# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	19	4.389494e-91	3.040071134e-88	2.020633	1010	0.03094932	647	0.004912632995826893	1.121094	211	248	0.01480702	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	62	6.471301e-56	1.3734814493387099e-53	2.380597	427	0.01308451	936	0.04433365511324786	1.14277	98	113	0.006877193	
GO Biological Process	endoplasmic reticulum unfolded protein response	64	3.6726e-55	7.55120990625e-53	2.237465	479	0.01467794	359	0.000012661575138161559	1.236774	107	114	0.007508772	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	67	4.559489e-54	8.954972500149254e-52	2.187756	493	0.01510694	365	0.00001545800708739726	1.236058	106	113	0.007438596	
GO Biological Process	cellular response to topologically incorrect protein	72	3.205679e-53	5.858823605694445e-51	2.070966	551	0.01688423	299	0.000001528531835986622	1.232367	130	139	0.009122807	
GO Biological Process	cellular response to unfolded protein	84	2.969837e-49	4.652391081309524e-47	2.084224	501	0.01535209	315	0.0000031320529617460323	1.241455	114	121	0.008	
GO Biological Process	regulation of DNA-templated transcription in response to stress	87	1.530842e-48	2.3154425147126436e-46	2.039989	520	0.0159343	329	0.00000465161850668693	1.240173	112	119	0.007859649	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	90	3.823495e-48	5.590374522777777e-46	3.587461	190	0.005822149	816	0.02138113345465686	1.317684	24	24	0.001684211	
GO Biological Process	regulation of mitochondrial membrane permeability	122	1.889683e-38	2.0382244751639346e-36	2.105883	378	0.01158301	434	0.00012041894892857145	1.263533	70	73	0.004912281	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	128	8.775289e-38	9.021408433671875e-36	2.101466	373	0.0114298	296	0.0000012154345914864867	1.250683	112	118	0.007859649	
GO Biological Process	viral gene expression	134	3.426335e-36	3.364712109328359e-34	2.015482	395	0.01210394	288	9.074240790625001e-7	1.245056	120	127	0.008421053	
GO Biological Process	IRE1-mediated unfolded protein response	149	3.700362e-34	3.267990842818792e-32	2.491594	234	0.007170436	601	0.0028440386865224627	1.249528	55	58	0.003859649	
GO Biological Process	cotranslational protein targeting to membrane	155	2.552139e-32	2.166683683935484e-30	2.114368	312	0.009560581	367	0.00001619086587002725	1.250455	93	98	0.006526316	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	179	1.700754e-29	1.2502917254748602e-27	2.024012	315	0.00965251	532	0.0009299455406015037	1.233217	73	78	0.005122807	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	206	1.803542e-26	1.1520781154368934e-24	2.026052	280	0.008580009	407	0.00005646155085503686	1.246071	87	92	0.006105263	
GO Biological Process	positive regulation of mRNA metabolic process	226	9.134159e-25	5.318424702699115e-23	2.010079	266	0.008151008	571	0.0020202724630823117	1.267004	50	52	0.003508772	
GO Biological Process	anterograde axonal transport	347	3.801785e-19	1.441720138760807e-17	2.374871	138	0.004228719	631	0.003995958703486529	1.317684	31	31	0.002175439	
GO Biological Process	maintenance of protein localization in organelle	482	2.244232e-15	6.126939603319502e-14	2.33477	112	0.003432003	872	0.03142844553784404	1.275178	30	31	0.002105263	
GO Biological Process	snRNA processing	940	1.691044e-9	2.3672817017021277e-8	2.355398	63	0.001930502	844	0.027249513760663507	1.317684	23	23	0.001614035	
GO Cellular Component	mitochondrial ribosome	73	5.352465e-25	1.2669944547945206e-23	2.167935	224	0.006864007	133	0.0018150795067669173	1.209169	78	85	0.005473684	
GO Cellular Component	DNA-directed RNA polymerase III complex	81	3.410364e-22	7.2754432e-21	4.05887	72	0.002206288	230	0.039640853426086954	1.317684	19	19	0.001333333	
GO Cellular Component	COPI-coated vesicle	84	1.466076e-21	3.0159277714285715e-20	2.777191	118	0.003615861	186	0.016237124129032256	1.317684	23	23	0.001614035	
GO Cellular Component	mitochondrial large ribosomal subunit	135	1.709184e-14	2.1877555200000002e-13	2.116816	130	0.003983575	200	0.022281989760000002	1.214336	47	51	0.003298246	
GO Cellular Component	nuclear ubiquitin ligase complex	145	6.108342e-13	7.279458604137931e-12	2.039812	125	0.003830361	107	0.00025701932859813084	1.317684	40	40	0.002807018	
GO Cellular Component	anaphase-promoting complex	266	4.70738e-7	0.0000030580273082706767	2.056811	59	0.00180793	204	0.025723558588235294	1.317684	21	21	0.001473684	
GO Molecular Function	rRNA binding	12	1.948547e-33	6.855637861666667e-31	2.829434	183	0.005607648	154	0.04193964823376624	1.207877	55	60	0.003859649	
GO Molecular Function	polyubiquitin binding	19	7.711614e-23	1.7136018056842105e-20	2.208195	195	0.005975363	126	0.015496221050793652	1.25912	43	45	0.003017544	
GO Molecular Function	mitogen-activated protein kinase binding	60	1.257359e-14	8.847616163333334e-13	2.067434	139	0.004259361	133	0.018372931365413535	1.317684	27	27	0.001894737	
Mouse Phenotype Single KO	increased skin tumor incidence	146	1.0375e-20	6.507114726027397e-19	2.108169	195	0.005975363	260	0.02058804233615385	1.257789	42	44	0.002947368	
Mouse Phenotype	increased circulating interferon-gamma level	27	9.877358e-62	3.4976822162222218e-59	3.13233	296	0.009070295	519	0.038806477867052026	1.216324	48	52	0.003368421	
Mouse Phenotype	increased circulating tumor necrosis factor level	48	9.341725e-45	1.8607548484375e-42	2.111413	440	0.01348287	547	0.04508546356672761	1.156335	86	98	0.006035088	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	61	3.919914e-41	6.143983238360655e-39	2.402776	305	0.009346081	504	0.03526466719642857	1.250111	37	39	0.002596491	
Mouse Phenotype	absent segment of posterior cerebral artery	297	2.896289e-15	9.323710144444445e-14	2.277609	117	0.003585218	526	0.04187638022053232	1.317684	22	22	0.00154386	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	389	1.495926e-12	3.67674768277635e-11	2.065683	117	0.003585218	550	0.046328798983636364	1.273761	29	30	0.002035088