# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 4 1.128922e-48 3.7138711495e-45 4.965538 133 0.008058652 667 0.0033754511934032984 1.636768 22 24 0.00209205 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 9 4.447362e-47 6.502537395333334e-44 2.614866 298 0.01805623 279 4.696495208172043e-7 1.453734 92 113 0.008748574 GO Biological Process regulation of DNA-templated transcription in response to stress 16 7.722139e-43 6.3509766938125005e-40 2.42025 312 0.01890451 268 1.7189729361940298e-7 1.45546 97 119 0.00922404 GO Biological Process endoplasmic reticulum unfolded protein response 21 5.24695e-41 3.287838811904762e-38 2.530768 274 0.01660204 406 0.000060543294958128085 1.378331 88 114 0.008368201 GO Biological Process cellular response to topologically incorrect protein 26 1.91369e-39 9.685479503846154e-37 2.318767 312 0.01890451 304 0.0000030398675157894736 1.387345 108 139 0.01027006 GO Biological Process nuclear-transcribed mRNA catabolic process 27 9.317415e-38 4.5410319994444447e-35 2.087575 376 0.02278236 161 3.0796089432919253e-12 1.451899 161 198 0.01531 GO Biological Process response to topologically incorrect protein 28 4.105542e-36 1.9294581135e-33 2.061464 370 0.02241881 331 0.000008104007917522658 1.329254 134 180 0.01274249 GO Biological Process cellular response to unfolded protein 32 1.016426e-34 4.179734291875e-32 2.295049 279 0.01690499 396 0.0000449426039419192 1.372376 93 121 0.008843667 GO Biological Process regulation of intrinsic apoptotic signaling pathway 40 2.871055e-33 9.44505318625e-31 2.03867 349 0.02114639 347 0.00001296076554293948 1.347813 117 155 0.0111259 GO Biological Process response to unfolded protein 45 4.878884e-31 1.4266941012444443e-28 2.01521 334 0.02023752 414 0.00007639794371256038 1.316854 118 160 0.011221 GO Biological Process IRE1-mediated unfolded protein response 50 1.307036e-29 3.4398573448e-27 3.031831 144 0.008725158 787 0.008546240461499365 1.385352 45 58 0.004279194 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 53 5.966288e-29 1.4813279960754716e-26 2.24264 242 0.01466311 584 0.0014787502860616436 1.348671 71 94 0.006751617 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 54 1.142247e-28 2.783486717222222e-26 2.372872 213 0.01290596 328 0.000006763593607621951 1.407267 93 118 0.008843667 GO Biological Process positive regulation of nuclease activity 58 1.501139e-27 3.405773810517241e-25 4.780256 76 0.004604944 997 0.028129784442326985 1.666527 14 15 0.001331305 GO Biological Process regulation of hematopoietic progenitor cell differentiation 59 2.355843e-27 5.254328480847457e-25 2.326063 211 0.01278478 772 0.0072396130532383415 1.279918 81 113 0.007702548 GO Biological Process translational initiation 76 4.394917e-25 7.609567474078947e-23 2.054764 254 0.01539021 444 0.00015445411814864866 1.323566 106 143 0.01007988 GO Biological Process viral gene expression 83 1.59398e-24 2.5271304602409636e-22 2.179298 216 0.01308774 507 0.0005039245538658777 1.321599 94 127 0.00893876 GO Biological Process tumor necrosis factor-mediated signaling pathway 91 7.120297e-24 1.0296262442087913e-21 2.050998 242 0.01466311 541 0.0008020969939926063 1.311274 94 128 0.00893876 GO Biological Process cotranslational protein targeting to membrane 93 1.055967e-23 1.4941365325806453e-21 2.358412 176 0.01066408 564 0.0010976806166134753 1.348284 74 98 0.007036896 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 98 1.625746e-23 2.182978736122449e-21 2.403715 168 0.01017935 722 0.005216262228947369 