# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process response to reactive oxygen species 52 7.727465e-74 1.9554944602884613e-71 2.40818 548 0.03787931 411 0.00037262029734793186 1.343516 113 183 0.01309386 GO Biological Process negative regulation of MAPK cascade 97 2.685375e-59 3.64297418814433e-57 2.207095 525 0.03628949 514 0.0020557489022762646 1.336755 94 153 0.01089224 GO Biological Process response to corticosteroid 113 3.072068e-54 3.577463965663716e-52 2.084159 546 0.03774107 527 0.002387431876679317 1.324389 98 161 0.01135574 GO Biological Process response to glucocorticoid 120 3.113081e-52 3.4137527399166663e-50 2.107514 512 0.03539089 526 0.0023700167052661597 1.341236 90 146 0.01042874 GO Biological Process regulation of DNA-templated transcription in response to stress 135 1.484725e-49 1.4472219462962963e-47 2.672534 302 0.0208751 415 0.00039313352773493983 1.426143 78 119 0.009038239 GO Biological Process cellular response to corticosteroid stimulus 173 8.100349e-46 6.161415750924855e-44 2.601538 292 0.02018387 627 0.006042342064593301 1.485058 43 63 0.004982619 GO Biological Process positive regulation of peptidase activity 176 1.526951e-45 1.1416561482386365e-43 2.122309 438 0.0302758 903 0.03208502282834994 1.247095 94 164 0.01089224 GO Biological Process cellular response to reactive oxygen species 177 2.072105e-45 1.5404988528248587e-43 2.33251 356 0.02460773 485 0.0011684774167835053 1.396127 77 120 0.008922364 GO Biological Process cellular response to decreased oxygen levels 193 5.690297e-44 3.879721151450778e-42 2.010664 481 0.03324808 359 0.00009280265622562675 1.362727 119 190 0.01378911 GO Biological Process cellular response to glucocorticoid stimulus 197 1.4942e-43 9.980800913705585e-42 2.566042 284 0.01963088 651 0.00771429900983103 1.486784 41 60 0.004750869 GO Biological Process cellular response to hypoxia 200 2.897268e-43 1.9062574805999998e-41 2.014217 471 0.03255685 392 0.00019819098875 1.355405 114 183 0.01320973 GO Biological Process regulation of transforming growth factor beta2 production 250 6.857657e-39 3.6095963385199996e-37 5.531466 95 0.006566669 868 0.03013132053456221 2.175782 8 8 0.0009269988 GO Biological Process transforming growth factor beta receptor signaling pathway 258 6.545725e-38 3.338573460271318e-36 2.231747 324 0.0223958 535 0.0025420974336448597 1.427126 61 93 0.007068366 GO Biological Process interaction with host 275 8.368249e-37 4.0042832214909093e-35 2.100837 360 0.02488422 926 0.03699353006695465 1.25143 88 153 0.01019699 GO Biological Process embryonic placenta development 290 1.410514e-35 6.400328871034483e-34 2.131533 336 0.02322527 858 0.028853362013986014 1.344584 55 89 0.006373117 GO Biological Process regulation of kidney development 295 2.196151e-35 9.796322375932204e-34 2.230244 302 0.0208751 701 0.012615546440228245 1.490814 37 54 0.00428737 GO Biological Process positive regulation of cell-matrix adhesion 306 1.029315e-34 4.426390877450981e-33 2.58048 222 0.01534527 941 0.038097164879914984 1.466288 31 46 0.003592121 GO Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 308 1.487721e-34 6.35614306461039e-33 5.918854 79 0.005460704 700 0.012455502941285715 2.008414 12 13 0.001390498 GO Biological Process positive regulation of mRNA catabolic process 354 9.751245e-33 3.62476364279661e-31 3.578246 127 0.0087786 904 0.03232132794469027 1.653594 19 25 0.002201622 GO Biological Process regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 358 1.700776e-32 6.25153949273743e-31 4.608203 94 0.006497546 638 0.007095902060815048 1.797385 19 23 0.002201622 GO Cellular Component ruffle membrane 69 1.498335e-22 3.7523519999999995e-21 2.013533 238 0.01645123 70 0.0012762435291428572 1.458763 59 88 0.006836616 GO Cellular Component cytosolic large ribosomal subunit 91 1.016227e-18 1.929714567032967e-17 2.505497 121 0.008363863 94 0.011932942978723406 1.462411 41 61 0.004750869 GO Molecular Function cadherin binding 3 6.364921e-89 8.957565487333333e-86 2.146396 837 0.05785581 4 