# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process liver regeneration 14 3.418347e-29 3.213002012357143e-26 4.935001 78 0.01415094 403 0.019942180422332506 2.001026 19 35 0.003729878 GO Biological Process regulation of intrinsic apoptotic signaling pathway 38 1.566466e-21 5.4245068668421055e-19 2.483647 142 0.02576197 461 0.030843953843817783 1.426878 60 155 0.01177856 GO Biological Process regulation of stem cell differentiation 73 1.248219e-17 2.2500429891780823e-15 2.201215 146 0.02648766 232 0.0014455274939655172 1.594696 61 141 0.01197487 GO Biological Process positive regulation of endoplasmic reticulum unfolded protein response 86 3.46199e-16 5.2972472569767446e-14 4.436061 46 0.008345428 520 0.04714140893846154 2.551916 9 13 0.001766784 GO Biological Process regulation of cellular amino acid metabolic process 97 2.292149e-15 3.109524607319588e-13 3.729348 53 0.009615385 444 0.02729125623693694 1.720181 28 60 0.005496663 GO Biological Process regulation of hematopoietic stem cell differentiation 108 1.441087e-14 1.7558577623148148e-12 2.800301 75 0.01360668 339 0.0082293164179941 1.610433 45 103 0.008833922 GO Biological Process regulation of hematopoietic progenitor cell differentiation 119 1.075352e-13 1.1891224342857142e-11 2.607631 79 0.01433237 470 0.03314595311914893 1.500537 46 113 0.009030232 GO Biological Process negative regulation of T cell proliferation 163 1.242263e-11 1.00287968202454e-9 2.477752 72 0.01306241 429 0.02373190988764569 1.77479 26 54 0.005104044 GO Biological Process nucleoside triphosphate catabolic process 169 1.929421e-11 1.5023225407692306e-9 5.793747 24 0.004354136 426 0.023339528307276997 2.764576 9 12 0.001766784 GO Biological Process negative regulation of leukocyte proliferation 182 4.023881e-11 2.909354399945055e-9 2.178758 89 0.01614659 396 0.01672895694848485 1.689463 33 72 0.00647821 GO Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 201 1.623102e-10 1.0626069262686567e-8 2.788468 52 0.009433962 430 0.023800827130930232 2.106344 16 28 0.00314095 GO Biological Process protein-lipid complex subunit organization 204 2.075045e-10 1.3385057428921568e-8 2.835491 50 0.009071118 309 0.005777788989644013 1.960692 25 47 0.004907735 GO Biological Process cellular response to epidermal growth factor stimulus 218 4.412677e-10 2.6635970937155964e-8 2.498159 60 0.01088534 423 0.023287423193380615 1.940053 20 38 0.003926188 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 220 4.680802e-10 2.799757887181818e-8 2.616299 55 0.009978229 368 0.012627061728260868 2.160818 17 29 0.00333726 GO Biological Process negative regulation of lymphocyte proliferation 224 5.758033e-10 3.3825873324553575e-8 2.134515 82 0.01487663 364 0.012288029649725274 1.734636 32 68 0.0062819 GO Biological Process negative regulation of fat cell differentiation 239 1.057958e-9 5.824966243514644e-8 2.084178 84 0.01523948 231 0.001411688975194805 2.083449 26 46 0.005104044 GO Biological Process response to epidermal growth factor 259 2.831997e-9 1.4388512943243243e-7 2.353493 61 0.01106676 487 0.03580442307597536 1.843051 21 42 0.004122497 GO Biological Process plasma lipoprotein particle organization 301 1.453461e-8 6.354183820265782e-7 2.698685 43 0.007801161 367 0.01251948335667575 1.926826 23 44 0.004515116 GO Biological Process positive regulation of gene expression, epigenetic 324 3.247373e-8 0.0000013188944847839505 2.415999 50 0.009071118 382 0.015253723337958115 1.658746 36 80 0.007067138 GO Biological Process regulation of plasma lipoprotein particle levels 456 7.137682e-7 0.000020597534525877194 2.068508 56 0.01015965 416 0.021570969830528846 1.66632 33 73 0.00647821 Human Phenotype Papillary thyroid carcinoma 179 0.0000104434 0.00038932295083798885 2.811465 24 0.004354136 40 0.013432019974750001 3.071751 10 12 0.001963094 Human Phenotype Hypermethioninemia 307 0.0001737108 0.0037758051087947884 3.07406 15 0.002721335 42 0.017131513459523812 3.686101 7 7 0.001374166 Mouse Phenotype Single KO abnormal branching of the mammary ductal tree 57 9.394746e-13 1.509257703894737e-10 2.566049 75 0.01360668 226 0.009266855637610618 2.037056 21 38 0.004122497 Mouse Phenotype Single KO absent segment of posterior cerebral artery 121 8.887521e-10 6.725870231157024e-8 3.688115 32 0.005805515 343 0.04271836608454811 2.178151 13 22 0.002552022 Mouse Phenotype Single KO abnormal mammary gland duct morphology 135 2.109621e-9 1.4309481108888888e-7 2.05216 84 0.01523948 328 