# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	3.681477e-71	3.2296370562e-68	2.986946	366	0.02062553	600	0.009352645205333333	1.279796	81	113	0.007701816	
GO Biological Process	regulation of DNA-templated transcription in response to stress	19	6.92991e-66	4.7995097731578945e-63	2.763234	383	0.02158354	465	0.002392184797612903	1.305289	87	119	0.008272321	
GO Biological Process	endoplasmic reticulum unfolded protein response	25	1.657248e-57	8.7230905728e-55	2.800481	326	0.01837137	153	1.0401011210457517e-8	1.503491	96	114	0.009128078	
GO Biological Process	liver regeneration	35	5.41597e-53	2.0362499780000002e-50	3.812655	194	0.01093266	415	0.0011360142504096386	1.58135	31	35	0.002947609	
GO Biological Process	response to topologically incorrect protein	40	2.34727e-51	7.721931482499999e-49	2.254117	435	0.02451395	165	2.0868666696363636e-8	1.398559	141	180	0.01340687	
GO Biological Process	cellular response to topologically incorrect protein	42	1.441128e-50	4.515191274285714e-48	2.467652	357	0.02011834	215	0.0000015229504385116279	1.400058	109	139	0.01036417	
GO Biological Process	cellular response to unfolded protein	43	4.544894e-50	1.3908432592093023e-47	2.547682	333	0.01876585	184	1.1676559982065216e-7	1.460778	99	121	0.009413331	
GO Biological Process	response to unfolded protein	48	4.394641e-49	1.2047725191458334e-46	2.278312	406	0.02287968	126	1.2673798427777777e-9	1.450633	130	160	0.01236094	
GO Biological Process	IRE1-mediated unfolded protein response	54	4.963717e-47	1.209584296351852e-44	3.603077	184	0.01036912	331	0.0001505884950876133	1.508351	49	58	0.004659123	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	60	3.511443e-45	7.7011797395e-43	2.194907	404	0.02276698	392	0.0007015888694387755	1.290092	112	155	0.01064942	
GO Biological Process	mRNA catabolic process	80	4.285869e-40	7.049718771375e-38	2.021872	433	0.02440124	344	0.00019408174672383722	1.265703	151	213	0.01435771	
GO Biological Process	nuclear-transcribed mRNA catabolic process	84	2.173871e-39	3.4054724391666665e-37	2.070674	401	0.02259791	356	0.00025828267115449437	1.271418	141	198	0.01340687	
GO Biological Process	cellular response to epidermal growth factor stimulus	97	1.087168e-36	1.4748498672164948e-34	2.741813	212	0.01194703	667	0.016752649904047977	1.456507	31	38	0.002947609	
GO Biological Process	protein targeting to ER	103	2.746862e-35	3.509316219223301e-33	2.614242	221	0.01245421	239	0.000004460756195941422	1.449529	82	101	0.0077969	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	126	1.913267e-31	1.9981492423015873e-29	2.393425	231	0.01301775	427	0.0015503567073770492	1.316351	87	118	0.008272321	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	132	1.015579e-30	1.0124245500757575e-28	2.374354	229	0.01290504	234	0.0000034165678942735042	1.44532	85	105	0.008082153	
GO Biological Process	cotranslational protein targeting to membrane	139	2.332372e-30	2.208034758848921e-28	2.517512	202	0.01138349	262	0.000012574037247328242	1.439247	79	98	0.007511648	
GO Biological Process	multi-organism metabolic process	150	1.207118e-29	1.0589643841333332e-27	2.08796	292	0.01645534	172	3.5822156605232554e-8	1.433174	118	147	0.01121993	
GO Biological Process	protein localization to endoplasmic reticulum	166	3.991415e-28	3.1640379509036144e-26	2.17207	252	0.01420118	277	0.000024042238835018048	1.382241	96	124	0.009128078	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	175	2.954172e-27	2.2213685341714284e-25	2.475141	186	0.01048183	285	0.000032709783402105266	1.436079	74	92	0.007036227	
