# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	55	3.95674e-53	9.466680301818182e-51	2.060941	555	0.0213774	428	0.00001908000273317757	1.266156	130	155	0.01045184	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	67	4.826803e-49	9.47998517567164e-47	2.464478	348	0.01340421	503	0.00012306707528230617	1.279363	100	118	0.008039878	
GO Biological Process	viral gene expression	86	1.61484e-42	2.4708929720930232e-40	2.270478	354	0.01363531	418	0.000014288457747368421	1.295682	109	127	0.008763467	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	90	4.887499e-40	7.146066593444446e-38	2.167919	368	0.01417456	601	0.0006670967092346089	1.284807	80	94	0.006431902	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	95	2.31091e-39	3.2009752305263157e-37	2.483061	273	0.01051537	508	0.0001342265921555118	1.312737	80	92	0.006431902	
GO Biological Process	multi-organism metabolic process	100	5.598429e-38	7.366972721099999e-36	2.018493	413	0.01590787	356	0.0000025236104722752808	1.293984	126	147	0.01013025	
GO Biological Process	cotranslational protein targeting to membrane	103	4.845033e-37	6.189882451165049e-35	2.376634	279	0.01074648	538	0.00026137491784386616	1.293984	84	98	0.006753497	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	108	1.028283e-35	1.2528866663888888e-33	2.058309	369	0.01421308	780	0.004339053721153846	1.229094	92	113	0.007396688	
GO Biological Process	viral transcription	109	2.833766e-35	3.421057504036698e-33	2.187225	316	0.01217164	472	0.00005361364121398305	1.295892	97	113	0.007798681	
GO Biological Process	protein targeting to ER	115	1.700882e-34	1.946252716347826e-32	2.28003	282	0.01086203	632	0.000877348632800633	1.270496	85	101	0.006833896	
GO Biological Process	regulation of mitochondrial membrane permeability	130	2.128596e-31	2.1546303664615385e-29	2.114859	302	0.01163239	690	0.0016901766692463767	1.302847	63	73	0.005065123	
GO Biological Process	positive regulation of release of cytochrome c from mitochondria	137	8.35335e-30	8.0234841350364965e-28	3.122241	139	0.005353979	1234	0.04167538476823339	1.353477	26	29	0.002090368	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	140	1.334995e-29	1.2547999432142857e-27	2.083508	294	0.01132424	635	0.0008899444133700787	1.265229	88	105	0.007075092	
GO Biological Process	translational elongation	156	2.019083e-27	1.7031482818589743e-25	2.038275	286	0.0110161	386	0.00000772597617046632	1.320942	98	112	0.00787908	
GO Biological Process	cellular protein complex localization	171	4.381962e-26	3.372060699298246e-24	2.678761	154	0.005931746	800	0.0052021589841249995	1.451584	25	26	0.002009969	
GO Biological Process	heterochromatin organization	192	9.01363e-25	6.177622769270834e-23	3.594067	94	0.003620676	1278	0.04857228869092332	1.509648	13	13	0.001045184	
GO Biological Process	gene silencing by miRNA	195	1.14864e-24	7.751258338461538e-23	2.322504	190	0.007318388	593	0.0005947457474704891	1.406717	41	44	0.00329635	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	196	1.258801e-24	8.451307326020409e-23	2.942981	124	0.004776211	887	0.009939866505073279	1.446746	23	24	0.001849172	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	209	9.035154e-24	5.688688587846891e-22	2.071055	236	0.009090209	781	0.004376472788604354	1.290858	59	69	0.004743528	
GO Biological Process	posttranscriptional gene silencing by RNA	221	3.501906e-23	2.085139414208145e-21	2.160234	208	0.008011709	558	0.0003479083955913978	1.391244	47	51	0.003778743	
GO Cellular Component	large ribosomal subunit	37	1.047548e-32	4.892332281081081e-31	2.17034	297	0.0114398	110	0.0004255888058181818	1.260228	96	115	0.007718283	
GO Cellular Component	cleavage furrow	51	4.284944e-24	1.4518398494117647e-22	2.106163	230	0.008859102	133	0.0029868622917293237	1.335458	46	52	0.003698344	
GO Cellular Component	mitochondrial ribosome	56	5.520939e-23	1.7036040342857142e-21	2.262786	186	0.007164317	121	0.0015048495074380165	1.278761	72	85	0.005788712	
GO Cellular Component	cytoplasmic stress granule	70	6.212064e-21	1.5334923702857143e-19	2.187567	181	0.006971728	115	0.0005690553433043478	1.404324	40	43	0.003215951	
GO Cellular Component	cytosolic large ribosomal subunit	89	2.515089e-18	4.8832289797752806e-17	2.065389	179	0.006894692	191	0.018097163057591625	1.262165	51	61	0.004100338	
