# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	47	7.65159e-53	2.1422824002127663e-50	2.113788	519	0.02192556	319	4.5919258642633226e-7	1.313623	132	155	0.01084367	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	56	4.814178e-50	1.1312458625357143e-47	2.772003	288	0.01216679	311	3.485098105273312e-7	1.453091	65	69	0.005339686	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	61	8.657846e-48	1.8676818936721312e-45	2.298646	389	0.01643361	371	0.0000075581890975741245	1.313545	109	128	0.008954243	
GO Biological Process	regulation of type I interferon production	65	9.191734e-44	1.8608311954769233e-41	2.185544	396	0.01672933	409	0.000027271731502933985	1.304238	104	123	0.008543498	
GO Biological Process	regulation of antigen receptor-mediated signaling pathway	112	4.277059e-34	5.025162444732142e-32	2.305393	272	0.01149085	804	0.004904933778731343	1.338784	46	53	0.003778855	
GO Biological Process	positive regulation of intrinsic apoptotic signaling pathway	114	1.263901e-33	1.4589187069298244e-31	2.569893	217	0.009167336	771	0.003780305914137484	1.342557	47	54	0.003861004	
GO Biological Process	negative regulation of type I interferon production	128	2.573196e-32	2.6453661065625003e-30	2.997002	161	0.006801572	584	0.000578959722619863	1.411234	43	47	0.003532408	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	129	3.518693e-32	3.5893396268992245e-30	2.080524	322	0.01360314	462	0.00008147352125974026	1.329186	81	94	0.00665407	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	149	9.94198e-30	8.780303008053692e-28	2.143761	276	0.01165984	267	1.9032497471910114e-8	1.385646	106	118	0.008707796	
GO Biological Process	B cell receptor signaling pathway	189	1.385364e-26	9.645505225396824e-25	2.284505	213	0.008998352	1026	0.018976881192007796	1.366225	31	35	0.00254662	
GO Biological Process	regulation of T cell receptor signaling pathway	200	1.115019e-25	7.3362675105e-24	2.614449	158	0.006674834	973	0.014473926261048306	1.371122	32	36	0.002628769	
GO Biological Process	photoperiodism	222	6.832465e-25	4.0499282403153154e-23	3.153288	113	0.004773774	949	0.012897151152792413	1.472398	21	22	0.001725129	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	223	7.026317e-25	4.146157192959641e-23	2.021471	263	0.01111064	1164	0.040236694845360826	1.187598	87	113	0.007146965	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	229	3.271229e-24	1.8797424633624455e-22	3.071906	114	0.00481602	644	0.0011779244113509317	1.489322	28	29	0.002300173	
GO Biological Process	regulation of erythrocyte differentiation	238	2.730141e-23	1.5094926646638655e-21	2.164545	208	0.008787123	992	0.015801106998991937	1.349698	35	40	0.002875216	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	264	1.412473e-21	7.04042886628788e-20	2.07284	212	0.008956107	402	0.000023750476150248757	1.404377	61	67	0.00501109	
GO Biological Process	entrainment of circadian clock by photoperiod	267	1.964479e-21	9.681864854307115e-20	3.112353	98	0.004140087	841	0.006373692301189061	1.542512	18	18	0.001478682	
GO Biological Process	cotranslational protein targeting to membrane	271	2.828386e-21	1.3733849215498155e-19	2.036742	218	0.009209581	344	0.000002219732417994186	1.369373	87	98	0.007146965	
GO Biological Process	myeloid dendritic cell activation	289	1.52975e-20	6.965391089965399e-19	2.548689	130	0.005491952	1121	0.033803933239964314	1.413969	22	24	0.001807278	
