# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	liver regeneration	1	2.23903e-78	2.9463395769999997e-74	4.897097	220	0.01404225	738	0.012018608608265584	1.4881	29	35	0.002773792	
GO Biological Process	endoplasmic reticulum unfolded protein response	25	2.295708e-35	1.2083688628799999e-32	2.442187	251	0.01602094	639	0.005219541032081377	1.291847	82	114	0.007843137	
GO Biological Process	response to topologically incorrect protein	38	8.897131e-32	3.080982811289474e-29	2.013129	343	0.02189315	470	0.0007694966031702128	1.267166	127	180	0.0121473	
GO Biological Process	cellular response to topologically incorrect protein	39	1.006231e-31	3.395126597179487e-29	2.192118	280	0.01787196	420	0.00036726236373809523	1.317915	102	139	0.009756098	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	40	1.024286e-31	3.3696448685e-29	2.310875	250	0.01595711	231	3.8489277484848487e-7	1.462216	92	113	0.008799617	
GO Biological Process	cellular response to unfolded protein	51	7.169012e-30	1.849745664862745e-27	2.218355	256	0.01634008	545	0.001920590335834862	1.306169	88	121	0.008417025	
GO Biological Process	response to unfolded protein	52	1.53639e-29	3.887953078846154e-27	2.014821	317	0.02023361	587	0.0030283633901192508	1.257188	112	160	0.01071258	
GO Biological Process	regulation of DNA-templated transcription in response to stress	63	1.177443e-26	2.459360704285714e-24	2.10011	257	0.01640391	256	0.0000013507523311328125	1.433768	95	119	0.009086561	
GO Biological Process	negative regulation of Notch signaling pathway	98	3.106209e-21	4.1708779827551015e-19	2.71934	120	0.007659412	544	0.0018941526616360292	1.578288	29	33	0.002773792	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	111	4.60513e-20	5.459360871171171e-18	2.135844	182	0.01161677	308	0.000014667700712012989	1.400258	92	118	0.008799617	
GO Biological Process	viral gene expression	121	4.58026e-19	4.9811273834710745e-17	2.040645	192	0.01225506	267	0.0000021143102502621723	1.41416	100	127	0.009564802	
GO Biological Process	activation of JUN kinase activity	125	9.988176e-19	1.0514752638719999e-16	2.351846	137	0.008744495	559	0.002410387466368515	1.546541	31	36	0.002965088	
GO Biological Process	translational elongation	138	5.023884e-18	4.790528228695652e-16	2.066746	175	0.01116998	261	0.0000016996991249042145	1.4432	90	112	0.008608321	
GO Biological Process	protein peptidyl-prolyl isomerization	140	6.458349e-18	6.070386749357143e-16	2.412756	124	0.007914725	882	0.025678475583900226	1.411129	33	42	0.003156385	
GO Biological Process	regulation of mitochondrial membrane permeability	146	2.480742e-17	2.235896162876712e-15	2.030789	175	0.01116998	911	0.031162808686059276	1.303933	53	73	0.005069345	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	151	5.835503e-17	5.085389667350993e-15	2.865771	86	0.005489245	823	0.018672700945321995	1.683734	15	16	0.00143472	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	152	6.159139e-17	5.332112506644737e-15	2.101293	157	0.01002106	332	0.000031471563807831325	1.473627	64	78	0.006121473	
GO Biological Process	endosome organization	171	1.392071e-15	1.0712434087134503e-13	2.072013	148	0.009446608	401	0.00026729351652618455	1.446764	58	72	0.005547585	
GO Biological Process	positive regulation of mRNA catabolic process	174	1.626118e-15	1.2297751012643679e-13	2.52366	97	0.006191358	950	0.03900858115473684	1.508626	21	25	0.002008608	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	184	4.31219e-15	3.083918924456522e-13	2.509925	95	0.006063701	863	0.023037215807647744	1.561724	20	23	0.00191296	
GO Cellular Component	large ribosomal subunit	42	4.366266e-17	1.7964065828571427e-15	2.046494	169	0.010787	63	0.0000030962084571428574	1.421169	91	115	0.008703969	
GO Cellular Component	mitochondrial ribosome	44	3.359927e-15	1.3195349672727271e-13	2.298199	114	0.007276441	139	0.004183526538129496	1.33114	63	85	0.006025825	
