# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to topologically incorrect protein	2	8.599207e-51	5.65784824565e-47	2.619094	321	0.02135302	233	7.310022167381974e-7	1.412684	109	139	0.01045764	
GO Biological Process	endoplasmic reticulum unfolded protein response	3	9.158476e-51	4.017212856133334e-47	2.839248	280	0.01862569	289	0.00001814306914567474	1.406432	89	114	0.008538808	
GO Biological Process	response to topologically incorrect protein	8	2.128478e-48	3.50108025025e-45	2.330465	381	0.02534424	221	3.9255964525791857e-7	1.371139	137	180	0.01314401	
GO Biological Process	IRE1-mediated unfolded protein response	10	1.489054e-46	1.9594461586e-43	3.860135	167	0.01110889	391	0.0003693791878516624	1.490894	48	58	0.0046052	
GO Biological Process	cellular response to unfolded protein	14	9.436573e-45	8.869704579071428e-42	2.59187	287	0.01909133	280	0.000013523964865	1.39951	94	121	0.009018517	
GO Biological Process	response to unfolded protein	18	6.744088e-42	4.9303029995555554e-39	2.278641	344	0.02288299	263	0.000004695910232813688	1.362382	121	160	0.01160894	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	19	2.616581e-41	1.8121889146842107e-38	2.24457	350	0.02328211	342	0.00009603330465497076	1.324972	114	155	0.01093735	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	23	1.056658e-36	6.045462009565218e-34	2.466134	256	0.0170292	492	0.001629767826097561	1.323223	83	113	0.007963158	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	26	6.933982e-34	3.5093949668461536e-31	2.441737	240	0.01596488	473	0.0012397319244397463	1.360705	71	94	0.006811858	
GO Biological Process	regulation of DNA-templated transcription in response to stress	28	1.935078e-33	9.094175500714286e-31	2.290875	269	0.01789397	486	0.0014786928049176954	1.317061	87	119	0.008346925	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	75	1.466591e-21	2.5731827958666666e-19	2.912597	109	0.007250715	571	0.004239917373029772	1.569046	27	31	0.002590425	
GO Biological Process	translational elongation	81	2.170635e-20	3.526343946296296e-18	2.178525	177	0.0117741	226	4.7321359383185846e-7	1.463716	91	112	0.008730692	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	84	3.841606e-20	6.018058732619047e-18	2.863588	104	0.006918113	598	0.005246662738628762	1.644845	21	23	0.002014775	
GO Biological Process	DNA-templated transcription, elongation	102	6.26939e-18	8.088127746078433e-16	2.076252	172	0.0114415	553	0.003436274156238698	1.310179	80	110	0.007675333	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	110	4.201728e-17	5.026412613818182e-15	2.134119	153	0.01017761	765	0.01788502474771242	1.316478	57	78	0.005468675	
GO Biological Process	mitochondrial translational termination	116	1.46926e-16	1.666723477586207e-14	2.275965	128	0.008514601	382	0.0002971192656492147	1.408066	68	87	0.006524033	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	123	3.927119e-16	4.2013787740650405e-14	2.384314	113	0.007516796	344	0.00009670223950290698	1.621347	36	40	0.0034539	
GO Biological Process	mitochondrial translational elongation	125	5.503131e-16	5.79325606632e-14	2.259471	125	0.00831504	366	0.00021267216264480874	1.420003	67	85	0.006428092	
GO Biological Process	regulation of pri-miRNA transcription from RNA polymerase II promoter	133	1.333932e-15	1.319790314887218e-13	2.215093	127	0.008448081	865	0.029897947784971096	1.490894	24	29	0.0023026	
GO Biological Process	mitochondrial translation	142	3.227759e-15	2.9911324423239435e-13	2.032897	151	0.01004457	329	0.00006331386855015197	1.397423	83	107	0.007963158	
GO Cellular Component	mitochondrial ribosome	42	2.284346e-18	9.398452114285715e-17	2.500172	119	0.007915918	99	0.00010324698763636364	1.420003	67	85	0.006428092	
GO Cellular Component	nuclear ubiquitin ligase complex	49	1.438735e-16	5.073743020408163e-15	2.904817	82	0.005454666	146	0.003645702443835616	1.486235	33	40	0.003166075	
GO Cellular Component	PcG protein complex	52	7.399007e-16	2.4587469415384615e-14	2.172859	135	0.008980243	84	0.000018482757942857142	1.605682	41	46	0.003933608	
GO Cellular Component	mitochondrial large ribosomal subunit	64	8.453115e-14	2.28234105e-12	2.686445	76	0.005055544	133	0.002287288637593985	1.448262	41	51	0.003933608	
GO Cellular Component	MLL1 complex	75	4.897304e-11	1.1283388416e-9	2.680668	59	0.003924699	153	0.005174695905882353	1.553014	25	29	0.002398542	
GO Cellular Component	endoribonuclease complex	127	4.182674e-7	0.000005691071395275591	2.196999	51	0.003392536	153	0.005174695905882353	1.553014	25	29	0.002398542	
GO Cellular Component	Ino80 complex	130	4.505076e-7	0.000005988285636923077	3.206357	26	0.001729528	173	0.011177592971098266	1.688903	15	16	0.001439125	
GO Cellular Component	INO80-type complex	153	0.000004787356	0.000054068961882352934	2.53573	31	0.00206213	223	0.0483524078206278	1.488193	19	23	0.001822892	
GO Cellular Component	mitochondrial small ribosomal subunit	197	0.00004753913	0.0004169929778680203	2.098035	36	0.002394732	204	0.025129194352941173	1.479801	23	28	0.002206658	
