# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	12	2.938898e-27	3.2227465651666662e-24	2.126316	251	0.04531504	80	8.702031896125e-8	1.537367	159	396	0.03242251	
GO Biological Process	rRNA processing	14	5.190756e-27	4.878939871714285e-24	2.496353	179	0.0323163	102	2.9598783818627455e-7	1.656158	109	252	0.02222675	
GO Biological Process	rRNA metabolic process	15	1.035195e-26	9.08142067e-24	2.458717	182	0.03285792	106	3.8485581077358493e-7	1.640964	111	259	0.02263458	
GO Biological Process	ribosome biogenesis	24	3.073535e-22	1.6851936277083333e-19	2.089324	211	0.03809352	90	1.4815016286666669e-7	1.588466	134	323	0.02732463	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	25	6.087904e-22	3.20442914944e-19	2.902111	111	0.02003972	298	0.010547048894295303	1.592558	47	113	0.009584013	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	27	1.556925e-21	7.587991138888889e-19	3.153321	96	0.01733165	276	0.005347889116304347	1.626442	48	113	0.009787928	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	2.552031e-20	1.0832959977096775e-17	3.086992	93	0.01679003	138	0.000006279766586521739	1.882009	58	118	0.01182708	
GO Biological Process	protein targeting to ER	32	8.571348e-20	3.524699010375e-17	3.221195	85	0.01534573	94	1.8093736991489362e-7	2.085053	55	101	0.01121533	
GO Biological Process	IRE1-mediated unfolded protein response	38	3.758694e-19	1.3015961669999998e-16	3.952218	63	0.01137389	425	0.04853590329882353	1.71641	26	58	0.005301794	
GO Biological Process	regulation of DNA-templated transcription in response to stress	40	5.744139e-19	1.8896781275250002e-16	2.611812	113	0.02040079	329	0.01924325763525836	1.544436	48	119	0.009787928	
GO Biological Process	regulation of hematopoietic stem cell differentiation	41	8.829407e-19	2.8338089442195124e-16	3.121049	84	0.01516519	287	0.008342026547038328	1.635653	44	103	0.008972268	
GO Biological Process	cotranslational protein targeting to membrane	44	1.615692e-18	4.832020688181819e-16	3.194146	80	0.01444304	91	1.4799464565934067e-7	2.10981	54	98	0.01101142	
GO Biological Process	RNA catabolic process	47	1.741175e-18	4.874919537234042e-16	2.127109	166	0.02996931	158	0.00002170467114050633	1.572874	99	241	0.0201876	
GO Biological Process	mRNA catabolic process	48	2.050083e-18	5.620217124375e-16	2.228931	149	0.02690016	156	0.00001703453638141026	1.617851	90	213	0.01835237	
GO Biological Process	response to topologically incorrect protein	52	4.22578e-18	1.069366135e-15	2.290925	138	0.02491424	275	0.005340415064363636	1.489023	70	180	0.01427406	
GO Biological Process	response to unfolded protein	54	8.625171e-18	2.101826392388889e-15	2.337088	130	0.02346994	230	0.0011784325040434783	1.579428	66	160	0.0134584	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	56	1.983136e-17	4.6600154685714285e-15	2.88984	87	0.01570681	86	1.1678158055465115e-7	2.078554	57	105	0.01162316	
GO Biological Process	nuclear-transcribed mRNA catabolic process	57	2.999982e-17	6.925747918947369e-15	2.249836	136	0.02455317	200	0.000244307033225	1.566374	81	198	0.01651713	
GO Biological Process	mitochondrial transport	60	4.694784e-17	1.0296443776e-14	2.020019	172	0.03105254	172	0.000050718909663372085	1.553995	97	239	0.01977977	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	62	5.690447e-17	1.207751485048387e-14	3.154738	74	0.01335981	119	8.692394186470588e-7	2.080932	50	92	0.01019576	
GO Cellular Component	ribosomal subunit	30	7.381167e-21	4.2515521919999995e-19	2.603039	126	0.02274779	29	7.728199944827587e-10	1.883412	91	185	0.01855628	
GO Cellular Component	ribosome	33	3.400118e-20	1.7804254254545454e-18	2.279544	157	0.02834447	28	1.9165698514285711e-10	1.800888	111	236	0.02263458	
GO Cellular Component	catalytic step 2 spliceosome	37	8.732458e-18	4.0782938983783783e-16	2.888904	89	0.01606788	60	0.000680097888	1.754919	44	96	0.008972268	
GO Cellular Component	mitochondrial ribosome	38	1.504119e-15	6.839783242105263e-14	3.421279	60	0.01083228	40	0.00001689236208	1.982027	44	85	0.008972268	
GO Cellular Component	spliceosomal complex	39	4.930286e-15	2.1844959507692305e-13	2.089071	138	0.02491424	44	0.00007114266327272727	1.605674	78	186	0.01590538	
GO Cellular Component	large ribosomal subunit	43	3.377901e-13	1.3574448669767444e-11	2.603105	76	0.01372089	41	0.000018831090731707317	1.83122	55	115	0.01121533	
GO Cellular Component	mitochondrial large ribosomal subunit	49	9.22089e-12	3.2517750857142856e-10	3.741478	39	0.007040982	61	0.001136327417704918	2.027073	27	51	0.00550571	
