# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	13	2.339663e-55	2.3682788782307688e-52	2.696615	334	0.01862073	334	0.000010646816885928144	1.39136	91	113	0.008373206	
GO Biological Process	regulation of DNA-templated transcription in response to stress	16	3.956988e-51	3.25437531825e-48	2.505256	351	0.01956849	295	0.0000015255679228474577	1.40832	97	119	0.008925285	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	25	1.760939e-44	9.2688785204e-42	2.176787	405	0.02257903	368	0.00005059102703532609	1.315306	118	155	0.01085756	
GO Biological Process	endoplasmic reticulum unfolded protein response	29	7.360667e-41	3.339966105275862e-38	2.45606	289	0.01611195	290	8.199617929655173e-7	1.424622	94	114	0.008649245	
GO Biological Process	cellular response to topologically incorrect protein	41	1.668141e-35	5.353918882682927e-33	2.181387	319	0.01778447	307	0.000003994425165798045	1.367271	110	139	0.01012146	
GO Biological Process	cellular response to unfolded protein	42	1.331683e-34	4.172289665952381e-32	2.232797	295	0.01644645	297	0.00000241802694976431	1.399321	98	121	0.009017298	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	45	3.339777e-34	9.766250120666666e-32	2.310749	271	0.01510844	646	0.005378177001857586	1.30499	71	94	0.006532941	
GO Biological Process	multi-organism metabolic process	60	3.311676e-31	7.263057414e-29	2.115129	299	0.01666945	166	1.8861460577108436e-11	1.480914	126	147	0.01159367	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	65	1.668541e-30	3.377897079846154e-28	2.466639	211	0.01176339	460	0.0004463936151956522	1.395476	63	78	0.005796835	
GO Biological Process	IRE1-mediated unfolded protein response	71	2.194357e-29	4.0669779947887325e-27	2.925222	151	0.008418353	609	0.003523852715435139	1.400059	47	58	0.004324623	
GO Biological Process	protein targeting to ER	72	2.234402e-29	4.083679988611111e-27	2.434126	208	0.01159614	158	1.0485182813291138e-11	1.573776	92	101	0.008465219	
GO Biological Process	regulation of cellular amino acid metabolic process	73	2.988987e-29	5.3879561552054794e-27	3.048846	141	0.007860846	848	0.028583768759433963	1.324595	46	60	0.004232609	
GO Biological Process	positive regulation of nuclease activity	82	5.00632e-28	8.033922546341463e-26	4.62985	80	0.004460055	952	0.04501029038760505	1.612551	14	15	0.001288185	
GO Biological Process	translational elongation	83	8.154904e-28	1.2928961654939758e-25	2.290014	222	0.01237665	168	2.007472811547619e-11	1.542619	100	112	0.009201325	
GO Biological Process	viral gene expression	85	1.275978e-27	1.9753640590588234e-25	2.209425	238	0.01326866	185	1.2893799915675676e-10	1.496461	110	127	0.01012146	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	87	1.813697e-27	2.743268830229885e-25	2.275554	222	0.01237665	268	2.0611943355223878e-7	1.434897	98	118	0.009017298	
GO Biological Process	mitochondrial translational termination	92	1.660068e-26	2.3744385665217392e-24	2.548283	171	0.009533367	183	1.0211153897267759e-10	1.58872	80	87	0.00736106	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	94	5.991609e-26	8.387615194787235e-24	2.422317	184	0.01025813	182	7.766152591208791e-11	1.577495	84	92	0.007729113	
GO Biological Process	cotranslational protein targeting to membrane	96	7.083796e-26	9.709965787916667e-24	2.367269	192	0.01070413	176	3.7097568685227273e-11	1.569063	89	98	0.008189179	
GO Biological Process	protein localization to endoplasmic reticulum	99	1.736842e-25	2.3085963513131313e-23	2.097658	246	0.01371467	149	4.1204061344966445e-12	1.532666	110	124	0.01012146	
GO Cellular Component	ribosomal subunit	36	1.333614e-36	6.401347200000001e-35	2.156296	338	0.01884373	37	4.6466868064864865e-15	1.484916	159	185	0.01463011	
GO Cellular Component	large ribosomal subunit	39	1.005958e-30	4.457167753846154e-29	2.390387	226	0.01259965	46	8.254937739130434e-11	1.5174	101	115	0.009293338	
GO Cellular Component	mitochondrial ribosome	41	8.913297e-30	3.756628589268293e-28	2.834945	161	0.00897586	53	8.588192603773586e-10	1.565123	77	85	0.00708502	
GO Cellular Component	nuclear ubiquitin ligase complex	45	6.147264e-25	2.3605493760000002e-23	3.236139	109	0.006076824	145	0.010275815371034483	1.42538	33	40	0.003036437	
GO Cellular Component	mitochondrial large ribosomal subunit	47	7.608672e-24	2.797401109787234e-22	3.169888	107	0.005965323	75	0.000009667830528	1.558347	46	51	0.004232609	
GO Cellular Component	endopeptidase complex	62	1.739753e-16	4.848859974193549e-15	2.173535	141	0.007860846	98	0.0006264038791836734	1.402218	56	69	0.005152742	
