# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	actin polymerization or depolymerization	7	4.00587e-92	7.530463332857144e-89	4.191597	306	0.01586396	827	0.03105490585368803	1.367171	35	43	0.00313087	
GO Biological Process	negative regulation of TOR signaling	16	2.97361e-66	2.445608374375e-63	3.471766	275	0.01425683	876	0.040584759470319635	1.359731	34	42	0.003041417	
GO Biological Process	regulation of protein polymerization	18	7.45835e-59	5.452468202777778e-56	2.068015	608	0.03152056	273	0.000010372964951648352	1.301281	141	182	0.01261293	
GO Biological Process	protein polymerization	19	2.533986e-56	1.7549853565263158e-53	2.644058	352	0.01824874	934	0.049025023875803	1.254435	59	79	0.005277753	
GO Biological Process	regulation of substrate adhesion-dependent cell spreading	20	2.823412e-56	1.8576639254000003e-53	2.800934	319	0.01653792	719	0.015231478443671766	1.371157	40	49	0.003578138	
GO Biological Process	regulation of actin filament polymerization	23	1.745691e-53	9.987629508260869e-51	2.145809	506	0.02623257	442	0.0009291572877149322	1.274641	107	141	0.009571518	
GO Biological Process	regulation of actin polymerization or depolymerization	27	1.268063e-49	6.180163339629631e-47	2.008425	549	0.02846182	381	0.00020380493417322836	1.280746	122	160	0.01091332	
GO Biological Process	endoplasmic reticulum unfolded protein response	34	1.089752e-46	4.2176607552941174e-44	2.513092	318	0.01648608	357	0.00011533992509803922	1.340787	91	114	0.008140263	
GO Biological Process	regulation of TOR signaling	38	4.329555e-45	1.499279322236842e-42	2.279479	372	0.0192856	542	0.0033584390088560886	1.317012	69	88	0.006172287	
GO Biological Process	positive regulation of nuclease activity	39	2.459363e-44	8.298143004358975e-42	5.70457	106	0.00549536	648	0.008465397924537037	1.679667	15	15	0.001341802	
GO Biological Process	response to topologically incorrect protein	44	2.012526e-41	6.018824916818182e-39	2.054617	431	0.02234434	370	0.00014946251823513514	1.269082	136	180	0.01216567	
GO Biological Process	response to unfolded protein	45	2.826792e-41	8.266167984000001e-39	2.101105	407	0.02110011	328	0.00004434374381707317	1.301742	124	160	0.01109223	
GO Biological Process	cellular response to unfolded protein	49	8.999233e-39	2.4167532050408163e-36	2.26633	322	0.01669345	463	0.0012163605492440605	1.290984	93	121	0.00831917	
GO Biological Process	cellular response to topologically incorrect protein	51	1.031292e-38	2.660935574117647e-36	2.193821	345	0.01788584	524	0.0027391940143129774	1.256729	104	139	0.009303158	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	52	2.801176e-38	7.088591343076924e-36	2.034208	407	0.02110011	397	0.0003163217099823677	1.278714	118	155	0.01055551	
GO Biological Process	IRE1-mediated unfolded protein response	55	1.296797e-36	3.102645767818182e-34	3.116507	173	0.008968842	755	0.01999946649933775	1.33215	46	58	0.004114858	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	60	2.36041e-34	5.176772531666667e-32	2.222308	296	0.01534553	492	0.0017927024571138212	1.293195	87	113	0.007782449	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	62	1.239854e-33	2.6314901267741933e-31	3.833323	120	0.006221162	894	0.04494522686577181	1.469709	21	24	0.001878522	
GO Biological Process	regulation of DNA-templated transcription in response to stress	82	4.762963e-29	7.643393916707317e-27	2.030984	306	0.01586396	501	0.0019044093528942116	1.284451	91	119	0.008140263	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	97	1.765812e-25	2.3954969183505156e-23	2.053636	259	0.01342734	933	0.049075326922829586	1.232947	69	94	0.006172287	
GO Cellular Component	histone methyltransferase complex	43	7.711343e-20	3.098883884651163e-18	2.060902	196	0.01016123	149	0.003500294786577181	1.338865	55	69	0.004919939	
GO Cellular Component	cleavage furrow	56	1.811444e-16	5.589598628571428e-15	2.033651	165	0.008554098	93	0.0000862447215483871	1.485859	46	52	0.004114858	
GO Cellular Component	proteasome accessory complex	71	8.575991e-14	2.0872271053521123e-12	2.985477	64	0.003317953	198	0.026648744727272727	1.469709	21	24	0.001878522	
GO Cellular Component	nuclear ubiquitin ligase complex	78	5.945866e-13	1.3172380061538459e-11	2.401929	87	0.004510343	215	0.041014168409302325	1.343734	32	40	0.00286251	
GO Cellular Component	proteasome regulatory particle	89	1.335198e-11	2.592384431460674e-10	2.774772	59	0.003058738	189	0.01904404114285714	1.519699	19	21	0.001699615	
GO Cellular Component	pre-autophagosomal structure membrane	131	4.37538e-9	5.77149361832061e-8	2.644012	48	0.002488465	147	0.0029158601142857147	1.679667	16	16	0.001431255	
GO Cellular Component	DNA-directed RNA polymerase III complex	202	0.000001886278	0.00001613608110891089	2.765867	29	0.001503448	166	0.0075787029975903615	1.591264	18	19	0.001610162	
GO Molecular Function	Rho guanyl-nucleotide exchange factor activity	9	2.82624e-50	1.3258205866666665e-47	2.337764	395	0.02047799	102	0.00448548591372549	1.339481	63	79	0.005635567	
GO Molecular Function	unfolded protein binding	21	3.218516e-22	6.470749786666666e-20	2.147753	201	0.01042045	89	0.0015527628905617978	1.315211	83	106	0.007424635	
GO Molecular Function	DNA polymerase binding	23	8.64362e-22	1.5866679843478262e-19	5.239553	54	0.002799523	117	0.008951022505982908	1.679667	16	16	0.001431255	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	56	2.477987e-10	1.8682251989285714e-8	2.135998	86	0.0044585	160	0.0495345358375	1.447989	25	29	0.002236336	
GO Molecular Function	3'-5' DNA helicase activity	89	2.183242e-8	0.000001035690755505618	2.380609	53	0.00274768	146	0.03404366323287671	1.679667	13	13	0.001162895	
GO Molecular Function	four-way junction DNA binding	127	4.905834e-7	0.00001630900090393701	2.039512	60	0.003110581	117	0.008951022505982908	1.679667	16	16	0.001431255	
Human Phenotype	Nevus	33	1.140823e-10	2.3068823875757578e-8	2.080992	95	0.004925087	154	0.03928061016688312	1.493038	24	27	0.002146883	
Human Phenotype	Progressive cerebellar ataxia	39	9.435689e-10	1.614470581974359e-7	2.257101	71	0.003680854	146	0.03201926157465754	1.679667	14	14	0.001252348	
Mouse Phenotype Single KO	abnormal fibroblast proliferation	4	3.737115e-52	8.55519051375e-49	2.092083	523	0.0271139	144	0.003345815183333333	1.265665	107	142	0.009571518	
Mouse Phenotype	abnormal fibroblast proliferation	6	2.003307e-58	3.1922697045e-55	2.092296	587	0.03043185	161	0.00013367263792546583	1.284451	130	170	0.01162895	
Mouse Phenotype	abnormal epidermis suprabasal layer morphology	66	1.248398e-18	1.8084747390909092e-16	2.381066	133	0.006895122	299	0.004774926480602007	1.555247	25	27	0.002236336