# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process viral life cycle 49 3.40287e-63 9.138442108163266e-61 2.092606 632 0.04125326 260 0.00006469576799615384 1.257266 197 298 0.01995341 GO Biological Process mitochondrial transport 93 3.245356e-47 4.5920042584946234e-45 2.063649 486 0.03172324 348 0.0009339180523275861 1.249335 157 239 0.01590195 GO Biological Process regulation of intrinsic apoptotic signaling pathway 98 3.397656e-46 4.562219928979592e-44 2.315793 368 0.02402089 371 0.001525034816522911 1.300622 106 155 0.01073635 GO Biological Process RNA catabolic process 106 1.501336e-43 1.863781172075472e-41 2.06628 446 0.02911227 382 0.0016480476280104712 1.238967 157 241 0.01590195 GO Biological Process nuclear-transcribed mRNA catabolic process 107 2.26786e-43 2.7890439009345794e-41 2.230969 373 0.02434726 489 0.005797858091002045 1.239086 129 198 0.01306594 GO Biological Process mRNA catabolic process 111 8.863416e-43 1.0507539742702702e-40 2.152613 398 0.02597911 436 0.003378177876376147 1.241116 139 213 0.0140788 GO Biological Process positive regulation of apoptotic signaling pathway 113 5.017669e-42 5.843142156725664e-40 2.046653 440 0.02872063 254 0.000039106496439370076 1.344414 123 174 0.01245822 GO Biological Process mitochondrial membrane organization 132 2.278326e-39 2.2712493813636366e-37 2.284035 321 0.020953 380 0.0016442295164210527 1.334365 87 124 0.008811911 GO Biological Process rRNA processing 142 1.244176e-37 1.1529656326760563e-35 2.02699 402 0.02624021 365 0.0012848970354794522 1.237714 164 252 0.01661096 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 143 1.722795e-37 1.5853328255244755e-35 2.688272 224 0.01462141 702 0.03670371263247864 1.257157 78 118 0.007900334 GO Biological Process multi-organism metabolic process 148 1.031154e-36 9.168213166216216e-35 2.343922 283 0.01847258 473 0.005224598727061311 1.28084 99 147 0.01002735 GO Biological Process viral gene expression 156 1.398958e-35 1.1800569437179486e-33 2.543368 234 0.01527415 724 0.04267218331906077 1.242944 83 127 0.008406766 GO Biological Process regulation of mitochondrial membrane permeability 160 4.29461e-35 3.532048311875e-33 2.610818 220 0.01436031 336 0.0007088255921130953 1.458956 56 73 0.005672035 GO Biological Process regulation of membrane permeability 161 4.478188e-35 3.6601537821118017e-33 2.494323 239 0.01560052 309 0.00031359430087378644 1.45574 62 81 0.006279753 GO Biological Process translational initiation 164 1.314934e-34 1.0550741771951219e-32 2.335573 268 0.01749347 510 0.007178275783137256 1.276769 96 143 0.009723488 GO Biological Process interaction with host 170 1.151301e-33 8.911746975882353e-32 2.011419 365 0.02382507 451 0.0042023864636363635 1.280333 103 153 0.01043249 GO Biological Process viral transcription 189 2.524416e-30 1.757607944126984e-28 2.463231 210 0.01370757 506 0.006936759048221344 1.312784 78 113 0.007900334 GO Biological Process platelet aggregation 217 3.565506e-27 2.162142555483871e-25 2.950385 137 0.008942559 590 0.015301905234237289 1.484373 32 41 0.003241163 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 266 6.687989e-24 3.3085431297368426e-22 2.634969 144 0.009399478 531 0.008814205491148775 1.444 41 54 0.00415274 GO Biological Process erythrocyte homeostasis 271 1.319056e-23 6.4049660162361625e-22 2.139886 216 0.01409922 748 0.047658256405080215 1.309068 53 77 0.005368176 GO Cellular Component melanosome 44 2.485831e-39 9.762536290909092e-38 2.310829 313 0.02043081 69 0.00009822144834782609 1.412805 78 105 0.007900334 GO Cellular Component ribosomal subunit 54 7.71189e-36 2.4678048e-34 2.248274 301 0.01964752 94 0.001490257899574468 1.264476 123 185 0.01245822 GO Cellular Component cytosolic ribosome 87 3.22192e-22 6.399399724137931e-21 2.081385 216 0.01409922 103 0.005949821079611651 1.307524 77 112 0.007799048 GO Cellular Component