1.319765 68 92 0.006466337 GO Cellular Component cytoplasmic stress granule 42 2.20348e-22 9.065746285714285e-21 2.604667 137 0.008301018 137 0.00032793088467153285 1.536416 37 43 0.003518448 GO Cellular Component large ribosomal subunit 43 3.243219e-22 1.3033214958139535e-20 2.195602 191 0.01157295 76 0.0000011866507957894738 1.428452 92 115 0.008748574 GO Cellular Component proteasome complex 69 2.140702e-14 5.3610624e-13 2.128909 127 0.007695104 107 0.00006413754616822431 1.470465 56 68 0.005325219 GO Cellular Component endopeptidase complex 70 2.225062e-14 5.492724479999999e-13 2.127707 127 0.007695104 123 0.00013440777365853658 1.449154 56 69 0.005325219 GO Cellular Component cytosolic large ribosomal subunit 71 2.431714e-14 5.918312383098591e-13 2.178106 120 0.007270965 96 0.000019046196 1.522121 52 61 0.004944846 GO Cellular Component mitochondrial ribosome 91 4.142568e-11 7.866326927472527e-10 2.028548 106 0.006422685 160 0.00188512596 1.344425 64 85 0.006085964 GO Cellular Component nuclear transcriptional repressor complex 100 2.472305e-10 4.2721430399999996e-9 2.125099 87 0.005271449 210 0.01903782034285714 1.477709 24 29 0.002282237 GO Cellular Component endoribonuclease complex 101 2.691995e-10 4.605710257425743e-9 2.472047 63 0.003817256 149 0.0011732006657718121 1.600851 26 29 0.002472423 GO Cellular Component proteasome accessory complex 103 2.831573e-10 4.7504448e-9 2.78051 51 0.00309016 239 0.03404682738075313 1.487971 20 24 0.001901864 GO Cellular Component mitochondrial large ribosomal subunit 120 2.956145e-9 4.2568488e-8 2.22162 69 0.004180805 242 0.03510291332231406 1.330421 38 51 0.003613541 GO Cellular Component proteasome regulatory particle 131 1.24383e-8 1.640716213740458e-7 2.583412 47 0.002847794 234 0.030055620923076926 1.530484 18 21 0.001711677 GO Cellular Component DNA polymerase complex 138 2.618113e-8 3.2783328e-7 2.760095 40 0.002423655 226 0.024522116814159292 1.587169 16 18 0.001521491 GO Cellular Component ESCRT complex 165 4.723167e-7 0.000004946443985454545 2.227891 49 0.002968977 102 0.00003428194447058823 1.721795 27 28 0.002567516 GO Cellular Component INO80-type complex 172 6.648375e-7 0.000006679297674418604 2.607749 35 0.002120698 203 0.014168655133004925 1.552665 20 23 0.001901864 GO Cellular Component pre-autophagosomal structure membrane 179 0.000001030447 0.000009947555396648044 2.446394 38 0.002302472 195 0.01122122436923077 1.673967 15 16 0.001426398 GO Cellular Component MLL1 complex 184 0.00000129583 0.000012169533913043478 2.110657 51 0.00309016 210 0.01903782034285714 1.477709 24 29 0.002282237 GO Cellular Component Ino80 complex 197 0.000002408921 0.000021130027857868016 2.920575 26 0.001575376 195 0.01122122436923077 1.673967 15 16 0.001426398 GO Cellular Component intrinsic component of mitochondrial outer membrane 264 0.0000492523 0.00032237869090909096 2.006229 40 0.002423655 255 0.04813917289411765 1.475032 19 23 0.001806771 GO Cellular Component RISC-loading complex 285 0.0001153791 0.0006995617010526315 2.405667 24 0.001454193 245 0.03817179506938776 1.785565 9 9 0.0008558387 GO Cellular Component ESCRT I complex 378 0.001504527 0.006877837714285715 2.154548 20 0.001211827 219 0.023907014136986298 1.785565 10 10 0.0009509319 GO Molecular Function protein phosphatase 2A binding 10 2.706948e-28 1.1428734456e-25 3.020378 138 0.008361609 109 0.001458105659266055 1.653301 25 27 0.00237733 GO Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity 30 8.939829e-16 1.2581319346e-13 