# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 15 1.001059e-38 8.781956920666666e-36 3.594168 150 0.01946283 337 0.007864677444510386 1.490238 57 114 0.009047619 GO Biological Process regulation of gene expression, epigenetic 37 7.144986e-31 2.5411046155135134e-28 2.219486 262 0.03399507 160 0.00012909390218750002 1.430148 119 248 0.01888889 GO Biological Process response to topologically incorrect protein 62 1.324087e-25 2.8102678762903224e-23 2.326551 195 0.02530167 125 0.000017990826892000004 1.556471 94 180 0.01492063 GO Biological Process cellular response to topologically incorrect protein 65 4.950324e-25 1.0021740540923077e-22 2.546399 160 0.02076035 233 0.0008062344223175965 1.522402 71 139 0.01126984 GO Biological Process platelet aggregation 72 1.527772e-23 2.7922155205555558e-21 3.681544 86 0.01115869 460 0.02536555158 1.744669 24 41 0.003809524 GO Biological Process chromatin assembly or disassembly 143 9.424332e-18 8.672362572587411e-16 2.041748 176 0.02283638 472 0.02751852456440678 1.33954 80 178 0.01269841 GO Biological Process response to unfolded protein 145 1.030566e-17 9.352564133793103e-16 2.106034 163 0.0211496 131 0.000024977700602290078 1.583378 85 160 0.01349206 GO Biological Process nucleosome assembly 147 1.050347e-17 9.40239195442177e-16 2.190158 149 0.01933307 525 0.04017645724571429 1.364302 65 142 0.01031746 GO Biological Process chromatin assembly 149 1.199841e-17 1.0596448133557048e-15 2.113483 161 0.0208901 482 0.029616977680497925 1.358192 72 158 0.01142857 GO Biological Process endoplasmic reticulum unfolded protein response 164 5.878446e-17 4.716736031341464e-15 2.373487 120 0.01557026 273 0.002158500172893773 1.542527 59 114 0.009365079 GO Biological Process IRE1-mediated unfolded protein response 168 1.237808e-16 9.695425876190475e-15 3.20114 71 0.009212404 413 0.018092076507506053 1.644401 32 58 0.005079365 GO Biological Process cellular response to unfolded protein 172 2.462143e-16 1.8836825428488373e-14 2.254767 128 0.01660828 271 0.0020865624190774907 1.527186 62 121 0.00984127 GO Biological Process gene silencing 173 2.699811e-16 2.05357300283237e-14 2.053302 158 0.02050084 328 0.006770706689024389 1.390889 84 180 0.01333333 GO Biological Process negative regulation of transcription from RNA polymerase II promoter in response to stress 254 1.025116e-13 5.31082734015748e-12 4.577632 37 0.00480083 541 0.04227629144916821 2.292674 10 13 0.001587302 GO Biological Process erythrocyte homeostasis 261 1.545295e-13 7.791010308429119e-12 2.185915 111 0.01440249 307 0.005081585740716613 1.625714 42 77 0.006666667 GO Biological Process erythrocyte differentiation 270 3.413266e-13 1.6635247145925924e-11 2.231748 103 0.01336447 401 0.01515502997032419 1.598226 37 69 0.005873016 GO Biological Process regulation of megakaryocyte differentiation 274 3.69849e-13 1.7762200697080294e-11 2.327419 94 0.0121967 582 0.049349664104810995 1.490238 38 76 0.006031746 GO Biological Process platelet formation 387 1.173858e-10 3.99142052248062e-9 3.424478 39 0.005060335 212 0.0004928128054103773 2.509875 16 19 0.002539683 GO Biological Process translational elongation 408 2.403907e-10 7.753189267892156e-9 2.112673 88 0.01141819 348 0.008622631378735632 1.490238 56 112 0.008888889 GO Biological Process platelet morphogenesis 463 1.237455e-9 3.5169914352051836e-8 3.143997 39 0.005060335 252 0.0014226330667460318 2.384381 16 20 0.002539683 GO Cellular Component PcG protein complex 45 2.334526e-17 8.96457984e-16 2.825534 90 0.0116777 79 0.008842764394936708 1.74941 27 46 0.004285714 GO Cellular Component ESC/E(Z) complex 55 1.534438e-14 4.820925207272728e-13 3.504179 54 0.007006617 90 0.01746921024 2.152566 13 18 0.002063492 GO Cellular Component histone methyltransferase complex 60 7.680558e-14 2.212000704e-12 2.421104 92 0.0119372 84 0.009500418514285715 1.598226 37 69 0.005873016 GO Cellular Component methyltransferase complex 63 1.069613e-13 2.9337956571428575e-12 2.287121 102 0.01323472 111 0.03726583005405405 1.441109 44 91 0.006984127 GO Cellular Component large ribosomal