# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrion organization	3	9.778257e-51	4.2890694621e-47	2.011987	544	0.07017544	46	6.357536276521739e-15	1.510188	279	540	0.04343088	
GO Biological Process	nuclear-transcribed mRNA catabolic process	19	5.116798e-33	3.543786572736842e-30	2.541371	215	0.02773478	168	0.0000028620174882738095	1.550047	105	198	0.01634496	
GO Biological Process	mRNA catabolic process	20	8.327516e-33	5.4790891522e-30	2.447729	229	0.02954076	176	0.000003887187291761364	1.523225	111	213	0.01727895	
GO Biological Process	ncRNA processing	22	4.361289e-31	2.6086455432272727e-28	2.009601	332	0.04282766	96	1.919610246875e-10	1.498378	203	396	0.03160025	
GO Biological Process	RNA catabolic process	23	2.601185e-30	1.4882171050000003e-27	2.261498	247	0.03186275	162	0.000001901513677345679	1.503922	124	241	0.01930262	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	25	1.134853e-29	5.9734122508e-27	3.178154	134	0.01728586	191	0.000010565581564921467	1.684409	68	118	0.01058531	
GO Biological Process	rRNA processing	27	2.415649e-28	1.1773157478148147e-25	2.271985	228	0.02941176	105	7.348666108285714e-10	1.612259	139	252	0.02163761	
GO Biological Process	rRNA metabolic process	30	5.421952e-28	2.378248878933333e-25	2.239457	232	0.02992776	110	1.804516399181818e-9	1.591256	141	259	0.02194894	
GO Biological Process	IRE1-mediated unfolded protein response	34	3.137562e-27	1.2143287752352942e-24	4.034228	90	0.01160991	390	0.004049503422564103	1.713451	34	58	0.005292653	
GO Biological Process	endoplasmic reticulum unfolded protein response	37	1.220759e-24	4.341612886756756e-22	2.73333	139	0.01793086	231	0.00007125792182251082	1.640952	64	114	0.00996264	
GO Biological Process	regulation of DNA-templated transcription in response to stress	38	1.628415e-24	5.639029732894736e-22	2.55984	155	0.01999484	577	0.031048421038128247	1.400066	57	119	0.008872976	
GO Biological Process	cellular response to topologically incorrect protein	45	3.72161e-23	1.0882814664444444e-20	2.468327	156	0.02012384	279	0.0003103820404731183	1.535072	73	139	0.01136364	
GO Biological Process	response to topologically incorrect protein	50	4.739747e-22	1.2474066154599998e-19	2.206289	186	0.02399381	285	0.0003931543518315789	1.461473	90	180	0.01400996	
GO Biological Process	cellular response to unfolded protein	51	6.68065e-22	1.7237386931372548e-19	2.504374	143	0.01844685	234	0.00007831983742307692	1.61849	67	121	0.01042964	
GO Biological Process	response to unfolded protein	61	3.272838e-20	7.060209056065575e-18	2.196572	171	0.02205882	254	0.00015687662451968506	1.516278	83	160	0.0129203	
GO Biological Process	macromolecular complex disassembly	68	1.025474e-19	1.984442995e-17	2.073684	190	0.0245098	138	1.1065002608695654e-7	1.622158	106	191	0.01650062	
GO Biological Process	multi-organism metabolic process	74	5.057624e-19	8.993685704864866e-17	2.324288	142	0.01831785	163	0.0000020051248257668713	1.65037	83	147	0.0129203	
GO Biological Process	mitochondrial translation	80	3.334195e-18	5.484334000625e-16	2.689104	103	0.01328689	190	0.000010248831743684212	1.720986	63	107	0.009806974	
GO Biological Process	liver regeneration	81	3.760607e-18	6.109361421358025e-16	3.329046	74	0.009545924	402	0.004563740876368159	1.920793	23	35	0.003580324	
GO Biological Process	viral gene expression	84	6.572956e-18	1.0296848571904763e-15	2.491704	116	0.01496388	192	0.000011266399971354168	1.657103	72	127	0.01120797	
GO Cellular Component	ribosomal subunit	35	1.45649e-18	7.190899199999999e-17	2.228973	151	0.01947884	66	0.000059129541818181815	1.485172	94	185	0.01463263	
GO Cellular Component	large ribosomal subunit	44	5.462807e-16	2.1453932945454545e-14	2.496295	102	0.01315789	78	0.0005447785846153846	1.550432	61	115	0.009495641	
