# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	40	1.061864e-47	3.493267094e-45	2.034483	512	0.02220295	246	1.3542082026422763e-9	1.300315	174	198	0.01371158	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	84	3.748961e-38	5.872925928452381e-36	2.153318	355	0.01539462	462	0.00004492875661038961	1.271591	110	128	0.008668243	
GO Biological Process	regulation of type I interferon production	90	4.674747e-37	6.834999530333332e-35	2.090489	369	0.01600173	425	0.00001799980597435294	1.287192	107	123	0.008431836	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	91	7.866209e-37	1.1374883981428573e-34	2.320158	291	0.01261925	426	0.000020135280917605634	1.291576	103	118	0.008116627	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	94	2.881938e-36	4.034406610851064e-34	2.479889	251	0.01088465	651	0.0011275267925806452	1.308113	61	69	0.004806935	
GO Biological Process	interferon-gamma-mediated signaling pathway	110	2.966394e-33	3.548616240545455e-31	2.410746	242	0.01049436	655	0.001206241331832061	1.31783	57	64	0.004491726	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	125	4.620599e-31	4.8641969792799996e-29	2.041016	325	0.01409367	527	0.00018163445105882353	1.270158	97	113	0.007643814	
GO Biological Process	telomere organization	148	9.580986e-28	8.518661809054053e-26	2.05077	285	0.01235906	581	0.0005002875138726334	1.252028	99	117	0.007801418	
GO Biological Process	positive regulation of intrinsic apoptotic signaling pathway	178	4.740569e-24	3.5045588466853926e-22	2.2976	189	0.00819601	773	0.00449701079404916	1.315261	48	54	0.003782506	
GO Biological Process	cytoplasmic sequestering of protein	183	1.177561e-23	8.467500108743168e-22	3.075128	111	0.00481353	1224	0.04973957939052288	1.289968	34	39	0.002679275	
GO Biological Process	regulation of antigen receptor-mediated signaling pathway	208	4.526758e-22	2.8638273327884615e-20	2.018465	232	0.01006071	800	0.00575566435625	1.312159	47	53	0.003703704	
GO Biological Process	positive regulation of release of cytochrome c from mitochondria	248	7.848168e-20	4.1642759158064514e-18	2.756493	109	0.0047268	967	0.017018614987590486	1.377623	27	29	0.00212766	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	256	2.801972e-19	1.44027927921875e-17	2.027537	198	0.008586297	1064	0.025526740920112784	1.206252	75	92	0.005910165	
GO Biological Process	regulation of T cell receptor signaling pathway	273	1.045118e-18	5.037621890842491e-17	2.34401	138	0.005984389	892	0.010406411591704036	1.356363	33	36	0.002600473	
GO Biological Process	B cell receptor signaling pathway	277	1.25959e-18	5.983734588447654e-17	2.047777	186	0.008065915	724	0.0030807981662983423	1.395117	33	35	0.002600473	
GO Biological Process	regulation of necrotic cell death	289	3.10257e-18	1.412689225951557e-16	3.224883	78	0.00338248	1091	0.028906957866177817	1.370064	25	27	0.001970055	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	298	6.613114e-18	2.9202002391275167e-16	2.69877	101	0.004379879	949	0.014223131861959957	1.418016	23	24	0.001812451	
GO Biological Process	regulation of mitophagy	310	1.148711e-17	4.876092919032258e-16	2.208825	147	0.006374675	845	0.0077987086023668635	1.322257	42	47	0.003309693	