GO Cellular Component	endopeptidase complex	52	1.504366e-13	4.9991239384615386e-12	2.117838	120	0.007659412	115	0.0011461078706086958	1.405552	54	69	0.005164993	
GO Cellular Component	proteasome complex	54	3.108241e-13	9.9463712e-12	2.101376	119	0.007595583	123	0.001521349463414634	1.39981	53	68	0.005069345	
GO Cellular Component	mitochondrial large ribosomal subunit	77	1.566744e-10	3.516017703896104e-9	2.374227	70	0.00446799	153	0.006804171670588235	1.408614	40	51	0.003825921	
GO Cellular Component	DNA-directed RNA polymerase III complex	94	2.238309e-9	4.1146786723404256e-8	3.640146	31	0.001978681	185	0.01705482758918919	1.606932	17	19	0.001626016	
GO Cellular Component	proteasome accessory complex	96	3.358217e-9	6.0447906e-8	2.699327	47	0.002999936	128	0.00205919145	1.646318	22	24	0.002104256	
GO Cellular Component	proteasome regulatory particle	138	8.36163e-7	0.000010470214956521739	2.374013	41	0.002616966	156	0.007585661907692307	1.624937	19	21	0.001817312	
GO Cellular Component	preribosome, large subunit precursor	141	9.70038e-7	0.000011888125276595745	2.256046	45	0.002872279	191	0.025478346722513086	1.508626	21	25	0.002008608	
GO Cellular Component	endoribonuclease complex	170	0.000006047049	0.00006146647454117647	2.025422	49	0.003127593	144	0.005854482	1.548261	25	29	0.0023912	
GO Cellular Component	INO80-type complex	224	0.00006319267	0.0004874863114285714	2.276141	29	0.001851024	179	0.014585072983240223	1.561724	20	23	0.00191296	
GO Cellular Component	Ino80 complex	228	0.00007275739	0.0005514244294736842	2.603281	22	0.001404225	169	0.011941011692307695	1.683734	15	16	0.00143472	
GO Cellular Component	RISC-loading complex	245	0.0001380582	0.0009737329371428572	2.428597	23	0.001468054	214	0.041471273271028036	1.795983	9	9	0.0008608321	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	319	0.001711437	0.009270730833855798	2.045885	22	0.001404225	163	0.009386730287116564	1.795983	12	12	0.001147776	
GO Cellular Component	micro-ribonucleoprotein complex	346	0.00319488	0.015955932485549135	2.013881	20	0.001276569	214	0.041471273271028036	1.795983	9	9	0.0008608321	
GO Cellular Component	nuclear pore outer ring	380	0.005953264	0.02707168471578947	2.132408	15	0.0009574264	194	0.025461937484536082	1.795983	10	10	0.0009564802	
GO Molecular Function	peptidyl-prolyl cis-trans isomerase activity	19	6.458349e-18	1.4351131304210527e-15	2.412756	124	0.007914725	152	0.047806789276315785	1.411129	33	42	0.003156385	
GO Molecular Function	mitogen-activated protein kinase binding	65	1.25358e-7	0.000008142484246153846	2.044774	66	0.004212676	115	0.008522169412173913	1.596429	24	27	0.002295552	
GO Molecular Function	translation elongation factor activity	85	7.479229e-7	0.000037149770397647063	2.967804	28	0.001787196	143	0.034479922545454546	1.683734	15	16	0.00143472	
Human Phenotype	Aplasia/Hypoplasia involving the carpal bones	210	0.00001835814	0.0005833517534285713	2.173233	37	0.002361652	220	0.008317475920909092	1.795983	14	14	0.001339072	
Mouse Phenotype Single KO	fusion of vertebral bodies	19	4.900044e-22	2.3615633109473684e-19	5.204281	55	0.003510564	338	0.04310221573372781	1.795983	11	11	0.001052128	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	179	2.173893e-7	0.000011120859330167598	2.189634	54	0.003446735	260	0.014674990590384615	1.632712	20	22	0.00191296	
Mouse Phenotype Single KO	increased cellular sensitivity to alkylating agents	180	2.297401e-7	0.000011687389420555557	2.833272	33	0.002106338	338	0.04310221573372781	1.795983	11	11	0.001052128	
Mouse Phenotype	fusion of vertebral bodies	33	4.900044e-22	1.4196763843636363e-19	5.204281	55	0.003510564	465	0.03271247830967742	1.795983	11	11	0.001052128	
Mouse Phenotype	increased body temperature	84	1.067382e-14	1.2149094407142857e-12	2.248481	115	0.007340269	521	0.04356094366986564	1.436786	28	35	0.002678144	
Mouse Phenotype	absent segment of posterior cerebral artery	242	2.173893e-7	0.000008588673955785124	2.189634	54	0.003446735	358	0.011128029205307262	1.632712	20	22	0.00191296