# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 6 6.171958e-24 1.3536132553666666e-20 23.8293 23 0.009519868 119 0.0027276185301680672 3.274188 14 32 0.005579912 GO Biological Process negative regulation of gene expression, epigenetic 7 1.773683e-23 3.334270656714286e-20 4.815442 63 0.02607616 36 0.00004378916774722222 2.428971 37 114 0.01474691 GO Biological Process regulation of hematopoietic progenitor cell differentiation 8 3.752419e-23 6.172260202625e-20 4.744298 63 0.02607616 159 0.011320282171069184 1.986865 30 113 0.01195695 GO Biological Process regulation of hematopoietic stem cell differentiation 9 2.981604e-22 4.359436337333333e-19 4.940646 58 0.02400662 166 0.011534806825903614 2.034447 28 103 0.01115982 GO Biological Process negative regulation of megakaryocyte differentiation 11 3.773642e-21 4.5143050070909095e-18 36.58504 17 0.007036424 179 0.015292323847486033 3.741929 9 18 0.003587086 GO Biological Process regulation of gene expression, epigenetic 12 7.126588e-21 7.814897624333334e-18 2.864477 106 0.04387417 40 0.00007710621322 1.901141 63 248 0.02510961 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 13 9.53059e-21 9.647156446923079e-18 4.01606 67 0.02773179 201 0.021496535853233828 1.920636 29 113 0.01155839 GO Biological Process regulation of DNA-templated transcription in response to stress 15 2.203128e-20 1.9327307568e-17 3.762325 71 0.02938742 169 0.01211132558106509 1.949576 31 119 0.01235552 GO Biological Process chromatin silencing at rDNA 17 2.557514e-18 1.979666278e-15 11.3635 25 0.01034768 121 0.0028050311661157027 3.118274 15 36 0.005978477 GO Biological Process chromatin assembly 24 3.352223e-16 1.8379959357083333e-13 3.056921 73 0.03021523 48 0.00011230230540833333 2.131479 45 158 0.01793543 GO Biological Process protein-DNA complex subunit organization 26 3.969116e-16 2.0088306709230766e-13 2.448756 105 0.04346026 67 0.00030717132261194027 1.826061 61 250 0.02431248 GO Biological Process chromatin assembly or disassembly 27 6.75371e-16 3.291558144074074e-13 2.886506 78 0.03228477 46 0.00011339382061956522 2.060163 49 178 0.01952969 GO Biological Process nucleosome organization 28 7.655744e-16 3.5979262605714286e-13 2.953495 75 0.03104305 56 0.00016734572879285715 2.056967 47 171 0.01873256 GO Biological Process chromatin silencing 30 1.265503e-15 5.550917992333334e-13 4.753644 41 0.0169702 84 0.0008674112022857142 2.314595 30 97 0.01195695 GO Biological Process nucleosome assembly 31 1.541614e-15 6.543902782580646e-13 3.141611 67 0.02773179 62 0.00018903485042903224 2.160832 41 142 0.01634117 GO Biological Process protein-DNA complex assembly 35 4.931977e-15 1.8542824383714286e-12 2.49354 94 0.03890728 83 0.0006900108729759036 1.845335 54 219 0.02152252 GO Biological Process regulation of megakaryocyte differentiation 36 5.575623e-15 2.0380450849166667e-12 3.870181 49 0.02028146 29 0.000023933117291034482 2.855683 29 76 0.01155839 GO Biological Process DNA conformation change 43 3.493809e-14 1.069186805372093e-11 2.279114 105 0.04346026 74 0.0004393948363648648 1.757775 66 281 0.0263053 GO Biological Process blood coagulation 48 1.687394e-13 4.625920342916667e-11 2.040959 127 0.05256623 88 0.0009988742692045454 1.687537 69 306 0.027501 GO Biological Process coagulation 49 1.808154e-13 4.855816017551021e-11 2.038865 127 0.05256623 93 0.0011936364766236558 1.676579 69 308 0.027501 GO Cellular Component nucleosome 18 2.285531e-23 2.1941097599999998e-21 6.024451 51 0.02110927 17 7.205765082352941e-8 2.779719 39 105 0.01554404 GO Cellular Component DNA packaging complex 20 1.434071e-19 1.239037344e-17 4.891308 51 0.02110927 19 5.499539166315789e-7 2.605986 39 112 0.01554404 GO Cellular Component nuclear nucleosome 21 1.051029e-18 8.6484672e-17 11.05398 26 0.01076159 35 0.005444621897142857 2.806447 15 40 0.005978477 GO Cellular Component protein-DNA complex 28 5.572467e-14 3.4390082057142857e-12 2.646765 78 0.03228477 21 