# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	35	2.74124e-54	1.0306279188571428e-51	2.387205	411	0.01648418	264	0.000009775168134469697	1.320065	99	113	0.00794415	
GO Biological Process	endoplasmic reticulum unfolded protein response	41	1.416261e-49	4.54550695097561e-47	2.353841	385	0.01544138	518	0.002461484434787645	1.2424	94	114	0.007542931	
GO Biological Process	cellular response to topologically incorrect protein	42	1.722658e-49	5.397251576666667e-47	2.194078	446	0.01788794	384	0.00041492006143229165	1.246584	115	139	0.009228053	
GO Biological Process	response to topologically incorrect protein	43	1.789919e-49	5.477568400232557e-47	2.013638	546	0.02189869	291	0.000027427145430240547	1.247246	149	180	0.01195635	
GO Biological Process	regulation of DNA-templated transcription in response to stress	44	2.04064e-48	6.102904945454546e-46	2.207948	430	0.01724622	248	0.000006814478352822581	1.316815	104	119	0.00834537	
GO Biological Process	cellular response to unfolded protein	49	2.864079e-46	7.691513379795918e-44	2.216138	407	0.01632375	419	0.0006007479212171838	1.257692	101	121	0.008104638	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	74	6.388377e-41	1.1360088235540541e-38	2.344966	318	0.01275418	401	0.0004864419601995013	1.26413	99	118	0.00794415	
GO Biological Process	multi-organism metabolic process	82	3.492957e-39	5.605344044268293e-37	2.061085	405	0.01624353	190	3.946282290894737e-8	1.332492	130	147	0.01043171	
GO Biological Process	cotranslational protein targeting to membrane	105	3.682413e-34	4.6149402540000004e-32	2.341669	264	0.01058838	269	0.000013721290429368031	1.337617	87	98	0.006981223	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	106	4.590698e-34	5.698961790754717e-32	2.085632	340	0.01363655	748	0.024639189557486632	1.218216	76	94	0.00609854	
GO Biological Process	viral gene expression	114	5.807053e-33	6.70307109008772e-31	2.117078	317	0.01271407	213	8.069352095305164e-7	1.328779	112	127	0.008987321	
GO Biological Process	protein import into mitochondrial matrix	119	2.140573e-32	2.3670420257983194e-30	4.905465	88	0.003529459	702	0.0175645413494302	1.50674	17	17	0.001364147	
GO Biological Process	cellular response to epidermal growth factor stimulus	128	5.536891e-31	5.692183489765625e-29	2.291938	249	0.009986765	566	0.005122831248763251	1.387787	35	38	0.002808538	
GO Biological Process	regulation of cholesterol metabolic process	129	8.427347e-31	8.596547222713177e-29	2.452167	216	0.008663217	463	0.0012114914350323973	1.364595	48	53	0.003851709	
GO Biological Process	protein targeting to ER	130	9.115924e-31	9.22741876276923e-29	2.222588	264	0.01058838	283	0.000020992059818727915	1.327722	89	101	0.007141711	
GO Biological Process	response to cadmium ion	133	1.256514e-30	1.2431930621052632e-28	2.493353	208	0.008342358	647	0.011130449643740341	1.298914	50	58	0.004012197	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	137	3.686592e-30	3.5410119801459855e-28	2.291943	242	0.009706012	279	0.00001953407328422939	1.342964	82	92	0.006580003	
GO Biological Process	mitochondrial transmembrane transport	139	4.740293e-30	4.487591049424461e-28	2.224566	257	0.01030762	489	0.0017681180498568508	1.288898	71	83	0.00569732	
GO Biological Process	response to epidermal growth factor	150	3.840386e-29	3.369042624933333e-27	2.192052	257	0.01030762	485	0.0015466725031752576	1.399116	39	42	0.003129514	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	154	1.268793e-28	1.0841589017532468e-26	2.169792	258	0.01034773	363	0.00024125112463636362	1.332886	69	78	0.005536832	
GO Cellular Component	large ribosomal subunit	51	9.953219e-29	3.372384790588235e-27	2.107729	277	0.01110977	69	0.000009815395617391304	1.310209	100	115	0.008024394	
GO Cellular Component	mitochondrial ribosome	63	5.278993e-23	1.4479523657142859e-21	2.292834	181	0.007259455	87	0.00023560862896551725	1.311751	74	85	0.005938052	
GO Cellular Component	mitochondrial large ribosomal subunit	104	2.977107e-15	4.9465777846153846e-14	2.344381	110	0.004411824	125	0.0045657921024	1.329477	45	51	0.003610977	
