# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	13	1.8314e-61	1.8537994307692307e-58	2.456245	442	0.01611316	424	0.00005519300474056604	1.277024	100	114	0.00775314	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	16	2.577988e-58	2.12023400575e-55	2.37043	449	0.01636834	357	0.0000067723327969187685	1.301208	101	113	0.007830671	
GO Biological Process	cellular response to topologically incorrect protein	17	3.134553e-58	2.4263284074705884e-55	2.244677	502	0.01830046	290	4.370736893275862e-7	1.298706	124	139	0.009613894	
GO Biological Process	cellular response to unfolded protein	22	2.876757e-53	1.7206929710454544e-50	2.251888	455	0.01658707	371	0.000010610261310512128	1.287367	107	121	0.00829586	
GO Biological Process	regulation of DNA-templated transcription in response to stress	23	4.844581e-53	2.7717322338695656e-50	2.207569	473	0.01724326	323	0.000001466528587863777	1.309003	107	119	0.00829586	
GO Biological Process	IRE1-mediated unfolded protein response	26	9.062137e-50	4.586486953192308e-47	3.078196	243	0.008858591	554	0.0009009401985559566	1.330306	53	58	0.004109164	
GO Biological Process	positive regulation of nuclease activity	46	1.116651e-41	3.194350110652174e-39	4.616841	122	0.004447523	1026	0.0457520345994152	1.455807	15	15	0.001162971	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	9.400773e-40	2.3789379212884617e-37	2.252068	336	0.01224892	517	0.00046916289206963254	1.246072	101	118	0.007830671	
GO Biological Process	regulation of mitochondrial membrane permeability	58	1.935556e-37	4.3913761041379313e-35	2.200438	332	0.0121031	559	0.0009536920514311271	1.296267	65	73	0.005039541	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	60	6.080437e-37	1.3335411747166667e-34	2.079699	373	0.01359775	1000	0.036594428937000004	1.192523	77	94	0.005969918	
GO Biological Process	regulation of membrane permeability	88	2.225979e-31	3.328597461477273e-29	2.005074	344	0.01254056	576	0.0013991731676041667	1.276078	71	81	0.005504729	
GO Biological Process	liver regeneration	89	2.317214e-31	3.4260920253932583e-29	2.568098	202	0.007363931	894	0.021722756502237137	1.331024	32	35	0.002481005	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	90	2.34709e-31	3.4317063677777776e-29	2.170949	284	0.01035325	440	0.0000742146366159091	1.325158	71	78	0.005504729	
GO Biological Process	cellular response to epidermal growth factor stimulus	95	2.368103e-30	3.2801965659999996e-28	2.208718	264	0.009624148	988	0.03476711686842105	1.302564	34	38	0.002636068	
GO Biological Process	viral gene expression	97	4.221005e-30	5.726206679896907e-28	2.003201	330	0.01203018	255	4.41841652345098e-8	1.329714	116	127	0.008993642	
GO Biological Process	protein targeting to ER	101	9.738934e-30	1.2688577475841583e-27	2.134971	279	0.01017097	411	0.00003849465343552312	1.297254	90	101	0.006977826	
GO Biological Process	cotranslational protein targeting to membrane	106	2.199063e-29	2.7299500016037737e-27	2.160675	268	0.009769968	445	0.00007857463637977528	1.2924	87	98	0.006745232	
GO Biological Process	response to cadmium ion	108	2.831276e-29	3.449700081851852e-27	2.375253	218	0.007947213	767	0.009978819691655802	1.280106	51	58	0.003954101	
GO Biological Process	response to epidermal growth factor	112	6.501854e-29	7.639097927321428e-27	2.124228	274	0.009988699	823	0.013663613273511545	1.317159	38	42	0.002946193	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	117	8.713857e-28	9.800482415641026e-26	2.151519	255	0.009296052	380	0.00001503675813394737	1.368893	63	67	0.004884478	
GO Cellular Component	PcG protein complex	42	9.78125e-29	4.024285714285714e-27	2.205168	250	0.009113776	123	0.0001026754419512195	1.392511	44	46	0.003411382	