3.535616794e-15 1.531636 214 304 0.02479722 GO Molecular Function glucocorticoid receptor binding 76 3.708525e-23 2.060183230263158e-21 3.120607 106 0.00732702 101 0.027697034813861383 2.008414 12 13 0.001390498 GO Molecular Function xenobiotic transporter activity 122 1.735383e-18 6.005563136065574e-17 4.11561 58 0.004009124 107 0.03602601822803738 2.175782 9 9 0.001042874 GO Molecular Function R-SMAD binding 143 8.613154e-17 2.5429885446153847e-15 2.416827 115 0.007949126 85 0.01708853009882353 1.797385 19 23 0.002201622 GO Molecular Function protein phosphatase 2A binding 199 3.30545e-12 7.012869296482411e-11 2.272136 91 0.006290178 103 0.031243148417475726 1.692275 21 27 0.002433372 Human Phenotype Aortic dilatation 40 1.177336e-26 1.964090782e-24 2.996542 131 0.009055091 142 0.03581843183450704 1.692275 21 27 0.002433372 Human Phenotype Hypoalbuminemia 46 4.561573e-26 6.617255788913044e-24 3.959815 88 0.006082809 124 0.0286287951983871 1.740626 20 25 0.002317497 Human Phenotype Dermal atrophy 53 8.859138e-24 1.115415620264151e-21 2.539568 153 0.01057579 133 0.033223171154887224 1.527677 33 47 0.00382387 Human Phenotype Bronchomalacia 344 2.003531e-7 0.000003886500686918605 2.097029 60 0.00414737 134 0.03299535065895522 2.008414 12 13 0.001390498 Mouse Phenotype Single KO abnormal T cell proliferation 36 5.057113e-76 1.2863328816944446e-73 2.141711 720 0.04976844 250 0.000090876192424 1.308804 157 261 0.01819235 Mouse Phenotype Single KO abnormal T cell activation 37 4.703976e-75 1.1641704927567566e-72 2.080033 760 0.05253335 184 0.000009744063232608696 1.325044 176 289 0.02039397 Mouse Phenotype Single KO abnormal cytokine level 50 6.03921e-68 1.1060209194000001e-65 2.023573 735 0.05080528 886 0.034574299872460496 1.161268 182 341 0.02108922 Mouse Phenotype Single KO abnormal tumor necrosis factor level 53 1.303179e-64 2.251549076037736e-62 2.574312 423 0.02923896 801 0.02626392220224719 1.267902 81 139 0.009385863 Mouse Phenotype Single KO abnormal placenta labyrinth morphology 56 1.17715e-62 1.924850455357143e-60 2.249323 533 0.03684247 494 0.005442238659109311 1.305469 93 155 0.01077636 Mouse Phenotype Single KO abnormal trophoblast layer morphology 63 1.626163e-59 2.3636150144444444e-57 2.311723 478 0.03304071 564 0.009434684401418439 1.302405 85 142 0.009849363 Mouse Phenotype Single KO abnormal cell chemotaxis 73 3.356035e-58 4.209755136301369e-56 2.660102 359 0.0248151 852 0.030733331717136148 1.293708 66 111 0.00764774 Mouse Phenotype Single KO abnormal lymph node size 79 9.534925e-56 1.105206433227848e-53 2.117546 541 0.03739545 424 0.0030405019422169812 1.295958 109 183 0.01263036 Mouse Phenotype Single KO enlarged lymph nodes 89 3.7448e-53 3.852936359550562e-51 2.356028 410 0.02834036 453 0.0038065062790286976 1.34146 82 133 0.009501738 Mouse Phenotype Single KO abnormal liver parenchyma morphology 97 1.034599e-50 9.766827879381443e-49 2.127747 486 0.0335937 308 0.0003990596815584415 1.335401 116 189 0.01344148 Mouse Phenotype Single KO altered tumor pathology 101 4.73474e-50 4.2926746712871297e-48 2.252353 423 0.02923896 274 0.00017590556896350363 1.400846 94 146 0.01089224 Mouse Phenotype Single KO abnormal B cell activation 102 7.50807e-50 6.740333038235294e-48 2.226012 432 0.02986106 213 0.000025956105471361503 1.431436 100 152 0.01158749 Mouse Phenotype Single KO abnormal circulating interleukin-6 level 104 1.739401e-49 1.5315091304807691e-47 2.606727 315 0.02177369 785 0.025171403173248407 1.301584 67 112 0.007763615 Mouse Phenotype Single KO abnormal circulating interleukin level 107 3.264103e-49 2.7934010440186917e-47 2.196277 439 0.03034492 885 0.034592631705084746 1.209947 114 205 0.01320973 Mouse Phenotype Single KO abnormal artery development 110 1.656092e-48 1.3786213130909093e-46 2.002713 537 0.03711896 242 0.00007343308578512397 1.469118 79 117 0.009154114 Mouse Phenotype Single KO abnormal common myeloid progenitor cell morphology 113 9.189483e-48 7.446734144336283e-46 2.219791 416 0.0287551 555 0.008881111964324324 1.374178 