GO Biological Process	mitochondrial translational termination	315	2.976494e-17	1.243418557015873e-15	2.028524	175	0.007588899	350	0.000002310551212857143	1.360615	80	87	0.006304177	
GO Biological Process	mitochondrial translational elongation	332	1.214111e-16	4.812194773795181e-15	2.01502	171	0.007415438	421	0.000017424875868171022	1.340406	77	85	0.00606777	
GO Cellular Component	large ribosomal subunit	43	9.249352e-24	3.716948896744186e-22	2.03211	247	0.01071119	77	1.5559529142857142e-7	1.338135	104	115	0.008195429	
GO Cellular Component	mitochondrial ribosome	46	2.285108e-22	8.584057878260869e-21	2.328403	170	0.007372073	138	0.00038853641739130433	1.288182	74	85	0.005831363	
GO Cellular Component	mitochondrial large ribosomal subunit	69	1.032787e-14	2.58645787826087e-13	2.373493	103	0.004466609	184	0.0057289379478260875	1.30559	45	51	0.003546099	
GO Cellular Component	cytoplasmic stress granule	73	2.672472e-14	6.326070706849314e-13	2.000225	147	0.006374675	249	0.03544643624096386	1.273204	37	43	0.002915682	
GO Cellular Component	MLL1 complex	109	1.229958e-10	1.949878370642202e-9	2.2807	77	0.003339115	157	0.0018912354649681527	1.428646	28	29	0.002206462	
GO Cellular Component	sex chromosome	110	1.813291e-10	2.8485153163636365e-9	2.184592	83	0.003599306	180	0.00483713088	1.422759	25	26	0.001970055	
GO Cellular Component	INO80-type complex	135	4.414246e-9	5.65023488e-8	2.612906	49	0.002124892	208	0.012131880923076923	1.415336	22	23	0.001733649	
GO Cellular Component	exon-exon junction complex	195	2.477752e-7	0.000002195669464615385	2.163135	55	0.002385082	168	0.0027317838857142855	1.479669	21	21	0.001654846	
GO Molecular Function	DNA polymerase binding	21	3.595309e-17	7.228283141904762e-15	4.220406	52	0.002254987	197	0.040465641126903554	1.479669	16	16	0.001260835	
GO Molecular Function	polyubiquitin binding	22	4.43468e-17	8.510554072727271e-15	2.227556	139	0.006027754	115	0.0014442345923478261	1.381024	42	45	0.003309693	
GO Molecular Function	mitogen-activated protein kinase binding	34	4.158385e-13	5.163735726470588e-11	2.210127	105	0.004553339	152	0.009789634728947368	1.424866	26	27	0.002048857	
GO Molecular Function	snRNA binding	55	2.442704e-11	1.875108416e-9	2.364835	77	0.003339115	190	0.037805387915789475	1.323914	34	38	0.002679275	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	61	4.198201e-11	2.9057056757377046e-9	2.077557	100	0.004336513	131	0.005537942610687022	1.428646	28	29	0.002206462	
GO Molecular Function	four-way junction DNA binding	145	7.05568e-8	0.0000020544193765517244	2.018756	71	0.003078925	197	0.040465641126903554	1.479669	16	16	0.001260835	
Human Phenotype	Abnormality of fatty-acid metabolism	203	0.000001149862	0.00003779817303448276	2.039473	56	0.002428448	314	0.01528870581464968	1.420482	24	25	0.001891253	
Mouse Phenotype Single KO	abnormal B cell activation	30	1.26798e-88	3.87029762e-86	2.317833	717	0.0310928	127	0.0000025567576950393703	1.284976	132	152	0.01040189	
Mouse Phenotype Single KO	abnormal B cell proliferation	44	6.138741e-73	1.2775557122045456e-70	2.216909	647	0.02805724	157	0.000023041117526751594	1.275946	119	138	0.009377463	
Mouse Phenotype Single KO	decreased B cell proliferation	52	1.123287e-66	1.9780652036538464e-64	2.589009	435	0.01886383	240	0.0010202660722500002	1.296994	71	81	0.005594957	