subunit 90 1.591873e-10 3.0563961599999998e-9 2.141625 87 0.01128844 104 0.03179313969230769 1.399528 54 115 0.008571429 GO Cellular Component tertiary granule lumen 109 4.153528e-9 6.584675581651376e-8 2.504354 53 0.006876865 113 0.039404715610619465 1.571524 29 55 0.004603175 GO Cellular Component vesicle coat 116 1.676991e-8 2.498138317241379e-7 2.133416 68 0.008823148 115 0.049840057878260874 1.577899 27 51 0.004285714 GO Cellular Component nuclear inner membrane 117 3.008272e-8 4.442986338461539e-7 2.140867 65 0.008433891 100 0.02725913088 1.596684 30 56 0.004761905 GO Cellular Component autophagosome membrane 121 5.321203e-8 7.599205606611571e-7 2.42808 48 0.006228104 52 0.0003223784713846154 2.185683 22 30 0.003492063 GO Cellular Component podosome 144 9.51718e-7 0.000011420615999999999 2.21103 47 0.006098352 81 0.0091217664 1.952726 19 29 0.003015873 GO Cellular Component Cul4-RING E3 ubiquitin ligase complex 183 0.00003117451 0.00029436914360655736 2.259494 32 0.00415207 88 0.014680667781818181 1.862798 20 32 0.003174603 GO Cellular Component perinuclear endoplasmic reticulum 267 0.001085705 0.007026585168539326 2.122799 22 0.002854548 99 0.025175057454545454 2.438571 9 11 0.001428571 GO Molecular Function ribonucleoprotein complex binding 13 1.268289e-19 4.1190124292307686e-17 2.525558 125 0.01621902 45 0.005826522312444445 1.529114 59 115 0.009365079 Mouse Phenotype Single KO decreased erythroid progenitor cell number 22 1.044292e-41 4.3466281109090916e-39 3.388494 175 0.02270663 89 0.00013880129156179776 1.986984 34 51 0.005396825 Mouse Phenotype Single KO abnormal erythropoiesis 26 1.899984e-40 6.691597495384614e-38 2.64 248 0.03217854 63 0.000014082724719047618 1.734095 64 110 0.01015873 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 29 8.333133e-40 2.6312585821034485e-37 4.854387 110 0.01427274 244 0.01604662171967213 1.952726 19 29 0.003015873 Mouse Phenotype Single KO abnormal T cell activation 33 2.263066e-37 6.279665261212122e-35 2.024166 394 0.05112236 151 0.001899750637549669 1.340699 130 289 0.02063492 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 35 7.104006e-37 1.8586109411999999e-34 4.380454 113 0.014662 241 0.013823711166804978 1.873442 22 35 0.003492063 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 43 2.197628e-34 4.6799254874418606e-32 3.102536 162 0.02101985 107 0.00042735359566355147 1.912004 34 53 0.005396825 Mouse Phenotype Single KO decreased T cell proliferation 48 1.364222e-30 2.6025376779166666e-28 2.263045 249 0.03230829 200 0.0075889873695 1.430629 72 150 0.01142857 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 55 4.436297e-29 7.386031205272728e-27 2.421737 206 0.02672895 65 0.000023111281861538463 1.82335 52 85 0.008253968 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 69 2.212237e-24 2.9358629288405793e-22 2.094176 233 0.03023226 183 0.004650389955737705 1.413597 83 175 0.0131746 Mouse Phenotype Single KO abnormal induced cell death 72 5.185876e-24 6.595425907222222e-22 2.013824 252 0.03269755 175 0.003354253576857143 1.384297 98 211 0.01555556 Mouse Phenotype Single KO decreased vascular endothelial cell number 83 1.369558e-22 1.5109689886746988e-20 5.685462 52 0.006747113 249 0.017562725151405622 2.980476 7 7 0.001111111 Mouse Phenotype Single KO extramedullary hematopoiesis 91 1.240952e-20 1.248724996043956e-18 2.317565 156 0.02024134 157 0.0026118330292993633 1.542527 59 114 0.009365079 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 120 1.56694e-17 1.1957057983333334e-15 2.770074 94 0.0121967 321 0.04392196413395639 1.849951 18 29 0.002857143 Mouse Phenotype Single KO abnormal platelet physiology 140 2.430049e-15 1.5894256209285712e-13 2.014085 155 0.02011159 254 0.01878477074330709 1.463143 54 110 0.008571429 Mouse Phenotype Single KO decreased sensitivity to induced cell death 154 1.023266e-14 6.084445949350649e-13 2.245247 115 0.0149215 243 0.015327563151851851 1.566661 41 78 0.006507937 Mouse Phenotype Single KO abnormal circulating interferon level 171 7.853119e-14 4.205322262163743e-12 2.393736 94 0.0121967 