2.641584 91 0.005513815 97 0.0005892005571134021 1.662422 27 29 0.002567516 GO Molecular Function rRNA binding 31 9.431989e-16 1.2845760502580647e-13 2.690372 88 0.005332041 134 0.00808632728358209 1.398692 47 60 0.00446938 GO Molecular Function mRNA 5'-UTR binding 36 4.431298e-13 5.1969278211111116e-11 2.872286 64 0.003877848 146 0.013360735883561644 1.623241 20 22 0.001901864 GO Molecular Function DNA polymerase binding 44 1.30045e-12 1.2478408863636363e-10 4.195876 37 0.002241881 174 0.03072558073563218 1.673967 15 16 0.001426398 GO Molecular Function protein deacetylase activity 48 6.469123e-12 5.690132772083334e-10 2.001314 119 0.007210373 158 0.0176471102556962 1.428452 36 45 0.003423355 GO Molecular Function histone deacetylase activity 49 6.689873e-12 5.764213021632653e-10 2.006827 118 0.007149782 169 0.023845346362130176 1.420336 35 44 0.003328262 GO Molecular Function phosphatase activator activity 66 1.477568e-10 9.451957721212123e-9 2.489991 64 0.003877848 185 0.03870925865945946 1.785565 11 11 0.001046025 GO Molecular Function snRNA binding 67 1.560969e-10 9.836434504477612e-9 2.574728 60 0.003635482 164 0.02181301706219512 1.456645 31 38 0.002947889 GO Molecular Function ubiquitin protein ligase activity involved in ERAD pathway 305 0.0001564044 0.0021650471370491804 2.355903 24 0.001454193 151 0.014860727013245036 1.785565 13 13 0.001236211 Human Phenotype Dermal atrophy 1 1.29167e-32 8.61931391e-29 2.735367 188 0.01139118 162 0.003581107877098765 1.481639 39 47 0.003708634 Human Phenotype Scarring 6 7.871965e-22 8.754937074166667e-19 2.516445 142 0.008603975 241 0.015839545042738587 1.465079 32 39 0.003042982 Human Phenotype Hemorrhage of the eye 403 0.00004179057 0.0006919813240942928 2.372947 28 0.001696558 266 0.023819469174436093 1.785565 12 12 0.001141118 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 99 1.386499e-13 1.2824415497979796e-11 2.136086 118 0.007149782 266 0.026389090122556393 1.479468 29 35 0.002757703 Mouse Phenotype Single KO absent segment of posterior cerebral artery 125 4.982141e-12 3.6497172109600003e-10 2.61748 68 0.004120213 238 0.017776295573529412 1.623241 20 22 0.001901864 Mouse Phenotype Single KO decreased spongiotrophoblast size 138 1.443617e-11 9.579131064492754e-10 2.714448 61 0.003696074 144 0.00185629559375 1.785565 18 18 0.001711677 Mouse Phenotype Single KO delayed hepatic development 144 2.232359e-11 1.4195632890972223e-9 2.824715 56 0.003393117 276 0.03150189812898551 1.785565 12 12 0.001141118 Mouse Phenotype Single KO increased cellular sensitivity to ultraviolet irradiation 152 3.036323e-11 1.829184849407895e-9 2.614738 63 0.003817256 132 0.0012367589879545453 1.711166 23 24 0.002187143 Mouse Phenotype Single KO decreased transitional stage T1 B cell number 232 2.366323e-9 9.339836082327585e-8 3.460236 33 0.001999515 327 0.04749783505198777 1.785565 11 11 0.001046025 Mouse Phenotype Single KO fusion of vertebral bodies 235 2.617142e-9 1.0197944380425532e-7 3.233681 36 0.002181289 327 0.04749783505198777 1.785565 11 11 0.001046025 Mouse Phenotype Single KO abnormal cerebral artery morphology 246 5.002989e-9 1.862291474512195e-7 2.17751 70 0.004241396 289 0.03344624350865052 1.562369 21 24 0.001996957 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 271 1.64396e-8 5.554886243542435e-7 2.425261 52 0.003150751 299 0.038780476882943136 1.673967 15 16 0.001426398 Mouse Phenotype Single KO decreased transitional stage T2 B cell number 274 1.905329e-8 6.367553887956204e-7 2.676565 43 