# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of extrinsic apoptotic signaling pathway via death domain receptors 302 3.149815e-19 1.3724640922185431e-17 2.027978 197 0.01110673 480 0.0033390935085416667 1.381824 48 57 0.004194704 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 306 4.088137e-19 1.758032509248366e-17 2.526488 122 0.006878277 916 0.048411544394104805 1.36743 30 36 0.00262169 GO Biological Process regulation of regulatory T cell differentiation 538 1.439068e-12 3.519831935315985e-11 2.11938 110 0.006201725 903 0.04537575855370986 1.444006 22 25 0.001922573 GO Biological Process ER-nucleus signaling pathway 546 2.017549e-12 4.8624408957875454e-11 2.237753 96 0.005412415 568 0.007359613244542255 1.453383 31 35 0.00270908 GO Biological Process regulation of immunoglobulin mediated immune response 570 6.284205e-12 1.4507693613157894e-10 2.074413 109 0.006145346 832 0.03389555953846153 1.333244 39 48 0.003408197 GO Biological Process release of cytochrome c from mitochondria 679 1.6006e-10 3.1019580854197346e-9 2.390514 69 0.003890173 896 0.0448155446171875 1.484638 19 21 0.001660404 GO Biological Process macrophage differentiation 783 1.147564e-9 1.928581695530013e-8 2.203866 74 0.00417207 596 0.00965829974899329 1.562777 20 21 0.001747793 GO Biological Process heme biosynthetic process 825 2.484367e-9 3.962640648848485e-8 3.015313 40 0.002255173 657 0.013747918326636225 1.55887 19 20 0.001660404 GO Biological Process regulation of exit from mitosis 835 3.195777e-9 5.036314915329342e-8 2.671184 48 0.002706207 777 0.028428131175032175 1.549754 17 18 0.001485624 GO Biological Process porphyrin-containing compound biosynthetic process 1395 0.00000359887 0.00003394805041577061 2.163574 44 0.00248069 679 0.017213008828424154 1.504173 22 24 0.001922573 GO Molecular Function ankyrin binding 119 2.87557e-8 0.000001020223238655462 2.067582 71 0.004002932 106 0.04280526479245283 1.554552 18 19 0.001573014 Mouse Phenotype Single KO abnormal iron level 83 2.727565e-36 3.0091943018072292e-34 2.18844 324 0.0182669 466 0.004659849923390557 1.254818 91 119 0.00795246 Mouse Phenotype Single KO abnormal platelet physiology 93 2.257141e-33 2.2224344233333334e-31 2.021317 358 0.0201838 455 0.004056055918241758 1.26798 85 110 0.007428122 Mouse Phenotype Single KO abnormal iron homeostasis 94 2.480919e-33 2.4167846045744684e-31 2.088804 330 0.01860518 523 0.007186208749330784 1.240692 93 123 0.008127239 Mouse Phenotype Single KO abnormal platelet activation 96 3.151987e-33 3.0065359332291668e-31 2.231694 283 0.01595535 737 0.022203811597014927 1.254818 65 85 0.005680329 Mouse Phenotype Single KO decreased platelet aggregation 99 1.164895e-32 1.0774690419191919e-30 2.544103 214 0.01206517 680 0.017392011295588237 1.312733 48 60 0.004194704 Mouse Phenotype Single KO abnormal platelet aggregation 102 5.862345e-32 5.262891486764706e-30 2.230358 272 0.01533518 608 0.013576576349177633 1.28328 61 78 0.00533077 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 103 7.845589e-32 6.97495713330097e-30 2.863484 170 0.009584484 690 0.017922571427536234 1.406499 30 35 0.00262169 Mouse Phenotype Single KO increased circulating interferon-gamma level 123 2.026537e-28 1.508699130813008e-26 3.044991 137 0.007723967 490 0.0057343600783673464 1.411951 37 43 0.003233418 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 136 9.020756e-26 6.073754609705882e-24 2.093801 250 0.01409483 577 0.010752043070883883 1.250222 80 105 0.006991174 Mouse Phenotype Single KO abnormal circulating interferon level 153 7.410948e-23 4.435428159215687e-21 2.190881 198 0.01116311 788 0.028428034326142132 1.239803 68 90 0.005942498 Mouse Phenotype Single KO abnormal circulating interferon-gamma level 166 3.42543e-21 1.8895579825301202e-19 2.275551 168 0.009471726 956 0.04999485412238494 1.248021 54 71 0.004719042 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 177 2.57458e-20 1.3319451446327684e-18 2.069474 199 0.01121948 582 0.010807638931958763 1.307976 55 69 0.004806432 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 197 2.630237e-18 1.2225929040101524e-16 2.175365 158 0.008907933 748 0.023149067387700534 1.296853 49 62 0.004282094 Mouse Phenotype Single KO abnormal platelet volume 229 7.235047e-17 2.893070977248908e-15 2.04516 167 0.009415346 515 0.00702472942893204 1.353036 