ficolin-1-rich granule lumen 89 7.170089e-22 1.3921251451685392e-20 2.040043 223 0.01455614 95 0.0018482760757894737 1.319027 86 124 0.008710625 GO Cellular Component large ribosomal subunit 94 2.801916e-19 5.150756221276596e-18 2.142382 173 0.01129243 110 0.009796228363636363 1.289953 78 115 0.007900334 GO Cellular Component cytosolic large ribosomal subunit 124 1.211178e-13 1.687835148387097e-12 2.190011 112 0.007310705 106 0.009195542218867925 1.403007 45 61 0.004557885 GO Cellular Component platelet dense tubular network membrane 140 1.381439e-12 1.705090422857143e-11 3.688234 43 0.002806789 143 0.03705636788811189 1.901854 9 9 0.000911577 GO Cellular Component intrinsic component of mitochondrial membrane 143 2.607652e-12 3.151064794405594e-11 2.024226 120 0.007832898 114 0.013674239999999999 1.375186 47 65 0.004760458 GO Molecular Function structural constituent of ribosome 12 3.993631e-30 1.4050925068333334e-27 2.181448 268 0.01749347 68 0.006010519914705882 1.279642 109 162 0.01104021 Human Phenotype Abnormal venous morphology 106 5.581129e-10 3.5134786619811324e-8 2.532834 58 0.003785901 41 0.04231144227317073 1.720725 19 21 0.00192444 Mouse Phenotype Single KO extramedullary hematopoiesis 25 2.797385e-54 1.0246261777999998e-51 2.600837 348 0.0227154 220 0.008320087660454546 1.317951 79 114 0.008001621 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 37 1.343302e-44 3.324490922702702e-42 2.066332 457 0.02983029 93 0.000054636806051612904 1.347599 124 175 0.01255951 Mouse Phenotype Single KO abnormal erythropoiesis 38 3.125757e-44 7.532251802368421e-42 2.168871 405 0.02643603 75 0.000008832202430933333 1.469614 85 110 0.008609339 Mouse Phenotype Single KO decreased erythroid progenitor cell number 55 1.932076e-37 3.2167308967272726e-35 2.493649 256 0.01671018 198 0.0056117425818181825 1.49165 40 51 0.004051453 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 57 6.542412e-36 1.0510327488421053e-33 2.447158 254 0.01657963 266 0.01790054768007519 1.435361 40 53 0.004051453 Mouse Phenotype Single KO microcytosis 74 1.790263e-28 2.2153294987837837e-26 4.490037 84 0.005483029 153 0.0016236653752941177 1.811289 20 21 0.002025727 Mouse Phenotype Single KO reticulocytosis 88 4.990302e-26 5.192749478863636e-24 2.326111 200 0.01305483 169 0.0030984481298224854 1.439975 53 70 0.005368176 Mouse Phenotype Single KO abnormal iron level 89 5.4479e-26 5.605215764044944e-24 2.05668 263 0.0171671 223 0.00843931704529148 1.310521 82 119 0.00830548 Mouse Phenotype Single KO abnormal reticulocyte cell number 94 1.689345e-25 1.6456736345744682e-23 2.22955 214 0.01396867 138 0.0011266162333333333 1.451415 58 76 0.005874608 Mouse Phenotype Single KO hemolytic anemia 95 1.719028e-25 1.6569620416842106e-23 3.404035 104 0.006788512 318 0.03131668083962264 1.490642 29 37 0.002937304 Mouse Phenotype Single KO abnormal platelet activation 101 2.372312e-24 2.1508179192079207e-22 2.109024 231 0.01507833 268 0.01815348940708955 1.342485 60 85 0.00607718 Mouse Phenotype Single KO abnormal reticulocyte morphology 103 3.298517e-24 2.9324776863106796e-22 2.131232 224 0.01462141 144 0.0013584116984722222 1.43226 61 81 0.006178467 Mouse Phenotype Single KO decreased mean corpuscular volume 106 8.089254e-24 6.988047063962264e-22 2.103455 227 0.01481723 235 0.009775116982978723 1.352429 64 90 0.006482326 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 111 2.713028e-23 2.2381258915315314e-21 2.263529 188 0.01227154 269 0.01955528751747212 1.378155 50 69 0.005064317 Mouse Phenotype Single KO abnormal erythrocyte physiology 123 3.01231e-22 2.242579078861789e-20 2.709346 127 0.008289817 118 0.0005658950726355932 1.60601 38 45 0.003848881 Mouse Phenotype Single KO abnormal cellular hemoglobin content 137 4.67531e-21 3.124949902919708e-19 5.138043 53 0.00345953 295 0.026292723801016948 1.901854 11 11 0.00111415 Mouse Phenotype Single