0.002605429 276 0.03150189812898551 1.785565 12 12 0.001141118 Mouse Phenotype Single KO osteosclerosis 292 3.030822e-8 9.504533237671233e-7 2.220652 60 0.003635482 276 0.03150189812898551 1.785565 12 12 0.001141118 Mouse Phenotype Single KO abnormal DNA replication 343 1.711173e-7 0.000004568283137317784 2.207129 54 0.003271934 147 0.001906168462312925 1.707932 22 23 0.00209205 Mouse Phenotype Single KO increased incidence of tumors by ionizing radiation induction 400 9.450131e-7 0.00002163371239175 2.608333 34 0.002060107 198 0.007700953754545455 1.785565 15 15 0.001426398 Mouse Phenotype abnormal keratinocyte physiology 12 1.272879e-31 1.01416634325e-28 2.016616 340 0.02060107 330 0.005868002907272727 1.29572 82 113 0.007797642 Mouse Phenotype increased body temperature 26 1.878839e-24 6.909069107307692e-22 2.672702 144 0.008725158 576 0.04426786157291667 1.428452 28 35 0.002662609 Mouse Phenotype abnormal epidermis stratum granulosum morphology 34 5.318518e-23 1.4955985469999998e-20 2.005197 246 0.01490548 467 0.02134084808993576 1.310921 58 79 0.005515405 Mouse Phenotype abnormal keratinocyte proliferation 36 1.113874e-22 2.9582636983333333e-20 2.062141 226 0.01369365 344 0.007199010537209302 1.363973 55 72 0.005230126 Mouse Phenotype delayed hepatic development 72 3.334446e-18 4.4278664174999997e-16 3.036058 85 0.005150267 352 0.008080669283522728 1.785565 14 14 0.001331305 Mouse Phenotype enlarged liver sinusoidal spaces 110 6.020312e-16 5.232745730181819e-14 2.125339 143 0.008664566 589 0.045333976594227506 1.393612 32 41 0.003042982 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 122 2.642011e-15 2.0705137025409834e-13 2.792858 80 0.00484731 156 0.000041466400215384615 1.726046 29 30 0.002757703 Mouse Phenotype decreased spongiotrophoblast size 140 1.917483e-14 1.3095039259285713e-12 2.96845 68 0.004120213 227 0.0006880668417621145 1.785565 19 19 0.001806771 Mouse Phenotype absent segment of posterior cerebral artery 194 4.982141e-12 2.455373716546392e-10 2.61748 68 0.004120213 395 0.011183332264556962 1.623241 20 22 0.001901864 Mouse Phenotype abnormal transitional stage T2 B cell morphology 236 4.578284e-11 1.8547870052542372e-9 2.118322 95 0.00575618 406 0.01294010702216749 1.53928 25 29 0.00237733 Mouse Phenotype decreased transitional stage T2 B cell number 248 1.093396e-10 4.215306111290322e-9 2.173073 86 0.005210858 543 0.0357174837403315 1.510863 22 26 0.00209205 Mouse Phenotype ruffled hair 261 2.375816e-10 8.703132864367817e-9 2.106418 89 0.005392632 576 0.04426786157291667 1.428452 28 35 0.002662609 Mouse Phenotype lipodystrophy 264 2.734043e-10 9.901585273863635e-9 2.852464 49 0.002968977 520 0.031186621396153847 1.785565 11 11 0.001046025 Mouse Phenotype fusion of vertebral bodies 323 2.617142e-9 7.746902372136224e-8 3.233681 36 0.002181289 520 0.031186621396153847 1.785565 11 11 0.001046025 Mouse Phenotype osteosclerosis 330 3.641822e-9 1.0551351558181817e-7 2.271474 65 0.003938439 404 0.012578264639851486 1.785565 13 13 0.001236211 Mouse Phenotype abnormal cerebral artery morphology 342 5.002989e-9 1.3986426265789474e-7 2.17751 70 0.004241396 471 0.02142764225477707 1.562369 21 24 0.001996957 Mouse Phenotype abnormal DNA replication 466 2.39904e-7 0.000004922150523605149 2.018777 65 0.003938439 186 0.00017957372533870968 1.719433 26 27 0.002472423 Mouse Phenotype abnormal antigen presentation via MHC class I 1162 0.001509136 0.01241725412736661 2.153972 20 0.001211827 483 0.02506613110559006 1.673967 15 16 0.001426398