# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6	7.115546e-32	1.5605578302333333e-28	4.360461	97	0.02371638	81	2.7590897687654324e-9	2.279869	59	118	0.01432734	
GO Biological Process	ribonucleoprotein complex biogenesis	13	2.999127e-27	3.035808630230769e-24	2.13186	247	0.0603912	56	2.3310667988035715e-12	1.717434	171	454	0.04152501	
GO Biological Process	nuclear-transcribed mRNA catabolic process	14	3.738561e-26	3.513980299928571e-23	2.934887	131	0.03202934	73	2.0762810980821918e-10	2.02655	88	198	0.0213696	
GO Biological Process	ncRNA metabolic process	15	6.983627e-26	6.126503179533333e-23	2.050875	256	0.06259169	64	3.56678601578125e-11	1.610286	196	555	0.04759592	
GO Biological Process	ncRNA processing	16	1.739782e-25	1.4308619586249999e-22	2.283049	199	0.04865526	70	1.086080132842857e-10	1.715659	149	396	0.03618261	
GO Biological Process	rRNA metabolic process	18	1.198888e-24	8.764537328888889e-22	2.652853	145	0.03545232	88	8.270087571590909e-9	1.813332	103	259	0.02501214	
GO Biological Process	rRNA processing	19	1.355921e-24	9.390823388947369e-22	2.681942	142	0.03471883	92	1.7340372372826086e-8	1.80942	100	252	0.02428363	
GO Biological Process	mRNA catabolic process	20	3.46392e-24	2.2790861640000003e-21	2.734967	135	0.03300733	75	4.649604569066667e-10	1.969464	92	213	0.02234094	
GO Biological Process	ribosome biogenesis	21	5.203428e-23	3.260567097714286e-20	2.319944	173	0.04229829	84	3.798412711547619e-9	1.736371	123	323	0.02986887	
GO Biological Process	RNA catabolic process	22	6.178099e-21	3.695345670045455e-18	2.446859	141	0.03447433	90	1.3274680769000003e-8	1.835247	97	241	0.02355512	
GO Biological Process	cotranslational protein targeting to membrane	24	9.548471e-21	5.235347078708334e-18	3.839116	71	0.01735941	112	0.000001243760482142857	2.186813	47	98	0.01141331	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	25	1.97074e-20	1.0373187064e-17	3.925984	68	0.01662592	123	0.000012034269244715448	2.131182	43	92	0.01044196	
GO Biological Process	protein localization to endoplasmic reticulum	29	5.464606e-19	2.4796120811724138e-16	3.14127	84	0.0205379	137	0.00004193776181532847	1.912148	52	124	0.01262749	
GO Biological Process	protein targeting to ER	30	5.51537e-19	2.4192251276666663e-16	3.592562	70	0.01711491	133	0.00003228790190451128	2.031566	45	101	0.01092763	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	31	9.399794e-19	3.9900609434193545e-16	3.373835	75	0.01833741	124	0.000016108271487096773	2.041025	47	105	0.01141331	
GO Biological Process	viral gene expression	33	5.356777e-18	2.1360554103939393e-15	3.175583	78	0.0190709	125	0.0000161369027544	1.938786	54	127	0.01311316	
GO Biological Process	multi-organism metabolic process	44	2.379973e-15	7.117741978863637e-13	2.668029	86	0.02102689	140	0.00004339210327714286	1.830099	59	147	0.01432734	
GO Biological Process	viral transcription	46	3.83276e-15	1.0964193226086957e-12	3.031589	69	0.01687042	144	0.00006956337207222222	1.93688	48	113	0.01165614	
GO Biological Process	nucleic acid phosphodiester bond hydrolysis	47	9.315788e-15	2.608222431744681e-12	2.047857	141	0.03447433	162	0.00020615750420987654	1.547348	94	277	0.02282661	
GO Biological Process	protein targeting to membrane	50	3.391079e-14	8.9246417122e-12	2.626474	81	0.0198044	164	0.00023450156425609757	1.803478	53	134	0.01287033	
GO Cellular Component	ribonucleoprotein complex	5	3.207355e-49	1.1084618880000001e-46	2.14878	439	0.107335	15	3.04042752e-26	1.758038	315	817	0.07649344	
GO Cellular Component	intracellular ribonucleoprotein complex	6	5.36414e-49	1.5448723199999999e-46	2.146619	438	0.1070905	16	1.72161396e-25	1.747713	312	814	0.07576493	
GO Cellular Component	ribosomal subunit	18	9.985047e-24	9.58564512e-22	3.077591	110	0.02689487	28	1.4147709942857145e-9	1.996426	81	185	0.01966974	
GO Cellular Component	ribosome	19	4.580737e-23	4.166059755789473e-21	2.654545	135	0.03300733	23	4.443209405217391e-12	1.990055	103	236	0.02501214	
GO Cellular Component	large ribosomal subunit	25	2.994902e-14	2.0700762624e-12	3.015085	65	0.01589242	41	0.00000798818575609756	1.982495	50	115	0.01214182	