209 0.008526810002392344 1.556471 47 90 0.007460317 Mouse Phenotype Single KO abnormal interferon level 189 9.673161e-13 4.686620914126984e-11 2.172947 105 0.01362398 326 0.04737371141104294 1.420601 51 107 0.008095238 Mouse Phenotype Single KO spleen hyperplasia 197 1.928243e-12 8.962904137563452e-11 2.104468 110 0.01427274 150 0.0016810396181333334 1.681294 44 78 0.006984127 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 202 2.308694e-12 1.0465698494059405e-10 2.249725 94 0.0121967 206 0.008387963134951456 1.641422 38 69 0.006031746 Mouse Phenotype Single KO increased circulating interferon-gamma level 256 2.956228e-10 1.0574288982812501e-8 2.711041 53 0.006876865 181 0.004125514340055249 1.871462 27 43 0.004285714 Mouse Phenotype abnormal erythropoiesis 19 1.854275e-43 9.330906986842105e-41 2.505871 293 0.03801739 67 4.399809520298507e-7 1.700272 85 149 0.01349206 Mouse Phenotype decreased erythroid progenitor cell number 24 2.103281e-40 8.378945683749999e-38 2.965561 205 0.0265992 142 0.0002632969451197183 1.764756 45 76 0.007142857 Mouse Phenotype abnormal embryonic erythropoiesis 38 3.978332e-38 1.0009692697894737e-35 4.451719 115 0.0149215 326 0.011994494461656442 1.922888 20 31 0.003174603 Mouse Phenotype abnormal embryonic erythrocyte morphology 42 1.846828e-35 4.2041720257142854e-33 4.002945 120 0.01557026 249 0.0035109247601204817 1.910562 25 39 0.003968254 Mouse Phenotype decreased T cell proliferation 49 4.744864e-33 9.25829483755102e-31 2.049666 337 0.04372648 129 0.00019222360853488372 1.455256 104 213 0.01650794 Mouse Phenotype abnormal embryonic hematopoiesis 52 4.426318e-32 8.138466614999999e-30 2.855954 171 0.02218762 145 0.0002635703948275862 1.85669 38 61 0.006031746 Mouse Phenotype abnormal erythroid progenitor cell morphology 58 1.838843e-30 3.0312375729310346e-28 2.303219 239 0.03101077 123 0.00013642474302439023 1.627991 65 119 0.01031746 Mouse Phenotype extramedullary hematopoiesis 61 5.124376e-30 8.031829333770492e-28 2.197449 260 0.03373557 113 0.00006316731020176991 1.532816 90 175 0.01428571 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 77 8.573886e-26 1.0646094031948051e-23 2.047315 261 0.03386532 309 0.009250982254368934 1.374331 83 180 0.0131746 Mouse Phenotype abnormal mean corpuscular hemoglobin 79 1.531223e-25 1.853167481392405e-23 2.071929 251 0.0325678 218 0.0017376205257798164 1.425445 88 184 0.01396825 Mouse Phenotype abnormal proerythroblast morphology 89 1.715718e-23 1.8431437975280897e-21 2.439522 162 0.02101985 443 0.041484617857787814 1.490238 39 78 0.006190476 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 95 1.439606e-22 1.448849785894737e-20 2.159286 200 0.02595043 349 0.01722762071776504 1.429659 59 123 0.009365079 Mouse Phenotype increased circulating interferon-gamma level 98 2.455782e-21 2.3958909900000004e-19 3.584683 80 0.01038017 173 0.0005344435412947977 1.891456 33 52 0.005238095 Mouse Phenotype abnormal platelet physiology 100 9.432676e-21 9.0185815236e-19 2.137675 187 0.02426366 238 0.0026588088486554622 1.490238 66 132 0.01047619 Mouse Phenotype abnormal circulating interferon level 111 7.550282e-20 6.503445603783784e-18 2.553892 124 0.01608927 301 0.00820141309435216 1.490238 55 110 0.008730159 Mouse Phenotype abnormal interferon level 127 5.99528e-18 4.513454494488189e-16 2.269766 140 0.0181653 427 0.03702531956206089 1.377341 61 132 0.00968254 Mouse Phenotype increased circulating tumor necrosis factor level 191 5.049667e-14 2.527741685183246e-12 2.235106 110 0.01427274 341 0.015295213955718473 1.490238 49 98 0.007777778 Mouse Phenotype abnormal splenic cell ratio 212 5.826077e-13 2.6275057640094335e-11 2.211183 103 0.01336447 433 0.03900817341339492 1.563528 32 61 0.005079365 Mouse Phenotype decreased sensitivity to induced cell death 214 6.196645e-13 2.768510413317757e-11 2.013777 128 0.01660828 339 0.014582016967256636 1.506262 47 93 0.007460317 Mouse Phenotype decreased mean corpuscular hemoglobin 237 3.472165e-12 1.4007328930379745e-10 2.09964 108 0.01401323 260 0.004359580652307692 1.625714 42 77 0.006666667