Mouse Phenotype Single KO	spleen hyperplasia	74	5.685486e-49	7.03540477054054e-47	2.378585	372	0.01613183	258	0.0021004191729457364	1.289968	68	78	0.00535855	
Mouse Phenotype Single KO	decreased IgM level	85	2.959815e-45	3.188591288823529e-43	2.141932	429	0.01860364	281	0.0032589502302491106	1.247564	86	102	0.00677699	
Mouse Phenotype Single KO	abnormal dendritic cell number	89	8.129421e-43	8.364169449101124e-41	2.305331	345	0.01496097	464	0.027226898851293105	1.212069	77	94	0.00606777	
Mouse Phenotype Single KO	abnormal marginal zone B cell morphology	93	2.794905e-41	2.7519295790322583e-39	2.248923	350	0.0151778	222	0.0004456786145945946	1.296789	78	89	0.006146572	
Mouse Phenotype Single KO	abnormal spleen marginal zone morphology	95	2.216771e-40	2.1367338996842107e-38	2.104928	397	0.01721596	238	0.0009420829329411765	1.260459	92	108	0.007249803	
Mouse Phenotype Single KO	abnormal circulating tumor necrosis factor level	97	1.009909e-39	9.533749188659795e-38	2.222467	345	0.01496097	410	0.016586308608536587	1.211919	86	105	0.00677699	
Mouse Phenotype Single KO	abnormal dendritic cell morphology	99	8.865269e-39	8.199926084141414e-37	2.029162	416	0.0180399	360	0.010209324983611111	1.211798	95	116	0.00748621	
Mouse Phenotype Single KO	increased T cell proliferation	101	6.848609e-38	6.209179466633663e-36	2.033376	404	0.01751951	409	0.016337917161124694	1.204686	92	113	0.007249803	
Mouse Phenotype Single KO	abnormal spleen secondary B follicle morphology	106	7.657687e-36	6.615230175377359e-34	2.01912	388	0.01682567	327	0.007122373406422018	1.233058	85	102	0.006698188	
Mouse Phenotype Single KO	abnormal spleen germinal center morphology	114	1.093489e-34	8.78340243245614e-33	2.016845	376	0.01630529	355	0.010126156244507044	1.228125	83	100	0.006540583	
Mouse Phenotype Single KO	abnormal B-2 B cell morphology	121	1.753317e-33	1.3268697329752065e-31	3.583587	130	0.005637467	539	0.050034170788497215	1.409209	20	21	0.001576044	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	122	1.85256e-33	1.3904829442622952e-31	2.940457	172	0.007458803	352	0.010063696483806818	1.342025	39	43	0.003073286	
Mouse Phenotype Single KO	abnormal class switch recombination	129	2.56931e-32	1.823811757364341e-30	2.229631	276	0.01196878	381	0.012818100787664042	1.274792	56	65	0.004412924	
Mouse Phenotype Single KO	abnormal transitional stage B cell morphology	130	3.824802e-32	2.6941316856923077e-30	2.353339	245	0.01062446	343	0.00934160832361516	1.312159	47	53	0.003703704	
Mouse Phenotype Single KO	decreased IgG3 level	155	1.940874e-28	1.1466182721290321e-26	2.001387	311	0.01348656	256	0.0018162040300390625	1.299709	65	74	0.005122143	
Mouse Phenotype Single KO	abnormal B cell apoptosis	157	2.924323e-28	1.7056067331847133e-26	2.240304	237	0.01027754	331	0.007575622064048339	1.365848	36	39	0.002836879	
Mouse Phenotype Single KO	increased anti-nuclear antigen antibody level	158	3.20183e-28	1.855642867721519e-26	2.005161	307	0.0133131	342	0.009222060217251462	1.250673	71	84	0.005594957	
Mouse Phenotype	abnormal B cell activation	32	4.368513e-110	1.30522977478125e-107	2.235757	960	0.04163053	117	8.319214051282051e-11	1.313657	182	205	0.014342	
