# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mRNA catabolic process 43 2.11959e-11 6.486438327906976e-9 2.148629 94 0.02593103 185 0.0003235775338486487 1.657493 70 213 0.01880204 GO Biological Process negative regulation of cell cycle G2/M phase transition 44 2.292225e-11 6.855315630681818e-9 2.843511 55 0.01517241 474 0.027653588529113926 1.71812 31 91 0.008326618 GO Biological Process negative regulation of G2/M transition of mitotic cell cycle 45 2.329786e-11 6.812811994222222e-9 2.875114 54 0.01489655 518 0.03664232784942085 1.700061 30 89 0.008058018 GO Biological Process nuclear-transcribed mRNA catabolic process 49 3.777019e-11 1.0143223065510205e-8 2.199149 87 0.024 237 0.0011430390451898733 1.630227 64 198 0.01719044 GO Biological Process RNA catabolic process 52 7.812781e-11 1.9770843303653846e-8 2.016705 103 0.02841379 173 0.00019677770834682082 1.63234 78 241 0.02095085 GO Biological Process regulation of intrinsic apoptotic signaling pathway 54 8.818772e-11 2.1490040879259257e-8 2.207399 83 0.02289655 150 0.000023354382656 1.88725 58 155 0.01557883 GO Biological Process NIK/NF-kappaB signaling 59 2.818133e-10 6.285391889322034e-8 2.805063 50 0.0137931 420 0.0192827630997619 1.780064 30 85 0.008058018 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 61 3.377049e-10 7.285014391967213e-8 4.176561 29 0.008 354 0.008475604100282487 3.152196 10 16 0.002686006 GO Biological Process endoplasmic reticulum unfolded protein response 69 7.399879e-10 1.4112319965362318e-7 2.481047 59 0.01627586 346 0.008264064978034683 1.725412 39 114 0.01047542 GO Biological Process ncRNA transcription 72 1.106802e-9 2.0228343775e-7 2.721633 49 0.01351724 357 0.008832151244257704 1.809086 33 92 0.00886382 GO Biological Process positive regulation of mRNA catabolic process 76 1.552529e-9 2.688122251447368e-7 3.598214 32 0.008827586 381 0.011538419069816272 2.622627 13 25 0.003491808 GO Biological Process cellular response to topologically incorrect protein 77 1.967989e-9 3.363216526103896e-7 2.267037 67 0.01848276 422 0.019366695885071093 1.596508 44 139 0.01181843 GO Biological Process response to topologically incorrect protein 82 3.522093e-9 5.652100217926829e-7 2.054661 81 0.02234483 437 0.021133221506636154 1.513054 54 180 0.01450443 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 89 7.079076e-9 0.0000010466692256629214 2.535981 50 0.0137931 353 0.008440137866855523 1.709666 40 118 0.01074402 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 92 1.0223e-8 0.0000014622223586956522 2.362726 56 0.01544828 209 0.0006144639123205742 1.985213 37 94 0.009938222 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 94 1.098877e-8 0.0000015383108981914893 2.317087 58 0.016 280 0.003663821832928572 1.785314 40 113 0.01074402 GO Biological Process cellular response to unfolded protein 101 1.798977e-8 0.0000023438354795049506 2.247089 60 0.01655172 390 0.013757343104102563 1.667277 40 121 0.01074402 GO Biological Process response to unfolded protein 119 5.144322e-8 0.000005688582621680672 2.005294 73 0.02013793 442 0.021783938532579185 1.544576 49 160 0.01316143 GO Biological Process regulation of DNA-templated transcription in response to stress 121 5.841523e-8 0.000006352776955123967 2.154352 61 0.01682759 270 0.0027569727943333334 1.780064 42 119 0.01128122 GO Biological Process regulation of ubiquitin protein ligase activity 131 1.25805e-7 0.000012637160267175573 2.458795 44 0.01213793 413 0.017625237882566584 1.754265 32 92 0.008595219 GO Cellular Component vesicle coat 31 8.435223e-10 4.7019565625806454e-8 2.934923 44 0.01213793 50 0.0012995766144 2.274526 23 51 0.006177814 GO Cellular Component methyltransferase complex 34 2.88641e-9 1.4669754352941178e-7 2.526633 53 0.01462069 37 0.00006385319610810809 2.106082 38 91 0.01020682 GO Cellular Component cytoplasmic