GO Cellular Component	nuclear ubiquitin ligase complex	43	4.916517e-28	1.975753808372093e-26	2.873231	148	0.005395356	100	0.000005071695552	1.455807	40	40	0.003101256	
GO Cellular Component	mitochondrial ribosome	45	3.500096e-26	1.344036864e-24	2.325832	202	0.007363931	139	0.00027535331913669064	1.284536	75	85	0.005814855	
GO Cellular Component	mitochondrial large ribosomal subunit	53	3.425198e-22	1.116743800754717e-20	2.615183	135	0.004921439	107	0.00002190937659813084	1.398717	49	51	0.003799039	
GO Cellular Component	spliceosomal snRNP complex	81	3.077195e-15	6.564682666666667e-14	2.015425	155	0.005650541	186	0.006361493574193548	1.267961	54	62	0.004186696	
GO Cellular Component	MLL1 complex	142	1.038173e-9	1.263354185915493e-8	2.091579	84	0.003062229	213	0.014799865690140846	1.355407	27	29	0.002093348	
GO Cellular Component	INO80-type complex	198	5.639793e-8	4.922001163636364e-7	2.331034	52	0.001895665	165	0.0018450233018181817	1.455807	23	23	0.001783222	
GO Cellular Component	Ino80 complex	211	1.239316e-7	0.000001014946942180095	2.635768	39	0.001421749	220	0.019239497018181822	1.455807	16	16	0.001240502	
GO Cellular Component	proteasome accessory complex	213	1.692832e-7	0.0000013733397633802818	2.066533	63	0.002296672	208	0.012016204615384616	1.395148	23	24	0.001783222	
GO Cellular Component	DNA-directed RNA polymerase I complex	354	0.0001221591	0.0005963020474576271	2.020702	35	0.001275929	239	0.037560574393305436	1.455807	14	14	0.00108544	
GO Molecular Function	unfolded protein binding	10	1.278628e-33	5.398367416e-31	2.209041	294	0.0107178	137	0.007848852087591241	1.222329	89	106	0.006900295	
Human Phenotype	Abnormality of transition element cation homeostasis	22	8.093783e-19	2.4549915435909094e-16	2.997296	90	0.003280959	291	0.006023650599312714	1.405607	28	29	0.002170879	
Human Phenotype	Abnormality of iron homeostasis	31	3.078763e-16	6.62728564483871e-14	2.911306	80	0.002916408	380	0.02539945746052632	1.395148	23	24	0.001783222	
Human Phenotype	Abnormality of the odontoid process	58	3.475482e-13	3.998601963103448e-11	2.50415	82	0.002989319	440	0.042981065986363635	1.389634	21	22	0.001628159	
Human Phenotype	Dysphonia	77	8.301405e-12	7.194191631818181e-10	2.15114	99	0.003609055	412	0.03281855904368932	1.392511	22	23	0.001705691	
Human Phenotype	Flat acetabular roof	215	2.664981e-8	8.271357308372093e-7	2.247327	59	0.002150851	425	0.03845960783294118	1.455807	16	16	0.001240502	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	500	0.00002000136	0.00026693815056	2.093237	40	0.001458204	362	0.0212877363839779	1.455807	18	18	0.001395565	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	237	5.635585e-11	2.1774283478902956e-9	2.293176	79	0.002879953	345	0.030651451707246376	1.455807	18	18	0.001395565	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	255	1.514717e-10	5.439319046666666e-9	2.10748	91	0.003317415	266	0.008833843962030075	1.455807	22	22	0.001705691	
Mouse Phenotype	pancytopenia	43	7.567624e-29	1.6826523968372094e-26	2.606259	180	0.006561919	501	0.03481442540718563	1.355407	27	29	0.002093348	
Mouse Phenotype	increased adrenal gland tumor incidence	274	3.732885e-12	1.3025588863138689e-10	2.534995	73	0.002661223	494	0.03255189542307692	1.455807	17	17	0.001318034	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	281	5.109081e-12	1.7383602648042705e-10	2.14243	102	0.003718421	474	0.026923433094936708	1.358753	28	30	0.002170879	
Mouse Phenotype	abnormal hypoglossal nerve topology	321	5.635585e-11	1.6785616257009348e-9	2.293176	79	0.002879953	463	0.023847302261339094	1.455807	18	18	0.001395565	
Mouse Phenotype	absent segment of posterior cerebral artery	341	1.514717e-10	4.246982180938417e-9	2.10748	91	0.003317415	359	0.00683418948384401	1.455807	22	22	0.001705691