# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	29	2.090108e-54	9.484045231724138e-52	2.036582	586	0.02112473	524	0.00006217471801908397	1.214903	136	155	0.01002876	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	43	3.009257e-49	9.209026247209302e-47	2.27156	412	0.0148522	541	0.00008355690144731978	1.266791	86	94	0.006341715	
GO Biological Process	endoplasmic reticulum unfolded protein response	57	5.580726e-44	1.2883644462105261e-41	2.187095	398	0.01434751	344	1.6699800003197674e-7	1.299611	107	114	0.007890274	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	61	1.308689e-42	2.8231210739344262e-40	3.64285	164	0.00591204	871	0.006091429517336395	1.384632	24	24	0.001769781	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	74	3.182129e-39	5.658599393378378e-37	2.077777	398	0.01434751	658	0.0004665671438753799	1.225338	100	113	0.007374087	
GO Biological Process	cellular response to unfolded protein	91	7.584599e-37	1.0967663542967034e-34	2.001676	409	0.01474405	312	2.8248859715705123e-8	1.30453	114	121	0.00840646	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	107	4.096138e-34	5.037484106728972e-32	2.283264	278	0.01002163	1166	0.03209383043910806	1.204028	60	69	0.004424452	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	113	4.879346e-33	5.682063187079646e-31	2.114308	319	0.01149964	523	0.00006213594253919695	1.243822	106	118	0.007816533	
GO Biological Process	regulation of mitochondrial membrane permeability	131	1.165553e-29	1.1708024371755725e-27	2.038293	311	0.01121125	679	0.0006406407793078056	1.270827	67	73	0.004940639	
GO Biological Process	positive regulation of mRNA metabolic process	133	1.479614e-29	1.4639278666165413e-27	2.231357	251	0.009048306	1263	0.04394268324940618	1.224867	46	52	0.00339208	
GO Biological Process	IRE1-mediated unfolded protein response	154	5.524861e-27	4.720886097337662e-25	2.417589	193	0.006957462	723	0.0012814700134163208	1.289141	54	58	0.003982007	
GO Biological Process	cellular response to epidermal growth factor stimulus	192	4.822119e-24	3.3049095792187496e-22	2.043471	247	0.00890411	886	0.0074941782284424375	1.311757	36	38	0.002654671	
GO Biological Process	regulation of mitophagy	211	4.310761e-23	2.6884030331279622e-21	2.285851	183	0.006596972	828	0.003933229867753623	1.296252	44	47	0.003244598	
GO Biological Process	positive regulation of mitochondrial membrane permeability	218	8.478167e-23	5.117623832706422e-21	2.729802	129	0.004650324	1030	0.01896724206699029	1.384632	20	20	0.001474817	
GO Biological Process	gene silencing by miRNA	222	1.245721e-22	7.383983170720721e-21	2.207964	193	0.006957462	1122	0.0272735052486631	1.258757	40	44	0.002949635	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	227	1.842076e-22	1.0678360389427314e-20	2.01746	237	0.008543619	648	0.0004247418562808642	1.249179	83	92	0.006120493	
GO Biological Process	mitochondrial outer membrane permeabilization involved in programmed cell death	234	3.569307e-22	2.0072013167948716e-20	2.78556	121	0.004361932	1167	0.03211951781919452	1.384632	18	18	0.001327336	
GO Biological Process	regulation of release of cytochrome c from mitochondria	250	2.449938e-21	1.28954936568e-19	2.161196	190	0.006849315	1074	0.02242202932774674	1.261554	41	45	0.003023376	
GO Biological Process	negative regulation of Notch signaling pathway	358	1.56443e-17	5.750372729050279e-16	2.098967	164	0.00591204	1086	0.02395043417403315	1.300715	31	33	0.002285967	
GO Biological Process	membrane protein proteolysis	569	2.771539e-13	6.4096101407732864e-12	2.013603	133	0.004794521	1253	0.0438197535538707	1.269246	33	36	0.002433449	
GO Cellular Component	cleavage furrow	43	2.199138e-28	8.837466195348837e-27	2.176855	254	0.009156453	235	0.031012938076595747	1.224867	46	52	0.00339208	
GO Cellular Component	nuclear ubiquitin ligase complex	104	8.161795e-14	1.3561136307692308e-12	2.188512	114	0.004109589	171	0.0029261931789473688	1.315401	38	40	0.002802153	