GO Cellular Component	small ribosomal subunit	62	2.544818e-9	7.092654038709678e-8	2.594744	51	0.009207438	50	0.00013944127104	1.967637	37	72	0.007544861	
GO Cellular Component	nuclear chromosome, telomeric region	77	5.910113e-8	0.000001326321462857143	2.012329	72	0.01299874	93	0.035909196387096776	1.450347	50	132	0.01019576	
GO Cellular Component	mitochondrial intermembrane space	80	9.941225e-8	0.0000021473046	2.326687	50	0.0090269	100	0.049570168319999997	1.570837	32	78	0.006525285	
GO Cellular Component	cytosolic small ribosomal subunit	93	0.000001552346	0.000028843590193548386	2.545536	34	0.006138292	70	0.00469172736	2.001478	23	44	0.004690049	
GO Cellular Component	ESCRT complex	100	0.000003135598	0.00005418313344	3.115901	23	0.004152374	91	0.03408962320879121	2.051205	15	28	0.003058728	
GO Cellular Component	mitochondrial nucleoid	116	0.00002213334	0.00032971044413793106	2.416127	29	0.005235602	73	0.005942241665753425	2.005622	22	42	0.004486134	
GO Cellular Component	cytosolic large ribosomal subunit	158	0.0000944801	0.0010333013468354429	2.001048	37	0.006679906	85	0.03291136602352941	1.694766	27	61	0.00550571	
GO Cellular Component	extrinsic component of organelle membrane	190	0.000475873	0.004327939705263158	2.007935	29	0.005235602	79	0.02229159372151899	2.034111	17	32	0.003466558	
GO Cellular Component	Bcl-2 family protein complex	208	0.0007967473	0.006619131415384615	3.480886	10	0.00180538	87	0.03417741682758621	3.281927	6	7	0.001223491	
GO Molecular Function	structural constituent of ribosome	7	9.462314e-18	5.707127101142857e-15	2.521479	112	0.02022026	8	9.0946102e-8	1.890822	80	162	0.01631321	
GO Molecular Function	unfolded protein binding	9	7.656945e-17	3.591957976666667e-14	2.976848	80	0.01444304	36	0.009767802236111112	1.661605	46	106	0.009380098	
GO Molecular Function	NF-kappaB binding	13	2.600669e-11	8.446172706153845e-9	3.764591	37	0.006679906	38	0.013049979789473684	2.324698	17	28	0.003466558	
GO Molecular Function	heat shock protein binding	21	1.084488e-9	2.180337302857143e-7	2.034077	89	0.01606788	26	0.0018189837461538463	1.750361	48	105	0.009787928	
GO Molecular Function	protein phosphatase activator activity	77	0.000001547641	0.00008485896496103896	3.76936	19	0.003430222	51	0.04222707805882353	3.350301	7	8	0.001427406	
GO Molecular Function	Hsp70 protein binding	78	0.000002472373	0.0001338251128974359	2.452207	35	0.00631883	35	0.009123859009714286	2.173168	21	37	0.004282219	
GO Molecular Function	phosphatase activator activity	174	0.0002518201	0.006110255529885059	2.434417	21	0.003791298	41	0.018667603892682925	3.132749	9	11	0.001835237	
GO Molecular Function	ribosomal small subunit binding	208	0.0008525298	0.017304715459615386	2.535342	16	0.002888608	50	0.042201938284000005	2.734939	10	14	0.002039152	
Human Phenotype	Abnormality of the mitochondrion	17	1.202334e-8	0.000004719514577647059	2.354723	56	0.01011013	10	0.043479539693	1.833565	34	71	0.006933116	
Human Phenotype	Abnormality of mitochondrial metabolism	19	3.285097e-8	0.00001153760646368421	2.323844	54	0.009749052	12	0.047645731596666664	1.83122	33	69	0.006729201	
Human Phenotype	Increased serum lactate	29	1.348958e-7	0.00003103998873793103	2.089762	62	0.01119336	11	0.04818376143181818	1.684723	44	100	0.008972268	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	69	8.642711e-9	0.0000011469754293768118	4.800222	21	0.003791298	71	0.022673299476056338	2.807871	11	15	0.002243067	
Mouse Phenotype Single KO	abnormal DNA replication	176	0.00001667675	0.0008676647713068181	2.801043	23	0.004152374	57	0.014972487000175439	2.497119	15	23	0.003058728	
Mouse Phenotype Single KO	abnormal adrenal chromaffin cell morphology	182	0.00002361591	0.0011881916915934066	2.896214	21	0.003791298	72	0.02305552003611111	3.132749	9	11	0.001835237	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	202	0.0000411981	0.0018675792163366338	2.637911	23	0.004152374	77	0.028089359128571433	2.436582	14	22	0.002854812	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	87	9.667926e-9	0.000001062471729724138	3.328639	32	0.005777216	122	0.029433632542622955	2.169719	17	30	0.003466558	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	102	5.823127e-8	0.000005458325220294118	3.949708	23	0.004152374	95	0.013568025164210525	2.619784	13	19	0.002650897	
Mouse Phenotype	absent segment of posterior cerebral artery	242	0.0000411981	0.0016276654301652892	2.637911	23	0.004152374	108	0.020910234552777778	2.436582	14	22	0.002854812	
Mouse Phenotype	abnormal DNA replication	296	0.0001501249	0.0048491357057432434	2.313518	25	0.00451345	111	0.02391292235135135	2.268987	16	27	0.003262643