GO Biological Process	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	291	1.855777e-20	8.391810839518901e-19	2.24916	166	0.0070128	357	0.000003923976940056023	1.542512	37	37	0.003039514	
GO Cellular Component	ficolin-1-rich granule lumen	28	1.459635e-33	9.008033142857143e-32	2.054499	347	0.01465929	94	0.000003785891744680851	1.318599	106	124	0.008707796	
GO Cellular Component	mitochondrial ribosome	79	1.810719e-16	3.9606613063291136e-15	2.081501	156	0.006590343	156	0.001192248	1.288451	71	85	0.00583258	
GO Cellular Component	PRC1 complex	92	1.54712e-14	2.9058949565217395e-13	4.23723	43	0.001816569	238	0.03993881384873949	1.542512	12	12	0.0009857882	
GO Cellular Component	mitochondrial large ribosomal subunit	98	2.671917e-13	4.711298546938776e-12	2.26733	101	0.004266824	183	0.00514097091147541	1.330795	44	51	0.003614557	
GO Cellular Component	COPI-coated vesicle	109	4.914694e-12	7.791368102752294e-11	2.465988	76	0.00321068	187	0.005802465060962566	1.475446	22	23	0.001807278	
GO Cellular Component	INO80-type complex	135	5.097445e-10	6.5247296e-9	2.701306	52	0.002196781	231	0.03069317735064935	1.408381	21	23	0.001725129	
GO Cellular Component	sex chromosome	151	5.734945e-9	6.562903947019869e-8	2.05128	80	0.003379663	205	0.011849823219512196	1.423857	24	26	0.001971576	
GO Cellular Component	MLL1 complex	155	9.106476e-9	1.0152251953548387e-7	2.10641	73	0.003083942	221	0.019457014153846156	1.382942	26	29	0.002135874	
GO Molecular Function	polyubiquitin binding	7	7.773033e-36	4.688249332285714e-33	2.91943	187	0.007899962	71	0.000004989922929859155	1.508234	44	45	0.003614557	
GO Molecular Function	K63-linked polyubiquitin binding	11	2.072501e-26	7.954635656363638e-24	3.255897	115	0.004858265	196	0.029624352306122446	1.469059	20	21	0.00164298	
GO Molecular Function	mitogen-activated protein kinase binding	30	3.408981e-17	4.797572594e-15	2.41965	118	0.004985003	129	0.004204074500775194	1.485382	26	27	0.002135874	
GO Molecular Function	tumor necrosis factor receptor superfamily binding	32	1.986799e-16	2.621332930625e-14	2.090328	154	0.006505851	128	0.004182029534375	1.378415	42	47	0.003450259	
GO Molecular Function	tumor necrosis factor receptor binding	50	3.982556e-13	3.3628702863999997e-11	2.149414	112	0.004731528	103	0.000704794856116505	1.494309	31	32	0.00254662	
GO Molecular Function	DNA polymerase binding	73	6.105467e-11	3.5311344758904113e-9	3.320801	42	0.001774323	184	0.02226056842608696	1.542512	16	16	0.001314384	
GO Molecular Function	snRNA binding	145	9.929569e-8	0.0000028912165736551726	2.034519	68	0.002872713	211	0.04406861570616114	1.33955	33	38	0.002710918	
GO Molecular Function	sequence-specific single stranded DNA binding	226	0.000005144066	0.00009609843651327434	2.111925	45	0.00190106	214	0.045578679915887856	1.542512	14	14	0.001150086	
Human Phenotype	Abnormality of T cell physiology	53	2.526152e-12	3.1805683577358494e-10	2.116409	108	0.004562545	322	0.03684320799378882	1.388261	27	30	0.002218023	
Human Phenotype	Abnormality of fatty-acid metabolism	83	3.671067e-10	2.951449408554217e-8	2.377099	67	0.002830468	334	0.04025591141017964	1.419111	23	25	0.001889427	
Mouse Phenotype Single KO	abnormal B cell activation	33	5.262575e-102	1.4602848265151516e-99	2.409168	765	0.03231803	96	2.32147119375e-7	1.329402	131	152	0.01076152	