GO Cellular Component	COPI-coated vesicle	110	1.272643e-12	1.9992064581818182e-11	2.381146	86	0.003100216	184	0.005245413495652174	1.384632	23	23	0.00169604	
GO Cellular Component	MLL1 complex	130	3.589274e-11	4.770973440000001e-10	2.191393	89	0.003208363	192	0.0086592699	1.336886	28	29	0.002064744	
GO Cellular Component	integral component of mitochondrial outer membrane	131	7.786941e-11	1.0271629044274808e-9	2.319304	76	0.002739726	260	0.04872317981538461	1.321695	21	22	0.001548558	
GO Cellular Component	COPI-coated vesicle membrane	134	1.693609e-10	2.1839972776119405e-9	2.388164	69	0.002487383	245	0.038544069746938775	1.384632	16	16	0.001179854	
GO Cellular Component	TOR complex	173	1.039825e-8	1.0386228901734104e-7	2.124411	71	0.002559481	265	0.04935666837735849	1.384632	15	15	0.001106113	
GO Molecular Function	mitogen-activated protein kinase binding	37	1.803809e-17	2.058292323783784e-15	2.309695	132	0.004758472	140	0.00457333373	1.384632	27	27	0.001991004	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	38	2.085416e-17	2.317006934736842e-15	2.296981	133	0.004794521	131	0.002546422594961832	1.384632	29	29	0.002138485	
GO Molecular Function	rRNA binding	52	1.003928e-14	8.151123107692308e-13	2.200887	121	0.004361932	164	0.018551053523170734	1.246169	54	60	0.003982007	
GO Molecular Function	snRNA binding	120	1.556742e-9	5.47713727e-8	2.093518	82	0.00295602	157	0.01356917454267516	1.311757	36	38	0.002654671	
Human Phenotype	Soft skin	28	6.462461e-23	1.5401429376071428e-20	2.790798	125	0.004506128	509	0.01946354157760314	1.384632	20	20	0.001474817	
Human Phenotype	Slender long bone	51	5.710256e-20	7.471478095686275e-18	2.657378	117	0.004217736	352	0.0020751342792613638	1.384632	28	28	0.002064744	
Human Phenotype	Abnormality of the acetabulum	61	3.853647e-19	4.215637119836066e-17	2.092441	182	0.006560923	532	0.022954392492481202	1.261554	41	45	0.003023376	
Mouse Phenotype Single KO	subcutaneous edema	259	7.195828e-15	2.5441002701158303e-13	2.101942	136	0.004902668	465	0.01410939704860215	1.338478	29	30	0.002138485	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	293	3.12083e-14	9.753392597269624e-13	2.525969	88	0.003172314	601	0.04340059947587355	1.384632	18	18	0.001327336	
Mouse Phenotype Single KO	absent ductus venosus valve	300	4.617212e-14	1.4093270094666666e-12	2.086232	130	0.004686373	469	0.015106529384434967	1.384632	22	22	0.001622299	
Mouse Phenotype	abnormal jejunum morphology	134	3.096684e-23	2.2095071435820897e-21	2.574025	146	0.005263158	809	0.027359138321384428	1.331377	25	26	0.001843522	
Mouse Phenotype	pancytopenia	204	2.077441e-19	9.736477157352943e-18	2.247915	157	0.005659697	453	0.0016675876191390728	1.384632	29	29	0.002138485	
Mouse Phenotype	abnormal cerebral artery morphology	304	5.962654e-16	1.875293910986842e-14	2.276408	123	0.00443403	913	0.043265106282584884	1.326939	23	24	0.00169604	
Mouse Phenotype	subcutaneous edema	353	7.195828e-15	1.9489889945609066e-13	2.101942	136	0.004902668	677	0.010118656270014771	1.338478	29	30	0.002138485	
Mouse Phenotype	abnormal hypoglossal nerve topology	381	3.12083e-14	7.831563157480314e-13	2.525969	88	0.003172314	847	0.032154139675324676	1.384632	18	18	0.001327336	
Mouse Phenotype	absent ductus venosus valve	389	4.617212e-14	1.13483711907455e-12	2.086232	130	0.004686373	687	0.010767897416157204	1.384632	22	22	0.001622299	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	487	4.383394e-12	8.605673518275154e-11	2.139335	103	0.00371305	677	0.010118656270014771	1.338478	29	30	0.002138485	
Mouse Phenotype	heterochrony	492	5.102715e-12	9.916068722560975e-11	2.170603	99	0.003568854	901	0.04186792673473918	1.384632	17	17	0.001253595	
Mouse Phenotype	abnormal exoccipital bone morphology	722	4.815644e-9	6.377059873130194e-8	2.180646	70	0.002523432	901	0.04186792673473918	1.384632	17	17	0.001253595