GO Cellular Component	cytosolic ribosome	27	6.946196e-14	4.44556544e-12	2.707044	75	0.01833741	37	0.0000010644101708108108	2.076309	51	112	0.01238465	
GO Cellular Component	catalytic step 2 spliceosome	31	2.594908e-12	1.4464519432258063e-10	2.769438	63	0.01540342	47	0.00014807871727659576	1.947388	41	96	0.009956289	
GO Cellular Component	spliceosomal complex	35	1.427512e-11	7.047830674285714e-10	2.091137	102	0.02493888	40	0.000002731181328	1.789574	73	186	0.01772705	
GO Cellular Component	mitochondrial ribosome	39	3.345244e-11	1.4822004184615385e-9	3.320578	43	0.01051345	49	0.00024267115102040817	1.984827	37	85	0.008984944	
GO Cellular Component	small ribosomal subunit	42	1.029684e-10	4.2364141714285715e-9	3.100594	45	0.01100244	55	0.0015169496203636364	1.96322	31	72	0.007527926	
GO Cellular Component	cytosolic small ribosomal subunit	50	1.701702e-8	5.881082112e-7	3.244579	32	0.007823961	69	0.010942595060869566	2.072608	20	44	0.004856727	
GO Cellular Component	mitochondrial protein complex	53	4.209818e-8	0.0000013725595290566039	2.006151	74	0.01809291	71	0.019850874591549297	1.501032	53	161	0.01287033	
GO Cellular Component	cytosolic large ribosomal subunit	54	4.406871e-8	0.00000141019872	2.783219	38	0.009290954	57	0.002485028311578947	2.018245	27	61	0.006556581	
GO Cellular Component	mitochondrial large ribosomal subunit	55	4.668326e-8	0.0000014667031505454546	3.507926	27	0.006601467	64	0.0051963579	2.056352	23	51	0.005585236	
GO Cellular Component	inner mitochondrial membrane protein complex	58	1.264246e-7	0.000003766581186206897	2.0641	64	0.01564792	77	0.02460660779220779	1.531007	46	137	0.01117047	
GO Cellular Component	P-body	60	1.70363e-7	0.0000049064544	2.165924	56	0.01369193	74	0.023206911567567566	1.703035	31	83	0.007527926	
GO Cellular Component	spliceosomal snRNP complex	61	4.594426e-7	0.000013015029718032788	2.790636	32	0.007823961	68	0.0081044064	1.912148	26	62	0.006313745	
GO Cellular Component	small nuclear ribonucleoprotein complex	66	0.000002903661	0.00007602312436363636	2.469542	34	0.008312958	73	0.02150635186849315	1.784245	27	69	0.006556581	
GO Cellular Component	preribosome	71	0.0000067826	0.00016507510985915494	2.274056	37	0.009046455	61	0.004627445193442623	1.859893	31	76	0.007527926	
GO Molecular Function	structural constituent of ribosome	6	1.558026e-18	1.096330962e-15	2.865981	94	0.02298289	10	4.3356351300000006e-7	1.970257	70	162	0.01699854	
GO Molecular Function	rRNA binding	7	1.063382e-13	6.413712577142857e-11	4.564542	37	0.009046455	35	0.0069547486079999995	2.051882	27	60	0.006556581	
GO Molecular Function	ribonuclease activity	11	4.286736e-9	0.0000016453272174545455	2.426091	56	0.01369193	29	0.0005528500811724139	1.934434	42	99	0.01019913	
GO Molecular Function	telomerase RNA binding	23	3.082706e-7	0.00005658775970434782	3.583859	23	0.005623472	43	0.01713678380465116	2.69439	13	22	0.003156872	
GO Molecular Function	endoribonuclease activity	24	5.65502e-7	0.00009948122683333333	2.665829	34	0.008312958	28	0.0005228921366428571	2.279869	28	56	0.006799417	
GO Molecular Function	tRNA-specific ribonuclease activity	71	0.0003210548	0.019091455853521126	3.191893	13	0.003178484	38	0.008888856585263158	3.13482	11	16	0.0026712	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	107	0.001166014	0.046008515028037385	2.25406	19	0.004645477	51	0.03394790162745098	2.358485	15	29	0.003642545	
Mouse Phenotype Single KO	preaxial polydactyly	19	0.00004130152	0.01990515887578947	2.223216	32	0.007823961	17	0.0034354839387647058	2.605564	20	35	0.004856727	
Mouse Phenotype Single KO	embryonic lethality before implantation, incomplete penetrance	21	0.00006895831	0.030069106889047615	3.064482	17	0.004156479	63	0.04664623765238095	2.577243	13	23	0.003156872	
Mouse Phenotype	early cellular replicative senescence	5	1.096648e-8	0.000020970103056	2.475182	51	0.01246944	86	0.04947469524069767	1.811403	29	73	0.007042254	
Mouse Phenotype	embryonic lethality before implantation, incomplete penetrance	25	0.00006895831	0.026372416076399997	3.064482	17	0.004156479	79	0.038840085991139243	2.577243	13	23	0.003156872