KO abnormal platelet aggregation 139 7.446047e-21 4.90528434381295e-19 2.031612 214 0.01396867 303 0.028179845485478548 1.341051 55 78 0.005570749 Mouse Phenotype Single KO abnormal liver iron level 148 8.788063e-20 5.4373170872297295e-18 3.016816 94 0.00613577 367 0.04447277944414169 1.521483 24 30 0.002430872 Mouse Phenotype Single KO hemolysis 179 3.73446e-18 1.9104162134078214e-16 2.879425 92 0.006005222 166 0.002961399174819277 1.656453 27 31 0.002734731 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 184 8.608448e-18 4.2841064313043474e-16 2.963334 86 0.005613577 148 0.0014883249516891891 1.70511 26 29 0.002633445 Mouse Phenotype extramedullary hematopoiesis 42 2.597355e-51 5.9126931321428565e-49 2.117392 498 0.03250653 165 0.00015329272985454545 1.325864 122 175 0.01235693 Mouse Phenotype abnormal mean corpuscular hemoglobin 45 1.346702e-48 2.8612928493333335e-46 2.068031 498 0.03250653 122 0.000013509740021311474 1.354037 131 184 0.01326851 Mouse Phenotype abnormal embryonic erythrocyte morphology 53 5.784e-44 1.0434117735849056e-41 3.272349 195 0.01272846 473 0.03114775707399577 1.462964 30 39 0.00303859 Mouse Phenotype abnormal erythropoiesis 54 7.458866e-44 1.3206336634444445e-41 2.026463 471 0.03074413 149 0.00007396992777181208 1.365761 107 149 0.01083764 Mouse Phenotype decreased erythroid progenitor cell number 60 1.504313e-41 2.3971227654999998e-39 2.343341 322 0.02101828 247 0.0018813845486234818 1.42639 57 76 0.005773321 Mouse Phenotype microcytosis 70 1.159739e-36 1.5840377969999999e-34 4.864179 101 0.006592689 171 0.00024970323919298247 1.82261 23 24 0.002329586 Mouse Phenotype reticulocytosis 75 2.700771e-36 3.4429428707999996e-34 2.350735 278 0.01814621 216 0.0011011005325 1.392078 71 97 0.00719133 Mouse Phenotype abnormal reticulocyte cell number 80 5.095943e-35 6.0902888778749994e-33 2.20984 305 0.01990862 184 0.00033910248117391303 1.395856 80 109 0.008102907 Mouse Phenotype abnormal iron homeostasis 83 1.449596e-34 1.669829801927711e-32 2.121174 330 0.02154047 319 0.00493009518244514 1.290543 95 140 0.009622202 Mouse Phenotype poikilocytosis 85 1.086907e-33 1.222578567882353e-31 3.76 123 0.008028721 473 0.03114775707399577 1.462964 30 39 0.00303859 Mouse Phenotype abnormal reticulocyte morphology 87 5.196037e-32 5.710265489310345e-30 2.090855 315 0.02056136 198 0.0006286159519696969 1.372642 83 115 0.008406766 Mouse Phenotype abnormal iron level 89 1.038832e-31 1.1159857024719102e-29 2.104899 307 0.02003916 317 0.004926683769085173 1.296078 92 135 0.009318343 Mouse Phenotype abnormal embryonic hematopoiesis 91 1.833234e-31 1.9261044257142856e-29 2.234927 266 0.01736292 385 0.014008191123116883 1.403007 45 61 0.004557885 Mouse Phenotype increased circulating interferon-gamma level 98 5.291064e-30 5.162026826938776e-28 3.133301 139 0.009073107 407 0.01776198416167076 1.42639 39 52 0.003950167 Mouse Phenotype abnormal red blood cell distribution width 99 9.5025e-30 9.177111363636363e-28 2.095827 290 0.0189295 190 0.00044045453772631574 1.407372 74 100 0.007495189 Mouse Phenotype decreased mean corpuscular volume 106 9.87673e-29 8.908624106603772e-27 2.100753 278 0.01814621 207 0.0008361265397101449 1.381535 77 106 0.007799048 Mouse Phenotype increased red blood cell distribution width 110 1.110134e-27 9.649082885454546e-26 2.111706 264 0.01723238 226 0.001423506407123894 1.404778 65 88 0.006583612 Mouse Phenotype abnormal circulating tumor necrosis factor level 111 1.43697e-27 1.2377360513513513e-25 2.008403 297 0.01938642 468 0.029931466391025643 1.237507 95 146 0.009622202 Mouse Phenotype abnormal erythrocyte physiology 123 6.606159e-27 5.135080178780489e-25 2.738043 153 0.009986945 181 0.0003081407822983425 1.556062 45 55 0.004557885 Mouse Phenotype hemolysis 124 9.023607e-27 6.957637623145161e-25 3.30742 114 0.007441253 213 0.0010616022684507042 1.637707 31 36 0.003139876