GO Molecular Function	unfolded protein binding	11	1.735763e-17	6.662173987272727e-15	2.138833	156	0.01037717	147	0.005847840502040817	1.308634	77	106	0.007387508	
GO Molecular Function	SUMO transferase activity	16	3.504426e-15	9.2473041075e-13	3.322057	61	0.00405774	102	0.0005710962805882353	1.801497	19	19	0.001822892	
GO Molecular Function	snRNA binding	27	3.477769e-11	5.438200265925926e-9	2.732447	58	0.003858179	205	0.04710952909268293	1.422234	30	38	0.00287825	
GO Molecular Function	NF-kappaB binding	55	8.424615e-9	6.467040823636364e-7	2.286818	61	0.00405774	177	0.017127239510734464	1.54414	24	28	0.0023026	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	86	9.914358e-8	0.000004867258078604652	2.071476	65	0.004323821	198	0.04190710288888888	1.490894	24	29	0.0023026	
GO Molecular Function	inositol tetrakisphosphate phosphatase activity	233	0.00005136521	0.0009307464232618027	2.484445	25	0.001663008	191	0.034001379643979056	1.801497	11	11	0.001055358	
GO Molecular Function	tRNA-specific ribonuclease activity	256	0.00008631267	0.001423484737265625	2.13763	32	0.00212865	185	0.025538604140540544	1.688903	15	16	0.001439125	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	58	1.319275e-9	1.5178486336206896e-7	2.494971	57	0.003791658	295	0.03927311585762712	1.524343	22	26	0.002110717	
Human Phenotype	Short femoral neck	64	5.031335e-9	5.24595288359375e-7	2.467578	54	0.003592097	283	0.03384908724381625	1.566519	20	23	0.001918833	
Human Phenotype	External ophthalmoplegia	77	1.197425e-8	0.0000010377164967532467	2.090779	73	0.004855984	316	0.04493163187974684	1.463716	26	32	0.002494483	
Human Phenotype	Diminished motivation	79	1.423185e-8	0.00000120214095	2.486752	50	0.003326016	261	0.027300265681992338	1.621347	18	20	0.00172695	
Human Phenotype	Apathy	80	1.470476e-8	0.0000012265607935	2.510974	49	0.003259496	297	0.03920245951515152	1.611865	17	19	0.001631008	
Human Phenotype	Aplasia/hypoplasia of the femur	104	4.664394e-8	0.0000029928366501923075	2.018097	73	0.004855984	280	0.033983587100000004	1.473952	27	33	0.002590425	
Human Phenotype	Supranuclear gaze palsy	287	0.00003949566	0.0009183084988850173	2.200697	33	0.002195171	306	0.04143634241503268	1.681397	14	15	0.001343183	
Human Phenotype	Death in childhood	290	0.00004430508	0.0010194751684137933	2.105553	36	0.002394732	325	0.046630451756923076	1.555838	19	22	0.001822892	
Mouse Phenotype Single KO	increased mammary adenocarcinoma incidence	127	2.375636e-10	1.712889673385827e-8	3.071197	44	0.002926894	425	0.048932357856470585	1.555838	19	22	0.001822892	
Mouse Phenotype Single KO	multiple persisting craniopharyngeal ducts	330	0.000004640148	0.00012875707647272728	2.04622	49	0.003259496	399	0.04360758473934837	1.681397	14	15	0.001343183	
Mouse Phenotype Single KO	increased cellular sensitivity to alkylating agents	346	0.000006215899	0.00016450574318786125	2.594851	29	0.001929089	382	0.03687241039790576	1.801497	11	11	0.001055358	
Mouse Phenotype Single KO	increased cellular sensitivity to DNA damaging agents	423	0.0000313559	0.0006787848139479906	2.33121	30	0.00199561	326	0.02397230411380368	1.801497	12	12	0.0011513	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	448	0.0000463662	0.0009477127084821427	2.358228	28	0.001862569	399	0.04360758473934837	1.681397	14	15	0.001343183	
Mouse Phenotype Single KO	increased adrenal gland tumor incidence	716	0.0009764162	0.012487490423743017	2.14172	22	0.001463447	382	0.03687241039790576	1.801497	11	11	0.001055358	
Mouse Phenotype	dry eyes	43	2.669119e-18	5.934755060232558e-16	3.000952	87	0.005787268	578	0.01851084036851211	1.688903	15	16	0.001439125	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	46	8.051024e-18	1.6733878361739131e-15	2.456728	119	0.007915918	402	0.0032002617253731346	1.608479	25	28	0.002398542	
Mouse Phenotype	decreased circulating total protein level	67	1.308305e-15	1.8669707619402987e-13	2.073453	148	0.009845008	638	0.029150365057993732	1.343489	44	59	0.004221433	
Mouse Phenotype	pancytopenia	133	1.266976e-11	9.107937996992482e-10	2.272163	86	0.005720748	277	0.00037514084956678697	1.677256	27	29	0.002590425	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	169	2.215883e-10	1.2536128617159763e-8	2.129763	87	0.005787268	642	0.029268663373831775	1.490894	24	29	0.0023026	
Mouse Phenotype	small sebaceous gland	217	2.834046e-9	1.2486780555760368e-7	4.4917	24	0.001596488	681	0.03892125855947137	1.801497	10	10	0.0009594167	
Mouse Phenotype	decreased spongiotrophoblast size	300	1.060515e-7	0.000003379861305	2.348337	49	0.003259496	624	0.02673421078846154	1.611865	17	19	0.001631008	
Mouse Phenotype	multiple persisting craniopharyngeal ducts	429	0.000004640148	0.00010341364808391609	2.04622	49	0.003259496	636	0.02856458491037736	1.681397	14	15	0.001343183	
Mouse Phenotype	abnormal base-excision repair	919	0.001870126	0.01945622925571273	2.161848	19	0.001263886	681	0.03892125855947137	1.801497	10	10	0.0009594167