# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	1	2.773936e-30	3.6502223824e-26	2.124284	278	0.06483209	46	9.097806485652174e-10	1.574364	192	555	0.04653417	
GO Biological Process	ncRNA processing	6	7.607809e-24	1.668519310516667e-20	2.199514	201	0.046875	80	3.484445629375e-7	1.585919	138	396	0.03344644	
GO Biological Process	regulation of hematopoietic stem cell differentiation	15	3.79224e-19	3.326805744e-16	3.503651	73	0.01702425	169	0.00014815616876923075	1.944072	44	103	0.01066408	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	16	1.916618e-18	1.576298516375e-15	3.267114	77	0.01795709	172	0.00016409410710465118	1.892851	47	113	0.01139118	
GO Biological Process	rRNA metabolic process	17	1.262256e-17	9.770603943529412e-15	2.303497	132	0.03078358	153	0.00006385383248366013	1.598964	91	259	0.02205526	
GO Biological Process	rRNA processing	18	1.520015e-17	1.1112154102777778e-14	2.32391	129	0.03008396	166	0.00011918835593975904	1.589202	88	252	0.02132816	
GO Biological Process	RNA catabolic process	19	2.458232e-17	1.702519730947368e-14	2.251113	136	0.03171642	115	0.000008912768060434784	1.680622	89	241	0.02157053	
GO Biological Process	mRNA catabolic process	21	4.074299e-17	2.553033359095238e-14	2.357473	122	0.02845149	122	0.000016520574410655736	1.709257	80	213	0.01938924	
GO Biological Process	nuclear-transcribed mRNA catabolic process	23	1.162219e-16	6.649408617826087e-14	2.414722	113	0.02635261	119	0.000012244659601680672	1.746809	76	198	0.01841978	
GO Biological Process	ribosome biogenesis	26	7.070391e-16	3.5784336603461535e-13	2.020956	158	0.03684701	105	0.000005874230236	1.592109	113	323	0.0273873	
GO Biological Process	RNA 3'-end processing	29	4.858394e-15	2.2045381602068966e-12	3.046567	68	0.01585821	139	0.00003041020286043165	1.998992	47	107	0.01139118	
GO Biological Process	viral gene expression	30	5.747216e-15	2.520920511466667e-12	2.873618	74	0.01725746	98	0.0000028306553168367347	2.006695	56	127	0.01357247	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	34	3.647497e-14	1.4116886183235294e-11	2.915668	68	0.01585821	144	0.00004809924284791667	1.928346	50	118	0.01211827	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	37	8.744857e-14	3.110096574675676e-11	2.634281	78	0.0181903	347	0.028054874233429394	1.610937	40	113	0.009694619	
GO Biological Process	protein targeting to ER	38	8.82993e-14	3.057711812368421e-11	3.035054	62	0.01445896	179	0.0002028915636592179	1.93751	43	101	0.01042172	
GO Biological Process	RNA phosphodiester bond hydrolysis	42	1.365527e-13	4.2783261411904766e-11	2.573682	80	0.01865672	264	0.006830094214015151	1.642429	48	133	0.01163354	
GO Biological Process	termination of RNA polymerase II transcription	45	2.710869e-13	7.927183371333333e-11	3.601386	47	0.01096082	143	0.00004815509363916084	2.242471	34	69	0.008240427	
GO Biological Process	viral transcription	53	8.500291e-13	2.1104779107358494e-10	2.765882	66	0.01539179	155	0.00006859038759419355	1.933124	48	113	0.01163354	
GO Biological Process	regulation of cellular amino acid metabolic process	54	9.159026e-13	2.2319189469259262e-10	3.798925	42	0.009794776	317	0.019870696061198737	1.896207	25	60	0.006059137	
GO Biological Process	DNA-templated transcription, termination	56	1.854705e-12	4.3582255526785707e-10	2.766217	64	0.01492537	151	0.000054145929890728475	1.962313	47	109	0.01139118	
GO Cellular Component	ribosomal subunit	23	9.855067e-17	7.40415468521739e-15	2.615248	98	0.02285448	35	0.000006162941622857143	1.77116	72	185	0.01745032	
GO Cellular Component	proteasome core complex	31	4.491967e-13	2.5039093470967743e-11	7.3604	23	0.005363806	96	0.041508414	2.275448	12	24	0.002908386	
GO Cellular Component	ribosome	32	1.138095e-12	6.145713e-11	2.100598	112	0.0261194	39	0.000047216846769230766	1.619811	84	236	0.0203587	