GO Cellular Component	chromosome, telomeric region	47	1.990589e-13	7.31859104680851e-12	2.029404	131	0.01689886	132	0.020432094545454544	1.330203	76	167	0.01183064	
GO Cellular Component	mitochondrial ribosome	48	3.972019e-13	1.4299268400000001e-11	2.770536	68	0.00877193	117	0.009370619076923077	1.513054	44	85	0.006849315	
GO Cellular Component	spliceosomal snRNP complex	50	3.661396e-12	1.2653784576e-10	2.806678	61	0.007868937	133	0.020595226466165413	1.555761	33	62	0.005136986	
GO Cellular Component	catalytic step 2 spliceosome	54	1.206629e-11	3.8612128e-10	2.180161	94	0.0121259	91	0.001988003235164835	1.552815	51	96	0.007938979	
GO Cellular Component	small nuclear ribonucleoprotein complex	66	6.299533e-10	1.6493322763636364e-8	2.41428	63	0.008126935	151	0.038838333456953644	1.482653	35	69	0.005448319	
GO Cellular Component	peptidase complex	71	1.05811e-9	2.5752310985915494e-8	2.118914	81	0.01044892	149	0.036398592	1.428257	43	88	0.006693649	
GO Cellular Component	mitochondrial large ribosomal subunit	72	1.218537e-9	2.9244888e-8	2.947574	43	0.005546956	158	0.04931526075949367	1.547442	27	51	0.004202989	
GO Cellular Component	Bcl-2 family protein complex	75	2.063966e-9	4.7553776639999994e-8	5.223081	21	0.002708978	113	0.008371170605309734	2.922945	7	7	0.001089664	
GO Cellular Component	host cell	79	5.476792e-9	1.197961591898734e-7	2.169678	70	0.009029928	127	0.015344844094488188	1.547442	36	68	0.005603985	
GO Cellular Component	preribosome	83	1.086391e-8	2.2617875277108435e-7	2.17262	67	0.008642931	94	0.0024091739234042555	1.615312	42	76	0.006537983	
GO Cellular Component	other organism cell	95	3.385316e-8	6.157711629473684e-7	2.055946	71	0.009158927	154	0.040603579012987015	1.461473	37	74	0.005759651	
GO Cellular Component	cytosolic large ribosomal subunit	101	8.234928e-8	0.0000014089064934653467	2.202664	57	0.007352941	126	0.015073330285714287	1.581265	33	61	0.005136986	
GO Cellular Component	axon cytoplasm	114	4.503154e-7	0.000006825833431578948	2.229723	49	0.006320949	86	0.0013637659311627908	1.899914	26	40	0.004047323	
GO Cellular Component	cytoplasmic stress granule	115	4.96307e-7	0.000007457552139130434	2.145275	53	0.006836945	93	0.0022123565419354843	1.835338	27	43	0.004202989	
GO Cellular Component	mitochondrial nucleoid	131	0.0000025008	0.00003298765190839694	2.321688	39	0.00503096	120	0.009836798400000001	1.739848	25	42	0.003891656	
GO Cellular Component	small-subunit processome	138	0.000007065073	0.00008846700104347826	2.483641	31	0.003998968	157	0.049435977783439486	1.670254	20	35	0.003113325	
GO Cellular Component	proteasome accessory complex	148	0.00001216427	0.00014202607135135135	2.785743	24	0.003095975	128	0.015888771	1.94863	16	24	0.00249066	
GO Cellular Component	proteasome regulatory particle, lid subcomplex	164	0.00005085901	0.0005358803004878049	4.943433	10	0.00128999	113	0.008371170605309734	2.922945	7	7	0.001089664	
GO Molecular Function	ribonucleoprotein complex binding	8	2.279889e-22	1.20321141975e-19	2.651508	132	0.01702786	16	0.000001154237803	1.779184	70	115	0.01089664	
GO Molecular Function	structural constituent of ribosome	11	1.437572e-15	5.517662712727273e-13	2.155558	134	0.01728586	47	0.0001130530329787234	1.533644	85	162	0.01323163	
GO Molecular Function	snRNA binding	23	1.034785e-11	1.8995053347826084e-9	3.654396	40	0.005159959	95	0.03567847319789474	1.769151	23	38	0.003580324	
GO Molecular Function	ribosome binding	53	1.164872e-7	0.000009279414309433963	2.178816	57	0.007352941	62	0.0017631637203225805	1.806912	34	55	0.005292653	