GO Cellular Component	spliceosomal tri-snRNP complex	180	2.443821e-9	2.34606816e-8	2.204519	71	0.002847632	109	0.0016940519339449542	1.454784	28	29	0.00224683	
GO Cellular Component	U1 snRNP	212	6.723999e-8	5.480693524528302e-7	2.18537	59	0.002366342	174	0.043579375448275864	1.427438	18	19	0.001444391	
GO Molecular Function	unfolded protein binding	10	2.379242e-31	1.0045159724e-28	2.223698	269	0.01078891	138	0.03726080208695652	1.208235	85	106	0.006820735	
GO Molecular Function	protein phosphatase 2A binding	22	1.811778e-22	3.476966689090909e-20	2.375969	164	0.006577628	104	0.00922482236346154	1.450935	26	27	0.002086342	
GO Molecular Function	rRNA binding	30	1.451645e-19	2.0429483966666666e-17	2.529614	125	0.005013436	129	0.03221175227286822	1.280729	51	60	0.004092441	
GO Molecular Function	thyroid hormone receptor binding	61	2.055207e-14	1.4224727793442624e-12	2.346728	103	0.004131071	134	0.036371427238805966	1.399116	26	28	0.002086342	
Human Phenotype	Increased serum lactate	10	2.349932e-28	1.5681096235999998e-25	2.089134	279	0.01118999	50	0.000004802644849	1.356066	90	100	0.007221955	
Human Phenotype	Abnormal CSF metabolite level	13	1.284771e-25	6.594828371538461e-23	2.441591	179	0.00717924	62	0.000028401923961290326	1.411074	59	63	0.004734393	
Human Phenotype	Abnormality of mitochondrial metabolism	23	4.418369e-22	1.281903319e-19	2.074578	217	0.008703325	84	0.00009835064602380951	1.37572	63	69	0.005055368	
Human Phenotype	Abnormality of the mitochondrion	24	6.823852e-22	1.8973151831666668e-19	2.055092	220	0.008823647	96	0.00022041203992708333	1.358189	64	71	0.005135612	
Human Phenotype	Increased CSF lactate	26	1.217393e-20	3.1244859573076922e-18	2.334585	155	0.006216661	87	0.0001141277053908046	1.402827	54	58	0.004333173	
Human Phenotype	Exercise intolerance	52	8.270558e-16	1.0613352602692309e-13	2.007906	163	0.006537521	101	0.0002860140297029703	1.356066	63	70	0.005055368	
Human Phenotype	Glycosuria	117	1.301992e-11	7.425805654700855e-10	2.08897	104	0.004171179	246	0.02219403179878049	1.402827	27	29	0.002166586	
Human Phenotype	Progressive macrocephaly	308	2.882104e-7	0.0000062442467506493505	2.088883	59	0.002366342	241	0.019328518939419087	1.44396	23	24	0.001845611	
Human Phenotype	Abnormal mitochondria in muscle tissue	331	5.283171e-7	0.000010650936580966766	2.078117	57	0.002286127	162	0.0032881627651851855	1.50674	23	23	0.001845611	
Human Phenotype	Acute necrotizing encephalopathy	419	0.000003297406	0.000052514535174224346	2.02437	52	0.002085589	203	0.008991394144334976	1.50674	20	20	0.001604879	
Human Phenotype	Increased muscle lipid content	429	0.000003937385	0.00006124515175990677	2.178045	43	0.001724622	215	0.01279811876651163	1.50674	19	19	0.001524635	
Mouse Phenotype Single KO	pale liver	35	1.033752e-29	2.7045905897142855e-27	2.063653	302	0.01211246	229	0.01595589655764192	1.261895	67	80	0.005376344	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	171	3.566645e-14	1.9099279687134505e-12	2.420543	95	0.003810211	321	0.04177143840498442	1.438252	21	22	0.001685123	
Mouse Phenotype Single KO	spontaneous chromosome breakage	210	5.029999e-13	2.1933190877619048e-11	2.308019	95	0.003810211	239	0.01842345488535565	1.446471	24	25	0.001925855	
Mouse Phenotype	absent hypoglossal nerve	79	5.467879e-25	6.617517863164557e-23	3.889893	86	0.003449244	488	0.041713349913934425	1.50674	15	15	0.001203659	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	109	3.667823e-21	3.2172528167889904e-19	2.21565	178	0.007139133	420	0.02627852232142857	1.399116	26	28	0.002086342	
Mouse Phenotype	absent segment of posterior cerebral artery	232	3.566645e-14	1.4698574502155174e-12	2.420543	95	0.003810211	446	0.03139060660089686	1.438252	21	22	0.001685123	
Mouse Phenotype	increased liver adenoma incidence	244	7.863946e-14	3.0814421190983606e-12	2.305051	102	0.004090964	420	0.02627852232142857	1.399116	26	28	0.002086342	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	266	2.751819e-13	9.89103062368421e-12	2.287751	99	0.003970641	349	0.01585260098252149	1.406291	28	30	0.00224683