GO Cellular Component	large ribosomal subunit	33	2.008955e-12	1.0519618909090907e-10	2.787374	63	0.01469216	60	0.001537684128	1.741213	44	115	0.01066408	
GO Cellular Component	proteasome complex	34	2.49718e-12	1.269155011764706e-10	3.225952	50	0.01166045	54	0.0012089804800000002	2.007749	30	68	0.007270965	
GO Cellular Component	endopeptidase complex	35	2.547109e-12	1.2575441005714286e-10	3.22413	50	0.01166045	59	0.0015490755579661015	1.978651	30	69	0.007270965	
GO Cellular Component	peptidase complex	39	7.515871e-11	3.3301089969230766e-9	2.695642	57	0.01329291	62	0.0033971337290322583	1.810016	35	88	0.008482792	
GO Cellular Component	catalytic step 2 spliceosome	40	3.292634e-10	1.422417888e-8	2.51577	60	0.01399254	46	0.0004264534956521739	1.896207	40	96	0.009694619	
GO Cellular Component	cytosolic ribosome	42	1.038321e-9	4.2719492571428575e-8	2.306627	67	0.015625	33	0.000003823902196363636	2.03165	50	112	0.01211827	
GO Cellular Component	nucleosome	46	7.957873e-9	2.9893922921739133e-7	2.795366	42	0.009794776	80	0.01317378168	1.646991	38	105	0.009209889	
GO Cellular Component	mitochondrial outer membrane translocase complex	58	6.887899e-8	0.0000020521188744827587	6.513823	14	0.003264925	57	0.0012747634863157894	3.723461	9	11	0.002181289	
GO Cellular Component	outer mitochondrial membrane protein complex	63	1.654114e-7	0.0000045369984	5.591348	15	0.003498134	70	0.006378591085714285	3.033931	10	15	0.002423655	
GO Cellular Component	Golgi transport complex	66	2.76945e-7	0.000007250923636363636	4.458728	18	0.004197761	84	0.01636886057142857	2.925576	9	14	0.002181289	
GO Cellular Component	DNA packaging complex	67	3.111731e-7	0.00000802547935522388	2.377659	44	0.01026119	79	0.013220899564556961	1.62532	40	112	0.009694619	
GO Cellular Component	cytosolic large ribosomal subunit	68	3.836474e-7	0.000009749157458823531	2.584842	37	0.008628731	68	0.006129924988235294	1.939726	26	61	0.006301503	
GO Cellular Component	small ribosomal subunit	70	6.100625e-7	0.000015059828571428571	2.497379	38	0.00886194	73	0.008290813808219178	1.833	29	72	0.007028599	
GO Cellular Component	preribosome	76	0.000001444757	0.000032849211789473685	2.344919	40	0.009328358	85	0.020202651783529414	1.736526	29	76	0.007028599	
GO Cellular Component	U2 snRNP	83	0.000003343906	0.00006961770563855421	4.369512	15	0.003498134	64	0.0035258328	2.874251	12	19	0.002908386	
GO Cellular Component	cytosolic small ribosomal subunit	86	0.000004016865	0.00008071096186046511	2.707914	28	0.006529851	56	0.0012174765942857143	2.275448	22	44	0.005332041	
GO Cellular Component	methyltransferase complex	88	0.000005312393	0.00010431608072727274	2.015067	50	0.01166045	101	0.04599727271287129	1.600315	32	91	0.007755696	
GO Molecular Function	structural constituent of ribosome	6	5.010908e-13	3.526008929333333e-10	2.44283	84	0.01958955	21	0.0001545358354190476	1.769793	63	162	0.01526903	
GO Molecular Function	ribonuclease activity	8	3.169376e-11	1.6726381840000002e-8	2.603324	63	0.01469216	66	0.04838864265757576	1.654872	36	99	0.008725158	
GO Molecular Function	mismatch repair complex binding	46	0.00001535764	0.0014095642626086955	5.70682	10	0.00233209	50	0.013447348652000002	3.982035	7	8	0.001696558	
Human Phenotype	Abnormal CNS myelination	2	6.791255e-9	0.0000226590223075	2.14011	71	0.01655784	38	0.04087284498157895	1.638323	45	125	0.01090645	
Human Phenotype	Increased serum lactate	4	9.05863e-9	0.000015112059497499999	2.394663	55	0.01282649	35	0.037627979320000005	1.729341	38	100	0.009209889	
Mouse Phenotype Single KO	spontaneous chromosome breakage	4	5.249254e-10	0.0000012016854719500002	4.096694	29	0.00676306	46	0.04379086418478261	2.548502	14	25	0.003393117	
Mouse Phenotype	decreased hepatocyte proliferation	7	3.890026e-8	0.00005313219798	2.601767	43	0.01002799	33	0.0023030255764545453	2.514969	21	38	0.005089675