47 57 0.004107315 Mouse Phenotype Single KO increased liver iron level 239 1.199568e-16 4.5960017472803344e-15 2.829985 86 0.004848622 916 0.0454075936451965 1.435801 21 24 0.001835183 Mouse Phenotype Single KO increased body temperature 279 3.062295e-15 1.0050693661290324e-13 2.311764 113 0.006370863 418 0.0028987819808612434 1.491742 30 33 0.00262169 Mouse Phenotype Single KO increased respiratory quotient 289 4.098123e-15 1.2984952356747406e-13 2.116778 136 0.007667588 712 0.020334378873595505 1.339523 40 49 0.003495587 Mouse Phenotype Single KO increased mean platelet volume 292 6.879987e-15 2.1575356492808219e-13 2.070371 141 0.007949484 844 0.0370721145 1.335629 35 43 0.003058638 Mouse Phenotype Single KO increased spleen germinal center size 294 8.755395e-15 2.726977959693877e-13 2.792128 77 0.004341208 758 0.024518882259894455 1.491742 20 22 0.001747793 Mouse Phenotype Single KO microcytosis 311 4.39351e-14 1.2936132176848874e-12 3.000976 65 0.003664656 822 0.03399344643673966 1.484638 19 21 0.001660404 Mouse Phenotype abnormal platelet physiology 74 3.222658e-44 4.163761234864865e-42 2.120963 427 0.02407397 450 0.0004489913589333333 1.280412 103 132 0.009001136 Mouse Phenotype increased circulating interferon-gamma level 92 1.250626e-39 1.2996994767391302e-37 3.32937 171 0.009640864 410 0.0002600034663658536 1.451579 46 52 0.004019925 Mouse Phenotype abnormal platelet activation 101 1.492896e-37 1.4132256095049505e-35 2.270413 310 0.01747759 991 0.02055325565085772 1.230687 75 100 0.006554225 Mouse Phenotype abnormal platelet aggregation 102 1.586396e-37 1.4870129564705881e-35 2.283646 306 0.01725207 722 0.005651280655263157 1.274328 73 94 0.006379446 Mouse Phenotype abnormal iron level 105 6.235282e-37 5.677669638285714e-35 2.114169 357 0.02012742 820 0.010393026203414635 1.215493 100 135 0.008738967 Mouse Phenotype decreased platelet aggregation 107 1.141279e-36 1.0197914503738317e-34 2.553663 240 0.01353104 950 0.018448392325263158 1.276268 56 72 0.004893822 Mouse Phenotype abnormal iron homeostasis 114 7.856706e-35 6.589295268947369e-33 2.037544 367 0.02069121 859 0.012486298697322469 1.207245 103 140 0.009001136 Mouse Phenotype abnormal circulating tumor necrosis factor level 124 1.514869e-33 1.1680372991129032e-31 2.044283 350 0.01973276 489 0.0007275125227607361 1.258785 112 146 0.009787643 Mouse Phenotype increased circulating tumor necrosis factor level 140 1.210177e-30 8.264644497857143e-29 2.251391 255 0.01437673 454 0.000485377643061674 1.322779 79 98 0.006903784 Mouse Phenotype abnormal embryonic erythrocyte morphology 142 3.145126e-30 2.117644344084507e-28 2.652495 183 0.01031742 691 0.004411684770911722 1.430542 34 39 0.002971249 Mouse Phenotype abnormal circulating interferon-gamma level 146 5.262948e-30 3.446509988219178e-28 2.456348 209 0.01178328 1008 0.022407664208333334 1.244833 66 87 0.005767718 Mouse Phenotype abnormal embryonic erythropoiesis 156 3.73806e-28 2.2909994653846154e-26 2.724897 162 0.00913345 1271 0.040324484131392606 1.376252 26 31 0.002272131 Mouse Phenotype abnormal circulating interferon level 173 3.159784e-26 1.7462829378034682e-24 2.147817 240 0.01353104 1123 0.02976134117364203 1.208311 81 110 0.007078563 Mouse Phenotype abnormal splenic cell ratio 224 6.358387e-21 2.7139525940625e-19 2.024195 217 0.01223431 1019 0.023301780211972524 1.291212 48 61 0.004194704 Mouse Phenotype microcytic anemia 237 6.33257e-20 2.554670960759494e-18 2.87815 102 0.005750691 1071 0.026482550579831933 1.414583 25 29 0.002184742 Mouse Phenotype abnormal lymph node cortex morphology 245 2.649375e-19 1.0339050765306123e-17 2.031441 197 0.01110673 913 0.016472566265060242 1.292843 52 66 0.004544263 Mouse Phenotype ruffled hair 259 1.341431e-18 4.951900305405405e-17 2.554593 116 0.006540001 883 0.014623078488108721 1.406499 30 35 0.00262169 Mouse Phenotype increased respiratory quotient 260 1.355077e-18 4.983035075769231e-17 2.161973 163 0.009189829 906 0.01619348469536424 1.318593 45 56 0.003932535 Mouse Phenotype chronic inflammation 269 4.74181e-18 1.685369717843866e-16 2.045099 180 0.01014828 998 0.021255061016032063 1.278949 53 68 0.004631653 Mouse Phenotype abnormal fetal derived definitive erythrocyte cell number 277 1.465444e-17 5.058162485198555e-16 3.249124 74 0.00417207 1181 0.03479271377476714 1.640916 11 11 0.0009612864