0.039559722146341465 3.23574 5 5 0.0008616233 GO Cellular Component integral component of lumenal side of endoplasmic reticulum membrane 70 0.00001159612 0.00028625850514285713 3.546671 17 0.002958065 114 0.02347412210526316 2.059107 14 22 0.002412545 GO Cellular Component axon initial segment 75 0.00002067967 0.0004764595968 2.761924 23 0.004002088 119 0.03094869781512605 2.426805 9 12 0.001550922 GO Cellular Component neuronal cell body membrane 90 0.0001163798 0.00223449216 2.001067 36 0.006264138 69 0.0006299606817391305 2.465326 16 21 0.002757195 GO Cellular Component NMDA selective glutamate receptor complex 136 0.001530231 0.019442935058823527 2.026347 23 0.004002088 101 0.012585232728712871 2.647424 9 11 0.001550922 GO Molecular Function sodium channel activity 17 3.025296e-10 7.513411595294118e-8 2.400965 66 0.01148425 46 0.00032964577491304345 2.085255 29 45 0.004997415 GO Molecular Function DNA polymerase binding 32 1.663334e-7 0.000021945612962500002 5.210614 16 0.002784061 83 0.01834193471807229 2.426805 12 16 0.002067896 GO Molecular Function ankyrin binding 38 7.200907e-7 0.00008000586672105264 2.786154 31 0.005394119 96 0.037058002485416665 2.213927 13 19 0.002240221 GO Molecular Function neuropeptide hormone activity 62 0.00002653522 0.001806962884516129 2.351035 30 0.005220115 61 0.004297935092459016 2.195681 19 28 0.003274169 GO Molecular Function acid-thiol ligase activity 81 0.000214588 0.011185068345679013 2.053681 31 0.005394119 81 0.015779156854320988 2.115676 17 26 0.002929519 GO Molecular Function NMDA glutamate receptor activity 90 0.0003483229 0.016340214264444444 2.501843 19 0.003306073 79 0.014354538129113923 3.23574 7 7 0.001206273 GO Molecular Function voltage-gated sodium channel activity 129 0.001044553 0.034186843147286816 2.051684 24 0.004176092 71 0.009138007602816902 2.25095 16 23 0.002757195 Mouse Phenotype Single KO absence seizures 2 2.696285e-12 1.23449408725e-8 2.627013 69 0.01200626 85 0.0000016616820074117645 2.609468 25 31 0.004308116 Mouse Phenotype Single KO nonconvulsive seizures 7 9.495789e-10 0.0000012421848553285714 2.222598 73 0.01270228 79 0.0000010527217547468355 2.516687 28 36 0.00482509 Mouse Phenotype Single KO decreased leukotriene level 11 5.696016e-9 0.000004741674410181818 7.274767 15 0.002610057 349 0.014210231414899714 2.876213 8 9 0.001378597 Mouse Phenotype Single KO abnormal conditioned place preference behavior 15 1.92042e-8 0.00001172352396 2.321661 56 0.009744214 204 0.0011140567794117647 2.15716 22 33 0.003791143 Mouse Phenotype Single KO abnormal leukotriene level 16 2.019247e-8 0.000011556402986875 6.599567 15 0.002610057 476 0.037864021863445375 2.588592 8 10 0.001378597 Mouse Phenotype Single KO abnormal spike wave discharge 17 2.173635e-8 0.000011708220997058824 2.59205 45 0.007830172 239 0.002400492990753138 2.426805 15 20 0.00258487 Mouse Phenotype Single KO impaired conditioned place preference behavior 24 6.226129e-8 0.000023755276355416665 2.413463 48 0.008352184 211 0.0012186152959241707 2.329733 18 25 0.003101844 Mouse Phenotype Single KO increased bone volume 25 1.048614e-7 0.000038408633592 2.039041 67 0.01165826 361 0.015386443685872579 1.706118 29 55 0.004997415 Mouse Phenotype Single KO increased memory-marker CD4-positive NK T cell number 27 1.714339e-7 0.00005814148971481481 6.036916 14 0.002436054 447 0.032124947944071586 2.831273 7 8 0.001206273 Mouse Phenotype Single KO abnormal alcohol consumption 38 5.549955e-7 0.00013373931035526315 