# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of signal transduction by p53 class mediator 99 2.269723e-7 0.000030168974704040407 4.100069 20 0.007293946 230 0.0022674410211304345 3.336354 12 21 0.003731343 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 156 0.000003074698 0.0002593586601410256 3.447271 20 0.007293946 276 0.005709895113405797 2.91931 13 26 0.004042289 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 191 0.00000840171 0.0005788382297905759 3.475289 18 0.006564551 410 0.03277075636341464 2.676034 11 24 0.003420398 GO Biological Process histone citrullination 246 0.00003455261 0.0018482837194715447 14.11344 5 0.001823487 298 0.006491365610402685 5.838619 5 5 0.001554726 GO Biological Process T cell selection 390 0.0001674775 0.005650862621794872 2.14174 29 0.01057622 323 0.010577823447058824 2.458366 16 38 0.004975124 GO Biological Process regulation of granulocyte differentiation 409 0.0001896569 0.006101944124938876 3.19563 14 0.005105762 435 0.045545386289655175 3.11393 8 15 0.002487562 GO Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediator 418 0.0002059247 0.006482686907416268 3.169451 14 0.005105762 392 0.02774111899489796 3.336354 8 14 0.002487562 GO Biological Process nuclear migration 460 0.0003323483 0.009507328868913043 3.903154 10 0.003646973 439 0.045630196359908885 3.405861 7 12 0.002176617 GO Biological Process positive T cell selection 498 0.0004708353 0.012441208258433735 2.508512 18 0.006564551 369 0.02330941396666667 2.792383 11 23 0.003420398 GO Biological Process platelet-derived growth factor receptor signaling pathway 513 0.0005399713 0.01385084276159844 2.079622 26 0.00948213 294 0.006422724390136054 2.653918 15 33 0.004664179 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 21 4.75005e-13 3.9086125714285713e-11 2.654126 72 0.02625821 29 0.005658033302068966 1.874786 35 109 0.01088308 GO Cellular Component cytoplasmic side of membrane 22 8.442122e-13 6.630903098181817e-11 2.212381 100 0.03646973 43 0.02276228896744186 1.559003 51 191 0.01585821 GO Cellular Component cytoplasmic side of plasma membrane 23 1.672649e-12 1.2566684660869563e-10 2.249477 94 0.03428155 35 0.013540578377142856 1.629382 48 172 0.01492537 GO Cellular Component voltage-gated calcium channel complex 79 0.00005196473 0.0011366462460759494 2.225548 31 0.01130562 48 0.0352461132 2.224236 16 42 0.004975124 GO Molecular Function protein-arginine deiminase activity 53 0.00003455261 0.0027524739513207544 14.11344 5 0.001823487 52 0.011935602119230771 5.838619 5 5 0.001554726 GO Molecular Function CCR5 chemokine receptor binding 82 0.0001226236 0.006313619990243903 8.087626 6 0.002188184 72 0.044348439205555555 4.865516 5 6 0.001554726 Mouse Phenotype Single KO abnormal liver sinusoid morphology 62 1.806628e-7 0.000026682729993548384 2.58599 39 0.01422319 214 0.0439052048271028 1.946206 22 66 0.006840796 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 64 2.302006e-7 0.000032936670221875 4.772279 17 0.006199854 157 0.026236648064968154 3.284223 9 16 0.002798507 Mouse Phenotype Single KO heterochrony 106 0.000005252889 0.00045378023182075474 3.770797 17 0.006199854 195 0.03807875994564103 3.091034 9 17 0.002798507 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 110 0.000005794024 0.0004823261615272727 2.770009 26 0.00948213 183 0.032697475339890716 2.367008 15 37 0.004664179 Mouse Phenotype Single KO