Mouse Phenotype Single KO	decreased immunoglobulin level	37	2.074626e-97	5.134418995135135e-95	2.01427	1080	0.04562545	93	1.3392358655913977e-7	1.250537	227	280	0.01864783	
Mouse Phenotype Single KO	abnormal B cell proliferation	42	1.549736e-87	3.3787934647619046e-85	2.333262	699	0.0295298	119	0.0000031383863049579834	1.31896	118	138	0.009693584	
Mouse Phenotype Single KO	abnormal IgM level	44	2.450546e-84	5.0999203913636363e-82	2.120026	828	0.03497951	140	0.00002105148515	1.256862	154	189	0.01265095	
Mouse Phenotype Single KO	decreased IgG level	53	2.317967e-77	4.0048346828301885e-75	2.001367	872	0.03683833	137	0.000015285385747445258	1.239519	180	224	0.01478682	
Mouse Phenotype Single KO	decreased B cell proliferation	63	5.225559e-69	7.595308533809524e-67	2.597557	448	0.01892611	202	0.000496730078019802	1.333035	70	81	0.005750431	
Mouse Phenotype Single KO	spleen hyperplasia	69	2.524956e-64	3.3508727669565217e-62	2.597494	417	0.01761649	377	0.015574779392042442	1.265651	64	78	0.005257537	
Mouse Phenotype Single KO	decreased IgM level	78	5.191321e-59	6.094477743205129e-57	2.315251	476	0.02010899	459	0.040403696433551205	1.209813	80	102	0.006571921	
Mouse Phenotype Single KO	abnormal spleen secondary B follicle morphology	84	4.789461e-52	5.221082663928572e-50	2.2509	444	0.01875713	125	0.00000497976560048	1.36104	90	102	0.007393412	
Mouse Phenotype Single KO	abnormal class switch recombination	87	3.351436e-51	3.527482695632184e-49	2.597051	330	0.01394111	225	0.0011562193899111112	1.352664	57	65	0.004682494	
Mouse Phenotype Single KO	abnormal spleen germinal center morphology	88	1.265652e-50	1.3169972004545456e-48	2.252188	431	0.01820793	133	0.000008750394775187969	1.357411	88	100	0.007229114	
Mouse Phenotype Single KO	abnormal circulating interferon level	91	9.519315e-48	9.578941478571429e-46	2.578562	311	0.01313844	302	0.006548892344370861	1.268288	74	90	0.006079027	
Mouse Phenotype Single KO	decreased IgG1 level	96	6.452063e-46	6.154327176145834e-44	2.062934	476	0.02010899	386	0.017834462618134712	1.211063	95	121	0.007804157	
Mouse Phenotype Single KO	abnormal lymph node cortex morphology	106	5.74589e-43	4.963690068867925e-41	2.592836	276	0.01165984	342	0.010070330425438596	1.349698	42	48	0.003450259	
Mouse Phenotype Single KO	abnormal circulating interferon-gamma level	107	1.151846e-42	9.857433478504674e-41	2.659145	262	0.0110684	366	0.013586646209836066	1.281806	59	71	0.004846792	
Mouse Phenotype Single KO	abnormal marginal zone B cell morphology	108	1.39308e-42	1.1811512555555555e-40	2.253469	360	0.01520848	441	0.032162643975056686	1.230543	71	89	0.00583258	
Mouse Phenotype Single KO	abnormal T cell apoptosis	110	6.140713e-42	5.1118644491818185e-40	2.143349	396	0.01672933	149	0.000038705926106040274	1.36315	76	86	0.006243325	
Mouse Phenotype Single KO	abnormal transitional stage B cell morphology	111	7.605737e-42	6.274390424234235e-40	2.563963	274	0.01157535	415	0.02192888792819277	1.30968	45	53	0.003696706	
Mouse Phenotype Single KO	increased IgM level	116	5.903055e-40	4.659851261637931e-38	2.065362	411	0.01736302	193	0.0003424724167927462	1.308798	84	99	0.006900518	
Mouse Phenotype Single KO	abnormal B-1 B cell morphology	118	7.690629e-40	5.968058453644068e-38	2.086171	400	0.01689831	183	0.0002042241676338798	1.349698	70	80	0.005750431	
