# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	DNA replication-dependent nucleosome assembly	1	5.234725e-57	6.8883746275e-53	58.27804	41	0.02328223	10	2.9278998703000005e-16	7.676364	25	32	0.01308216	
GO Biological Process	chromatin silencing	2	2.98103e-50	1.9613686885e-46	11.45283	72	0.04088586	4	4.137229077e-20	4.963521	49	97	0.02564103	
GO Biological Process	chromatin silencing at rDNA	3	5.013583e-47	2.1991246232333334e-43	27.43864	44	0.0249858	13	1.259746498076923e-15	7.096372	26	36	0.01360544	
GO Biological Process	negative regulation of gene expression, epigenetic	4	5.410898e-45	1.78005016955e-41	8.284385	79	0.04486087	3	1.6230231646000003e-20	4.654301	54	114	0.02825746	
GO Biological Process	immune response	5	5.945889e-45	1.56483906702e-41	2.145021	373	0.2118115	71	2.1965836821126762e-8	1.497948	227	1489	0.118786	
GO Biological Process	protein heterotetramerization	6	1.070948e-42	2.3487674553333333e-39	14.20233	54	0.0306644	32	9.1904141996875e-13	5.806122	26	44	0.01360544	
GO Biological Process	regulation of gene expression, epigenetic	7	6.731967e-42	1.265513625042857e-38	4.523108	122	0.06927882	2	3.01922793595e-21	3.367695	85	248	0.04447933	
GO Biological Process	positive regulation of gene expression, epigenetic	8	1.470218e-39	2.41832483275e-36	9.528338	63	0.03577513	24	8.083431144166667e-14	4.544407	37	80	0.01936159	
GO Biological Process	nucleosome organization	9	5.123081e-37	7.490513653222222e-34	5.132584	95	0.05394662	11	2.8808831221818183e-16	3.505091	61	171	0.03192046	
GO Biological Process	protein-DNA complex subunit organization	11	3.227411e-35	3.860863759e-32	3.871499	121	0.06871096	23	6.311983251304347e-14	2.829815	72	250	0.03767661	
GO Biological Process	chromatin assembly	12	1.253586e-34	1.3746615145e-31	5.113154	89	0.05053947	5	5.9248318546e-18	3.793484	61	158	0.03192046	
GO Biological Process	gene silencing	13	2.601905e-34	2.633728299615385e-31	5.061879	89	0.05053947	9	2.7933471945555555e-16	3.439011	63	180	0.03296703	
GO Biological Process	nucleosome assembly	15	1.191847e-33	1.0455676448666669e-30	5.339409	83	0.04713231	7	5.629474715857143e-17	3.874942	56	142	0.02930403	
GO Biological Process	chromatin assembly or disassembly	17	1.547419e-33	1.197793330647059e-30	4.7217	93	0.0528109	6	4.269163404166667e-17	3.532852	64	178	0.03349032	
GO Biological Process	telomere organization	18	3.884923e-33	2.8400945420555556e-30	6.501612	69	0.03918228	68	7.076970189558823e-9	3.191268	38	117	0.01988488	
GO Biological Process	regulation of immune response	20	4.116289e-32	2.70831234755e-29	2.187174	262	0.1487791	115	0.000005850937661739131	1.548039	144	914	0.07535322	
GO Biological Process	protein-DNA complex assembly	21	4.586688e-32	2.8741060662857146e-29	3.930519	108	0.06132879	26	8.710417848461537e-14	2.961184	66	219	0.03453689	
GO Biological Process	negative regulation of megakaryocyte differentiation	22	1.686277e-30	1.0086235928636365e-27	62.00283	21	0.01192504	103	0.0000015776363427184466	6.550497	12	18	0.006279435	
