# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	13	1.989127e-53	2.0134555533076922e-50	2.093686	535	0.02797971	100	2.8864713906000003e-14	1.398845	214	259	0.01929492	
GO Biological Process	rRNA processing	14	5.003399e-53	4.702837674357143e-50	2.108843	522	0.02729983	108	8.833567249722222e-14	1.397392	208	252	0.01875394	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	20	4.552485e-46	2.9953075057499996e-43	2.682734	279	0.01459129	102	4.237573418529412e-14	1.563868	109	118	0.009827788	
GO Biological Process	nuclear-transcribed mRNA catabolic process	25	7.08412e-45	3.7287974032000005e-42	2.108558	440	0.02301135	126	1.0569862313492063e-12	1.42793	167	198	0.01505725	
GO Biological Process	mRNA catabolic process	26	8.1883e-44	4.144224603846154e-41	2.032375	469	0.02452801	124	8.962412371935484e-13	1.414803	178	213	0.01604905	
GO Biological Process	multi-organism metabolic process	40	1.050271e-38	3.45512902225e-36	2.223052	335	0.01752	120	3.9343085243333333e-13	1.497206	130	147	0.01172122	
GO Biological Process	protein targeting to ER	47	9.901317e-36	2.7721580936808508e-33	2.557849	233	0.01218556	127	1.0803549361417322e-12	1.575658	94	101	0.00847534	
GO Biological Process	regulation of DNA-templated transcription in response to stress	48	3.024829e-35	8.292442668958333e-33	2.162653	323	0.01689242	334	0.00004578843462275449	1.35155	95	119	0.008565504	
GO Biological Process	viral gene expression	49	3.054662e-35	8.203325971020408e-33	2.351285	270	0.0141206	103	4.40889995368932e-14	1.546357	116	127	0.01045893	
GO Biological Process	cotranslational protein targeting to membrane	50	3.496075e-35	9.200970185000001e-33	2.590798	224	0.01171487	104	5.0689733288461543e-14	1.606617	93	98	0.008385177	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	51	7.736389e-35	1.9961400559019607e-32	2.642811	214	0.01119188	123	7.484237951382113e-13	1.600984	87	92	0.007844198	
GO Biological Process	translational initiation	54	1.222301e-34	2.9785664553703703e-32	2.178519	312	0.01631714	94	1.3950040685957446e-14	1.527247	129	143	0.01163105	
GO Biological Process	viral transcription	75	7.644757e-31	1.3412980981733333e-28	2.302502	245	0.01281314	118	3.4826062966949154e-13	1.558154	104	113	0.009376972	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	76	8.566232e-31	1.4831979853684209e-28	2.318955	241	0.01260394	141	1.0274183227659574e-11	1.547881	96	105	0.008655667	
GO Biological Process	protein localization to endoplasmic reticulum	88	5.835839e-29	8.726568795568182e-27	2.143747	268	0.014016	186	2.409000443172043e-9	1.46089	107	124	0.009647462	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	93	1.634773e-27	2.313115903978495e-25	2.075211	274	0.01432979	384	0.0002463474801015625	1.33342	89	113	0.008024524	
GO Biological Process	cellular aldehyde metabolic process	109	2.358669e-25	2.8474977404587154e-23	2.360596	189	0.00988442	693	0.014596993873160172	1.328349	51	65	0.004598323	
GO Biological Process	NIK/NF-kappaB signaling	179	4.993636e-20	3.67101989519553e-18	2.073981	195	0.01019821	653	0.01136152493353752	1.294643	65	85	0.005860608	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	210	1.608718e-18	1.008053341047619e-16	2.757653	101	0.005282151	861	0.04042939981881533	1.587182	15	16	0.001352448	
GO Biological Process	rRNA modification	240	2.664823e-17	1.4611002440416667e-15	2.670091	99	0.005177553	791	0.028289737240202277	1.410829	30	36	0.002704896	
GO Cellular Component	ribosomal subunit	31	9.019099e-37	5.027420345806451e-35	2.118528	354	0.01851368	27	8.2853824e-16	1.482514	162	185	0.01460644	
GO Cellular Component	large ribosomal subunit	36	1.824579e-27	8.7579792e-26	2.252292	227	0.01187176	42	1.64619936e-11	1.516334	103	115	0.009286809	
GO Cellular Component	cytosolic large ribosomal subunit	49	3.507242e-19	1.236839627755102e-17	2.302999	147	0.007687882	52	4.584972184615385e-9	1.609732	58	61	0.005229465	
GO Cellular Component	mitochondrial ribosome	71	5.936219e-14	1.4447586523943662e-12	2.097789	127	0.006641912	125	0.0012733189631999999	1.334478	67	85	0.006040934	
GO Cellular Component	small ribosomal subunit	74	9.823451e-14	2.293908557837838e-12	2.019136	137	0.007164897	82	0.00004967593287804878	1.434342	61	72	0.005499955	
GO Cellular Component	mitochondrial large ribosomal subunit	97	7.559997e-11	1.3467705995876288e-9	2.251046	81	0.00423618	142	0.004110655233802817	1.394231	42	51	0.003786854	
GO Cellular Component	MLL1 complex	124	3.783517e-9	5.272514012903226e-8	2.286157	64	0.003347105	141	0.004070415523404255	1.517857	26	29	0.002344243	
GO Cellular Component	U1 snRNP	218	0.00000556834	0.00004413803449541285	2.12515	44	0.002301135	151	0.007299602988079471	1.603889	18	19	0.001622938	
GO Molecular Function	structural constituent of ribosome	8	6.167454e-36	3.2548738485000005e-33	2.158669	331	0.01731081	9	1.8783753057777778e-14	1.504884	144	162	0.0129835	
GO Molecular Function	rRNA binding	14	1.731054e-25	5.220364277142857e-23	3.113796	118	0.006171225	97	0.007089299482474227	1.382612	49	60	0.004417997	
GO Molecular Function	rRNA methyltransferase activity	23	1.727343e-18	3.170800933043478e-16	3.568952	69	0.003608598	111	0.01502266714954955	1.608345	19	20	0.001713101	
GO Molecular Function	cadherin binding involved in cell-cell adhesion	25	1.816803e-18	3.0682169063999996e-16	2.633413	109	0.005700539	130	0.03337578687692308	1.598939	17	18	0.001532774	
Human Phenotype	Exercise intolerance	20	4.248503e-15	1.41751302595e-12	2.136345	133	0.006955703	122	0.003074847841229508	1.378581	57	70	0.005139302	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	5	9.340042e-27	1.71053529188e-23	2.068766	268	0.014016	344	0.04144732377616279	1.341618	42	53	0.003786854	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	72	2.106297e-15	2.67880022625e-13	2.061889	148	0.007740181	156	0.002892606490961538	1.410829	50	60	0.00450816	
Mouse Phenotype Single KO	early cellular replicative senescence	102	2.687416e-13	2.4126145403921566e-11	2.038051	129	0.006746509	221	0.009902180914932125	1.399976	43	52	0.003877017	
Mouse Phenotype	absent proamniotic cavity	899	0.00005418702	0.0005762870947942159	2.591582	23	0.001202866	601	0.04847706989351082	1.692994	11	11	0.0009917951