0.00000382704768 2.074733 56 202 0.02231965 GO Cellular Component myelin sheath 43 1.085453e-9 4.362006474418604e-8 2.263895 69 0.0285596 26 0.0001495544787692308 2.032653 44 162 0.01753687 GO Cellular Component protein serine/threonine phosphatase complex 80 0.000001049924 0.000022678358399999998 2.586446 34 0.01407285 39 0.01861290830769231 2.443709 16 49 0.006377043 GO Molecular Function nucleosomal DNA binding 22 7.165265e-9 0.0000013750794922727274 3.970853 26 0.01076159 26 0.007872513327692308 2.765774 17 46 0.006775608 GO Molecular Function nucleosome binding 43 3.956107e-7 0.00003884345059069767 2.861834 31 0.01283113 29 0.01253184085448276 2.381228 21 66 0.008369868 GO Molecular Function phospholipase A2 inhibitor activity 81 0.00007750203 0.004039673711851852 4.689771 10 0.004139073 39 0.03443904886153846 7.483858 4 4 0.001594261 GO Molecular Function 1-acylglycerol-3-phosphate O-acyltransferase activity 120 0.0007246779 0.025496584115000002 2.784298 14 0.005794702 27 0.008125493883703703 3.938873 10 19 0.003985652 GO Molecular Function lysophosphatidic acid acyltransferase activity 122 0.0007866546 0.027223407550819673 2.760187 14 0.005794702 30 0.012874355700000001 3.741929 10 20 0.003985652 Mouse Phenotype Single KO abnormal T cell physiology 1 2.075599e-22 1.9006260043e-18 2.027731 221 0.09147351 22 0.000051251312772727275 1.610811 113 525 0.04503786 Mouse Phenotype Single KO abnormal interleukin secretion 8 1.334745e-18 1.5277824956250002e-15 2.073028 173 0.07160596 25 0.00006478152615200001 1.682973 94 418 0.03746513 Mouse Phenotype Single KO abnormal T cell activation 15 3.753882e-16 2.2916198316e-13 2.179666 133 0.05504967 92 0.016488472423913044 1.579638 61 289 0.02431248 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 17 8.267657e-16 4.453349126411765e-13 3.543384 58 0.02400662 81 0.011972540096296296 2.541688 18 53 0.007174173 Mouse Phenotype Single KO abnormal platelet aggregation 19 1.539312e-15 7.418673675789474e-13 3.491539 58 0.02400662 120 0.03149605092 2.110832 22 78 0.008768434 Mouse Phenotype Single KO abnormal platelet physiology 20 1.733443e-15 7.9365687755e-13 2.984469 72 0.02980132 126 0.03458513143968254 1.904982 28 110 0.01115982 Mouse Phenotype Single KO abnormal platelet activation 22 2.245295e-15 9.345530143181818e-13 3.415729 59 0.02442053 133 0.040615481057142855 2.025044 23 85 0.009166999 Mouse Phenotype Single KO abnormal T cell proliferation 33 3.96154e-14 1.0992673266666668e-11 2.137426 120 0.04966887 117 0.02757733077094017 1.577058 55 261 0.02192108 Mouse Phenotype Single KO abnormal erythropoiesis 38 5.372129e-14 1.2945417171842103e-11 2.648715 78 0.03228477 17 0.000022592829095294118 2.517298 37 110 0.01474691 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 40 1.455891e-13 3.33289847175e-11 2.59583 78 0.03228477 55 0.0014417824697999999 2.009089 40 149 0.01594261 Mouse Phenotype Single KO abnormal platelet morphology 45 4.661054e-13 9.484726995111111e-11 2.058067 120 0.04966887 59 0.0020066975727118645 1.716223 61 266 0.02431248 Mouse Phenotype Single KO decreased T cell proliferation 46 4.66254e-13 9.281495386956521e-11 2.435351 84 0.03476821 87 0.013759655534482761 1.846018 37 150 0.01474691 Mouse Phenotype Single KO decreased erythroid progenitor cell number 49 9.65889e-13 1.8050297087755104e-10 3.211888 52 0.02152318 101 0.01919619081980198 2.494619 17 51 0.006775608 Mouse Phenotype Single KO abnormal platelet cell number 76 2.83755e-10 3.418874388157895e-8 2.008533 97 0.04014901 116 0.027623195655172416 1.643651 47 214 0.01873256 Mouse Phenotype Single KO decreased circulating alanine transaminase level 94 5.113185e-9 4.98100372819149e-7 2.586359 49 0.02028146 136 0.041414788084558826 2.09548 21 75 0.008369868 Mouse Phenotype Single KO abnormal eosinophil morphology 116 3.351705e-8 0.0000026458243693965515 2.184951 61 0.02524834 74 0.00870799145472973 1.957317 34 130 0.01355122 