GO Biological Process	cytokine-mediated signaling pathway	23	6.870588e-30	3.930872499652174e-27	2.635083	174	0.0988075	107	0.0000030732192699065417	1.752017	97	544	0.05075877	
GO Biological Process	chromatin organization	24	8.017837e-30	4.396113211791667e-27	2.22334	236	0.1340148	1	9.6441942548e-22	2.325285	164	693	0.08581894	
GO Cellular Component	nuclear nucleosome	1	4.274126e-65	7.385689727999999e-62	33.2474	57	0.03236797	19	3.9648796294736842e-16	6.632378	27	40	0.01412873	
GO Cellular Component	nucleosome	2	2.932336e-64	2.533538304e-61	13.61332	84	0.04770017	1	1.0908190080000001e-32	5.895447	63	105	0.03296703	
GO Cellular Component	DNA packaging complex	3	3.038418e-57	1.750128768e-54	11.05278	84	0.04770017	2	1.1233944e-30	5.526982	63	112	0.03296703	
GO Cellular Component	protein-DNA complex	6	1.717401e-35	4.9461148800000004e-33	4.655414	100	0.05678592	6	2.0832264e-19	3.453604	71	202	0.03715332	
GO Cellular Component	nuclear chromatin	11	5.377804e-30	8.448041192727272e-28	2.983829	144	0.08177172	17	1.666198588235294e-16	2.705189	87	316	0.0455259	
GO Cellular Component	nuclear chromosome part	14	6.299389e-29	7.775245851428572e-27	2.516514	182	0.1033504	23	4.083954448695652e-12	2.08367	109	514	0.0570382	
GO Cellular Component	nuclear chromosome	19	3.624271e-26	3.2961790989473688e-24	2.358145	185	0.1050539	24	1.26860688e-11	2.018744	113	550	0.05913134	
GO Cellular Component	chromosome, telomeric region	26	9.421197e-24	6.261472467692308e-22	4.569056	67	0.03804656	36	0.00000318424752	2.412309	41	167	0.02145474	
GO Cellular Component	nuclear chromosome, telomeric region	28	1.07392e-23	6.627620571428571e-22	5.186692	59	0.03350369	35	3.282894390857143e-7	2.754186	37	132	0.01936159	
GO Cellular Component	chromatin	29	1.968973e-23	1.1732363255172414e-21	2.353509	166	0.09426462	11	1.3550410472727273e-17	2.385675	118	486	0.06174778	
GO Cellular Component	MHC protein complex	36	1.012813e-19	4.8615024e-18	20.37229	20	0.01135718	51	0.0023017776564705885	4.421586	9	20	0.004709576	
GO Cellular Component	MHC class II protein complex	38	1.765473e-17	8.028256168421053e-16	29.4982	15	0.008517888	85	0.04983887435294118	3.930298	6	15	0.003139717	
GO Cellular Component	chromosomal region	41	1.871383e-14	7.887194692682928e-13	2.336893	101	0.05735378	41	0.0001402022072195122	1.781438	64	353	0.03349032	
GO Cellular Component	lysosomal membrane	47	2.828194e-11	1.0398126025531913e-9	2.185173	88	0.04997161	59	0.009320014861016948	1.590294	56	346	0.02930403	
GO Cellular Component	vacuolar membrane	48	3.748941e-11	1.3496187599999998e-9	2.071587	98	0.0556502	55	0.004057281163636363	1.587999	64	396	0.03349032	
GO Cellular Component	ER to Golgi transport vesicle membrane	57	1.172935e-8	3.555845052631579e-7	3.867426	26	0.01476434	67	0.016532805062686565	2.59548	14	53	0.007326007	
GO Cellular Component	ER to Golgi transport vesicle	70	2.746411e-7	0.000006779711725714286	3.111978	28	0.01590006	84	0.04888086171428572	2.153588	16	73	0.00837258	
