# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	37	4.572076e-61	1.6260526509189188e-58	2.325135	490	0.01605557	538	0.0006276904147769517	1.223624	100	113	0.00736377	
GO Biological Process	regulation of DNA-templated transcription in response to stress	42	2.365375e-58	7.410945148809524e-56	2.202337	525	0.0172024	474	0.00020054513107383966	1.231644	106	119	0.007805596	
GO Biological Process	endoplasmic reticulum unfolded protein response	68	5.046021e-51	9.764792696911765e-49	2.227694	446	0.01461385	528	0.0005190906493939395	1.225019	101	114	0.007437408	
GO Biological Process	cellular response to topologically incorrect protein	81	6.755842e-48	1.0975324059012346e-45	2.045687	509	0.01667813	443	0.00009064691511512415	1.223536	123	139	0.009057437	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	85	7.111772e-46	1.1009859735058824e-43	2.283247	379	0.01241849	331	0.0000018163455161631417	1.277235	109	118	0.00802651	
GO Biological Process	cellular response to unfolded protein	93	8.880969e-44	1.2566093663548387e-41	2.050726	461	0.01510534	509	0.0003740609914341847	1.222714	107	121	0.007879234	
GO Biological Process	cellular response to epidermal growth factor stimulus	116	3.233482e-37	3.6680508308620687e-35	2.286027	304	0.009961008	1009	0.03437987634786918	1.273535	35	38	0.00257732	
GO Biological Process	cotranslational protein targeting to membrane	121	1.36631e-36	1.4858903545454544e-34	2.246403	310	0.01015761	343	0.000002310192121778426	1.29804	92	98	0.006774669	
GO Biological Process	viral gene expression	122	2.379327e-36	2.5663577043442625e-34	2.056948	377	0.01235296	198	1.4788243703030303e-9	1.317371	121	127	0.008910162	
GO Biological Process	response to epidermal growth factor	126	4.320866e-36	4.512561563015873e-34	2.208926	317	0.01038697	1072	0.04770753714365671	1.25101	38	42	0.002798233	
GO Biological Process	protein targeting to ER	129	8.583109e-36	8.755436537286823e-34	2.194067	319	0.0104525	257	2.8361352049027238e-8	1.327935	97	101	0.007142857	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	157	7.52165e-33	6.304292506369427e-31	2.212884	286	0.009371211	298	3.174840136442953e-7	1.322578	88	92	0.006480118	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	164	5.320966e-32	4.269426316707317e-30	2.116183	308	0.01009207	781	0.00819436708834827	1.223153	69	78	0.005081001	
GO Biological Process	viral transcription	169	8.137146e-32	6.335899657633137e-30	2.019614	343	0.0112389	232	8.456620006034483e-9	1.321514	108	113	0.007952872	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	176	8.359312e-31	6.250010602727272e-29	2.153747	284	0.009305678	562	0.0008409411144839858	1.279509	62	67	0.004565538	
GO Biological Process	mitochondrial transmembrane transport	197	8.711229e-29	5.818835655380711e-27	2.064902	292	0.00956781	579	0.0011330923992918826	1.249423	75	83	0.005522828	
GO Biological Process	RNA phosphodiester bond hydrolysis, endonucleolytic	238	3.413585e-26	1.8873682779411763e-24	2.149796	240	0.007863954	1003	0.032386621176470586	1.20492	61	70	0.0044919	
GO Biological Process	snRNA metabolic process	262	4.939419e-24	2.480832619122137e-22	2.023981	253	0.008289918	288	2.1487052385069447e-7	1.334462	83	86	0.006111929	
GO Biological Process	mitochondrial translational termination	289	2.204613e-22	1.0038236147750864e-20	2.031978	232	0.007601822	243	1.6884383297942384e-8	1.350909	85	87	0.006259205	
GO Biological Process	mitochondrial translational elongation	304	5.599062e-22	2.4236202913815792e-20	2.030051	228	0.007470756	259	2.9036552866795364e-8	1.350161	83	85	0.006111929	
GO Cellular Component	large ribosomal subunit	46	3.400682e-31	1.2774735860869566e-29	2.03898	328	0.0107474	42	2.4080918400000003e-12	1.358648	113	115	0.00832106	
GO Cellular Component	mitochondrial ribosome	58	2.098222e-25	6.251254510344827e-24	2.225035	215	0.007044792	66	1.496310545454545e-8	1.350161	83	85	0.006111929	
GO Cellular Component	mitochondrial large ribosomal subunit	84	1.463068e-19	3.009739885714286e-18	2.402806	138	0.004521773	80	0.0000013998962160000002	1.382695	51	51	0.003755523	
GO Cellular Component	endoribonuclease complex	101	7.791852e-18	1.3331010154455445e-16	2.482681	117	0.003833677	232	0.04401379862068966	1.287337	27	29	0.001988218	
GO Cellular Component	nuclear ubiquitin ligase complex	117	6.232888e-16	9.205496123076924e-15	2.233522	128	0.004194109	234	0.0455739396923077	1.244426	36	40	0.002650957	
GO Cellular Component	ESCRT complex	158	3.346179e-12	3.659618551898734e-11	2.262063	92	0.003014516	188	0.012281346382978724	1.333313	27	28	0.001988218	
GO Molecular Function	unfolded protein binding	15	9.333261e-32	2.6270018628000004e-29	2.100333	311	0.01019037	132	0.009174853787878788	1.200075	92	106	0.006774669	
GO Molecular Function	rRNA binding	20	1.800982e-26	3.801873002e-24	2.645261	160	0.005242636	103	0.001829792255339806	1.290515	56	60	0.004123711	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	80	1.005037e-13	5.3040827674999996e-12	2.056426	131	0.004292408	160	0.026319354281250002	1.335016	28	29	0.002061856	
Human Phenotype	Abnormal CSF metabolite level	8	7.753757e-28	6.467602557625e-25	2.351292	211	0.006913726	82	0.00027358054915853656	1.316853	60	63	0.004418262	
Human Phenotype	Abnormality of mitochondrial metabolism	12	8.719835e-26	4.848954912916666e-23	2.05414	263	0.008617582	83	0.0003322516447108434	1.302539	65	69	0.004786451	
Human Phenotype	Abnormality of the mitochondrion	13	1.143113e-25	5.867686960769231e-23	2.037625	267	0.008748648	80	0.00020118661255000004	1.304797	67	71	0.004933726	
Human Phenotype	Increased CSF lactate	19	1.714231e-23	6.020559717368421e-21	2.288734	186	0.006094564	99	0.0009050313543434342	1.311176	55	58	0.004050074	
Mouse Phenotype Single KO	increased liver adenoma incidence	305	4.298868e-12	1.2906470254426228e-10	2.218293	95	0.003112815	345	0.04052492723768116	1.382695	20	20	0.001472754	
Mouse Phenotype	increased liver adenoma incidence	161	1.867236e-20	1.1088598382608697e-18	2.492404	135	0.004423474	286	0.0038058128811188814	1.382695	28	28	0.002061856	
Mouse Phenotype	abnormal hypoglossal nerve topology	272	3.703676e-15	1.3018693469117648e-13	2.504683	96	0.003145581	563	0.049609379770870335	1.382695	18	18	0.001325479