# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	platelet-derived growth factor receptor signaling pathway	40	1.63296e-17	5.37203016e-15	3.511676	66	0.01601164	284	0.04024709804084507	2.263325	15	33	0.003977725	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	56	5.93258e-16	1.3940503610714285e-13	3.122295	70	0.01698205	149	0.002338355183154362	1.814496	43	118	0.01140281	
GO Biological Process	rRNA processing	59	4.384462e-15	9.778836518305084e-13	2.230095	119	0.02886948	225	0.015155267087555555	1.46218	74	252	0.01962344	
GO Biological Process	rRNA metabolic process	62	1.628701e-14	3.4567865256451616e-12	2.17842	120	0.02911208	239	0.020683519916736403	1.441887	75	259	0.01988862	
GO Biological Process	nuclear-transcribed mRNA catabolic process	67	6.277638e-14	1.2329468424179103e-11	2.289669	103	0.02498787	136	0.0015127673481617648	1.634624	65	198	0.01723681	
GO Biological Process	RNA catabolic process	76	2.392987e-13	4.14333104381579e-11	2.083485	121	0.02935468	137	0.0015290124062773724	1.570241	76	241	0.02015381	
GO Biological Process	mRNA catabolic process	83	4.02462e-13	6.380719828915662e-11	2.170988	108	0.02620087	150	0.0024595934306	1.589641	68	213	0.01803235	
GO Biological Process	cotranslational protein targeting to membrane	90	6.322525e-13	9.244234052777778e-11	3.05818	57	0.01382824	95	0.0002855490533578947	2.032374	40	98	0.01060727	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	102	1.64098e-12	2.1170250803921568e-10	3.09349	54	0.01310044	118	0.0008238299006271187	2.002551	37	92	0.009811721	
GO Biological Process	protein targeting to ER	108	4.720653e-12	5.7517660025e-10	2.902661	57	0.01382824	109	0.0006068499812568807	1.972006	40	101	0.01060727	
GO Biological Process	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	125	3.758376e-11	3.95651758272e-9	2.466447	69	0.01673945	256	0.0288591879484375	1.691088	36	106	0.009546539	
GO Biological Process	PERK-mediated unfolded protein response	134	7.174201e-11	7.045172459626865e-9	5.979798	22	0.005337215	259	0.030280764260617758	3.319544	8	12	0.002121453	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	136	8.46122e-11	8.186852498529412e-9	2.633479	59	0.01431344	112	0.0006862528941607143	1.944304	41	105	0.01087245	
GO Biological Process	protein targeting to membrane	156	4.979209e-10	4.200090463525641e-8	2.284345	71	0.01722465	116	0.0007643679673965517	1.820795	49	134	0.0129939	
GO Biological Process	response to epidermal growth factor	160	5.763182e-10	4.739856996125e-8	2.682796	52	0.01261524	264	0.032566451460606057	2.133992	18	42	0.00477327	
GO Biological Process	protein complex disassembly	176	1.533518e-9	1.1465661001136366e-7	2.074558	83	0.02013586	218	0.014064296946330277	1.597139	51	159	0.01352426	
GO Biological Process	protein localization to endoplasmic reticulum	181	1.946651e-9	1.4152475419337016e-7	2.337663	63	0.01528384	182	0.0073189779582417585	1.726698	43	124	0.01140281	
GO Biological Process	multi-organism metabolic process	202	6.58868e-9	4.292100996039604e-7	2.154793	70	0.01698205	281	0.039057373070462635	1.558153	46	147	0.01219836	
GO Biological Process	cellular protein complex disassembly	206	7.201907e-9	4.6004803016019415e-7	2.207291	66	0.01601164	197	0.010216153302538073	1.69929	43	126	0.01140281	
GO Biological Process	translational termination	224	1.824957e-8	0.0000010720807662053572	2.543425	47	0.01140223	258	0.030386507780620152	1.729657	33	95	0.008750994	
GO Cellular Component	catalytic step 2 spliceosome	33	1.654339e-14	8.662720581818182e-13	2.966029	68	0.01649685	37	0.00014751001945945946	2.022847	39	96	0.01034208	