GO Cellular Component	coated vesicle membrane	72	3.136107e-7	0.0000075266567999999994	2.08189	58	0.03293583	76	0.02216942602105263	1.808419	30	163	0.01569859	
GO Cellular Component	myelin sheath	75	0.000001179561	0.00002717708544	2.160658	48	0.02725724	81	0.038935232	1.75893	29	162	0.0151753	
GO Cellular Component	NuA4 histone acetyltransferase complex	76	0.000001192845	0.000027121528421052632	5.529761	13	0.007382169	78	0.028641334153846152	3.821123	7	18	0.003663004	
GO Molecular Function	nucleosomal DNA binding	2	1.601106e-26	3.3799347660000003e-23	9.009828	43	0.02441794	7	4.403674469428571e-7	4.485667	21	46	0.01098901	
GO Molecular Function	nucleosome binding	8	1.028305e-20	5.4268796375e-18	5.826104	46	0.02612152	13	0.00000385734586	3.572998	24	66	0.01255887	
GO Molecular Function	histone binding	13	7.789822e-18	2.529894498769231e-15	2.948876	85	0.04826803	5	7.4158382944e-8	2.580499	52	198	0.02721088	
GO Molecular Function	MHC class II protein complex binding	14	2.108159e-17	6.357605212857143e-15	15.36726	20	0.01135718	35	0.008312210873142857	4.912873	8	16	0.00418629	
GO Molecular Function	chromatin DNA binding	17	1.331394e-15	3.3065561576470585e-13	3.753188	53	0.03009654	11	0.000002199695392181818	3.023306	32	104	0.01674516	
GO Molecular Function	structure-specific DNA binding	20	1.227539e-14	2.591334829e-12	3.087292	64	0.03634299	17	0.00002438395238352941	2.544797	36	139	0.0188383	
GO Molecular Function	MHC protein complex binding	21	1.317011e-14	2.647819258095238e-12	10.85914	20	0.01135718	43	0.045605906539534884	3.930298	8	20	0.00418629	
GO Molecular Function	cadherin binding	26	9.623432e-11	1.562697304e-8	2.043503	97	0.05508234	31	0.004621700825806451	1.745363	54	304	0.02825746	
GO Molecular Function	single-stranded DNA binding	37	8.450981e-8	0.000009643254535675676	2.621234	40	0.02271437	42	0.04451859753333333	2.140261	22	101	0.0115123	
GO Molecular Function	double-stranded RNA binding	51	9.194869e-7	0.00007611909199607843	2.92274	28	0.01590006	30	0.002840147844	2.828624	19	66	0.009942439	
GO Molecular Function	interferon receptor activity	88	0.0001157166	0.005551766877272727	10.88934	5	0.002839296	44	0.047156093727272724	7.860597	4	5	0.002093145	
GO Molecular Function	mRNA 3'-UTR AU-rich region binding	91	0.0001941608	0.009008207665934066	3.185351	14	0.007950028	33	0.007139880493333333	5.731685	7	12	0.003663004	
Mouse Phenotype Single KO	abnormal lymphocyte physiology	1	2.082191e-53	1.9066622986999998e-49	2.508033	331	0.1879614	1	9.385485464e-16	1.992475	175	863	0.09157509	
Mouse Phenotype Single KO	abnormal leukocyte physiology	2	4.833624e-46	2.2130747484e-42	2.131135	386	0.2191936	2	2.5733962885e-15	1.795321	222	1215	0.1161695	
Mouse Phenotype Single KO	abnormal immune cell physiology	3	1.120734e-45	3.420853746e-42	2.120511	387	0.2197615	4	6.10558770825e-15	1.769904	223	1238	0.1166928	
Mouse Phenotype Single KO	abnormal adaptive immunity	4	2.382641e-45	5.45446090925e-42	2.099823	392	0.2226008	7	3.6654790765714284e-14	1.733045	224	1270	0.1172161	
