# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	89	6.495436e-65	9.603757564494382e-63	2.174519	604	0.01501554	364	0.000012197153017307694	1.191558	110	113	0.007170795	
GO Biological Process	endoplasmic reticulum unfolded protein response	91	1.583934e-63	2.2904381874725273e-61	2.194186	579	0.01439403	358	0.000010381748941620112	1.191843	111	114	0.007235984	
GO Biological Process	cellular response to topologically incorrect protein	92	1.759338e-63	2.516427037173913e-61	2.055207	674	0.01675575	256	1.5967336209375e-7	1.197636	136	139	0.008865711	
GO Biological Process	regulation of DNA-templated transcription in response to stress	99	5.19225e-60	6.901496742424242e-58	2.046491	643	0.01598508	339	0.000004492342858407079	1.193196	116	119	0.00756193	
GO Biological Process	cellular response to unfolded protein	107	1.28002e-55	1.5741853439252337e-53	2.035159	603	0.01499068	325	0.0000032745248345538463	1.193706	118	121	0.007692308	
GO Biological Process	regulation of mitochondrial membrane permeability	127	1.291046e-49	1.3377066388976379e-47	2.142372	474	0.01178372	708	0.006028611847033898	1.173751	70	73	0.004563233	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	150	6.191452e-44	5.4315544578666674e-42	2.070552	453	0.01126165	345	0.000005278833926376811	1.192935	115	118	0.007496741	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	193	1.869085e-36	1.2743673323834199e-34	2.033019	390	0.009695463	633	0.0029523744440758293	1.176976	75	78	0.004889179	
GO Biological Process	cotranslational protein targeting to membrane	194	2.684836e-36	1.8211214909278352e-34	2.061728	375	0.009322561	441	0.00014060161739682541	1.186584	95	98	0.00619296	
GO Biological Process	IRE1-mediated unfolded protein response	201	2.694116e-35	1.7637747484577116e-33	2.349657	272	0.006761964	805	0.012644769165217392	1.181846	56	58	0.003650587	
GO Biological Process	gene silencing by miRNA	206	7.165007e-35	4.57690908315534e-33	2.272153	288	0.007159727	877	0.022128321444697834	1.196235	43	44	0.002803129	
GO Biological Process	cytoplasmic sequestering of protein	215	2.375678e-34	1.4540254326511627e-32	2.890513	182	0.004524549	1010	0.047453164991089106	1.192669	38	39	0.002477184	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	229	7.630959e-32	4.3849689729694324e-30	2.019414	344	0.008551896	491	0.00035611496849287166	1.18414	89	92	0.005801825	
GO Biological Process	posttranscriptional gene silencing by RNA	273	1.217329e-28	5.867704143223443e-27	2.031057	303	0.007532629	727	0.007394141652269602	1.200054	50	51	0.003259452	
GO Biological Process	posttranscriptional gene silencing	282	4.39583e-28	2.0512314528368792e-26	2.011663	304	0.007557489	715	0.006249409705734265	1.200515	51	52	0.003324641	
GO Biological Process	negative regulation of Notch signaling pathway	392	3.932588e-22	1.3201256503061224e-20	2.030018	230	0.005717837	857	0.0193230011201867	1.224055	33	33	0.002151239	
GO Biological Process	cytoplasmic translation	416	2.535737e-21	8.021096918990384e-20	2.312508	164	0.004077067	905	0.02571819678563536	1.195588	42	43	0.00273794	
GO Biological Process	maintenance of protein localization in organelle	462	1.15434e-19	3.2878701428571425e-18	2.384621	141	0.003505283	916	0.027107439439956336	1.224055	31	31	0.00202086	
GO Biological Process	anterograde axonal transport	639	4.368458e-16	8.996015465101722e-15	2.09424	150	0.003729024	916	0.027107439439956336	1.224055	31	31	0.00202086	
GO Cellular Component	PcG protein complex	52	4.288859e-42	1.4252208369230768e-40	2.219595	369	0.0091734	130	0.0012005719975384614	1.224055	46	46	0.002998696	
GO Cellular Component	mitochondrial ribosome	69	5.208316e-30	1.3043434852173914e-28	2.159261	275	0.006836544	84	0.000013673974628571428	1.209654	84	85	0.00547588	
GO Cellular Component	mitochondrial large ribosomal subunit	134	4.663193e-17	6.013430973134329e-16	2.100444	159	0.003952766	152	0.0046440773052631576	1.200054	50	51	0.003259452	
GO Cellular Component	mitochondrial small ribosomal subunit	168	2.444697e-14	2.514545485714286e-13	2.30869	106	0.002635177	206	0.029059742446601946	1.224055	28	28	0.001825293	
GO Molecular Function	polyubiquitin binding	31	6.354527e-23	8.654455804516129e-21	2.076278	226	0.005618397	138	0.03760391607246377	1.196854	44	45	0.002868318	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	94	3.064933e-37	2.9857012213829787e-35	2.499135	255	0.006339341	389	0.04163607864524421	1.195588	42	43	0.00273794	
Mouse Phenotype	increased circulating interferon-gamma level	63	1.385316e-53	2.1023819485714285e-51	2.730091	318	0.007905531	577	0.035328773220103984	1.176976	50	52	0.003259452	
Mouse Phenotype	absent spleen germinal center	173	8.293109e-29	4.5832609912716765e-27	2.691776	170	0.004226227	494	0.019890073451417002	1.224055	34	34	0.002216428