# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	29	1.45896e-56	6.620156772413793e-54	2.354633	441	0.01625926	604	0.003960214121854305	1.2189	95	113	0.007335341	
GO Biological Process	regulation of DNA-templated transcription in response to stress	33	2.456624e-54	9.795974307878787e-52	2.232638	473	0.01743907	511	0.0013197961970645793	1.230544	101	119	0.007798626	
GO Biological Process	cellular response to topologically incorrect protein	54	3.487457e-47	8.498416048703704e-45	2.107366	466	0.01718099	353	0.00005971632483002833	1.251669	120	139	0.009265694	
GO Biological Process	endoplasmic reticulum unfolded protein response	57	3.854643e-46	8.898815304736843e-44	2.236847	398	0.01467389	414	0.00023576293743478261	1.25908	99	114	0.007644197	
GO Biological Process	cellular response to unfolded protein	64	4.096327e-42	8.42243234265625e-40	2.097265	419	0.01544814	389	0.00014352507768894602	1.258134	105	121	0.008107482	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	112	1.97219e-31	2.3171471616071427e-29	2.18014	282	0.01039708	944	0.04154046780826271	1.208208	65	78	0.005018917	
GO Biological Process	IRE1-mediated unfolded protein response	124	2.588932e-29	2.7473996925806453e-27	2.511019	196	0.007226339	884	0.030874973608597287	1.24987	50	58	0.003860706	
GO Biological Process	regulation of mitochondrial membrane permeability	127	1.056034e-28	1.0942008981102363e-26	2.031036	303	0.01117133	443	0.0003765190907900677	1.310823	66	73	0.005096132	
GO Biological Process	photoperiodism	178	3.567279e-23	2.6371811438764045e-21	2.898084	119	0.00438742	950	0.042454563113684216	1.383947	21	22	0.001621496	
GO Biological Process	regulation of viral transcription	179	5.268153e-23	3.8728282305586595e-21	2.066848	229	0.008443019	954	0.043035019801886794	1.226796	55	65	0.004246776	
GO Biological Process	gene silencing by miRNA	213	6.848175e-21	4.2307575035211265e-19	2.164587	185	0.006820779	567	0.0025882963924162257	1.350996	41	44	0.003165779	
GO Biological Process	positive regulation of mitochondrial membrane permeability	300	1.224184e-17	5.369679085333333e-16	2.488903	115	0.004239944	736	0.010565947533695653	1.449849	20	20	0.001544282	
GO Biological Process	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	317	2.667698e-17	1.1073892107886436e-15	2.640985	101	0.003723777	615	0.0041427249386991865	1.449849	23	23	0.001775925	
GO Biological Process	positive regulation of membrane permeability	360	4.593709e-16	1.679128242527778e-14	2.350288	116	0.004276813	950	0.042454563113684216	1.383947	21	22	0.001621496	
GO Biological Process	maintenance of protein localization in organelle	375	9.257371e-16	3.2484731997066666e-14	2.50818	100	0.003686908	588	0.003307017830612245	1.40308	30	31	0.002316423	
GO Biological Process	anterograde synaptic vesicle transport	417	1.582354e-14	4.993332442685851e-13	3.011485	67	0.002470228	865	0.027434780750289017	1.449849	17	17	0.00131264	
GO Biological Process	apoptotic nuclear changes	422	2.468974e-14	7.698869399526066e-13	2.536913	88	0.003244479	575	0.0030544350406956525	1.449849	24	24	0.001853139	
GO Biological Process	cellular component disassembly involved in execution phase of apoptosis	434	3.824113e-14	1.1594816351843319e-12	2.486509	90	0.003318217	533	0.0015657229977861162	1.449849	26	26	0.002007567	
GO Biological Process	anterograde axonal transport	460	9.741954e-14	2.786834188826087e-12	2.236235	108	0.00398186	792	0.017948244633838383	1.356311	29	31	0.002239209	
GO Biological Process	mismatch repair	464	1.033988e-13	2.9323810543103443e-12	2.3753	95	0.003502562	683	0.007908011832210834	1.398069	27	28	0.002084781	
GO Cellular Component	PcG protein complex	56	1.188352e-24	3.666914742857143e-23	2.105318	236	0.008701102	120	0.0008676937440000001	1.355294	43	46	0.003320207	