0.039241737228658535 1.738727 25 53 0.004907735 Mouse Phenotype Single KO increased follicular B cell number 181 2.237965e-8 0.000001132212458839779 3.139458 33 0.005986938 342 0.04234914366081871 2.457401 10 15 0.001963094 Mouse Phenotype Single KO kinked neural tube 190 3.70993e-8 0.000001787991000526316 2.126409 65 0.01179245 354 0.04681288618361582 1.734636 24 51 0.004711425 Mouse Phenotype Single KO abnormal inferior vena cava valve morphology 194 4.106411e-8 0.0000019382683261340203 4.029039 23 0.004172714 131 0.0012434192438931298 3.351001 10 11 0.001963094 Mouse Phenotype Single KO ischuria 214 1.122309e-7 0.000004802328744392523 4.750012 18 0.003265602 334 0.040229908691616766 3.686101 5 5 0.0009815469 Mouse Phenotype Single KO decreased bone ossification 217 1.149539e-7 0.000004850842683410139 2.441093 45 0.008164006 346 0.04428835980635838 2.047834 15 27 0.002944641 Mouse Phenotype Single KO decreased bone mineralization 251 3.746727e-7 0.000013668836310358566 2.129578 55 0.009978229 168 0.0034483234378571434 2.134059 22 38 0.004318806 Mouse Phenotype Single KO darkened coat color 562 0.0001226625 0.0019986130115658366 2.300277 26 0.004716981 325 0.03700301436923077 2.385124 11 17 0.002159403 Mouse Phenotype increased pro-B cell number 121 1.161644e-11 9.178907672727272e-10 2.602329 66 0.01197388 589 0.04487811655517827 1.759276 21 44 0.004122497 Mouse Phenotype increased follicular B cell number 137 3.000497e-11 2.0939964829927006e-9 2.893336 53 0.009615385 508 0.030389996096456696 1.958241 17 32 0.00333726 Mouse Phenotype abnormal vertebral transverse process morphology 168 1.853788e-10 1.055003992142857e-8 4.04622 31 0.005624093 335 0.007114554152238807 3.015901 9 11 0.001766784 Mouse Phenotype abnormal Paneth cell morphology 170 2.785875e-10 1.566808875e-8 2.424573 65 0.01179245 253 0.0023908198809486168 2.134059 22 38 0.004318806 Mouse Phenotype abnormal circulating interferon-gamma level 179 4.054112e-10 2.1654393760893855e-8 2.420442 64 0.01161103 592 0.04471382533783783 1.525283 36 87 0.007067138 Mouse Phenotype absent segment of posterior cerebral artery 197 8.887521e-10 4.313380115786802e-8 3.688115 32 0.005805515 507 0.03017525146153846 2.178151 13 22 0.002552022 Mouse Phenotype abnormal enterocyte physiology 220 2.479664e-9 1.0776394319999999e-7 2.05471 83 0.01505806 306 0.005042143326470588 1.743426 35 74 0.006870828 Mouse Phenotype increased urine magnesium level 227 3.550354e-9 1.4953715680176211e-7 4.824084 22 0.003991292 544 0.03721373194852941 2.680801 8 11 0.001570475 Mouse Phenotype small intestinal inflammation 256 9.323072e-9 3.4819488825e-7 2.490422 51 0.00925254 254 0.0025140660792519684 2.057359 24 43 0.004711425 Mouse Phenotype abnormal ileum morphology 272 2.046682e-8 7.194237721323529e-7 2.403984 52 0.009433962 515 0.03184058058640776 1.843051 20 40 0.003926188 Mouse Phenotype abnormal inferior vena cava valve morphology 290 4.106411e-8 0.0000013538412265862068 4.029039 23 0.004172714 193 0.0008812145821243524 3.351001 10 11 0.001963094 Mouse Phenotype absent somites 299 5.551966e-8 0.0000017753293286287626 2.228054 57 0.01034107 566 0.03937961368727915 1.730211 23 49 0.004515116 Mouse Phenotype abnormal enterocyte proliferation 399 8.221789e-7 0.00001970138461879699 2.141968 51 0.00925254 393 0.012944151335114507 1.884007 23 45 0.004515116 Mouse Phenotype abnormal Paneth cell number 462 0.000002351769 0.000048669401318181816 2.27122 41 0.007438316 425 0.01573054232682353 2.243714 14 23 0.002748331 Mouse Phenotype abnormal hair medulla 501 0.000005366689 0.00010241699307185628 3.321222 20 0.003628447 524 0.03399030380152672 2.551916 9 13 0.001766784 Mouse Phenotype abnormal kidney inner medulla morphology 519 0.000006636888 0.0001222645205549133 2.691044 27 0.004898403 320 0.0059653140590625 3.276534 8 9 0.001570475 Mouse Phenotype decreased renal tubule number 576 0.00002029673 0.00033690457557291665 3.740595 15 0.002721335 416 0.01512405865673077 3.225339 7 8 0.001374166 Mouse Phenotype conotruncal ridge hypoplasia 617 0.00003043881 0.0004716782210858995 2.295937 31 0.005624093 544 0.03721373194852941 2.680801 8 11 0.001570475 Mouse Phenotype abnormal styloid process morphology 626 0.00003484612 0.0005322104685623003 2.104078 37 0.006712627 424 0.01571446636485849 2.632929 10 14 0.001963094 Mouse Phenotype abnormal foot pad morphology 642 0.00004203071 0.0006259433307009345 2.019057 40 0.007256894 459 0.020641857386928104 2.126597 15 26 0.002944641