GO Molecular Function	thyroid hormone receptor binding	74	9.443428e-7	0.00005387858515675676	2.564805	35	0.004514964	80	0.015149079582499999	1.983427	19	28	0.002957659	
Human Phenotype	Progressive external ophthalmoplegia	1	5.787121e-16	3.8617458433e-12	5.611146	36	0.004643963	90	0.027747972592222222	2.338356	12	15	0.001867995	
Human Phenotype	Increased serum lactate	3	7.124414e-13	1.584707154066667e-9	2.287949	95	0.0122549	43	0.0009734626715116278	1.636849	56	100	0.00871731	
Human Phenotype	Abnormality of mitochondrial metabolism	12	2.125711e-11	1.1820724585833333e-8	2.367672	77	0.009932921	110	0.042767778707272726	1.567376	37	69	0.005759651	
Human Phenotype	Abnormal CSF metabolite level	18	6.48685e-11	2.4048194472222225e-8	2.632279	60	0.007739938	94	0.02881823076808511	1.623858	35	63	0.005448319	
Human Phenotype	Increased CSF lactate	30	2.557144e-10	5.687940637333333e-8	2.664413	55	0.007094943	115	0.04832172874	1.612659	32	58	0.00498132	
Human Phenotype	External ophthalmoplegia	42	8.890925e-9	0.000001412598631547619	2.610448	47	0.006062951	62	0.007510831743870967	2.009525	22	32	0.003424658	
Human Phenotype	Basal cell carcinoma	218	0.0002826527	0.008652025078440368	2.21655	25	0.003224974	82	0.02086943316097561	2.125778	16	22	0.00249066	
Human Phenotype	Increased serum pyruvate	243	0.0004916997	0.013502518922222222	2.903188	14	0.001805986	95	0.031113649211578946	2.630651	9	10	0.001400996	
Human Phenotype	Abnormality of glycolysis	244	0.0004923206	0.01346416132704918	2.779381	15	0.001934985	74	0.014951361483783785	2.657223	10	11	0.001556663	
Human Phenotype	Atrophy/Degeneration affecting the brainstem	336	0.001472017	0.029234432860119047	2.696218	13	0.001676987	79	0.01580821029746835	2.922945	8	8	0.00124533	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	45	3.807109e-12	7.74704380288889e-10	2.09634	108	0.01393189	107	0.004033829658878505	1.648841	44	78	0.006849315	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	84	2.805792e-9	3.058647302857143e-7	2.395925	59	0.007610939	153	0.03484642485294118	1.987603	17	25	0.002646326	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	118	6.365233e-8	0.000004939528693305085	2.942271	34	0.004385965	112	0.005253979186428572	2.407131	14	17	0.002179328	
Mouse Phenotype Single KO	spontaneous chromosome breakage	124	7.845365e-8	0.000005793548976209677	2.81306	36	0.004643963	153	0.03484642485294118	1.987603	17	25	0.002646326	
Mouse Phenotype Single KO	increased circulating glucagon level	294	0.00005529414	0.0017222055781632652	2.105677	35	0.004514964	112	0.005253979186428572	2.407131	14	17	0.002179328	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	41	6.12753e-14	1.4289101056097563e-11	3.64192	49	0.006320949	182	0.015008290443956044	1.94863	20	30	0.003113325	
Mouse Phenotype	abnormal vitelline vein morphology	92	2.805792e-9	2.9158888382608694e-7	2.395925	59	0.007610939	222	0.02507533753378378	1.987603	17	25	0.002646326	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	123	2.215792e-8	0.000001722372952195122	2.73468	41	0.005288958	222	0.02507533753378378	1.987603	17	25	0.002646326	
Mouse Phenotype	absent segment of posterior cerebral artery	310	0.00002979446	0.0009189188130967743	2.376555	29	0.00374097	270	0.04205674974444444	1.992917	15	22	0.002334994	
Mouse Phenotype	abnormal hypoglossal nerve topology	361	0.00007989971	0.002116125006398892	2.465184	24	0.003095975	263	0.040787044231939164	2.111016	13	18	0.002023661	
Mouse Phenotype	absent embryonic cilia	392	0.0001141983	0.0027853314956632655	2.740285	19	0.00245098	263	0.040787044231939164	2.111016	13	18	0.002023661	
Mouse Phenotype	abnormal infrahyoid muscle connection	450	0.0002837961	0.0060297211379999995	2.933512	15	0.001934985	269	0.04167543934572491	2.598174	8	9	0.00124533