Mouse Phenotype	abnormal B cell activation	30	6.207913e-128	1.9784618731e-125	2.327788	1026	0.04334418	118	7.391867571101694e-10	1.324303	176	205	0.01445823	
Mouse Phenotype	abnormal B cell proliferation	38	1.522025e-122	3.829495006578947e-120	2.342237	971	0.04102066	117	5.602160082307693e-10	1.338476	164	189	0.01347244	
Mouse Phenotype	abnormal IgM level	56	4.12168e-96	7.037032585714287e-94	2.022561	1055	0.0445693	175	0.000001004757294857143	1.24635	202	250	0.0165941	
Mouse Phenotype	abnormal marginal zone B cell morphology	71	9.637649e-79	1.2978248181549295e-76	2.363763	612	0.02585442	252	0.00008601227361904762	1.276179	115	139	0.009447137	
Mouse Phenotype	decreased B cell proliferation	75	1.440058e-75	1.8357859384e-73	2.283375	630	0.02661485	159	2.012764883018868e-7	1.369644	103	116	0.008461349	
Mouse Phenotype	absent spleen germinal center	79	8.48594e-73	1.0270135739240507e-70	5.193102	193	0.008153437	483	0.008906508970186336	1.406408	31	34	0.00254662	
Mouse Phenotype	abnormal spleen marginal zone morphology	80	1.280012e-70	1.5297743415000002e-68	2.157914	665	0.02809345	230	0.00003697936237304347	1.266383	133	162	0.01092582	
Mouse Phenotype	abnormal class switch recombination	82	1.090943e-69	1.2720129296341464e-67	2.567692	462	0.01951755	178	0.0000010631246523033709	1.391614	83	92	0.006818369	
Mouse Phenotype	abnormal spleen germinal center morphology	83	1.477723e-69	1.7022300726506024e-67	2.24741	599	0.02530523	163	2.7428385636809813e-7	1.339846	119	137	0.009775733	
Mouse Phenotype	abnormal spleen secondary B follicle morphology	85	2.986645e-68	3.3594485700000003e-66	2.202233	614	0.02593891	167	3.905509340838324e-7	1.333171	121	140	0.009940031	
Mouse Phenotype	decreased IgM level	86	1.259637e-66	1.4003941112790699e-64	2.192562	605	0.0255587	306	0.0003974317104901961	1.262055	108	132	0.008872094	
Mouse Phenotype	abnormal follicular B cell morphology	88	2.737467e-65	2.9741956803409094e-63	2.368444	504	0.02129188	253	0.00008899446822924902	1.317874	88	103	0.007229114	
Mouse Phenotype	abnormal lymph node cortex morphology	96	1.009649e-60	1.0055473009375e-58	2.750752	356	0.0150395	614	0.029881021328990228	1.262055	54	66	0.004436047	
Mouse Phenotype	abnormal lymph node B cell domain morphology	102	7.955322e-58	7.456944474705881e-56	2.809143	327	0.01381437	377	0.0022356138857824934	1.353081	50	57	0.004107451	
Mouse Phenotype	decreased IgG1 level	103	3.391338e-56	3.148017729902912e-54	2.030186	609	0.02572768	232	0.000039772511300431035	1.272072	127	154	0.01043293	
Mouse Phenotype	abnormal transitional stage B cell morphology	104	3.696769e-56	3.3985392700961534e-54	2.368606	432	0.01825018	365	0.0016602244290410957	1.294292	73	87	0.005996878	
Mouse Phenotype	increased B cell proliferation	106	4.679145e-55	4.2205005042452835e-53	2.504567	380	0.0160534	260	0.00011034850213846154	1.352079	71	81	0.00583258	
Mouse Phenotype	decreased marginal zone B cell number	107	2.0805e-54	1.859033691588785e-52	2.280507	452	0.0190951	263	0.00011354868992395438	1.315672	87	102	0.007146965	
Mouse Phenotype	abnormal circulating interferon-gamma level	114	1.132433e-50	9.497536765789474e-49	2.694813	306	0.01292721	482	0.008917445519502075	1.258832	71	87	0.00583258	
Mouse Phenotype	decreased susceptibility to experimental autoimmune encephalomyelitis	115	9.196152e-50	7.645600806260871e-48	2.297515	406	0.01715179	494	0.009691385718218624	1.23401	84	105	0.006900518