2.135747 53 0.009222203 524 0.04451422159732825 1.820104 18 32 0.003101844 Mouse Phenotype Single KO abnormal carbon dioxide level 68 0.00001177676 0.0015858792841176468 3.14281 20 0.003480077 349 0.014210231414899714 2.876213 8 9 0.001378597 Mouse Phenotype Single KO abnormal hippocampus granule cell layer 103 0.00007601483 0.006757939789417476 2.28731 28 0.004872107 313 0.00961318535686901 2.542367 11 14 0.001895571 Mouse Phenotype Single KO sporadic seizures 147 0.0002495499 0.015545091389795916 2.035206 31 0.005394119 544 0.04775030429227941 1.969581 14 23 0.002412545 Mouse Phenotype Single KO clonic seizures 155 0.0003132035 0.018503254512903227 2.338261 22 0.003828084 502 0.03896037180876494 2.311243 10 14 0.001723247 Mouse Phenotype Single KO abnormal nerve fiber response 226 0.0009830016 0.03982896305840709 2.026947 25 0.004350096 502 0.03896037180876494 2.311243 10 14 0.001723247 Mouse Phenotype decreased neurotransmitter release 6 1.668724e-10 2.659111694e-7 2.497805 63 0.01096224 406 0.007126623394581281 1.923954 22 37 0.003791143 Mouse Phenotype absence seizures 8 7.918397e-10 9.463474214625e-7 2.218475 74 0.01287628 121 0.000005554611501074381 2.38423 28 38 0.00482509 Mouse Phenotype decreased leukotriene level 11 5.696016e-9 0.000004950873543272727 7.274767 15 0.002610057 461 0.011232482640780911 2.876213 8 9 0.001378597 Mouse Phenotype abnormal leukotriene level 16 2.019247e-8 0.000012066262854375001 6.599567 15 0.002610057 629 0.02991804103497615 2.588592 8 10 0.001378597 Mouse Phenotype abnormal spike wave discharge 17 2.995593e-8 0.00001684756745470588 2.532069 46 0.008004176 306 0.002051440967352941 2.353266 16 22 0.002757195 Mouse Phenotype abnormal conditioned place preference behavior 22 5.947975e-8 0.000025849358625 2.172558 60 0.01044023 199 0.0002396921079648241 2.218793 24 35 0.004135792 Mouse Phenotype impaired conditioned place preference behavior 23 8.152046e-8 0.000033887700785217395 2.366284 49 0.008526188 258 0.0010422116282558138 2.277002 19 27 0.003274169 Mouse Phenotype increased memory-marker CD4-positive NK T cell number 28 1.714339e-7 0.00005853855421071429 6.036916 14 0.002436054 597 0.025114568949748742 2.831273 7 8 0.001206273 Mouse Phenotype abnormal alcohol consumption 40 0.000001155773 0.000276258641325 2.065928 54 0.009396207 577 0.02215586934488735 1.863002 19 33 0.003274169 Mouse Phenotype abnormal liquid preference 46 0.000002111476 0.0004388656964347826 2.185497 45 0.007830172 696 0.04125682770258621 1.833586 17 30 0.002929519 Mouse Phenotype impaired behavioral response to cocaine 53 0.000005244084 0.0009460129646037736 2.858923 25 0.004350096 357 0.003858257188235294 2.47439 13 17 0.002240221 Mouse Phenotype abnormal NMDA-mediated synaptic currents 66 0.00001047995 0.001518163665909091 2.029642 46 0.008004176 618 0.028196100660194175 1.896813 17 29 0.002929519 Mouse Phenotype abnormal carbon dioxide level 68 0.00001177676 0.0016558470935294117 3.14281 20 0.003480077 461 0.011232482640780911 2.876213 8 9 0.001378597 Mouse Phenotype clonic seizures 102 0.00007939931 0.007442517675588235 2.321807 27 0.004698103 594 0.024926846868686868 2.059107 14 22 0.002412545 Mouse Phenotype impaired social transmission of food preference 117 0.0001616541 0.013210041453846154 2.259265 26 0.0045241 641 0.03179002668486739 2.426805 9 12 0.001550922 Mouse Phenotype catalepsy 200 0.0007164382 0.034249328151 2.493697 17 0.002958065 629 0.02991804103497615 2.588592 8 10 0.001378597