stress granule 36 1.976031e-8 9.4849488e-7 3.02957 35 0.009655172 109 0.03628151603669725 1.993947 17 43 0.00456621 GO Cellular Component ribosomal subunit 40 5.742145e-8 0.00000248060664 2.083423 66 0.0182069 112 0.037355549142857145 1.444898 53 185 0.01423583 GO Cellular Component membrane coat 47 4.601198e-7 0.00001691674498723404 2.09606 56 0.01544828 89 0.024480653662921344 1.681171 32 96 0.008595219 GO Cellular Component histone methyltransferase complex 51 7.526357e-7 0.000025501068423529414 2.349916 42 0.01158621 39 0.00008714755938461538 2.265926 31 69 0.008326618 GO Cellular Component cyclin-dependent protein kinase holoenzyme complex 57 0.000001782972 0.00005405220378947368 2.768593 29 0.008 82 0.018606874302439024 2.143493 17 40 0.00456621 GO Cellular Component endoribonuclease complex 58 0.00000183335 0.00005462118620689655 3.572953 20 0.005517241 98 0.03469961534693877 2.260885 13 29 0.003491808 GO Cellular Component histone acetyltransferase complex 61 0.00000329867 0.00009344429114754098 2.10446 47 0.01296552 72 0.0085645536 1.851416 29 79 0.007789417 GO Cellular Component protein phosphatase type 2A complex 77 0.00001491665 0.00033475287272727273 2.681401 25 0.006896552 84 0.018350070171428572 2.64184 11 21 0.002954607 GO Cellular Component protein serine/threonine phosphatase complex 79 0.00001759665 0.0003848988759493671 2.078726 41 0.01131034 55 0.0018853796421818183 2.264435 22 49 0.005909213 GO Cellular Component MLL1 complex 87 0.00004047109 0.0008038395806896552 3.203153 17 0.004689655 98 0.03469961534693877 2.260885 13 29 0.003491808 GO Cellular Component nuclear cyclin-dependent protein kinase holoenzyme complex 89 0.00004347256 0.0008440515020224718 3.92491 13 0.003586207 90 0.0264210432 2.836976 9 16 0.002417405 GO Cellular Component mRNA cleavage factor complex 97 0.00008021748 0.0014290289220618556 3.478894 14 0.003862069 111 0.037534214918918916 2.521757 10 20 0.002686006 GO Cellular Component clathrin vesicle coat 100 0.0000973442 0.001682107776 2.546429 22 0.006068966 44 0.00046959224727272726 3.026108 15 25 0.004029009 GO Cellular Component Bcl-2 family protein complex 107 0.0001503815 0.002428590953271028 4.786915 9 0.002482759 71 0.008566435876056338 4.323011 6 7 0.001611604 GO Cellular Component clathrin coat of coated pit 130 0.0005710072 0.0075900033969230766 2.545348 17 0.004689655 60 0.0041870736 3.082147 11 18 0.002954607 GO Cellular Component AP-type membrane coat adaptor complex 137 0.000787681 0.009935129693430658 2.094689 24 0.00662069 100 0.034072462080000004 1.973549 18 46 0.004834811 GO Cellular Component clathrin adaptor complex 213 0.005878016 0.047686439661971836 2.023287 17 0.004689655 116 0.042441944275862065 2.185522 13 30 0.003491808 GO Molecular Function protein phosphatase activator activity 9 6.26118e-11 2.9371891066666663e-8 6.365855 21 0.005793103 110 0.04490488494545454 3.782635 6 8 0.001611604 GO Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity 10 2.255838e-9 9.524148036e-7 3.832677 29 0.008 80 0.028039236117500005 2.4348 14 29 0.003760408 GO Molecular Function protein serine/threonine kinase inhibitor activity 29 0.000001994288 0.0002903408253793104 2.598905 32 0.008827586 89 0.03579995564269663 2.292506 15 33 0.004029009 GO Molecular Function protein phosphatase 2A binding 33 0.00000230366 0.0002947288642424242 2.790111 28 0.007724138 99 0.03689480845858586 2.428358 13 27 0.003491808 GO Molecular Function DNA helicase activity 39 0.000007747608 0.0008387282301538462 2.512274 30 0.008275862 63 0.01324496353015873 2.161506 21 49 0.005640612 GO Molecular Function RNA polymerase binding 41 0.00001615928 0.0016640117112195123 2.269216 34 0.00937931 67 0.017493044107462684 2.118276 21 50 0.005640612 GO Molecular Function RNA polymerase core enzyme binding 77 0.0002423989 0.013291015010389609 2.329664 23 