GO Cellular Component	very-low-density lipoprotein particle	64	3.316998e-16	8.9558946e-15	3.308671	66	0.003679545	166	0.021436568674698796	1.55496	18	20	0.001656238	
GO Cellular Component	proteasome complex	67	1.728352e-15	4.457600382089552e-14	2.128491	138	0.007693594	102	0.0008513271529411765	1.397431	55	68	0.005060729	
GO Cellular Component	mitochondrial nucleoid	96	3.878397e-12	6.9811146e-11	2.289777	89	0.004961811	83	0.0000786479213493976	1.563187	38	42	0.003496503	
GO Cellular Component	spliceosomal snRNP complex	102	9.594055e-11	1.6253457882352942e-9	2.028275	102	0.00568657	200	0.04882914144	1.281866	46	62	0.004232609	
GO Cellular Component	endoribonuclease complex	165	6.971061e-8	7.300602065454545e-7	2.166241	60	0.003345041	153	0.012087642352941175	1.489425	25	29	0.002300331	
GO Cellular Component	mitochondrial small ribosomal subunit	214	0.00000189441	0.00001529691813084112	2.197953	45	0.002508781	128	0.0044555724	1.542619	25	28	0.002300331	
GO Cellular Component	DNA-directed RNA polymerase III complex	228	0.000004076487	0.00003089548042105263	2.769217	27	0.001505268	134	0.005850939653731343	1.636799	18	19	0.001656238	
GO Cellular Component	signal recognition particle	316	0.0001925536	0.0010529513316455696	2.713002	18	0.001003512	189	0.038508662857142856	1.727733	10	10	0.0009201325	
GO Molecular Function	structural constituent of ribosome	9	1.202906e-31	5.642965702222222e-29	2.113453	304	0.01694821	12	6.943529346666666e-15	1.525097	143	162	0.01315789	
GO Molecular Function	unfolded protein binding	10	8.713029e-29	3.6786408437999996e-26	2.401566	209	0.01165189	104	0.004680456425	1.303949	80	106	0.00736106	
GO Molecular Function	rRNA binding	11	1.125984e-24	4.321731316363636e-22	3.150555	112	0.006244076	81	0.001215255267654321	1.439777	50	60	0.004600662	
GO Molecular Function	NF-kappaB binding	46	8.550724e-12	7.848077549565218e-10	2.419292	77	0.004292803	118	0.011808805193220338	1.542619	25	28	0.002300331	
GO Molecular Function	rRNA methyltransferase activity	154	0.000001151113	0.00003155843562337662	2.315803	42	0.002341529	76	0.0009816849963157894	1.727733	20	20	0.001840265	
Human Phenotype	Increased serum lactate	2	5.052518e-24	1.6857726307000002e-20	2.185778	210	0.01170764	39	0.000003163195345897436	1.451296	84	100	0.007729113	
Human Phenotype	Abnormal CSF metabolite level	13	2.432993e-16	1.2488740222307693e-13	2.313153	122	0.006801583	116	0.001576720600862069	1.426065	52	63	0.004784689	
Human Phenotype	Increased CSF lactate	18	2.081388e-14	7.716167846666667e-12	2.282072	109	0.006076824	155	0.007021042154193548	1.400059	47	58	0.004324623	
Human Phenotype	External ophthalmoplegia	59	2.47984e-9	2.8047410711864406e-7	2.040328	85	0.004738808	233	0.03817651939484978	1.457775	27	32	0.002484358	
Human Phenotype	CNS hypomyelination	114	2.188036e-7	0.000012807687919298246	2.137918	57	0.003177789	210	0.022504327073809526	1.497368	26	30	0.002392344	
Human Phenotype	3-Methylglutaconic aciduria	153	0.000001113027	0.000048543981509803926	2.375454	40	0.002230027	238	0.0395288052394958	1.727733	12	12	0.001104159	
Mouse Phenotype Single KO	pale liver	23	7.441803e-21	2.9628082639565213e-18	2.032676	214	0.01193065	168	0.009954978044047618	1.338993	62	80	0.005704821	
Mouse Phenotype Single KO	spontaneous chromosome breakage	171	1.064456e-9	5.700130755555556e-8	2.29641	68	0.003791046	174	0.010753649253448275	1.589514	23	25	0.002116305	
Mouse Phenotype Single KO	abnormal level of surface class I molecules	312	3.819169e-7	0.00001120901619647436	3.328387	25	0.001393767	282	0.045779772067375886	1.727733	12	12	0.001104159	
Mouse Phenotype	early cellular replicative senescence	53	3.106632e-18	5.604246896603773e-16	2.036237	184	0.01025813	108	0.000012751727019444445	1.491057	63	73	0.005796835	
Mouse Phenotype	pancytopenia	144	2.893655e-12	1.9212663510416666e-10	2.192159	99	0.005519318	394	0.025971461573604058	1.489425	25	29	0.002300331	
Mouse Phenotype	decreased level of surface class I molecules	339	9.638374e-8	0.000002718362649380531	3.988196	22	0.001226515	408	0.033037918330882356	1.727733	12	12	0.001104159	
Mouse Phenotype	abnormal level of surface class I molecules	348	1.139607e-7	0.000003130971990517241	3.356992	27	0.001505268	319	0.014141902885579937	1.727733	14	14	0.001288185	
Mouse Phenotype	abnormal antigen presentation via MHC class I	379	2.989828e-7	0.000007542413062796833	2.972835	30	0.00167252	452	0.04228104763938053	1.619749	15	16	0.001380199