# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of intrinsic apoptotic signaling pathway 1 4.4553e-12 5.8627292700000005e-8 2.650101 66 0.02748855 209 0.0007149095814832535 1.946427 42 155 0.01606733 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 36 8.809545e-9 0.0000032201334070833333 2.739111 43 0.0179092 338 0.013729345320118344 1.986855 26 94 0.009946442 GO Biological Process histone deacetylation 44 2.550669e-8 0.0000076282394025 2.793453 39 0.01624323 131 0.00000864078803923664 3.043747 25 59 0.009563887 GO Biological Process protein deacetylation 47 3.306184e-8 0.000009256611756595743 2.765319 39 0.01624323 140 0.000017705866867142854 2.943952 25 61 0.009563887 GO Biological Process protein deacylation 51 1.253023e-7 0.000032330450307843135 2.550238 41 0.01707622 165 0.00011557206768484849 2.630484 26 71 0.009946442 GO Biological Process macromolecule deacylation 52 1.271275e-7 0.00003217059177884615 2.548802 41 0.01707622 167 0.000155209144257485 2.593949 26 72 0.009946442 GO Biological Process negative regulation of cellular amide metabolic process 59 1.725102e-7 0.000038475622403389834 2.039642 64 0.02665556 243 0.002815211008436214 1.865778 40 154 0.01530222 GO Biological Process negative regulation of translation 60 1.920227e-7 0.000042113778488333335 2.074066 61 0.02540608 240 0.002542084679458333 1.908834 38 143 0.01453711 GO Biological Process cellular response to topologically incorrect protein 61 2.202831e-7 0.00004751975922786886 2.349944 46 0.01915868 379 0.02108584271873351 1.757053 34 139 0.01300689 GO Biological Process regulation of histone deacetylation 71 6.078533e-7 0.0001126583320380282 3.69153 21 0.008746356 489 0.045514908928425364 2.762786 10 26 0.003825555 GO Biological Process regulation of protein deacetylation 98 0.000005418085 0.0007275161277040817 2.779704 26 0.01082882 456 0.037178243901315786 2.457426 13 38 0.004973221 GO Biological Process DNA duplex unwinding 109 0.000008941894 0.0010795081022568808 2.447012 31 0.01291129 505 0.04786076827326732 1.968012 20 73 0.007651109 GO Biological Process vascular smooth muscle cell development 114 0.00001243664 0.0014355591733333332 5.847126 10 0.004164931 290 0.007143953036206897 5.387433 6 8 0.002295333 GO Biological Process regulation of intrinsic apoptotic signaling pathway in response to DNA damage 118 0.00001369418 0.0015271331747457627 3.003642 21 0.008746356 318 0.01069269718427673 2.717984 14 37 0.005355777 GO Biological Process histone methylation 133 0.00002146548 0.0021237913633082705 2.017563 43 0.0179092 313 0.010057575049520767 2.064151 25 87 0.009563887 GO Biological Process positive regulation of cell cycle arrest 137 0.00003212162 0.003085316770656935 2.159803 35 0.01457726 199 0.000546078331683417 2.338731 28 86 0.01071155 GO Biological Process regulation of chromatin silencing 139 0.00003531722 0.003343448186906475 4.004654 13 0.005414411 447 0.03434213446756152 3.078533 9 21 0.003442999 GO Biological Process cellular protein complex localization 142 0.00004097237 0.003796869132605634 3.197482 17 0.007080383 344 0.014600109415116278 3.039065 11 26 0.00420811 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 166 0.00009127463 0.007235438892590361 3.261579 15 0.006247397 383 0.0216987684002611 3.591622 8 16 0.003060444 GO Biological Process Notch receptor processing 167 0.00009980444 0.007864231293173653 3.605626 13 0.005414411 433 0.03184575248960739 3.38035 8 17 0.003060444 GO Cellular Component chromatin silencing complex 20 1.415421e-10 1.222923744e-8 14.03548 12 0.004997918 83 0.042060873253012054 4.489528 5 8 0.001912777 GO Cellular Component cytoplasmic stress granule 21 1.690515e-10 1.3910523428571429e-8 4.051263 31 0.01291129 41 0.0012595581658536585 2.839887 17 43 0.006503443 GO Cellular Component nuclear transcriptional repressor complex 22 1.067028e-9 