0.006344828 77 0.02566226457922078 2.305606 16 35 0.004297609 GO Molecular Function mRNA 3'-UTR AU-rich region binding 97 0.0004604108 0.02003973605773196 2.321132 21 0.005793103 81 0.028345100666666664 3.362342 8 12 0.002148805 GO Molecular Function RNA polymerase II core binding 103 0.0006902867 0.028295052887378644 2.300302 20 0.005517241 69 0.020544937310144926 2.521757 14 28 0.003760408 Human Phenotype Distal sensory impairment 1 7.342868e-12 4.8998958164e-8 2.582285 68 0.01875862 8 0.021955871615 1.971028 34 87 0.00913242 Human Phenotype Peripheral axonal degeneration 16 1.052487e-7 0.00004389528594375 2.132026 60 0.01655172 21 0.021999514623809523 1.913057 33 87 0.00886382 Human Phenotype Distal amyotrophy 18 1.666354e-7 0.00006177544578888889 2.240899 52 0.01434483 6 0.019123527886666665 1.983404 35 89 0.009401021 Human Phenotype Increased serum lactate 46 0.000002465447 0.00035765060502173914 2.214609 43 0.01186207 41 0.04435255021707317 1.76523 35 100 0.009401021 Mouse Phenotype Single KO absent hypoglossal nerve 3 2.601536e-10 7.940755050666666e-7 6.222083 20 0.005517241 150 0.044582191422000005 3.026108 9 15 0.002417405 Mouse Phenotype Single KO decreased fibroblast proliferation 4 5.614546e-10 0.00000128530994305 2.276157 71 0.01958621 26 0.000046417783919230764 2.133794 44 104 0.01181843 Mouse Phenotype Single KO extramedullary hematopoiesis 6 2.354823e-9 0.0000035938523685 2.210969 70 0.01931034 98 0.009097535563265306 1.769654 40 114 0.01074402 Mouse Phenotype Single KO decreased spongiotrophoblast size 10 1.401432e-8 0.000012832912824 4.457133 22 0.006068966 156 0.049463548866025636 2.801952 10 18 0.002686006 Mouse Phenotype Single KO abnormal spongiotrophoblast size 15 4.973333e-8 0.00003036054018733333 3.495663 27 0.007448276 101 0.010950130993069306 2.715738 14 26 0.003760408 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 17 9.480495e-8 0.000051066407479411766 3.002403 32 0.008827586 145 0.03355236578551724 2.4348 14 29 0.003760408 Mouse Phenotype Single KO abnormal cellular replicative senescence 18 1.144939e-7 0.00005824559123888889 2.718992 37 0.0102069 96 0.008409758276666667 2.101464 25 60 0.006715015 Mouse Phenotype Single KO increased cellular sensitivity to alkylating agents 20 1.745605e-7 0.000079922524925 5.566003 15 0.004137931 114 0.017638414211403507 3.66801 8 11 0.002148805 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 22 1.859279e-7 0.00007738826274090909 2.802186 34 0.00937931 138 0.031055719986231883 2.305606 16 35 0.004297609 Mouse Phenotype Single KO increased cellular sensitivity to DNA damaging agents 24 1.894793e-7 0.00007229424792083333 5.156057 16 0.004413793 80 0.006579360586625 3.782635 9 12 0.002417405 Mouse Phenotype Single KO increased fibroblast apoptosis 31 3.432444e-7 0.00010138996680000002 3.012842 29 0.008 103 0.011058757765048544 2.449706 17 35 0.00456621 Mouse Phenotype Single KO early cellular replicative senescence 33 4.190592e-7 0.00011628257861818182 2.750058 33 0.009103448 142 0.03389771147816901 2.036803 21 52 0.005640612 Mouse Phenotype Single KO absent segment of posterior cerebral artery 57 0.000002432515 0.0003907814009649123 3.504981 20 0.005517241 81 0.006583180963333333 2.980258 13 22 0.003491808 Mouse Phenotype Single KO abnormal fibroblast apoptosis 63 0.000003532464 0.0005134408388571428 2.255976 40 0.01103448 92 0.007846148576195653 2.188694 23 53 0.006177814 Mouse Phenotype Single KO abnormal spongiotrophoblast layer morphology 70 0.000005576553 0.0007294927974428571 2.079992 46 0.01268966 143 0.033966245801398606 1.966115 23 59 0.006177814 Mouse Phenotype Single KO abnormal cerebral artery morphology 95 0.00004878786 0.004702636147578947 2.832522 20 0.005517241 111 0.016153063493693692 2.731903 13 24 0.003491808 Mouse Phenotype Single KO blood in lymph vessels 109 0.000102015 0.008570195917431193 