GO Cellular Component	mitochondrial ribosome	74	5.065587e-21	1.1828830183783784e-19	2.165927	186	0.006857648	99	0.00003356064	1.313393	77	85	0.005945487	
GO Cellular Component	cytoplasmic stress granule	91	3.648276e-17	6.927715305494505e-16	2.024516	175	0.006452089	142	0.001842369261971831	1.348697	40	43	0.003088565	
GO Cellular Component	endoribonuclease complex	103	1.192463e-15	2.000559285436893e-14	2.459262	103	0.003797515	197	0.017592390822335026	1.34986	27	29	0.002084781	
GO Cellular Component	mitochondrial large ribosomal subunit	137	2.453564e-11	3.094714300729927e-10	2.057129	105	0.003871253	160	0.00351061992	1.307707	46	51	0.003551849	
GO Cellular Component	mitochondrial small ribosomal subunit	141	3.689067e-11	4.521069344680851e-10	2.390286	74	0.002728312	164	0.004324789931707317	1.398069	27	28	0.002084781	
GO Cellular Component	INO80-type complex	260	0.000002578314	0.000017135871507692308	2.130822	47	0.001732847	148	0.0022605824432432435	1.449849	23	23	0.001775925	
GO Cellular Component	Ino80 complex	307	0.00002489823	0.00014014378319218243	2.255591	33	0.00121668	206	0.021941212893203884	1.449849	16	16	0.001235426	
GO Molecular Function	unfolded protein binding	14	2.254766e-26	6.799730037142858e-24	2.051748	270	0.009954651	87	0.0007986606960919541	1.25836	92	106	0.007103699	
GO Molecular Function	rRNA binding	23	1.569424e-19	2.880916577391305e-17	2.455585	132	0.004866718	115	0.014945197137391304	1.2807	53	60	0.004092348	
GO Molecular Function	SUMO transferase activity	56	6.203955e-13	4.677338930357142e-11	2.475135	82	0.003023264	130	0.027839351616923077	1.449849	19	19	0.001467068	
Mouse Phenotype Single KO	abnormal platelet activation	31	1.101273e-44	3.2530183422580645e-42	2.155594	418	0.01541127	343	0.04537560467930029	1.211051	71	85	0.005482202	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	56	8.030233e-36	1.313086492517857e-33	2.052226	373	0.01375217	311	0.03530977476848875	1.279279	45	51	0.003474635	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	93	3.862855e-26	3.8034584123655914e-24	2.514514	173	0.00637835	284	0.023534589484859158	1.31498	39	43	0.00301135	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	390	8.707781e-11	2.0445423235128206e-9	2.131412	91	0.003355086	248	0.010370313577016128	1.449849	22	22	0.001698711	
Mouse Phenotype	abnormal platelet activation	35	2.082408e-51	5.688543682285715e-49	2.203147	460	0.01695978	556	0.03990735605935252	1.188877	82	100	0.006331557	
Mouse Phenotype	increased circulating interferon-gamma level	77	1.431333e-36	1.7772694562337664e-34	2.724722	214	0.007889983	468	0.018949137937179485	1.282559	46	52	0.003551849	
Mouse Phenotype	pancytopenia	87	4.046757e-31	4.447246399655173e-29	2.694429	184	0.00678391	257	0.0007726389189105059	1.449849	29	29	0.002239209	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	175	2.423051e-20	1.323816606342857e-18	2.612856	123	0.004534897	506	0.027839855845849804	1.353193	28	30	0.002161995	
Mouse Phenotype	interstitial pneumonia	263	8.522368e-16	3.0981886101901144e-14	2.300352	119	0.00438742	585	0.05009248150769231	1.383947	21	22	0.001621496	
Mouse Phenotype	decreased classified tumor incidence	301	3.391891e-14	1.077404313986711e-12	2.095539	130	0.00479298	569	0.045778420866432336	1.346289	26	28	0.002007567	
Mouse Phenotype	absent segment of posterior cerebral artery	434	8.707781e-11	1.918320141497696e-9	2.131412	91	0.003355086	364	0.007377212440384616	1.449849	22	22	0.001698711	
Mouse Phenotype	increased adrenal gland tumor incidence	756	7.834107e-7	0.000009907658336904761	2.036977	58	0.002138407	530	0.03253285390754717	1.449849	17	17	0.00131264