GO Cellular Component	large ribosomal subunit	56	2.972189e-21	9.171326057142857e-20	2.116892	198	0.01115807	152	0.022149788210526315	1.242014	80	115	0.007606732	
GO Cellular Component	mitochondrial ribosome	103	3.749715e-15	6.290784e-14	2.207061	124	0.006987884	154	0.02257481641558442	1.281284	61	85	0.005800133	
GO Cellular Component	spliceosomal snRNP complex	105	4.137587e-15	6.809286034285714e-14	2.291424	114	0.006424345	132	0.012710081454545455	1.353445	47	62	0.004468955	
GO Cellular Component	axon cytoplasm	137	4.999404e-12	6.3058176e-11	2.107164	106	0.005973514	94	0.0017572094502127662	1.517586	34	40	0.003232861	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	253	0.000004459658	0.00003045964041106719	2.545248	31	0.001746971	131	0.012538940482442749	1.785395	12	12	0.00114101	
GO Molecular Function	ribonucleoprotein complex binding	24	6.272266e-22	1.1033961271666667e-19	2.018295	230	0.0129614	83	0.002668845229879518	1.31964	85	115	0.008082153	
GO Molecular Function	snRNA binding	31	2.040182e-17	2.778596259354839e-15	3.113064	78	0.004395604	125	0.028681025503999997	1.456507	31	38	0.002947609	
GO Molecular Function	NF-kappaB binding	35	3.860097e-17	4.656379866857143e-15	2.826581	89	0.005015497	126	0.028657019346031747	1.530339	24	28	0.00228202	
GO Molecular Function	aminoacyl-tRNA editing activity	85	5.597338e-10	2.7802307101176466e-8	3.365439	37	0.002085094	115	0.019536926855652177	1.785395	13	13	0.001236094	
Human Phenotype	Death in infancy	19	3.566316e-15	1.2525277193684211e-12	2.177491	128	0.0072133	247	0.027091380400809717	1.370928	43	56	0.004088618	
Human Phenotype	Abnormality of mitochondrial metabolism	20	3.958978e-15	1.3209130096999999e-12	2.028363	151	0.008509439	183	0.009560286767213114	1.37139	53	69	0.00503946	
Human Phenotype	Abnormality of the mitochondrion	21	5.754769e-15	1.828646358904762e-12	2.008162	153	0.008622147	160	0.005617831875	1.383053	55	71	0.005229628	
Human Phenotype	Hypergonadotropic hypogonadism	35	2.815554e-13	5.368054812e-11	2.195894	108	0.006086221	262	0.033665717980916034	1.520892	23	27	0.002186935	
Human Phenotype	Increased serum ferritin	38	4.625802e-13	8.12315177526316e-11	3.499157	48	0.002704987	168	0.00608878679404762	1.696125	19	20	0.001806599	
Human Phenotype	CNS hypomyelination	79	4.027196e-10	3.401706190886076e-8	2.426442	64	0.00360665	198	0.011888542655555554	1.547342	26	30	0.002472188	
Mouse Phenotype Single KO	pale liver	78	1.111603e-25	1.3049934193589743e-23	2.179486	227	0.01279234	366	0.04342942429781421	1.294411	58	80	0.005514881	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	304	1.455154e-11	4.383172755921053e-10	2.391303	77	0.00433925	257	0.018960769242801555	1.785395	13	13	0.001236094	
Mouse Phenotype Single KO	abnormal hepatic vein morphology	637	9.443086e-7	0.000013574621428885398	2.566711	35	0.001972387	363	0.04283210714600551	1.785395	11	11	0.001045926	
Mouse Phenotype	extramedullary hematopoiesis	5	8.862454e-68	1.69467845388e-64	2.209791	602	0.03392505	434	0.016492806510829492	1.214069	119	175	0.01131501	
Mouse Phenotype	decreased circulating free fatty acid level	43	3.046068e-37	6.772896778604651e-35	2.076017	376	0.02118907	433	0.016514825704157042	1.260279	84	119	0.007987069	
Mouse Phenotype	pancytopenia	99	9.25408e-27	8.937197866666668e-25	2.976886	133	0.007495069	399	0.013192711104511276	1.539134	25	29	0.002377104	
Mouse Phenotype	abnormal hepatic vein morphology	770	9.443086e-7	0.000011725369512467533	2.566711	35	0.001972387	495	0.03279600699393939	1.785395	11	11	0.001045926	
Mouse Phenotype	abnormal sublingual gland morphology	915	0.000008476276	0.00008857013643278689	2.068672	45	0.002535926	453	0.020062891045033115	1.785395	12	12	0.00114101