2.372335 25 0.006896552 154 0.04849566822142857 2.35364 14 30 0.003760408 Mouse Phenotype Single KO abnormal paravertebral ganglion morphology 120 0.0001347749 0.010284447994166668 2.005996 35 0.009655172 115 0.017547893529565217 2.192832 20 46 0.005372012 Mouse Phenotype Single KO abnormal DNA replication 125 0.0001527962 0.0111932384272 2.977387 16 0.004413793 60 0.0028547908985000004 3.069965 14 23 0.003760408 Mouse Phenotype Single KO bradykinesia 128 0.0001648996 0.011796762790625 2.254757 26 0.007172414 151 0.04576469086556291 2.292506 15 33 0.004029009 Mouse Phenotype decreased fibroblast proliferation 1 5.898124e-14 5.6391963564e-10 2.465723 89 0.02455172 32 3.6190416712500005e-7 2.17259 56 130 0.01504163 Mouse Phenotype abnormal DNA repair 2 3.785993e-13 1.80989395365e-9 2.789838 67 0.01848276 260 0.01809581787 1.653611 40 122 0.01074402 Mouse Phenotype decreased spongiotrophoblast size 5 1.722403e-10 3.2935790166e-7 4.968691 25 0.006896552 220 0.012316267250454547 2.919929 11 19 0.002954607 Mouse Phenotype absent hypoglossal nerve 6 2.601536e-10 4.1455476159999995e-7 6.222083 20 0.005517241 285 0.024499539161052634 3.026108 9 15 0.002417405 Mouse Phenotype abnormal spongiotrophoblast size 9 2.467551e-9 0.000002621361679 3.712427 30 0.008275862 174 0.004099237538793103 2.701882 15 28 0.004029009 Mouse Phenotype early cellular replicative senescence 16 1.272582e-8 0.0000076044728137499996 2.573654 47 0.01296552 113 0.000700572714 2.141766 31 73 0.008326618 Mouse Phenotype abnormal cellular replicative senescence 22 7.115274e-8 0.00003092233396090909 2.374024 49 0.01351724 146 0.001986140582876712 1.98138 33 84 0.00886382 Mouse Phenotype abnormal embryonic erythrocyte morphology 29 2.665399e-7 0.00008787544772068966 2.624082 37 0.0102069 205 0.008416636914146342 2.327775 18 39 0.004834811 Mouse Phenotype abnormal placenta junctional zone morphology 34 3.60884e-7 0.00010148270364705882 2.096949 57 0.01572414 278 0.021553001183093525 1.840201 27 74 0.007252216 Mouse Phenotype increased fibroblast apoptosis 36 4.804182e-7 0.00012759106695000002 2.732679 33 0.009103448 196 0.006763670912755102 2.206537 21 48 0.005640612 Mouse Phenotype abnormal spongiotrophoblast layer morphology 39 6.274187e-7 0.00015381410745384614 2.090418 55 0.01517241 232 0.013972634971551724 1.928402 26 68 0.006983615 Mouse Phenotype abnormal embryonic erythropoiesis 48 0.00000152119 0.000303002033125 2.633645 32 0.008827586 325 0.03583224510461539 2.277716 14 31 0.003760408 Mouse Phenotype absent segment of posterior cerebral artery 56 0.000002432515 0.00041530849848214285 3.504981 20 0.005517241 167 0.00333391440233533 2.980258 13 22 0.003491808 Mouse Phenotype pale kidney 59 0.000002736959 0.0004435265254067797 2.28094 40 0.01103448 157 0.002645248568789809 2.35364 21 45 0.005640612 Mouse Phenotype abnormal fibroblast apoptosis 60 0.000002904043 0.00046275925205000004 2.134708 46 0.01268966 144 0.0018728737479166667 2.089456 29 70 0.007789417 Mouse Phenotype increased cellular sensitivity to alkylating agents 74 0.000007791674 0.0010067053393783784 3.124773 21 0.005793103 176 0.005007835591022727 3.026108 12 20 0.003223207 Mouse Phenotype increased cellular sensitivity to DNA damaging agents 76 0.000007925815 0.0009970883844078948 3.0241 22 0.006068966 167 0.00333391440233533 2.980258 13 22 0.003491808 Mouse Phenotype abnormal hypoglossal nerve morphology 110 0.00004684461 0.004071648329181819 2.121123 35 0.009655172 318 0.03244729799056603 2.063255 18 44 0.004834811 Mouse Phenotype abnormal cerebral artery morphology 111 0.00004878786 0.004202348914054054 2.832522 20 0.005517241 208 0.009000458795192307 2.731903 13 24 0.003491808 Mouse Phenotype abnormal DNA replication 114 0.00004983592 0.004179659922105263 2.828045 20 0.005517241 111 0.0006559005350000001 2.988749 16 27 0.004297609