decreased gamma-delta T cell number 207 0.0001312646 0.005806714696618358 2.208796 28 0.01021152 194 0.03779569214381443 2.144799 18 49 0.005597015 Mouse Phenotype abnormal liver parenchyma morphology 13 1.012131e-12 7.443834223846154e-10 2.029359 121 0.04412837 258 0.008429251830232559 1.517122 66 254 0.02052239 Mouse Phenotype abnormal liver lobule morphology 18 3.770397e-12 2.0027092065e-9 2.058768 111 0.0404814 283 0.012253857339222615 1.514621 62 239 0.01927861 Mouse Phenotype abnormal marginal zone B cell morphology 33 2.476797e-10 7.175956399090911e-8 2.333994 70 0.02552881 129 0.001425094473023256 1.848196 44 139 0.01368159 Mouse Phenotype abnormal liver sinusoid morphology 47 1.97801e-9 4.0237773638297867e-7 2.579396 52 0.01896426 226 0.00608377429380531 2.021061 27 78 0.008395522 Mouse Phenotype abnormal spleen marginal zone morphology 55 4.98176e-9 8.660110429090909e-7 2.100985 75 0.0273523 214 0.005218719946261683 1.69392 47 162 0.01461443 Mouse Phenotype enlarged liver sinusoidal spaces 67 2.781522e-8 0.000003969273409253731 3.041535 34 0.01239971 180 0.0029675229956666665 2.563296 18 41 0.005597015 Mouse Phenotype abnormal transitional stage T2 B cell morphology 110 0.000001082301 0.00009407163509999999 3.221079 24 0.008752735 305 0.014720407132131148 2.617312 13 29 0.004042289 Mouse Phenotype abnormal B cell apoptosis 116 0.000001569171 0.00012933486147413792 2.105544 50 0.01823487 366 0.02515967223278688 1.893606 24 74 0.007462687 Mouse Phenotype vascular smooth muscle hypoplasia 133 0.000003328361 0.00023926661293984967 2.732884 28 0.01021152 314 0.01702918235732484 2.694747 12 26 0.003731343 Mouse Phenotype abnormal lung alveolus development 134 0.00000378615 0.00027014462798507463 2.110228 46 0.01677608 479 0.045487964505219206 2.025643 17 49 0.00528607 Mouse Phenotype overexpanded pulmonary alveoli 136 0.000004003542 0.00028145489016176466 2.392902 35 0.01276441 400 0.03141228306 2.17251 16 43 0.004975124 Mouse Phenotype ectopic Bergmann glia cells 140 0.000004850811 0.00033127574265 5.821031 11 0.00401167 339 0.021330263838938053 4.865516 5 6 0.001554726 Mouse Phenotype heterochrony 142 0.000005252889 0.00035368219527464787 3.770797 17 0.006199854 346 0.0224073972433526 3.091034 9 17 0.002798507 Mouse Phenotype impaired lung alveolus development 143 0.00000565109 0.00037783266776223774 2.096133 45 0.01641138 478 0.04556084528033473 2.075954 16 45 0.004975124 Mouse Phenotype decreased marginal zone B cell number 151 0.000006474319 0.0004099401586688742 2.047104 47 0.01714077 330 0.01957731799818182 1.774482 31 102 0.009639303 Mouse Phenotype abnormal Bergmann glial cell morphology 164 0.00001029501 0.0006001865281097561 3.576523 17 0.006199854 351 0.022510407504273505 3.336354 8 14 0.002487562 Mouse Phenotype increased lung squamous cell carcinoma incidence 167 0.00001298454 0.0007433843529341317 12.17861 6 0.002188184 355 0.023139957731830987 5.838619 4 4 0.001243781 Mouse Phenotype increased B cell apoptosis 168 0.00001309738 0.0007453812510714286 2.202239 37 0.0134938 322 0.017871634986335403 2.189482 18 48 0.005597015 Mouse Phenotype absent ductus venosus valve 198 0.0000242576 0.0011713480484848485 3.084692 19 0.006929249 448 0.03987526025892857 2.653918 10 22 0.003109453 Mouse Phenotype abnormal collagen level 294 0.0001506518 0.004899258026530612 2.979908 16 0.005835157 335 0.02121517403283582 2.91931 10 20 0.003109453