# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	7.687014e-28	5.3238640645263155e-25	2.37863	205	0.01642497	552	0.014782057759420288	1.328447	71	113	0.007994595	
GO Biological Process	regulation of DNA-templated transcription in response to stress	23	8.556692e-26	4.895543914260869e-23	2.225898	217	0.01738643	400	0.0030732824761499997	1.368069	77	119	0.008670195	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	36	7.56233e-22	2.7642416797222223e-19	2.469681	147	0.0117779	300	0.0004222392370466666	1.517951	56	78	0.006305596	
GO Biological Process	mitochondrial membrane organization	37	9.288204e-22	3.3033372009729733e-19	2.008792	230	0.01842801	133	8.852771666917293e-8	1.568666	92	124	0.01035919	
GO Biological Process	mitochondrial transmembrane transport	59	1.273104e-18	2.839453480677966e-16	2.35167	136	0.01089656	211	0.000020369926195734597	1.579348	62	83	0.006981196	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	61	1.504085e-18	3.2446318877049176e-16	2.107718	172	0.01378095	448	0.005785759694196429	1.394531	62	94	0.006981196	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	78	3.628049e-17	6.1207047167948725e-15	2.33651	126	0.01009534	581	0.018115481170395867	1.420045	45	67	0.005066997	
GO Biological Process	regulation of mitochondrial membrane permeability	99	1.242241e-15	1.651176698888889e-13	2.097615	144	0.01153754	208	0.000016615065841826924	1.62192	56	73	0.006305596	
GO Biological Process	regulation of cholesterol metabolic process	126	2.526499e-14	2.6385873286507936e-12	2.335924	103	0.008252544	690	0.03677774582173913	1.436121	36	53	0.004053598	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	130	3.549567e-14	3.592980934846154e-12	2.172278	119	0.009534492	329	0.0007579544003039514	1.532093	50	69	0.005629997	
GO Biological Process	protein transmembrane transport	136	5.862716e-14	5.672608812058824e-12	2.252103	108	0.008653153	342	0.0011369098968421053	1.543767	46	63	0.005179597	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	138	6.607575e-14	6.3006579293478264e-12	2.764307	73	0.00584889	695	0.03839856788201439	1.626376	20	26	0.002251999	
GO Biological Process	protein targeting to mitochondrion	149	3.669017e-13	3.240308369328859e-11	2.242151	102	0.008172422	350	0.0013348515918	1.576106	41	55	0.004616597	
GO Biological Process	regulation of cholesterol biosynthetic process	162	1.417192e-12	1.15116231654321e-10	2.346648	88	0.007050717	635	0.027310913899212603	1.510206	30	42	0.003377998	
GO Biological Process	establishment of protein localization to mitochondrion	174	4.987671e-12	3.771997855689655e-10	2.002135	120	0.009614614	392	0.002797980042806122	1.492439	48	68	0.005404797	
GO Biological Process	intracellular protein transmembrane transport	183	9.495612e-12	6.828019579672131e-10	2.192922	94	0.007531448	550	0.014116695272181819	1.472451	39	56	0.004391397	
GO Biological Process	gene silencing by miRNA	209	3.550414e-11	2.2354018098564593e-9	2.212131	87	0.006970595	436	0.005116735298394496	1.585717	33	44	0.003715798	
GO Biological Process	cellular protein complex localization	345	1.255049e-8	4.787011533623189e-7	2.243332	62	0.004967551	320	0.00057553148203125	1.870333	23	26	0.002589798	
GO Biological Process	regulation of mitochondrial translation	454	2.388578e-7	0.000006923193370484582	3.415732	25	0.002003045	543	0.013506196458747698	1.865549	15	17	0.001688999	
GO Biological Process	regulation of receptor catabolic process	525	7.665673e-7	0.00001921382685847619	2.727658	32	0.002563897	624	0.024924769786858973	2.114289	9	9	0.001013399	
GO Cellular Component	PcG protein complex	37	6.348145e-16	2.964755286486487e-14	2.306965	119	0.009534492	53	0.0001288505044528302	1.700624	37	46	0.004166198	
GO Cellular Component	intrinsic component of mitochondrial membrane	43	4.579146e-13	1.840177741395349e-11	2.19479	106	0.008492909	71	0.002571906523943662	1.496266	46	65	0.005179597	
GO Cellular Component	integral component of mitochondrial membrane	44	6.803306e-13	2.671843810909091e-11	2.189244	105	0.008412787	80	0.00345899376	1.486609	45	64	0.005066997	
GO Cellular Component	DNA-directed RNA polymerase I complex	75	2.119821e-8	4.884067584e-7	3.552912	28	0.00224341	133	0.04706721203007519	1.812248	12	14	0.001351199	
GO Cellular Component	spliceosomal tri-snRNP complex	126	0.000005766155	0.00007907869714285715	2.294998	37	0.002964506	111	0.025767718054054055	1.603943	22	29	0.002477199	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	218	0.000231766	0.001837117651376147	2.451401	21	0.001682557	114	0.027224928	1.938098	11	12	0.001238599	
GO Cellular Component	cytoplasmic ubiquitin ligase complex	333	0.003143764	0.016313586162162164	2.01672	20	0.001602436	102	0.015498057599999998	1.951651	12	13	0.001351199	
GO Molecular Function	ubiquitin-specific protease binding	130	0.000007801016	0.0002533529965538462	2.728262	26	0.002083166	69	0.007185519701449276	1.982146	15	16	0.001688999	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	67	4.020966e-10	5.4955202480597014e-8	2.027629	95	0.00761157	169	0.0019932702937869827	1.550479	44	60	0.004954397	
Mouse Phenotype Single KO	increased inguinal fat pad weight	307	0.00002279296	0.0006798538590228013	2.079753	40	0.003204871	400	0.044795815074999995	1.832384	13	15	0.001463799	
Mouse Phenotype Single KO	decreased white fat cell number	328	0.00003848947	0.0010745368194817074	2.342699	29	0.002323532	388	0.04238862621907217	1.938098	11	12	0.001238599	
Mouse Phenotype	increased macrophage apoptosis	797	0.00171798	0.020609293324968633	2.008564	23	0.001842801	674	0.049718831327893176	1.922081	10	11	0.001125999