8.381019927272727e-8 4.365462 26 0.01082882 60 0.0076898592 2.972377 12 29 0.004590666 GO Cellular Component transcriptional repressor complex 23 1.817538e-9 1.3655242017391305e-7 2.505204 55 0.02290712 19 1.1422534736842105e-7 2.942534 34 83 0.01300689 GO Cellular Component methyltransferase complex 26 4.942247e-7 0.000032846933907692306 2.591103 36 0.01499375 40 0.001165976208 2.210229 28 91 0.01071155 GO Cellular Component histone methyltransferase complex 38 0.000006433642 0.0002925614046315789 2.534195 30 0.01249479 43 0.0013604564093023257 2.394415 23 69 0.008798776 GO Cellular Component transcription factor AP-1 complex 43 0.00001462422 0.0005876895851162791 9.237174 7 0.002915452 81 0.03553696 5.746595 4 5 0.001530222 GO Cellular Component pseudopodium 46 0.00001685586 0.0006331940452173914 5.081285 11 0.004581424 75 0.024143431679999997 3.38035 8 17 0.003060444 GO Cellular Component Sin3 complex 49 0.00002185262 0.000770639333877551 4.526217 12 0.004997918 50 0.003225602304 4.420458 8 13 0.003060444 GO Cellular Component Sin3-type complex 51 0.00003614871 0.0012248033505882353 3.995393 13 0.005414411 49 0.003089932721632653 4.040575 9 16 0.003442999 GO Cellular Component nuclear inner membrane 52 0.00005031128 0.0016718825353846155 2.537353 24 0.009995835 76 0.026463024 2.180628 17 56 0.006503443 GO Cellular Component platelet dense tubular network membrane 73 0.0006140424 0.014535140646575344 4.378311 8 0.003331945 63 0.0114208704 4.788829 6 9 0.002295333 GO Cellular Component platelet dense tubular network 81 0.00114485 0.024423466666666668 3.968532 8 0.003331945 82 0.037551484097560976 3.918133 6 11 0.002295333 GO Molecular Function histone deacetylase activity 4 1.512559e-10 1.5965060244999998e-7 3.857792 33 0.01374427 37 0.00024494891508108105 3.101855 19 44 0.007268554 GO Molecular Function protein deacetylase activity 5 1.996611e-10 1.6859383284e-7 3.814865 33 0.01374427 38 0.00035908221105263163 3.032925 19 45 0.007268554 GO Molecular Function histone deacetylase binding 9 6.35291e-9 0.000002980220668888889 2.291601 61 0.02540608 23 7.795161204347826e-8 2.726972 41 108 0.01568477 GO Molecular Function deacetylase activity 10 3.021862e-8 0.000012758301364 3.02903 34 0.01416077 52 0.005106431055384616 2.476981 20 58 0.007651109 GO Molecular Function chromatin DNA binding 12 1.397744e-7 0.000049177293066666665 2.389183 46 0.01915868 84 0.040817743119047616 1.864881 27 104 0.010329 GO Molecular Function histone methyltransferase activity 21 0.000001387035 0.0002788600842857143 2.512768 35 0.01457726 82 0.040697737304878044 2.191498 18 59 0.006885998 GO Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity 56 0.0001535084 0.011573436871428573 5.406878 8 0.003331945 72 0.024525410355555558 4.190226 7 12 0.002677888 GO Molecular Function NAD-dependent histone deacetylase activity 66 0.0005804814 0.037133219254545456 3.367749 11 0.004581424 76 0.03508452557105263 3.591622 8 16 0.003060444 GO Molecular Function NAD-dependent protein deacetylase activity 70 0.0007334016 0.04423459364571428 3.271344 11 0.004581424 90 0.04915777804444443 3.38035 8 17 0.003060444 Mouse Phenotype Single KO lethality during fetal growth through weaning, incomplete penetrance 3 3.239053e-7 0.0009886669440333333 6.886074 12 0.004997918 225 0.016945980828 4.788829 6 9 0.002295333 Mouse Phenotype Single KO abnormal sternebra number 4 4.71004e-7 0.0010782459069999999 7.441326 11 0.004581424 263 0.027760267192775665 3.867901 7 13 0.002677888 Mouse Phenotype Single KO absent hypoglossal canal 11 0.000006468323 0.005384584882818182 8.521236 8 0.003331945 177 0.008145048031073446 5.387433 6 8 0.002295333 Mouse Phenotype Single KO abnormal cellular replicative senescence 13 0.000008417343 0.005929046911615386 2.773716 25 0.01041233 168 0.005892038946428571 2.394415 20 60 0.007651109 Mouse Phenotype Single KO increased