GO Cellular Component	ribosomal subunit	38	3.48351e-13	1.584080336842105e-11	2.415199	87	0.02110626	42	0.0009959994514285714	1.641828	61	185	0.01617608	
GO Cellular Component	spliceosomal complex	39	4.424295e-13	1.9603030153846152e-11	2.176614	107	0.02595827	38	0.0003119848976842105	1.686542	63	186	0.01670644	
GO Cellular Component	ribosome	42	1.077184e-11	4.431842742857142e-10	2.068129	106	0.02571567	45	0.00181380672	1.540212	73	236	0.01935826	
GO Cellular Component	Bcl-2 family protein complex	51	1.199703e-9	4.064876047058824e-8	7.48399	16	0.003881611	61	0.010739497337704918	4.267985	6	7	0.00159109	
GO Cellular Component	ATP-binding cassette (ABC) transporter complex	54	1.44425e-9	4.6216e-8	15.95738	10	0.002426007	50	0.0029905452288	4.356901	7	8	0.001856272	
GO Cellular Component	spliceosomal snRNP complex	56	1.945463e-9	6.003142971428572e-8	3.201624	37	0.008976225	81	0.030319637333333337	1.847166	23	62	0.006099178	
GO Cellular Component	condensed chromosome, centromeric region	58	3.029766e-9	9.026613186206895e-8	2.052863	82	0.01989326	72	0.021147525599999998	1.631155	38	116	0.0100769	
GO Cellular Component	large ribosomal subunit	59	3.624403e-9	1.0615200650847458e-7	2.485394	54	0.01310044	49	0.002528458266122449	1.775234	41	115	0.01087245	
GO Cellular Component	U5 snRNP	61	1.037065e-8	2.937784131147541e-7	4.985815	20	0.004852014	59	0.010556557016949152	2.71599	12	22	0.00318218	
GO Cellular Component	Fanconi anaemia nuclear complex	72	3.479762e-7	0.0000083514288	3.991124	20	0.004852014	53	0.005564254550943397	3.447219	9	13	0.002386635	
GO Cellular Component	U1 snRNP	140	0.0002296088	0.002834028617142857	3.13666	14	0.00339641	85	0.03299992094117647	2.620693	10	19	0.002651816	
GO Cellular Component	U2-type spliceosomal complex	144	0.0003141572	0.0037698864	2.286508	23	0.005579816	70	0.019698207634285717	2.213029	16	36	0.004242906	
GO Molecular Function	structural constituent of ribosome	20	9.420347e-11	1.9886352517e-8	2.299187	76	0.01843765	16	0.006243414437500001	1.690508	55	162	0.01458499	
GO Molecular Function	transcription corepressor binding	161	0.0003825216	0.010031094380124225	2.736688	16	0.003881611	27	0.03773460974814814	3.621321	8	11	0.002121453	
Mouse Phenotype Single KO	cortical renal glomerulopathies	15	2.218829e-20	1.3545211435333333e-17	2.506412	131	0.03178069	15	0.0006872511639999999	1.895113	51	134	0.01352426	
Mouse Phenotype Single KO	glomerulonephritis	39	6.957889e-15	1.6336766557179486e-12	2.749165	79	0.01916545	93	0.04788943613978495	1.799753	30	83	0.007955449	
Mouse Phenotype Single KO	glomerulosclerosis	110	7.494669e-9	6.238971275727274e-7	2.324908	59	0.01431344	68	0.016526688261764705	2.096554	24	57	0.00636436	
Mouse Phenotype Single KO	decreased circulating chloride level	118	1.438203e-8	0.000001116069904322034	3.071022	35	0.008491024	62	0.012450031478387096	2.315961	20	43	0.005303633	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	330	0.00008061114	0.0022368369969090907	2.016282	37	0.008976225	73	0.02130122664520548	2.060407	24	58	0.00636436	
Mouse Phenotype Single KO	increased circulating glucagon level	577	0.001970908	0.03127834411785095	2.149726	19	0.004609413	94	0.04944320201702128	2.929009	10	17	0.002651816	
Mouse Phenotype	cortical renal glomerulopathies	34	3.010339e-16	8.465250346764706e-14	2.086111	150	0.0363901	94	0.02168881319042553	1.546209	59	190	0.01564572	
Mouse Phenotype	decreased circulating chloride level	143	2.408943e-8	0.000001610622658951049	3.005719	35	0.008491024	88	0.019944865292045453	2.213029	20	45	0.005303633	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	374	0.00008061114	0.0020607569773796793	2.016282	37	0.008976225	86	0.018879006073255815	2.060407	24	58	0.00636436