GO Cellular Component	axon cytoplasm	103	8.203178e-16	1.3762224838834952e-14	2.065256	152	0.005854711	147	0.006265103804081632	1.358683	36	40	0.002894356	
GO Cellular Component	nuclear ubiquitin ligase complex	116	7.589802e-14	1.1306187806896552e-12	2.235831	109	0.004198444	103	0.0002589312372815534	1.434165	38	40	0.003055154	
GO Cellular Component	precatalytic spliceosome	210	4.628663e-8	3.808728411428571e-7	2.14689	63	0.002426624	211	0.04372252754502369	1.3479	25	28	0.002009969	
GO Cellular Component	INO80-type complex	255	0.000001853038	0.000012557057505882353	2.178746	46	0.00177182	214	0.04851082228037383	1.378374	21	23	0.001688374	
GO Cellular Component	anaphase-promoting complex	272	0.00000611728	0.00003886272	2.05955	47	0.001810338	192	0.018377982	1.43776	20	21	0.001607976	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	36	4.272997e-18	5.011275926111111e-16	2.380476	129	0.004968801	141	0.023413807660992908	1.405534	27	29	0.002170767	
GO Molecular Function	snRNA binding	161	4.137877e-9	1.0851004157763976e-7	2.100497	77	0.002965873	147	0.02859242944761905	1.350738	34	38	0.002733558	
Human Phenotype	Onion bulb formation	123	8.714773e-12	4.727941482032521e-10	2.019633	115	0.004429551	277	0.01109717009169675	1.449262	24	25	0.001929571	
Human Phenotype	Abnormal ovarian morphology	196	1.007563e-9	3.430340764795918e-8	2.072545	86	0.003312534	363	0.03753788609917356	1.43776	20	21	0.001607976	
Mouse Phenotype Single KO	absent hypoglossal nerve	51	3.722929e-22	6.684482520196079e-20	3.605402	83	0.00319698	525	0.03607619045904762	1.509648	15	15	0.001205982	
Mouse Phenotype Single KO	abnormal Mullerian duct morphology	68	7.110259e-20	9.574800244558824e-18	2.047032	200	0.007703567	545	0.04185132081834862	1.337117	31	35	0.002492362	
Mouse Phenotype Single KO	subcutaneous edema	107	1.172946e-16	1.0038006095327102e-14	2.229379	135	0.005199908	378	0.013371477757671958	1.409005	28	30	0.002251166	
Mouse Phenotype Single KO	small superior cervical ganglion	126	1.982717e-15	1.440931711825397e-13	2.189421	129	0.004968801	325	0.007703789735076923	1.415295	30	32	0.002411963	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	149	2.476776e-14	1.5221367672483222e-12	2.398013	98	0.003774748	466	0.027723426656652363	1.441027	21	22	0.001688374	
Mouse Phenotype Single KO	abnormal adrenal medulla morphology	220	2.090865e-12	8.702750365909092e-11	2.19624	100	0.003851783	391	0.014060791300767261	1.509648	18	18	0.001447178	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	253	1.249505e-11	4.522417899209486e-10	2.340592	81	0.003119945	421	0.01972335147743468	1.509648	17	17	0.001366779	
Mouse Phenotype Single KO	absent stapedial artery	264	1.996362e-11	6.924502588636364e-10	2.345724	79	0.003042909	460	0.02726273796956522	1.509648	16	16	0.00128638	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	286	6.387602e-11	2.045149353636364e-9	2.03681	103	0.003967337	397	0.01545410974811083	1.446746	23	24	0.001849172	
Mouse Phenotype	absent hypoglossal nerve	82	3.722929e-22	4.3408444108536585e-20	3.605402	83	0.00319698	772	0.025616086325129534	1.509648	15	15	0.001205982	
Mouse Phenotype	decreased DN4 thymocyte number	118	3.764784e-19	3.050432188474576e-17	2.294939	148	0.005700639	920	0.04419128494891304	1.430193	18	19	0.001447178	
Mouse Phenotype	increased lactate dehydrogenase level	152	4.382423e-17	2.7566017304605263e-15	2.23569	138	0.005315461	828	0.032928084	1.358683	27	30	0.002170767	
Mouse Phenotype	subcutaneous edema	163	1.172946e-16	6.880083868711656e-15	2.229379	135	0.005199908	592	0.008914553657432434	1.409005	28	30	0.002251166	
Mouse Phenotype	abnormal pituitary intermediate lobe morphology	210	6.109985e-15	2.781788885e-13	2.406306	102	0.003928819	942	0.047879427614649674	1.509648	13	13	0.001045184	
Mouse Phenotype	absent segment of posterior cerebral artery	228	2.476776e-14	1.0386164621052632e-12	2.398013	98	0.003774748	711	0.018972009291139243	1.441027	21	22	0.001688374	
Mouse Phenotype	abnormal stapedial artery morphology	302	1.376338e-12	4.357340270860927e-11	2.202924	101	0.003890301	520	0.0048388846142307694	1.509648	20	20	0.001607976	
Mouse Phenotype	absent stapedial artery	309	2.212002e-12	6.84432075145631e-11	2.203926	99	0.003813266	562	0.006762576959786477	1.509648	19	19	0.001527577	
Mouse Phenotype	abnormal cerebral artery morphology	394	6.387602e-11	1.5500472772081218e-9	2.03681	103	0.003967337	610	0.010501582967213114	1.446746	23	24	0.001849172