mammary gland apoptosis 15 0.00001217185 0.007430508696666667 5.861993 10 0.004164931 370 0.049999323635135144 4.489528 5 8 0.001912777 Mouse Phenotype Single KO abnormal hypoglossal nerve topology 16 0.00001669376 0.00955404752 4.311249 13 0.005414411 142 0.002597277937957746 3.990691 10 18 0.003825555 Mouse Phenotype Single KO kinked neural tube 24 0.00005446895 0.020782173964583334 2.253055 30 0.01249479 133 0.0019190882581954886 2.676111 19 51 0.007268554 Mouse Phenotype Single KO absent hypoglossal nerve 27 0.00007653344 0.025956174447407408 4.697012 10 0.004164931 218 0.015104311882568807 3.831064 8 15 0.003060444 Mouse Phenotype Single KO early cellular replicative senescence 30 0.0000831158 0.025369712686666664 2.642184 21 0.008746356 318 0.03951248379559748 2.210229 16 52 0.006120888 Mouse Phenotype decreased fibroblast proliferation 1 2.0783e-9 0.000019870626300000002 2.426041 58 0.0241566 172 0.00008846076225 2.154973 39 130 0.01491966 Mouse Phenotype abnormal cellular replicative senescence 2 4.951239e-9 0.0000236693980395 2.925936 40 0.01665973 138 0.000030045982904347825 2.565444 30 84 0.01147666 Mouse Phenotype abnormal fibroblast proliferation 3 9.31601e-9 0.00002969012387 2.090381 73 0.030404 90 0.0000016281734976666666 2.197228 52 170 0.01989288 Mouse Phenotype early cellular replicative senescence 4 1.860326e-8 0.000044466442215 2.976259 36 0.01499375 185 0.0001373122912216216 2.558416 26 73 0.009946442 Mouse Phenotype abnormal sternebra number 9 4.71004e-7 0.0005003632493333333 7.441326 11 0.004581424 427 0.017852605958079623 3.867901 7 13 0.002677888 Mouse Phenotype lethality during fetal growth through weaning, incomplete penetrance 10 4.723197e-7 0.00045158486517 5.132967 15 0.006247397 454 0.022068051568281937 3.38035 8 17 0.003060444 Mouse Phenotype absent hypoglossal canal 26 0.000006468323 0.002378601392423077 8.521236 8 0.003331945 316 0.0047635413275316455 5.387433 6 8 0.002295333 Mouse Phenotype abnormal hypoglossal nerve topology 33 0.00001669376 0.004836637556363637 4.311249 13 0.005414411 255 0.0015101382034117647 3.990691 10 18 0.003825555 Mouse Phenotype increased mortality induced by gamma-irradiation 37 0.00001972267 0.005096444537027027 3.131977 19 0.007913369 281 0.0030153236820640566 2.957806 14 34 0.005355777 Mouse Phenotype tumor regression 38 0.00002124138 0.005344443004736843 8.707941 7 0.002915452 528 0.036583228948863636 4.489528 5 8 0.001912777 Mouse Phenotype absent hypoglossal nerve 49 0.00007653344 0.014933392241632652 4.697012 10 0.004164931 367 0.009367883431062669 3.831064 8 15 0.003060444 Mouse Phenotype absent stapedial artery 53 0.0001104976 0.019933350067924526 3.370047 14 0.005830904 271 0.0026252050481180814 3.780655 10 19 0.003825555 Mouse Phenotype abnormal stapedial artery morphology 59 0.0001360918 0.022053791522033895 3.301811 14 0.005830904 307 0.004056710499674268 3.591622 10 20 0.003825555 Mouse Phenotype intermingled spleen red and white pulp 60 0.0001363696 0.02173049576 3.721923 12 0.004997918 509 0.032538261931237725 2.9386 9 22 0.003442999 Mouse Phenotype decreased tumor latency 63 0.0001486708 0.022562563790476192 2.358752 24 0.009995835 277 0.0028324814565703973 2.654677 17 46 0.006503443 Mouse Phenotype abnormal granulocyte differentiation 72 0.0002157973 0.028656083129166662 2.253868 25 0.01041233 593 0.04839947492580102 2.186205 14 46 0.005355777 Mouse Phenotype abnormal intestine development 73 0.0002478874 0.032466457964383556 2.569972 19 0.007913369 176 0.00009984737001136364 3.867901 14 26 0.005355777 Mouse Phenotype thin lung-associated mesenchyme 74 0.0002501024 0.032313906032432435 9.208412 5 0.002082466 580 0.04443080770862069 7.183244 3 3 0.001147666 Mouse Phenotype abnormal response to vitamins 75 0.0002686289 0.034244812172000004 5.761995 7 0.002915452 501 0.031789752485029944 5.746595 4 5 0.001530222