# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4	1.420536e-28	4.673208305999999e-25	2.818801	155	0.01533136	138	6.152308321811595e-7	1.674107	77	118	0.01052056	
GO Biological Process	RNA catabolic process	5	1.105691e-27	2.9099575737999997e-24	2.028896	289	0.02858556	98	3.264153059489796e-8	1.511631	142	241	0.01940156	
GO Biological Process	nuclear-transcribed mRNA catabolic process	6	9.252837e-27	2.0293013680499997e-23	2.166158	239	0.02363996	158	0.0000013591539661392407	1.503029	116	198	0.01584916	
GO Biological Process	mRNA catabolic process	7	1.078971e-24	2.0283113412857143e-21	2.048946	250	0.02472799	146	8.097150903835617e-7	1.493539	124	213	0.01694221	
GO Biological Process	protein targeting to ER	9	5.620721e-24	8.218118626555557e-21	2.761404	133	0.01315529	139	6.753041649352518e-7	1.727277	68	101	0.009290887	
GO Biological Process	cotranslational protein targeting to membrane	11	2.741115e-22	3.279121116818181e-19	2.734356	125	0.012364	115	1.1240267901826087e-7	1.780153	68	98	0.009290887	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	12	7.666792e-22	8.407276327333332e-19	2.779449	119	0.01177052	147	8.189928855782312e-7	1.75682	63	92	0.008607733	
GO Biological Process	viral gene expression	13	4.040671e-21	4.090091514538462e-18	2.421131	147	0.01454006	229	0.000035201324854148475	1.555469	77	127	0.01052056	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	14	7.671222e-21	7.21040073557143e-18	2.49319	137	0.01355094	169	0.000001978941520769231	1.685909	69	105	0.009427517	
GO Biological Process	multi-organism metabolic process	17	3.092902e-20	2.3940880834117645e-17	2.183803	174	0.01721068	225	0.00003087428328044444	1.518366	87	147	0.01188687	
GO Biological Process	protein localization to endoplasmic reticulum	18	3.633735e-20	2.656462159166667e-17	2.314673	153	0.01513353	216	0.000023793592061111113	1.572412	76	124	0.01038393	
GO Biological Process	viral transcription	23	7.881579e-19	4.509291220043478e-16	2.381761	134	0.0132542	232	0.00003547812169956897	1.589257	70	113	0.009564148	
GO Biological Process	protein targeting to membrane	31	3.062287e-17	1.2998914397741936e-14	2.098844	160	0.01582591	180	0.000004330966109777778	1.589087	83	134	0.01134035	
GO Biological Process	translational initiation	41	7.318342e-16	2.348830789707317e-13	2.046906	155	0.01533136	271	0.00013918667613284133	1.489075	83	143	0.01134035	
GO Biological Process	regulation of DNA-templated transcription in response to stress	44	1.214883e-15	3.633328499318182e-13	2.01345	159	0.015727	687	0.04648072930422125	1.336655	62	119	0.008471103	
GO Biological Process	ER-nucleus signaling pathway	74	3.467577e-13	6.166195370675677e-11	2.780858	68	0.006726014	156	0.0000013275229398076924	2.199012	30	35	0.004098921	
GO Biological Process	negative regulation of mRNA processing	90	3.804868e-12	5.563139779111111e-10	2.778068	62	0.006132542	405	0.004573457562469136	1.881377	22	30	0.003005875	
GO Biological Process	negative regulation of mRNA splicing, via spliceosome	99	1.388754e-11	1.8459205945454546e-9	2.997947	52	0.005143422	435	0.006688029986896552	2.052412	16	20	0.002186091	
GO Biological Process	regulation of alternative mRNA splicing, via spliceosome	103	3.186546e-11	4.071044545048544e-9	2.151086	93	0.009198813	553	0.018700740331464738	1.649259	27	42	0.003689029	
GO Biological Process	negative regulation of mRNA metabolic process	129	5.423756e-10	5.5326515662015505e-8	2.242042	74	0.007319486	400	0.004107437101	1.776125	27	39	0.003689029	