Mouse Phenotype Single KO	abnormal cell-mediated immunity	5	4.007043e-45	7.3384985502e-42	2.108716	387	0.2197615	5	1.5681133575e-14	1.752913	223	1250	0.1166928	
Mouse Phenotype Single KO	abnormal T cell physiology	6	1.980789e-44	3.0230141455e-41	2.857469	227	0.128904	10	2.237448851e-12	2.13359	114	525	0.05965463	
Mouse Phenotype Single KO	abnormal lymphocyte morphology	7	1.136922e-43	1.4872563934285716e-40	2.085868	384	0.2180579	9	1.1728753624444443e-12	1.726031	205	1167	0.1072737	
Mouse Phenotype Single KO	abnormal blood cell physiology	8	6.09246e-43	6.9735820275e-40	2.034365	398	0.226008	3	5.171547000333333e-15	1.745314	235	1323	0.1229723	
Mouse Phenotype Single KO	abnormal B cell physiology	9	4.025431e-40	4.095652407444445e-37	2.707948	223	0.1266326	21	3.734748729238095e-10	1.994155	110	542	0.05756149	
Mouse Phenotype Single KO	abnormal immunoglobulin level	11	2.988622e-39	2.487891968545454e-36	2.927385	194	0.1101647	32	3.2994988865625e-8	1.982578	91	451	0.04761905	
Mouse Phenotype Single KO	abnormal lymphocyte cell number	15	7.032852e-38	4.2933217176000004e-35	2.046093	351	0.1993186	16	6.905791611875e-11	1.700083	186	1075	0.09733124	
Mouse Phenotype Single KO	abnormal hemopoiesis	17	4.52847e-37	2.4392470464705887e-34	2.239487	287	0.1629756	8	4.29875136075e-13	1.965149	147	735	0.07692308	
Mouse Phenotype Single KO	abnormal humoral immune response	18	8.009256e-37	4.074486510666667e-34	2.75088	200	0.1135718	31	2.819997400064516e-8	1.941135	97	491	0.05075877	
Mouse Phenotype Single KO	decreased immunoglobulin level	19	8.976476e-37	4.326188985894737e-34	3.534845	141	0.08006814	72	0.00037232501898611114	1.894965	54	280	0.02825746	
Mouse Phenotype Single KO	abnormal immune serum protein physiology	20	1.814185e-36	8.3062460225e-34	2.182807	297	0.1686542	14	6.271457279214286e-11	1.757197	169	945	0.08843537	
Mouse Phenotype Single KO	decreased lymphocyte cell number	21	8.91261e-34	3.8863223699999994e-31	2.152444	284	0.161272	37	1.8633606523513513e-7	1.669893	138	812	0.0722135	
Mouse Phenotype Single KO	abnormal professional antigen presenting cell physiology	22	1.145168e-33	4.766501534545455e-31	2.179932	276	0.1567291	22	7.016351460909091e-10	1.759144	152	849	0.07953951	
Mouse Phenotype Single KO	abnormal blood cell morphology/development	24	4.869006e-33	1.85772866425e-30	2.062104	304	0.1726292	11	5.094489457909091e-12	1.841612	161	859	0.08424908	
Mouse Phenotype Single KO	abnormal IgG level	25	6.40488e-33	2.3459794464e-30	3.013599	156	0.08858603	42	3.921092807142857e-7	2.04937	73	350	0.0381999	
Mouse Phenotype Single KO	abnormal effector T cell morphology	26	1.067635e-32	3.7601283442307695e-30	2.374027	228	0.1294719	39	2.7714317925641026e-7	1.789512	108	593	0.05651491	
Mouse Phenotype	abnormal lymphocyte morphology	1	3.201735e-50	3.0611788335e-46	2.027323	460	0.2612152	6	1.5349806247e-14	1.689648	249	1448	0.1302983	