Mouse Phenotype	abnormal B cell proliferation	42	2.552151e-100	5.809789455e-98	2.213638	894	0.03876843	135	4.230064731333333e-10	1.315261	168	189	0.01323877	
Mouse Phenotype	decreased B cell proliferation	68	3.921206e-74	5.513330965588236e-72	2.288069	615	0.02666956	180	2.7371767278333333e-7	1.339356	105	116	0.008274232	
Mouse Phenotype	abnormal marginal zone B cell morphology	74	7.483478e-69	9.668855832162163e-67	2.2797	575	0.02493495	186	4.1539794927419356e-7	1.309347	123	139	0.009692671	
Mouse Phenotype	abnormal spleen marginal zone morphology	84	7.239242e-63	8.239808662142857e-61	2.098507	630	0.02732003	196	0.000001344319039132653	1.278726	140	162	0.01103231	
Mouse Phenotype	abnormal follicular B cell morphology	85	3.833198e-62	4.311671303294118e-60	2.349194	487	0.02111882	161	2.20008527310559e-8	1.379109	96	103	0.007565012	
Mouse Phenotype	abnormal spleen germinal center morphology	95	6.615482e-54	6.6579603581052635e-52	2.091282	543	0.02354727	305	0.00012912249620655736	1.252858	116	137	0.009141056	
Mouse Phenotype	decreased susceptibility to experimental autoimmune encephalomyelitis	98	8.186869e-53	7.987209643775511e-51	2.3642	407	0.01764961	742	0.04266266382614555	1.183735	84	105	0.006619385	
Mouse Phenotype	abnormal spleen secondary B follicle morphology	99	8.872797e-53	8.568970920909091e-51	2.050725	557	0.02415438	284	0.00006863946263028168	1.257719	119	140	0.009377463	
Mouse Phenotype	abnormal single-positive T cell number	100	6.502341e-52	6.216888230099999e-50	2.002515	581	0.02519514	156	1.1434300213461539e-8	1.351509	116	127	0.009141056	
Mouse Phenotype	abnormal class switch recombination	103	1.351254e-50	1.2543048052427185e-48	2.316244	406	0.01760624	312	0.00014779154775	1.302752	81	92	0.006382979	
Mouse Phenotype	decreased IgM level	104	2.860338e-50	2.6295857325000004e-48	2.02745	545	0.023634	313	0.00014907389014696487	1.255477	112	132	0.008825847	
Mouse Phenotype	decreased follicular B cell number	105	5.486324e-50	4.995689882285714e-48	2.462939	355	0.01539462	237	0.000015889825283544306	1.351796	74	81	0.005831363	
Mouse Phenotype	decreased marginal zone B cell number	106	2.391621e-49	2.1571970170754716e-47	2.226992	430	0.01864701	232	0.000012407750659913794	1.320097	91	102	0.007171001	
Mouse Phenotype	abnormal dendritic cell number	109	2.188705e-48	1.9198356426605506e-46	2.11367	474	0.02055507	411	0.001761641002189781	1.22908	103	124	0.008116627	
Mouse Phenotype	abnormal transitional stage B cell morphology	114	1.228279e-45	1.0301382034210527e-43	2.228751	396	0.01717259	353	0.0004974490794050991	1.292584	76	87	0.005988968	
Mouse Phenotype	increased circulating interferon-gamma level	124	4.103357e-43	3.1638867965322583e-41	3.099968	207	0.008976583	643	0.023170674592534992	1.280483	45	52	0.003546099	
Mouse Phenotype	abnormal lymph node cortex morphology	127	3.841339e-42	2.89189308496063e-40	2.427058	306	0.01326973	438	0.0027639956020547945	1.300315	58	66	0.004570528	
Mouse Phenotype	abnormal circulating tumor necrosis factor level	128	4.421762e-42	3.30284894390625e-40	2.030637	452	0.01960104	481	0.004937222878378378	1.195897	118	146	0.00929866	
Mouse Phenotype	abnormal lymph node B cell domain morphology	131	9.583606e-41	6.994569234045802e-39	2.486752	282	0.01222897	369	0.0006627659289430894	1.349874	52	57	0.004097715