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 118 3.670737e-8 0.000002848554127881356 2.212586 59 0.02442053 133 0.040615481057142855 2.025044 23 85 0.009166999 Mouse Phenotype Single KO abnormal myeloblast morphology/development 120 3.801788e-8 0.0000029010810596666667 2.005205 74 0.03062914 39 0.0005283450471025642 2.032653 44 162 0.01753687 Mouse Phenotype Single KO increased susceptibility to bacterial infection induced morbidity/mortality 133 8.939708e-8 0.000006154955350075188 2.946088 33 0.01365894 114 0.02718710890263158 2.138245 22 77 0.008768434 Mouse Phenotype Single KO increased bleeding time 163 4.673568e-7 0.000026255130169325153 2.310087 45 0.01862583 118 0.03164327064745762 2.07384 23 83 0.009166999 Mouse Phenotype abnormal embryonic erythropoiesis 9 9.970606e-19 1.0592107107333332e-15 5.433392 44 0.01821192 162 0.02232599143148148 2.896977 12 31 0.004782782 Mouse Phenotype abnormal platelet physiology 13 5.595135e-18 4.1150065950000004e-15 3.02668 83 0.0343543 101 0.0038609154469306933 1.984356 35 132 0.01394978 Mouse Phenotype abnormal embryonic erythrocyte morphology 15 4.098774e-17 2.6125585476e-14 4.788498 45 0.01862583 231 0.04764647779220779 2.494619 13 39 0.005181347 Mouse Phenotype abnormal platelet activation 20 1.061151e-16 5.072832355499999e-14 3.441172 64 0.02649007 143 0.014323307355944058 2.020642 27 100 0.01076126 Mouse Phenotype abnormal platelet aggregation 21 1.597221e-16 7.271919038571428e-14 3.451685 63 0.02607616 139 0.012555443294244606 2.070003 26 94 0.01036269 Mouse Phenotype abnormal embryonic hematopoiesis 22 1.618911e-16 7.035640032272727e-14 3.409757 64 0.02649007 122 0.006162262773196721 2.453724 20 61 0.007971303 Mouse Phenotype increased myeloid cell number 24 4.77892e-16 1.9038022549999998e-13 2.116167 141 0.05836093 167 0.024720675418562876 1.538493 59 287 0.02351534 Mouse Phenotype decreased erythrocyte cell number 33 2.914389e-15 8.443779766363637e-13 2.19648 123 0.0509106 61 0.00036566499039344263 1.846666 57 231 0.02271821 Mouse Phenotype abnormal erythropoiesis 44 4.387697e-14 9.534266140227274e-12 2.455399 90 0.03725166 29 0.000006997488195517241 2.310453 46 149 0.018334 Mouse Phenotype decreased T cell proliferation 49 5.071453e-13 9.895543292448979e-11 2.134196 110 0.0455298 78 0.0010779896342692306 1.827045 52 213 0.02072539 Mouse Phenotype thrombocytosis 54 8.863824e-12 1.5693892826666665e-9 3.02003 52 0.02152318 219 0.04693604043835617 2.014885 21 78 0.008369868 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 55 1.015211e-11 1.7648058856363637e-9 2.227012 89 0.03683775 56 0.00024127166426785715 1.995695 48 180 0.01913113 Mouse Phenotype abnormal mean corpuscular hemoglobin 64 5.321332e-11 7.949571133125001e-9 2.211917 84 0.03476821 230 0.04730919979565217 1.626926 40 184 0.01594261 Mouse Phenotype decreased erythroid progenitor cell number 66 5.958709e-11 8.632002537727273e-9 2.676513 58 0.02400662 152 0.017370569473026315 2.16638 22 76 0.008768434 Mouse Phenotype abnormal proerythroblast morphology 79 2.904168e-10 3.514778512405063e-8 2.642049 55 0.0227649 219 0.04693604043835617 2.014885 21 78 0.008369868 Mouse Phenotype abnormal platelet dense granule morphology 112 1.578179e-8 0.0000013472294124107146 3.814761 26 0.01076159 227 0.04732505464757709 2.744081 11 30 0.004384217 Mouse Phenotype abnormal erythroid progenitor cell morphology 121 2.955375e-8 0.0000023352347417355374 2.090425 68 0.0281457 136 0.010935028182352941 1.949576 31 119 0.01235552 Mouse Phenotype abnormal eosinophil morphology 132 6.520098e-8 0.000004722625528636363 2.033319 69 0.0285596 92 0.0027526711366304348 1.905827 41 161 0.01634117 Mouse Phenotype abnormal T-helper 2 physiology 156 3.257002e-7 0.00001996166418076923 2.522995 39 0.01614238 229 0.047064335633187765 2.091078 19 68 0.007572738 Mouse Phenotype glomerulosclerosis 161 4.051318e-7 0.00002405878968819876 2.29779 46 0.01903974 146 0.01483300088630137 2.151609 23 80 0.009166999