Mouse Phenotype	abnormal lymphocyte physiology	2	3.37308e-50	1.612500894e-46	2.249479	377	0.2140829	1	1.1651770797000002e-15	1.86428	207	1091	0.1083203	
Mouse Phenotype	abnormal lymphocyte cell number	3	5.86993e-46	1.870746691e-42	2.015221	431	0.2447473	8	1.4887038708749999e-13	1.692333	232	1347	0.1214024	
Mouse Phenotype	abnormal hemopoiesis	7	1.792326e-43	2.4480612694285715e-40	2.163001	356	0.2021579	10	1.1878892352000001e-12	1.790948	183	1004	0.09576138	
Mouse Phenotype	abnormal humoral immune response	12	2.170513e-41	1.7293562327499997e-38	2.635084	240	0.1362862	37	1.3343052522162163e-9	1.902816	116	599	0.0607012	
Mouse Phenotype	abnormal immunoglobulin level	15	1.662262e-40	1.0595257988e-37	2.708593	225	0.1277683	42	2.7015447778571427e-9	1.929419	108	550	0.05651491	
Mouse Phenotype	abnormal B cell physiology	16	1.273644e-39	7.6108189275e-37	2.482097	254	0.1442362	21	7.045619274285716e-11	1.909752	131	674	0.0685505	
Mouse Phenotype	decreased lymphocyte cell number	17	1.938451e-39	1.0902076477058822e-36	2.063063	358	0.2032936	29	5.500172954482758e-10	1.663522	182	1075	0.0952381	
Mouse Phenotype	abnormal lymphopoiesis	18	2.698261e-39	1.4332263011666665e-36	2.395682	268	0.1521863	33	8.781355498181817e-10	1.871571	124	651	0.06488749	
Mouse Phenotype	abnormal immune serum protein physiology	20	7.268423e-39	3.47466961515e-36	2.075112	349	0.1981829	11	3.482008421454545e-12	1.71399	202	1158	0.1057038	
Mouse Phenotype	abnormal leukopoiesis	21	1.165117e-38	5.304611255714286e-36	2.278777	289	0.1641113	23	8.514257563043477e-11	1.848021	142	755	0.07430665	
Mouse Phenotype	abnormal blood cell morphology/development	22	1.206196e-38	5.242018161818182e-36	2.005477	373	0.2118115	18	1.7924909683333333e-11	1.692021	197	1144	0.1030874	
Mouse Phenotype	abnormal T cell physiology	23	2.21007e-38	9.1871649e-36	2.411464	259	0.1470755	13	4.806332351076922e-12	1.948208	138	696	0.0722135	
Mouse Phenotype	abnormal B cell morphology	24	2.45479e-38	9.779269662500001e-36	2.286073	285	0.1618399	28	2.2967116638214287e-10	1.848273	136	723	0.07116693	
Mouse Phenotype	decreased B cell number	25	3.080807e-38	1.1782238290800001e-35	2.586715	229	0.1300398	32	8.3507297784375e-10	2.034316	100	483	0.05232862	
Mouse Phenotype	abnormal definitive hematopoiesis	26	3.190143e-37	1.1731137393461538e-34	2.082239	333	0.1890971	15	9.921972368e-12	1.768232	176	978	0.09209838	
Mouse Phenotype	decreased immunoglobulin level	27	5.728451e-37	2.0285081485555557e-34	3.160668	164	0.0931289	78	0.00005588742812307692	1.863503	66	348	0.03453689	
Mouse Phenotype	abnormal IgG level	29	4.258987e-36	1.4041439554137931e-33	2.847498	186	0.1056218	46	9.530456761956523e-9	2.033701	89	430	0.04657248	
Mouse Phenotype	decreased IgG level	31	2.064197e-35	6.366383070000001e-33	3.467876	139	0.07893242	74	0.000024489777964864864	2.030412	56	271	0.02930403	
Mouse Phenotype	abnormal B cell number	33	9.326007e-35	2.7019985735454543e-32	2.288377	259	0.1470755	30	5.508162214e-10	1.880885	125	653	0.06541078