60 95 0.006952491 Mouse Phenotype Single KO abnormal liver lobule morphology 118 1.130663e-46 8.774136517796611e-45 2.126721 447 0.03089791 311 0.0004228540659485531 1.344584 110 178 0.01274623 Mouse Phenotype Single KO decreased common myeloid progenitor cell number 135 1.705483e-44 1.1568228022962964e-42 2.709218 264 0.01824843 696 0.017951232814655174 1.517988 30 43 0.003476246 Mouse Phenotype Single KO decreased T cell proliferation 138 3.92705e-44 2.605796873188406e-42 2.101312 434 0.02999931 460 0.003928096205869565 1.319975 91 150 0.01054461 Mouse Phenotype Single KO decreased tumor incidence 153 6.137029e-42 3.6729918008496727e-40 2.339381 326 0.02253404 416 0.002719844717788462 1.413137 63 97 0.007300116 Mouse Phenotype abnormal liver parenchyma morphology 49 1.930719e-81 3.7672661957142856e-79 2.234692 703 0.04859335 371 0.00004146847946361186 1.319175 154 254 0.01784473 Mouse Phenotype abnormal tumor necrosis factor level 51 6.287695e-81 1.1787578802941175e-78 2.492647 563 0.03891615 733 0.0036574698965893583 1.273904 113 193 0.01309386 Mouse Phenotype abnormal liver lobule morphology 57 2.157907e-77 3.619605057368421e-75 2.270941 646 0.04465335 420 0.00012769134362857143 1.310932 144 239 0.01668598 Mouse Phenotype gastrointestinal tract polyps 67 2.990823e-73 4.267949060149253e-71 3.836805 268 0.01852492 711 0.0030576118341772156 1.646538 28 37 0.003244496 Mouse Phenotype intestine polyps 68 1.568118e-72 2.204820029117647e-70 4.166839 241 0.0166586 815 0.005664505367484663 1.64832 25 33 0.002896871 Mouse Phenotype pale kidney 81 2.933103e-67 3.4621478744444446e-65 3.686405 258 0.01783369 1293 0.030107655549883993 1.450521 30 45 0.003476246 Mouse Phenotype abnormal wound healing 83 9.776177e-66 1.1261449192409638e-63 2.077137 668 0.04617405 369 0.00003936180786178862 1.342712 137 222 0.01587486 Mouse Phenotype decreased erythroid progenitor cell number 84 2.709956e-65 3.084510632857143e-63 2.820596 366 0.02529896 1082 0.016501437704251387 1.374178 48 76 0.005561993 Mouse Phenotype abnormal liver vasculature morphology 99 8.58201e-61 8.288141172727274e-59 2.41721 447 0.03089791 408 0.00008899036666176471 1.463358 76 113 0.008806489 Mouse Phenotype enlarged lymph nodes 115 4.671748e-56 3.8840506633043483e-54 2.020869 608 0.04202668 384 0.000051372697109374995 1.338943 136 221 0.01575898 Mouse Phenotype increased eosinophil cell number 124 2.087295e-54 1.6094054431451613e-52 2.976926 279 0.01928527 1485 0.046079281349494954 1.286753 55 93 0.006373117 Mouse Phenotype abnormal interleukin-6 secretion 133 5.129584e-52 3.687515234887218e-50 2.164051 480 0.03317896 1437 0.040482445006263044 1.201213 106 192 0.01228273 Mouse Phenotype abnormal common myeloid progenitor cell morphology 139 1.731348e-51 1.1908933976978417e-49 2.113989 501 0.03463054 964 0.010316507442946057 1.287082 84 142 0.009733488 Mouse Phenotype abnormal trophoblast layer morphology 159 1.714965e-47 1.0312440481132075e-45 2.064237 488 0.03373194 1319 0.031865689455648216 1.231575 90 159 0.01042874 Mouse Phenotype abnormal keratinocyte physiology 174 1.245818e-45 6.845555113793102e-44 2.361459 349 0.02412387 922 0.008934652875488069 1.328575 69 113 0.007995365 Mouse Phenotype increased B cell proliferation 176 1.965235e-45 1.067591581534091e-43 2.782318 258 0.01783369 271 0.000002444128175424354 1.638552 61 81 0.007068366 Mouse Phenotype abnormal spleen B cell follicle morphology 182 9.69733e-45 5.094295171978022e-43 2.025082 481 0.03324808 1358 0.034873430677466864 1.206263 107 193 0.01239861 Mouse Phenotype enlarged liver sinusoidal spaces 184 1.363381e-44 7.084394424456521e-43 3.306263 195 0.01347895 980 0.011309355679591838 1.538968 29 41 0.003360371 Mouse Phenotype decreased fibroblast proliferation 187 4.581122e-44 2.34225173486631e-42 2.353333 339 0.02343264 1503 0.04875371455688623 1.238522 74 130 0.008574739 Mouse Phenotype abnormal hepatocyte morphology 199 1.154786e-42 5.548195450251257e-41 2.056926 441 0.03048317 721 0.0032967985593619973 1.284068 108 183 0.01251448