GO Cellular Component	ribosomal subunit	23	6.402953e-21	4.810566427826086e-19	2.139204	189	0.01869436	62	0.00007948543587096774	1.428367	103	185	0.01407296	
GO Cellular Component	small ribosomal subunit	30	2.148668e-14	1.2376327679999999e-12	2.50869	90	0.008902077	71	0.0010860842636619718	1.603447	45	72	0.006148381	
GO Cellular Component	cytosolic small ribosomal subunit	47	2.004974e-9	7.371478876595745e-8	2.420096	59	0.005835806	88	0.0052863957818181815	1.690907	29	44	0.00396229	
GO Cellular Component	axon initial segment	65	9.498216e-8	0.000002525064192	2.662187	39	0.003857567	117	0.0328846523076923	2.137929	10	12	0.001366307	
GO Cellular Component	node of Ranvier	120	0.00003189162	0.000459239328	2.047113	40	0.003956479	109	0.023322562348623854	2.052412	12	15	0.001639568	
GO Molecular Function	structural constituent of ribosome	6	6.080069e-16	4.278341886333333e-13	2.010505	163	0.01612265	60	0.00045537429463333334	1.441122	91	162	0.01243339	
GO Molecular Function	O-methyltransferase activity	26	4.616769e-9	7.496922583846154e-7	3.046168	38	0.003758655	79	0.005633142040506329	2.076845	17	21	0.002322722	
GO Molecular Function	DNA polymerase binding	33	1.559296e-8	0.000001994953852121212	4.257815	23	0.002274975	96	0.030680913370833337	2.08448	13	16	0.001776199	
GO Molecular Function	peptide hormone receptor binding	52	0.000003143119	0.00025519708496153843	2.245534	41	0.004055391	104	0.047568177903846154	1.924136	15	20	0.00204946	
GO Molecular Function	pre-mRNA intronic binding	58	0.00000535805	0.00039002908793103454	2.668238	28	0.002769535	93	0.024133778240860212	2.565514	8	8	0.001093045	
Human Phenotype	Ulnar claw	265	0.0009002303	0.022668818082641512	2.113788	23	0.002274975	87	0.040774806581609195	2.565514	8	8	0.001093045	
Mouse Phenotype Single KO	absence seizures	17	8.494141e-10	4.5753440668823533e-7	2.012733	93	0.009198813	129	0.00018230728087596898	2.068963	25	31	0.003415767	
Mouse Phenotype Single KO	abnormal frequency of paradoxical sleep	62	0.000001308664	0.0001932812298064516	2.228981	45	0.004451039	416	0.03238313617548077	2.052412	12	15	0.001639568	
Mouse Phenotype Single KO	abnormal inhibitory postsynaptic potential	230	0.0001222815	0.004868398676086957	2.222792	28	0.002769535	329	0.014796103262613982	2.565514	8	8	0.001093045	
Mouse Phenotype	decreased neurotransmitter release	9	2.517221e-11	2.6741277756666668e-8	2.141074	95	0.009396637	451	0.00849583676141907	1.733456	25	37	0.003415767	
Mouse Phenotype	impaired conditioned place preference behavior	24	1.379364e-8	0.000005495041335	2.058838	75	0.007418398	543	0.016561918115469615	1.805362	19	27	0.002595983	
Mouse Phenotype	bicuspid aortic valve	134	0.00002589923	0.001847929388283582	2.007519	43	0.004253215	598	0.022102825615384614	1.865829	16	22	0.002186091	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	150	0.00003387529	0.0021592109845999996	2.108621	37	0.003659743	482	0.01122387212987552	1.79586	21	30	0.002869244	
Mouse Phenotype	abnormal inhibitory postsynaptic potential	211	0.0001222815	0.00554091668957346	2.222792	28	0.002769535	474	0.010722968097468354	2.565514	8	8	0.001093045	
Mouse Phenotype	abnormal periosteum morphology	246	0.0002497977	0.009708600852439023	2.159097	27	0.002670623	589	0.022151652020373516	2.565514	7	7	0.0009564148	
Mouse Phenotype	decreased corticospinal tract size	270	0.0003443778	0.012194800539999998	2.273068	23	0.002274975	589	0.022151652020373516	2.565514	7	7	0.0009564148	
Mouse Phenotype	abnormal Purkinje cell differentiation	358	0.0008368437	0.02234933691536313	2.167884	22	0.002176063	589	0.022151652020373516	2.565514	7	7	0.0009564148